Chemoradiotherapy-induced Cytodifferentiation in Bladder/Prostate Rhabdomyosarcoma With Genetic Downregulation of Myogenin and MyoD1 Gene Expression: A Case Study and Review of the Literature.

Abstract:

:Rhabdomyosarcoma is the most common sarcoma diagnosed in childhood and adolescence, arising from the bladder/prostate in only 5%-10% of cases. Treatment-induced cytodifferention of tumor cells into mature rhabdomyoblasts has been reported following chemoradiation and is thought to suggest a more favorable outcome. We report a case of embryonal rhabdomyosarcoma of the bladder/prostate that exhibited extensive cytodifferentiation with downregulation of myogenin and MyoD1 gene expression in rhabdomyoblasts following treatment with chemoradiation therapy. The downregulation of myogenin and MyoD1 expression in rhabdomyoblasts following chemoradiation treatment has not previously been described in the literature and its significant remains uncertain.

journal_name

Urology

journal_title

Urology

authors

Agard H,Clark C,Massanyi E,Steele M,McMahon D

doi

10.1016/j.urology.2019.11.050

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

173-177

eissn

0090-4295

issn

1527-9995

pii

S0090-4295(20)30013-3

journal_volume

137

pub_type

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