Abstract:
:Rhabdomyosarcoma is the most common sarcoma diagnosed in childhood and adolescence, arising from the bladder/prostate in only 5%-10% of cases. Treatment-induced cytodifferention of tumor cells into mature rhabdomyoblasts has been reported following chemoradiation and is thought to suggest a more favorable outcome. We report a case of embryonal rhabdomyosarcoma of the bladder/prostate that exhibited extensive cytodifferentiation with downregulation of myogenin and MyoD1 gene expression in rhabdomyoblasts following treatment with chemoradiation therapy. The downregulation of myogenin and MyoD1 expression in rhabdomyoblasts following chemoradiation treatment has not previously been described in the literature and its significant remains uncertain.
journal_name
Urologyjournal_title
Urologyauthors
Agard H,Clark C,Massanyi E,Steele M,McMahon Ddoi
10.1016/j.urology.2019.11.050subject
Has Abstractpub_date
2020-03-01 00:00:00pages
173-177eissn
0090-4295issn
1527-9995pii
S0090-4295(20)30013-3journal_volume
137pub_type
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