Can biopsy be a reliable predictor of spatial distribution of prostate cancer? Comparison of a novel biopsy regimen with radical prostatectomy findings.


OBJECTIVES:To obtain accurate spatial information on cancer distribution with a novel prostate biopsy regimen. METHODS:From 2003 to 2005, 265 patients underwent a three fan-shaped biopsy (3FSB) technique of 12 to 14 cores and sextant biopsy (SB) simultaneously. When both techniques had positive findings, and radical prostatectomy was performed, the concordance among the positive biopsy locations of the SB, 3FSB, and the combination of both (the reference standard biopsy [RSB]), the proven locations of cancer, and the presence of extracapsular extension and positive surgical margins was calculated. RESULTS:A total of 41 patients were selected, and 74 locations (left and right apex, left and right lobe) had cancer. Of these, 61 were confirmed by RSB, 58 by 3FSB, and 43 by SB with a sensitivity of 95%, 78%, and 58%, respectively. The sensitivity at the apical location was consistently greater for the 3FSB at 68% (19 of 28) compared with 40% (11 of 28) for all proven apical positive localizations and 100% (19 of 19) compared with 58% (11 of 19) for the RSB. The receiver operating characteristic analysis showed 78% accuracy for 3FSB and 68% accuracy for SB compared with the RSB. At the apex, the 3FSB and SB revealed positive surgical margins with a sensitivity of 1 and 0.4, specificity of 0.067 and 0.4, positive predictive value of 0.263 and 0.182, and negative predictive value of 1 and 0.667, respectively. CONCLUSIONS:The 3FSB had a great ability to find cancer in the gland, especially at the apex.






Introini C,Naselli A,Vigliercio G,Spina B,Truini M,Puppo P




Has Abstract


2006-12-01 00:00:00
















  • Genitourinary injuries in pediatric all-terrain vehicle trauma--a mechanistic relationship?

    abstract:OBJECTIVES:To define and discuss the characteristics of all-terrain vehicle (ATV)-related pediatric (<16 years) genitourinary (GU) trauma. ATV collisions represent a significant and growing portion of trauma cases in rural America. ATV-related renal injuries have been reported in adults but a comprehensive review of AT...


    pub_type: 杂志文章


    authors: Kluemper C,Rogers A,Fallat M,Bernard AC

    更新日期:2010-05-01 00:00:00

  • Clinical and Radiographic Factors Associated With Failed Renal Angioembolization: Results From the Multi-institutional Genitourinary Trauma Study (Mi-GUTS).

    abstract:OBJECTIVE:To find clinical or radiographic factors that are associated with angioembolization failure after high-grade renal trauma. MATERIAL AND METHODS:Patients were selected from the Multi-institutional Genito-Urinary Trauma Study. Included were patients who initially received renal angioembolization after high-gra...


    pub_type: 杂志文章


    authors: Armas-Phan M,Keihani S,Agochukwu-Mmonu N,Cohen AJ,Rogers DM,Wang SS,Gross JA,Joyce RP,Hagedorn JC,Voelzke B,Moses RA,Sensenig RL,Selph JP,Gupta S,Baradaran N,Erickson BA,Schwartz I,Elliott SP,Mukherjee K,Smith BP,

    更新日期:2020-10-28 00:00:00

  • Radiotherapy for bladder cancer.

    abstract::The radiotherapy panel met to develop international consensus about the optimal use of radiotherapy, alone or in combination with surgery and chemotherapy, in the radical treatment of patients with bladder cancer. A consensus meeting of experts in the treatment of bladder cancer was convened by the Société Internation...


    pub_type: 杂志文章,评审


    authors: Milosevic M,Gospodarowicz M,Zietman A,Abbas F,Haustermans K,Moonen L,Rödel C,Schoenberg M,Shipley W

    更新日期:2007-01-01 00:00:00

  • Laparoscopic repair of spontaneous perforation of augmentation ileocystoplasty.

    abstract::Spontaneous perforation complicating augmentation cystoplasty is reported to occur in ≤ 13% of cases. The standard treatment is open surgical repair of the perforation. To our knowledge, this is the first report of laparoscopic repair of a perforated augmentation cystoplasty. ...


    pub_type: 杂志文章


    authors: Chang JI,Gilbourd D,Louie-Johnsun M

    更新日期:2013-02-01 00:00:00

  • Biological considerations in the assessment of urothelial cancer: a retrospective.

    abstract::In bladder cancer, variations in clinical course and treatment outcomes support the concept that the condition may comprise a compendium of different types of tumor diathesis with unique, albeit interrelated, pathways of development. This concept and the schema of developmental pathways of bladder cancer derived from ...


    pub_type: 杂志文章,评审


    authors: Droller MJ

    更新日期:2005-11-01 00:00:00

  • Patterns of inheritance and outcome in patients treated with external beam radiation for prostate cancer.

    abstract:OBJECTIVES:To evaluate biochemical outcome after definitive radiotherapy as a function of family history groupings. METHODS:Biochemical freedom from disease for 920 men treated for prostate cancer with external beam radiation alone between March 1987 and December 1997 was compared according to hereditary/familial hist...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hanlon AL,Hanks GE

    更新日期:1998-11-01 00:00:00

  • Analysis of the mechanism of discrepant nuclear morphometric results comparing preoperative biopsy and prostatectomy specimens.

    abstract:OBJECTIVES:To explore the mechanism for the differing nuclear morphometric results between needle biopsy and surgical specimens of the prostate. METHODS:In experiment 1, a comparison of mean nuclear area (MNA), volume-weighted mean nuclear volume (MNV), and form factor (FF) for prostatic epithelial cells was performed...


    pub_type: 杂志文章


    authors: Kanamaru H,Zhang YH,Takahashi M,Nakamura N,Ishida H,Akino H,Muranaka K,Okada K

    更新日期:2000-08-01 00:00:00

  • Dissemination of carcinoma: unusual complication of percutaneous nephrostomy.

    abstract::Percutaneous nephrostomy is a safe and highly effective means of urinary diversion. We report a case of unusual complications: severe peritonitis and massive intraperitoneal dissemination of carcinoma. ...


    pub_type: 杂志文章


    authors: Chiang MS,Wise HA 2nd

    更新日期:1985-04-01 00:00:00

  • Simultaneous thoracoscopic wedge resection of a solitary lung nodule and laparoscopic partial nephrectomy for a renal mass.

    abstract::Approximately 33% of patients with renal cell carcinoma will present with metastases. Patients have a reported 35% 5-year survival rate in instances in which nephrectomy and surgical resection of a solitary metastasis have been performed. Laparoscopic partial nephrectomy has become an increasingly viable option in the...


    pub_type: 杂志文章


    authors: Nelson BA,Sprunger JK,Ninan M,Herrell SD

    更新日期:2004-08-01 00:00:00

  • Transrectal ultrasound evaluation of local prostate cancer in patients treated with LHRH agonist and in combination with flutamide.

    abstract::We followed total prostate and prostatic tumor volumes in patients who received combination endocrine therapy with the antiandrogen flutamide and the LHRH agonist [D-Trp6,des-Gly-NH2(10)]LHRH ethylamide. Twenty-three men with proved prostatic adenocarcinoma (Stages B1 to D2) were subjected to a transrectal ultrasound ...


    pub_type: 杂志文章


    authors: Pinault S,Têtu B,Gagnon J,Monfette G,Dupont A,Labrie F

    更新日期:1992-03-01 00:00:00

  • Epidemiology of Traumatic Adrenal Injuries Requiring Surgery.

    abstract:OBJECTIVE:To analyze adrenal injuries using the National Trauma Data Bank. Adrenal trauma is rare and current literature is lacking in data from large case series. METHODS:A retrospective analysis of the National Trauma Data Bank from the years 2007-2011 was performed. Patient demographics, Injury Severity Score (ISS)...


    pub_type: 杂志文章


    authors: Raup VT,Eswara JR,Vetter JM,Brandes SB

    更新日期:2016-08-01 00:00:00

  • Urothelial cell platelet-activating factor production mediated by calcium-independent phospholipase A2γ.

    abstract:OBJECTIVES:To determine the effect of phospholipase A(2) (PLA(2)) inhibitors on urothelial cell platelet-activating factor (PAF) production in response to tryptase stimulation. METHODS:Urothelial cells isolated from normal human ureters were immortalized with the human papillomavirus type 16E6E7 cell line (TEU-2 cells...


    pub_type: 杂志文章


    authors: Rastogi P,Rickard A,Klumpp DJ,McHowat J

    更新日期:2011-01-01 00:00:00

  • Likelihood of tadalafil-associated adverse events in integrated multiclinical trial database: classification tree analysis in men with erectile dysfunction.

    abstract:OBJECTIVES:To identify the patient demographic factors, comorbidities, and concomitant medications associated with a change in the likelihood of tadalafil-associated adverse events (AEs) in men with erectile dysfunction. METHODS:Pooled safety data were analyzed from 3488 tadalafil-treated men who participated in 21 pl...


    pub_type: 杂志文章,多中心研究


    authors: Brock G,Glina S,Moncada I,Watts S,Xu L,Wolka A,Kopernicky V

    更新日期:2009-04-01 00:00:00

  • The protective effects of spirulina in cyclophosphamide induced nephrotoxicity and urotoxicity in rats.

    abstract:OBJECTIVE:To evaluate the role of Spirulina, a blue-green algae with antioxidant properties in the protection of cyclophosphamide-induced nephrotoxicity and hemorrhagic cystitis in rats. METHODS:The control group (C) was sacrificed 24 hours after being given a single dose of saline intraperitoneally (150 mg/kg) on the...


    pub_type: 杂志文章


    authors: Sinanoglu O,Yener AN,Ekici S,Midi A,Aksungar FB

    更新日期:2012-12-01 00:00:00

  • Changing trends in the American diet and the rising prevalence of kidney stones.

    abstract:OBJECTIVE:To evaluate the trends in the American diet over the last 40 years (1974-2010), during which time the National Health and Nutrition Examination Survey data set has documented an increase in stone prevalence from 3.8% to 8.8%. MATERIALS AND METHODS:We used the National Health and Nutrition Examination Survey ...


    pub_type: 杂志文章


    authors: De SK,Liu X,Monga M

    更新日期:2014-11-01 00:00:00

  • Multiple Reflex Pathways Contribute to Bladder Activation by Intraurethral Stimulation in Persons With Spinal Cord Injury.

    abstract:OBJECTIVE:To measure the urodynamic effects of electrical co-stimulation of 2 individual sites in the proximal and distal urethra in persons with spinal cord injury (SCI). This work was motivated by preclinical findings that selective co-stimulation of the cranial urethral sensory nerve and the dorsal genital nerve, wh...


    pub_type: 杂志文章


    authors: McGee MJ,Swan BD,Danziger ZC,Amundsen CL,Grill WM

    更新日期:2017-11-01 00:00:00

  • The Minimum Clinically Important Difference of the International Consultation on Incontinence Questionnaires (ICIQ-UI SF and ICIQ-LUTSqol).

    abstract:OBJECTIVE:To estimate the minimum clinically important difference (MCID) of the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-UI SF) and the International Consultation on Incontinence Questionnaire-Lower Urinary Tract Symptoms Quality of Life (ICIQ-LUTSqol) using both an...


    pub_type: 杂志文章,随机对照试验


    authors: Lim R,Liong ML,Lim KK,Leong WS,Yuen KH

    更新日期:2019-11-01 00:00:00

  • Accessory urethral-like channel in female child.

    abstract::The rare occurrence of an accessory urethral-like channel passing anterior to the pubis in a female child is reported. ...


    pub_type: 杂志文章


    authors: Redman JF,O'Donnell PD

    更新日期:1983-09-01 00:00:00

  • Prevalence of epididymal, seminal vesicle, prostate, and testicular cysts in autosomal dominant polycystic kidney disease.

    abstract:OBJECTIVES:To assess the prevalence of cysts in the epididymis, seminal vesicles, prostate, and testes of patients with autosomal dominant polycystic kidney disease (ADPKD) and determine their clinical significance. Extrarenal cystic involvement is a well-known manifestation of ADPKD. Although a few reports exist about...


    pub_type: 杂志文章,多中心研究


    authors: Belet U,Danaci M,Sarikaya S,Odabaş F,Utaş C,Tokgöz B,Sezer T,Turgut T,Erdoğan N,Akpolat T

    更新日期:2002-07-01 00:00:00

  • Extracorporeal shock-wave lithotripsy in horseshoe kidneys.

    abstract::Using the Dornier HM-3 lithotriptor, 10 patients (11 renal units) with calculi in horseshoe kidneys were treated with extracorporeal shock-wave lithotripsy (ESWL) and ancillary procedures. Six renal units (55%) underwent pre-ESWL manipulation consisting of a Double J stent, ureteral catheter, or percutaneous nephrosto...


    pub_type: 杂志文章


    authors: Locke DR,Newman RC,Steinbock GS,Finlayson B

    更新日期:1990-05-01 00:00:00

  • Complete Excision of Sacrocolpopexy Mesh With Autologous Fascia Sacrocolpopexy.

    abstract:OBJECTIVE:To evaluate the safety and short-term efficacy of complete sacrocolpopexy mesh excision with concomitant autologous fascia sacrocolpopexy. METHODS:A retrospective cohort study of patients undergoing complete sacrocolpopexy mesh excision and concomitant autologous fascia sacrocolpopexy from March 2013 to Sept...


    pub_type: 杂志文章


    authors: Oliver JL,Chaudhry ZQ,Medendorp AR,Wood LN,Baxter ZC,Kim JH,Raz S

    更新日期:2017-08-01 00:00:00

  • Identification of a novel transcript up-regulated in a clinically aggressive prostate carcinoma.

    abstract:OBJECTIVES:To identify differentially expressed genes in tumor cells of patients with prostate cancer by means of tissue microdissection and targeted differential display. METHODS:RNA was recovered from pure populations of microdissected normal epithelium and invasive tumor from frozen tissue sections of a radical pro...


    pub_type: 杂志文章


    authors: Chuaqui RF,Englert CR,Strup SE,Vocke CD,Zhuang Z,Duray PH,Bostwick DG,Linehan WM,Liotta LA,Emmert-Buck MR

    更新日期:1997-08-01 00:00:00

  • Pilot study of changes in stretched penile length 3 months after radical retropubic prostatectomy.

    abstract:OBJECTIVES:To evaluate changes in stretched penile length after radical retropubic prostatectomy (RRP) in a prospective penile measurement study because an occasional complaint from patients after RRP is that their penis is shortened. METHODS:Thirty-one patients undergoing RRP by one surgeon were enrolled. The same ph...


    pub_type: 杂志文章


    authors: Munding MD,Wessells HB,Dalkin BL

    更新日期:2001-10-01 00:00:00

  • Role of tamsulosin in treatment of patients with steinstrasse developing after extracorporeal shock wave lithotripsy.

    abstract:OBJECTIVES:To evaluate whether tamsulosin, as an alpha(1)-blocker, was effective for the treatment of steinstrasse in the lower ureter after shock wave lithotripsy. METHODS:A total of 67 patients (43 men and 24 women) with steinstrasse in the lower portion of the ureters were randomly divided into two groups. Only hyd...


    pub_type: 杂志文章,随机对照试验


    authors: Resim S,Ekerbicer HC,Ciftci A

    更新日期:2005-11-01 00:00:00

  • Renal failure after intravesical mitomycin C.

    abstract::Severe side effects, local or systemic, are uncommon with intravesically administered mitomycin C. Bladder fibrosis and contracture, with resultant renal failure, are unusual but possible. ...


    pub_type: 杂志文章


    authors: Farha AJ,Krauss DJ

    更新日期:1989-10-01 00:00:00

  • Renal rhabdomyosarcoma in a pancake kidney.

    abstract::Renal rhabdomyosarcoma (RMS) is a rare pediatric tumor. Pancake kidneys are unusual anatomic anomalies resulting when both upper and lower poles of the embryonic kidney become fused. We report on a 4-year-old boy who was discovered to have a stage 4, group IV renal embryonal RMS arising from a pancake kidney with meta...


    pub_type: 杂志文章


    authors: Walther A,Cost NG,Garrison AP,Geller JI,Alam S,Tiao GM

    更新日期:2013-08-01 00:00:00

  • Laparoscopic retroperitoneal lymph node dissection: duplication of open technique.

    abstract::Laparoscopic retroperitoneal lymph node dissection has been used to stage germ cell testicular cancer. Since its initial description, this minimally invasive procedure has evolved into a therapeutic operation that adheres to established strict oncologic principles. A modified template dissection that fully duplicates ...


    pub_type: 杂志文章


    authors: Allaf ME,Bhayani SB,Link RE,Schaeffer EM,Varkarakis JM,Shadpour P,Lima G,Kavoussi LR

    更新日期:2005-03-01 00:00:00

  • Tape mobilization for urinary retention after tension-free vaginal tape procedures.

    abstract:OBJECTIVES:To evaluate the efficacy of transvaginal tape mobilization as a method of treating urinary retention after tension-free vaginal tape (TVT) procedures, and secondly to evaluate the time to resumption of voiding function after TVT procedures. METHODS:Postoperative voiding function and the 1-year continence st...


    pub_type: 杂志文章


    authors: Nguyen JN

    更新日期:2005-09-01 00:00:00

  • Testicular extrusion due to scrotoschisis.

    abstract::We present the eighth case of testicular extrusion through a congenital defect in the scrotal wall, along with a review of the published reports and a discussion of its possible embryogenesis. ...


    pub_type: 杂志文章


    authors: Togami J,Radhakrishnan J

    更新日期:2002-12-01 00:00:00

  • Ulcerative and nonulcerative forms of bladder pain syndrome/interstitial cystitis do not differ in symptom intensity or response to onabotulinum toxin A.

    abstract:OBJECTIVE:To determine whether intratrigonal Onabotulinum toxin A (OnabotA) injection produces a different symptomatic outcome and duration of effect on ulcerative (Ulc) and nonulcerative (NUlc) bladder pain syndrome/interstitial cystitis (BPS/IC) patients and to compare the urinary levels of neurotrophines (NGF, BDNF,...


    pub_type: 杂志文章


    authors: Pinto R,Lopes T,Costa D,Barros S,Silva J,Silva C,Cruz C,Dinis P,Cruz F

    更新日期:2014-05-01 00:00:00