Clinical stage I nonseminomatous germ cell tumors of testis. Observation vs retroperitoneal lymph node dissection.


:Between 1980 and 1989, 186 patients with testicular tumors were seen at Roswell Park Memorial Institute. Of these, 66.6 percent (124/186) were diagnosed to have nonseminomatous germ cell tumors (NSGT) and 22 percent (41/186) were clinically determined to have Stage I disease. Patients with clinical Stage I NSGT either underwent observation or retroperitoneal lymph node dissection (RPLND). Recurrence in the observation group of patients was 23.5 percent (4/17) between four and eighteen months (mean 10 months) with the retroperitoneum being the most common site. All but 1 patient (80%) were salvaged with platinum-based combination chemotherapy. Of the 24 patients who had RPLND, 21 percent (5/24) had a false-negative metastatic evaluation. All the patients who had surgically documented metastatic disease were successfully treated with chemotherapy. The similar recurrence rates in the observation group and the false-negative RPLND group suggest that the failure rate in the observation group is a result of the inability to stage accurately patients with NSGT. RPLND continues to be the standard therapy in patients with clinical Stage I disease. Despite its high recurrence rate, observation should, however, be offered to well-motivated and selected patients since salvage platinum-based combination chemotherapy is very effective and the majority of patients in this group are spared a major operative procedure.






Sujka SK,Huben RP




Has Abstract


1991-07-01 00:00:00
















  • Androgen receptor as a target in androgen-independent prostate cancer.

    abstract::Prostate cancer is dependent on androgen stimulation mediated by the androgen receptor (AR), a member of the steroid hormone receptor family of ligand-dependent nuclear receptors. Most patients respond to standard androgen ablation therapies, but virtually all patients eventually relapse with disease that has been ter...


    pub_type: 杂志文章,评审


    authors: Balk SP

    更新日期:2002-09-01 00:00:00

  • Holmium laser enucleation of prostate: outcome and complications of self-taught learning curve.

    abstract:OBJECTIVES:To analyze the self-learning curve of a single surgeon with holmium laser enucleation of the prostate and to evaluate the safety, effectiveness, and outcome of the procedure after 2 years of experience. METHODS:The data from the first 125 patients who underwent holmium laser enucleation of the prostate were...


    pub_type: 杂志文章


    authors: Placer J,Gelabert-Mas A,Vallmanya F,Manresa JM,Menéndez V,Cortadellas R,Arango O

    更新日期:2009-05-01 00:00:00

  • Correlation of presumed circle area ratio with infravesical obstruction in men with lower urinary tract symptoms.

    abstract:OBJECTIVES:To examine the predictive value of ultrasonic measurements obtained by transrectal ultrasonography for infravesical obstruction as evaluated by pressure flow studies. METHODS:In 85 men with moderate to severe lower urinary tract symptoms, ultrasonic measurements including prostatic volume, transition zone v...


    pub_type: 临床试验,杂志文章


    authors: Kojima M,Ochiai A,Naya Y,Ukimura O,Watanabe M,Watanabe H

    更新日期:1997-10-01 00:00:00

  • Long-term Outcomes of Robot-assisted Laparoscopic Pyeloplasty for Ureteropelvic Junction Obstruction.

    abstract:OBJECTIVE:To describe the long-term outcomes of robot-assisted laparoscopic pyeloplasty (RALP) for the correction of ureteropelvic junction (UPJ) obstruction. METHODS:A retrospective electronic medical record review of RALPs from October 2002 to July 2014 was performed, with additional follow-up for patients released ...


    pub_type: 杂志文章


    authors: Hopf HL,Bahler CD,Sundaram CP

    更新日期:2016-04-01 00:00:00

  • A modified ureteroileal anastomosis technique for Bricker urinary diversion.

    abstract:OBJECTIVE:Up to 10% of patients who have undergone the Bricker ileal conduit urinary diversion may develop ureteroileal anastomotic complications that are more frequently associated with the left side ureter. We have therefore modified the standard Bricker ileal conduit technique to minimize the anastomotic complicatio...


    pub_type: 杂志文章


    authors: Li Y,Zhuang Q,Hu Z,Wang Z,Zhu H,Ye Z

    更新日期:2011-11-01 00:00:00

  • The Feasibility and Impact of a Presurgical Exercise Intervention Program (Prehabilitation) for Patients Undergoing Cystectomy for Bladder Cancer.

    abstract:OBJECTIVE:To assess the feasibility of a prehabilitation program for cystectomy patients and to determine the effectiveness of the program in improving strength and functional capacity in the peri-operative period. MATERIALS AND METHODS:This phase I/II study accrued patients ≥60 years old from January 2013 to October ...


    pub_type: 杂志文章


    authors: Kaye DR,Schafer C,Thelen-Perry S,Parker C,Iglay-Reger H,Daignault-Newton S,Qin Y,Morgan TM,Weizer AZ,Kaffenberger SD,Herrel LA,Hafez KS,Lee CT,Skolarus TA,Englesbe MJ,Montgomery JS

    更新日期:2020-11-01 00:00:00

  • Peripheral blood steroid levels in Cushing syndrome due to adrenocortical carcinoma or adenoma.

    abstract::Measurement of the peripheral vein levels of the steroids in the adrenal biosynthetic pathway affords a further possible definitive method of differentiating adrenocortical carcinoma from adrenal adenoma in the presence of Cushing syndrome. In patients with adrenal carcinoma the blood levels of 17-hydroxyprogesterone,...


    pub_type: 杂志文章


    authors: Gabrilove JL,Freiberg EK,Nicolis GL

    更新日期:1983-12-01 00:00:00

  • Long-term Clinical Efficacy and Safety Profile of Transurethral Resection of Prostate Versus Plasmakinetic Resection of the Prostate for Benign Prostatic Hyperplasia.

    abstract:OBJECTIVE:To investigate the differences on clinical efficacy, complications, and safety profile between transurethral resection of the prostate (TURP) and bipolar plasmakinetic resection of the prostate (PKRP) for benign prostatic hyperplasia (BPH). PATIENTS AND METHODS:Six hundred ninety patients of BPH were recruit...


    pub_type: 杂志文章


    authors: Liu Z,Li YW,Wu WR,Lu Q

    更新日期:2017-05-01 00:00:00

  • Pudendal Nerve Identified on Sectioned Images of Female Cadaveric Pelvis.

    abstract:OBJECTIVE:To provide an anatomical atlas made of serially sectioned images of a female cadaver that clearly demonstrated the pudendal nerve. MATERIALS AND METHODS:The courses of the pudendal nerve, internal pudendal artery, and internal pudendal vein were observed on the sectioned images of a female cadaver. The spati...


    pub_type: 杂志文章


    authors: Choi BJ,Chung MS,Chung BS

    更新日期:2020-08-01 00:00:00

  • Unexpected response of hormone-refractory prostate cancer to treatment with an antileukemic chemotherapy regimen.

    abstract::Our patient was a 61-year-old man with hormone-refractory prostate cancer and a rapidly rising serum prostate-specific antigen level. During the course of therapy for prostate cancer, abnormal blood counts and subsequent bone marrow biopsy led to a diagnosis of acute lymphoblastic leukemia. He was treated with a chemo...


    pub_type: 杂志文章


    authors: Gandhok N,Sartor O

    更新日期:2004-10-01 00:00:00

  • Relationship between body mass index and quantitative 24-hour urine chemistries in patients with nephrolithiasis.

    abstract:OBJECTIVES:To examine the relationship between body mass index and 24-hour urine constituents in a population of stone-forming patients. METHODS:A total of 880 patients who presented to a metabolic stone clinic for initial evaluation were analyzed. Patients were stratified by gender and divided into quartiles of body ...


    pub_type: 杂志文章


    authors: Eisner BH,Eisenberg ML,Stoller ML

    更新日期:2010-06-01 00:00:00

  • Racial disparity in outcomes of a clinical trial population with metastatic renal cell carcinoma.

    abstract:OBJECTIVES:Population studies have revealed that black Americans with renal cell carcinoma (RCC) have a shorter survival than do white Americans. Differences in socioeconomic status and treatment are frequently cited as the reasons for this disparity. The effect of these social obstacles may be reduced by studying a pa...


    pub_type: 杂志文章


    authors: Tripathi RT,Heilbrun LK,Jain V,Vaishampayan UN

    更新日期:2006-08-01 00:00:00

  • Finasteride effects on hypoxia and angiogenetic markers in benign prostatic hyperplasia.

    abstract:OBJECTIVES:To assess the effects of finasteride on angiogenetic and hypoxia markers in benign prostatic hyperplasia. METHODS:A total of 178 patients aged 51 to 85 years (mean 68.7) with benign prostatic hyperplasia and awaiting transurethral prostate resection were prospectively randomized into a group of patients rec...


    pub_type: 杂志文章,随机对照试验


    authors: Lekas AG,Lazaris AC,Chrisofos M,Papatsoris AG,Lappas D,Patsouris E,Deliveliotis C

    更新日期:2006-08-01 00:00:00

  • Urinary solute transport by gastric mucosa: a comparison with ileum using a rat model.

    abstract:OBJECTIVES:This study was conducted to quantitate and compare urinary solute transport by stomach and ileum using an in vivo rat model. METHODS:An artificial urine solution was perfused through isolated gastric and ileal segments in the anesthetized rat. Concentrations of solutes and a volume marker were periodically ...


    pub_type: 杂志文章


    authors: Brandell RA,Scaletscky R,Koch MO

    更新日期:1994-09-01 00:00:00

  • Activated Akt prevents antitumor activity of gefitinib in renal cancer cells.

    abstract:OBJECTIVES:To investigate the mechanism of gefitinib resistance in renal cell carcinoma (RCC) cells. Although epidermal growth factor receptor (EGFR) is frequently overexpressed in RCC, gefitinib, a tyrosine kinase inhibitor of EGFR, has only a limited antitumor effect on RCC. METHODS:The effects of gefitinib on the a...


    pub_type: 杂志文章


    authors: Kuroda K,Horiguchi A,Sumitomo M,Asano T,Ito K,Hayakawa M,Asano T

    更新日期:2009-07-01 00:00:00

  • Evaluation of Sacks solution for hypothermic preservation of kidneys.

    abstract::The efficacy of Sacks solution for hypothermic preservation of dog kidneys was determined. Complete ischemia was produced in one kidney for thirty minutes by clamping the renal pedicle in situ, followed by excision and immediate washout with the cold preservation fluid. Kidneys were stored in Sacks solution at 2 degre...


    pub_type: 杂志文章


    authors: Welch LT,Redman JF,Seager LD

    更新日期:1975-11-01 00:00:00

  • Uncovering a Novel Stone in 27 Patients: Calcium Tartrate Tetrahydrate.

    abstract:OBJECTIVE:To further analyze calcium tartrate tetrahydrate stones after a recent case report described this novel stone. Prior to this, there was only one previously reported occurrence of this stone in a human. This unusual stone composition is not tested for routinely. True prevalence and possible causes of this ston...


    pub_type: 杂志文章


    authors: Kleinguetl C,Williams JC Jr,Lieske JC,Daudon M,Rivera ME,Jannetto PJ,Bornhorst J,Rokke D,Bird ET,Lingeman JE,El Tayeb MM

    更新日期:2019-04-01 00:00:00

  • Compartment syndrome: an unusual complication of the lithotomy position.

    abstract::The compartment syndrome is a rare complication of surgery in the lithotomy position, but one that may result in neurovascular damage and permanent disability. Herein, we present a case of bilateral three-compartment syndrome following urethroplasty in the dorsolithotomy position, with review of the literature and dis...


    pub_type: 杂志文章,评审


    authors: Moses TA,Kreder KJ,Thrasher JB

    更新日期:1994-05-01 00:00:00

  • Measuring patients' expectations regarding health-related quality-of-life outcomes associated with prostate cancer surgery or radiotherapy.

    abstract:OBJECTIVES:Establishing realistic health-related quality-of-life (HRQOL) expectations before the choice of cancer treatment is made is an important goal of patient counseling. We prospectively studied the pretreatment expectations of prostate cancer-specific HRQOL with an adapted Expanded Prostate Cancer Index Composit...


    pub_type: 杂志文章


    authors: Symon Z,Daignault S,Symon R,Dunn RL,Sanda MG,Sandler HM

    更新日期:2006-12-01 00:00:00

  • Tubularized incised plate repair for penoscrotal hypospadias: role of surgeon's experience.

    abstract:OBJECTIVE:To give a retrospective analysis of factors affecting outcome of tubularized incised plate (TIP) repair for penoscrotal hypospadias. METHODS:Data of all patients who underwent TIP repair for penoscrotal hypospadias by a single surgeon were retrieved. Follow-up was carried out every 3 months within the first ...


    pub_type: 杂志文章


    authors: Hafez AT,Helmy T

    更新日期:2012-02-01 00:00:00

  • Cavernous hepatic hemangioma simulating metastatic renal cell carcinoma.

    abstract::A case of cavernous hemangioma of the liver resembling a metastatic deposit is reported in a patient with renal cell carcinoma. The clinical and angiographic features that distinguish hepatic hemangiomas from metastatic renal cell carcinoma are discussed. The importance of this distinction in patient management is emp...


    pub_type: 杂志文章


    authors: Gore RM,Bernstein JR,Crampton AR,Graham JB

    更新日期:1980-09-01 00:00:00

  • Urodynamic studies in interstitial cystitis.

    abstract::Urodynamics, although not diagnostic of IC, are useful in the differential diagnosis of painful voiding disorders and provide a convenient way to quantitate response to therapy. They may prove useful as prognostic indicators of response to treatment and are of value in those patients in whom surgery is considered. Our...


    pub_type: 杂志文章


    authors: Perez-Marrero R,Emerson L,Juma S

    更新日期:1987-04-01 00:00:00

  • A learning package for medical students in a busy urology department: design, implementation, and evaluation.

    abstract:OBJECTIVES:The need for innovation in the delivery of quality teaching and learning for undergraduates in urology is driven by a number of factors. An increasing proportion of care is delivered in ambulatory settings, hospital inpatients are increasingly unwell, and the National Health Service staff must find a balance...


    pub_type: 杂志文章


    authors: Owen LE,Byrne DJ,Ker JS

    更新日期:2008-11-01 00:00:00

  • Lower moiety hydronephrosis in duplicated kidneys.

    abstract::Because of the high incidence of lower pole reflux in complete duplications, decreased, delayed, or absent function in a hydronephrotic lower pole moiety is usually initially attributed to reflux nephropathy. Obstruction occurs commonly in the upper pole moiety due to an ectopic ureteral orifice or ureterocele. Howeve...


    pub_type: 杂志文章


    authors: Amis ES Jr,Cronan JJ,Pfister RC

    更新日期:1985-07-01 00:00:00

  • Safety and efficacy of holmium laser resection for primary nonmuscle-invasive bladder cancer versus transurethral electroresection: single-center experience.

    abstract:OBJECTIVES:To assess the safety and efficacy of holmium laser resection for primary, clinically nonmuscle-invasive, bladder cancer (HoLRBT) compared with standard transurethral resection of bladder tumor (TURBT). METHODS:The data from a total of 212 consecutive patients with primary nonmuscle-invasive bladder cancer w...


    pub_type: 杂志文章


    authors: Zhu Y,Jiang X,Zhang J,Chen W,Shi B,Xu Z

    更新日期:2008-09-01 00:00:00

  • Prevalence of baseline chronic kidney disease in patients presenting with solid renal tumors.

    abstract:OBJECTIVES:To evaluate the prevalence of baseline chronic kidney disease (CKD) in a large cohort of patients presenting with renal masses to a tertiary care center, comparing serum creatinine (sCr) and estimated glomerular filtration rate (eGFR). sCr inadequately reflects renal function. eGFR and chronic kidney disease...


    pub_type: 杂志文章


    authors: Canter D,Kutikov A,Sirohi M,Street R,Viterbo R,Chen DY,Greenberg RE,Uzzo RG

    更新日期:2011-04-01 00:00:00

  • Seminal oxidative stress in patients with chronic prostatitis.

    abstract:OBJECTIVES:An association between prostatitis and male infertility has been suspected, yet is poorly understood. Prostatitis is often associated with granulocytes in the prostatic fluid that generate reactive oxygen species (ROS), known to impair male fertility. We compared ROS, the total antioxidant capacity (TAC), an...


    pub_type: 杂志文章


    authors: Pasqualotto FF,Sharma RK,Potts JM,Nelson DR,Thomas AJ,Agarwal A

    更新日期:2000-06-01 00:00:00

  • Observation After Cytoreductive Nephrectomy in Patients With Synchronous Not Completely Resected Metastases of Renal Cell Carcinoma.

    abstract:OBJECTIVE:To determine the time-to-targeted therapy (TTT) in patients with not completely resected low-volume oligometastatic disease who were observed following debulking cytoreductive nephrectomy (CN) for metastatic renal cell carcinoma (mRCC). METHODS:Patients with synchronous mRCC with not completely resected low-...


    pub_type: 杂志文章


    authors: de Bruijn RE,Kuusk T,Noe AP,Blank CU,Haanen JBAG,Hendricksen K,Horenblas S,Bex A

    更新日期:2017-11-01 00:00:00

  • Long-term follow-up after epididymectomy for chronic epididymal pain.

    abstract:OBJECTIVES:Epididymectomy is an option for the relief of epididymal pain related to postoperative obstruction, epididymal cysts, or epididymitis. We performed 66 epididymectomies on 52 patients from 1996 to 2006 at our institution for localized epididymal pain. We evaluated the long-term symptomatic relief after epidid...


    pub_type: 杂志文章


    authors: Siu W,Ohl DA,Schuster TG

    更新日期:2007-08-01 00:00:00

  • Renal plasmacytoma: Mayo Clinic experience and review of the literature.

    abstract::Extramedullary plasmacytoma arising in the kidney is rare. Only 8 cases have been reported. Recently, we noted the ninth case, the second case seen at the Mayo Clinic. Clinically, the tumor mimics a renal cell carcinoma or a transitional cell carcinoma of the renal pelvis. ...


    pub_type: 杂志文章,评审


    authors: Igel TC,Engen DE,Banks PM,Keeney GL

    更新日期:1991-04-01 00:00:00