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Antiandrogen withdrawal syndrome with cyproterone acetate.

Abstract：

OBJECTIVES:To determine whether the antiandrogen withdrawal syndrome occurs with the steroidal antiandrogen cyproterone acetate. METHODS:Cyproterone acetate was withheld in 12 patients with progressing androgen-independent metastatic prostate cancer. Eight patients had been receiving cyproterone acetate concomitant with androgen ablation, and in 4 patients it was prescribed after failure of androgen suppression. Time to response and to disease progression were defined by serum prostate-specific antigen (PSA) levels and imaging studies. RESULTS:PSA levels decreased in 5 of the 1 2 patients; in 4 of them (33%), the decrease exceeded 50%. The decline lasted a median of 24 weeks (range 9 to 37.8). All 5 patients had received initial concomitant exposure to androgen ablation and cyproterone acetate. CONCLUSIONS:We recommend that the steroidal antiandrogen cyproterone acetate be added to the list of agents capable of inducing antiandrogen withdrawal syndrome.

journal_name

Urology

journal_title

Urology

authors

Sella A,Flex D,Sulkes A,Baniel J

doi

10.1016/s0090-4295(98)00354-9

subject

Has Abstract

pub_date

1998-12-01 00:00:00

pages

1091-3

issue

6

eissn

0090-4295

issn

1527-9995

pii

S0090429598003549

journal_volume

52

pub_type

临床试验,杂志文章

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