Abstract:
OBJECTIVE:To offer recommendations on identification of disease progression, treatment management strategies, and suggestions on timing of initiating and discontinuing specific castration-resistant prostate cancer (CRPC) treatments. MATERIALS AND METHODS:The Prostate Cancer Radiographic Assessments for Detection of Advanced Recurrence II Working Group convened to provide guidance on sequencing, combination, or layering of approved treatments for metastatic CRPC based on available data and clinical experience. RESULTS:A consensus was developed to address important questions on management of patients with metastatic CRPC. CONCLUSION:In the absence of large-scale clinical trials, the Working Group recommends that patients may best be managed with a layered approach of approved therapies with unique or complimentary mechanisms of action.
journal_name
Urologyjournal_title
Urologyauthors
Crawford ED,Petrylak DP,Shore N,Saad F,Slovin SF,Vogelzang NJ,Keane TE,Koo PJ,Gomella LG,O'Sullivan JM,Tombal B,Concepcion RS,Sieber P,Stone NN,Finkelstein SE,Yu EY,Prostate Cancer Radiographic Assessments for Detection odoi
10.1016/j.urology.2016.12.033subject
Has Abstractpub_date
2017-06-01 00:00:00pages
150-159eissn
0090-4295issn
1527-9995pii
S0090-4295(16)31023-8journal_volume
104pub_type
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