Abstract:
OBJECTIVES:To investigate the effects of terazosin and melatonin on isolated rabbit bladder strips after partial bladder outlet obstruction and determine responses to agonist-induced contractility and changes in oxidant-antioxidant system. METHODS:We created partial bladder outlet obstruction in 5 groups of rabbits, each containing 8. Rabbits with sham operation (group 1) received no drug treatment. Similarly, animals in group 2 underwent partial bladder outlet obstruction and received no drug treatment. Rabbits in groups 3 were administered 5 mg/day oral terazosin, and rabbits in group 4 received 10 mg/kg/day melatonin intraperitoneally. Animals in group 5 received both terazosin and melatonin. We removed their bladders and performed histopathological and biochemical measurements. We assessed tissue malondialdehyde and antioxidant enzyme activity levels and recorded in vitro contractility response to KCl in isolated organ baths. RESULTS:The thickness of muscularis propria was significantly increased in group 2 compared with all other groups. KCl-evoked contractions after partial outlet obstruction were significantly impaired in group 3 and 4 animals receiving terazosin and melatonin, respectively. However, combined use of melatonin and terazosin in group 5 showed contractility responses similar to sham-operated animals (P <0.05). Melatonin administration to groups 4 and 5 showed decreased levels of lipid peroxidation. Similarly, animals receiving melatonin and melatonin plus terazosin showed statistically significant increase in antioxidant enzyme activities. CONCLUSIONS:In the present study, we showed that oxidative stress induced by partial bladder outlet obstruction can be successfully antagonized by the potent antioxidant melatonin, and its combined use with an alpha-antagonist such as terazosin may restore in vitro contractility.
journal_name
Urologyjournal_title
Urologyauthors
Onur R,Tasdemir C,Seckin D,Ilhan N,Kutlu S,Akpolat Ndoi
10.1016/j.urology.2008.02.053subject
Has Abstractpub_date
2008-08-01 00:00:00pages
439-43issue
2eissn
0090-4295issn
1527-9995pii
S0090-4295(08)00268-9journal_volume
72pub_type
杂志文章相关文献
UROLOGY文献大全abstract::We report a case of congenital intrathoracic kidney, a rare developmental anomaly, which may present as an asymptomatic posterior mediastinal mass. The evaluation of such lesions can be performed expeditiously with computed tomography and obviate the need for any further clinical studies or operation. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(83)90359-x
更新日期:1983-07-01 00:00:00
abstract::Primary urethral carcinoma is an uncommon diagnosis, and carcinomas arising from within a urethral diverticulum are rare. Because of the limited number of diagnosed cases, optimal treatment guidelines are not available. However, patients require an aggressive treatment approach to provide the best chance for cure. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(02)02407-x
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVES:To report experience with 100 robot-assisted partial nephrectomy (RAPN) operations performed at our institution. Nephron-sparing surgery is an established treatment for patients with small renal masses. The laparoscopic approach has emerged as an alternative to open nephron-sparing surgery, but it is recogni...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2009.10.040
更新日期:2010-06-01 00:00:00
abstract::Long-term analyses of the UroLume Endoprosthesis have shown conflicting results with regard to efficacy and restricture rates. The best management of recurrent urethra stricture disease at the site of a previous UroLume stent is unknown. We describe a previously unreported technique for transperineal excision of the U...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2005.08.038
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVES:To assess the efficacy of tramadol and lidocaine in reducing pain using the periprostatic nerve block technique with a spinal needle, guided by transrectal ultrasound (TRUS) before the biopsy application. METHODS:Of the 112 eligible candidates who were asked to participate in the study, 90 agreed and provid...
journal_title:Urology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.urology.2011.03.010
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVES:A recent Best Practice Statement published by the American Urological Association (AUA) recommends that antibiotic therapy in patients undergoing midurethral synthetic slings (MUS) should be 24 hours or less. Subjects at our institution are routinely administered a single dose of intravenous antibiotics befo...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2010.05.038
更新日期:2010-10-01 00:00:00
abstract::The surgical riks were analyzed in 305 patients with end stage renal failure who underwent bilateral nephrectomy through midabdominal approach in preparation for kidney transplantation. The over-all mortality rate was 3.6 per cent. Age was the most significant risk factor in the mortality. Patients less than fifty yea...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(78)90367-9
更新日期:1978-07-01 00:00:00
abstract:OBJECTIVES:Preoperative prostate-specific antigen (PSA) velocity (PSAV), the rate of PSA rise preceding diagnosis, predicts for relapse and cancer death after prostatectomy or radiotherapy. We studied the timing, cutoff levels, and method of calculation to better define its usefulness. METHODS:The rates of biochemical...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2007.01.019
更新日期:2007-04-01 00:00:00
abstract::A total of 311 patients who underwent consecutive transurethral resection of prostate (TURP) for obstructive voiding symptoms were reviewed. All patients had benign prostate glands by digital rectal examination. Results of preoperative ultrasound screening of the prostate in 65 of 311 patients showed 41 with nonmalign...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(93)90113-o
更新日期:1993-06-01 00:00:00
abstract::A seventy-seven-year-old female with progressive abdominal sighs for twenty-four hours was found to have had a spontaneous rupture of the renal pelvis with massive urinary extravasation. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(76)90504-5
更新日期:1976-10-01 00:00:00
abstract::A murine transitional cell carcinoma tumor model has been used to evaluate the combined use of radiotherapy and three chemotherapeutic agents, doxorubicin hydrochloride (Adriamycin), cyclophosphamide, and cis-diamminedichloroplatinum. The preliminary radiation therapy evaluation demonstrated that the tumor is radiosen...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(79)90212-7
更新日期:1979-07-01 00:00:00
abstract:OBJECTIVES:To estimate the acceptance rate on peer-reviewed journals, describe the time-course of subsequent full publication, and identify those with characteristics associated with publication from the abstracts presented at the Societè Internationale d'Urologie (SIU) meeting. METHODS:All abstracts accepted for pres...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2007.11.028
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVES:Peripheral primitive neuroectodermal tumor (PNET) is a highly aggressive neoplasm belonging to the Ewing family of tumors. It is characterized by the expression of MIC2 and neural markers (eg, neuron-specific enolase, synaptophysin, S-100, vimentin, Leu-7), and the presence of the EWS-FLI1 translocation. ME...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/j.urology.2006.02.037
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVE:To prospectively review our experience with extravesical robotic-assisted laparoscopic ureteral reimplantation to determine whether postoperative voiding dysfunction can be avoided with pelvic plexus visualization and to assess the efficacy of this approach for the treatment of vesicoureteral reflux (VUR). M...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2011.10.052
更新日期:2012-03-01 00:00:00
abstract::We report a case of symptomatic hypercalcemia in a patient with muscle-invasive, resectable squamous cell carcinoma of the bladder. Serum parathyroid hormone was consistent with secretion of parathyroid hormone-related protein. After radical cystoprostatectomy, calcium levels returned to normal. Patients with squamous...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(97)00638-9
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVE:To determine the effect of preoperative ureteral stenting on success rates of ureteroscopy (URS) for nephroureterolithiasis. MATERIALS AND METHODS:We retrospectively evaluated patients who underwent URS for nephroureterolithiasis without preoperative indwelling ureteral stents. These patients were matched ac...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2012.06.064
更新日期:2012-12-01 00:00:00
abstract::Nephrogenic adenoma of the bladder, which has been associated with either a chronic infection or severe trauma to the bladder, occurred in a six-year-old girl apparently secondary to urologic surgery. It was also a possible cause of enuresis. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(76)90472-6
更新日期:1976-03-01 00:00:00
abstract:OBJECTIVES:The maximal effect of transurethral microwave thermotherapy (TUMT) for lower urinary tract symptoms (LUTS) of benign prostatic hyperplasia (BPH) occurs 3 to 6 months after treatment. In the acute period after TUMT, little change in symptoms, quality of life (QOL), and peak urinary flow rate (Qmax) is observe...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(99)00029-1
更新日期:1999-07-01 00:00:00
abstract:OBJECTIVE:To retrospectively analyze the effects of treatment duration on outcomes of everolimus treatment of patients in the RAD001 Expanded-Access Clinical Trial in RCC (REACT) program. METHODS:Patients with metastatic renal cell carcinoma refractory to vascular endothelial growth factor receptor-tyrosine kinase inh...
journal_title:Urology
pub_type: 临床试验,杂志文章
doi:10.1016/j.urology.2012.09.019
更新日期:2013-01-01 00:00:00
abstract::Sacral neuromodulation (SNM) has been used off-label in the United States for over a decade in the pediatric population. Many published studies have demonstrated efficacy with SNM in this population; however, a significant number of children with refractory bowel bladder dysfunction (BBD) also have underlying comorbid...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2016.03.006
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:To present our experience of vaginal reconstruction in female cloacal exstrophy patients. PATIENTS AND METHODS:The records of 7 postpubertal female cloacal exstrophy patients (median age, 17 years; range, 11-26 years) were retrospectively reviewed. Complete duplication of the uterus and vagina was noted in a...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2014.05.042
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVES:To evaluate biochemical outcome after definitive radiotherapy as a function of family history groupings. METHODS:Biochemical freedom from disease for 920 men treated for prostate cancer with external beam radiation alone between March 1987 and December 1997 was compared according to hereditary/familial hist...
journal_title:Urology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0090-4295(98)00398-7
更新日期:1998-11-01 00:00:00
abstract::Large-burden bladder stones often require percutaneous cystolithotomy or an open procedure. These approaches may not be feasible in certain patients who are at increased risk of operative complications. We present a novel technique for transurethral cystolitholapaxy using Amplatz sheath in the male urethra. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2004.07.022
更新日期:2004-11-01 00:00:00
abstract::We analyzed 31 patients who underwent intravenous urograms (IVU) and radionuclide renal scans (RNRS) in the investigation of blunt abdominal trauma, and compared the IVU to the RNRS in the definition of blunt renal injuries, and their correlation with patients' symptoms and signs. Thirteen patients had abnormal IVU an...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(89)90162-3
更新日期:1989-07-01 00:00:00
abstract:OBJECTIVES:To conduct a preliminary investigation on statin use and its impact on clinical presentation and biochemical progression-free survival after brachytherapy. METHODS:A total of 512 consecutive patients were treated with permanent brachytherapy for clinical Stage T1c-T3aNxM0 prostate cancer at least 3 years be...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2005.08.053
更新日期:2005-12-01 00:00:00
abstract::Metanephric adenoma is an extremely rare renal tumor and, even more infrequently, is centrally located. Herein we summarize a series of images concerning a central metanephric adenoma in a female adult successfully treated with laparoscopic nephron-sparing surgery. The patient presented with no symptoms but was found ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2012.04.035
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVES:Multiple trials have shown the high specificity of urine prostate cancer gene 3 (PCA3) compared with serum prostate-specific antigen (PSA) for biopsy detection of prostate carcinoma. We characterized the patterns of use of PCA3 by community urologists and determined the performance of PCA3 testing as a labor...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2008.08.459
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVES:To ascertain the potential utility of magnetic resonance imaging in providing additional clarification of those solid renal mass lesions identified at routine antenatal ultrasonography in early pregnancy and influencing the management of such lesions. METHODS:We present 7 patients in whom magnetic resonance...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2008.07.050
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:To examine our short-term experience of antegrade continence enema (ACE) delivered via a Chait Trapdoor (Cook Medical, Bloomington, IN) in adults with intractable neurogenic bowel. METHODS:We performed a retrospective review at the Universities of Utah and Minnesota of 15 patients with Chait Trapdoor placed ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2014.01.023
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE:To measure past active surveillance (AS) adoption rates, institute the best practice, and measure the AS adoption rates following implementation. We report our findings over a 3-year period. METHODS:Patient prostate needle biopsy and treatment data from the period August 2011 to August 2014 were retrieved fr...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2015.11.053
更新日期:2016-07-01 00:00:00