Abstract：
:A murine transitional cell carcinoma tumor model has been used to evaluate the combined use of radiotherapy and three chemotherapeutic agents, doxorubicin hydrochloride (Adriamycin), cyclophosphamide, and cis-diamminedichloroplatinum. The preliminary radiation therapy evaluation demonstrated that the tumor is radiosensitive. The combined use of cyclophosphamide and radiation therapy was the most effective regimen, especially when the drug was started prior to radiotherapy. Cis-diamminedichloroplatinum and radiation were a lethal combination, but a synergistic effect was produced when the drug was given after completion of radiotherapy. Doxorubicin hydrochloride and radiotherapy may be synergistic, but more evaluation is necessary.
journal_name
Urologyjournal_title
Urologyauthors
Weldon TE,Kursh E,Novak LJ,Persky Ldoi
10.1016/0090-4295(79)90212-7subject
Has Abstractpub_date
1979-07-01 00:00:00pages
47 52issue
1eissn
0090-4295issn
1527-9995pii
0090-4295(79)90212-7journal_volume
14pub_type
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