Abstract:
OBJECTIVES:To examine the safety, efficacy, and tolerability of tolterodine in four randomized, double-blind, parallel, multicenter, 12-week studies of patients with overactive bladder. METHODS:Two of the four studies compared tolterodine (2 mg twice daily) to oxybutynin (5 mg three times daily) and placebo, one study compared tolterodine (2 mg twice daily) to oxybutynin (5 mg three times daily), and one study compared two dosages of tolterodine (1 and 2 mg twice daily) to placebo. Efficacy was determined from micturition diaries and patient perception of their bladder condition. Safety and tolerability were assessed from adverse events and laboratory measures. RESULTS:A total of 1,120 patients were randomized and treated at 134 centers. For the primary efficacy variable, the number of micturitions/24 hours, pooled results showed a significant decrease from baseline for the 1 mg tolterodine (P < 0.001), 2 mg tolterodine (P < 0.001), and 5 mg oxybutynin (P < 0.01) groups, compared to placebo. Both tolterodine doses and oxybutynin significantly decreased incontinence episodes/24 hours and significantly increased volume voided/micturition, compared to placebo. Tolterodine at a dose of 2 mg twice daily and 5 mg oxybutynin twice daily were significantly more effective in improving patient perception of bladder condition than placebo. Tolterodine at a dose of 2 mg and 5 mg oxybutynin were equivalent in their effectiveness. Tolterodine at doses of 1 mg and 2 mg were tolerated significantly better than oxybutynin when adverse events, dry mouth (both frequency and intensity), dose reductions, and patient withdrawals were considered. CONCLUSIONS:Although oxybutynin is highly effective, its clinical utility is limited by systemic side effects that lead to frequent discontinuation of treatment or dose reductions. Patients receiving tolterodine should not experience these limitations and instead will get safe and long-term effective treatment for their condition.
journal_name
Urologyjournal_title
Urologyauthors
Appell RAdoi
10.1016/s0090-4295(97)00599-2subject
Has Abstractpub_date
1997-12-01 00:00:00pages
90-6; discussion 97-9issue
6A Suppleissn
0090-4295issn
1527-9995pii
S0090-4295(97)00599-2journal_volume
50pub_type
临床试验,杂志文章,多中心研究,随机对照试验相关文献
UROLOGY文献大全abstract::We report a rare case of primary epithelial bladder tumor in a thirteen-year-old boy. Histologically, the tumor was that of a solitary and papillary transitional cell carcinoma, grade 1. This tumor was detectable at cystoscopic examination, and cytologic procedures were without benefit for a diagnosis. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(92)90274-z
更新日期:1992-02-01 00:00:00
abstract::High-pressure chronic retention (HPCR) is a well-recognized common urological emergency which requires prompt treatment. It usually presents with nocturnal enuresis, a tense and palpable bladder, and symptoms of uraemia from renal failure George et al 1983.1 There have been isolated cases in the literature of HPCR pre...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2020.04.038
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVES:To evaluate the effectiveness and morbidity of salvage brachytherapy for locally recurrent or persistent prostate cancer after radiotherapy failure. METHODS:In this retrospective study, 49 patients of median age 73.3 years (range 52.9 to 86.9) with biopsy-proven localized prostate cancer underwent interacti...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(98)00492-0
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the safety and efficacy of 1.9 µm Vela laser in treatment of primary non-muscle-invasive bladder cancer. METHODS:The data of the patients with non-muscle-invasive bladder cancer treated by either en bloc transurethral resection with 1.9 µm Vela laser (n = 26) or conventional transurethral resect...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2017.11.030
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVES:To compare the stone-free rate and complications between horseshoe and normal kidneys. METHODS:Between December 1997 and June 2008, a total of 2401 patients with 2618 renal units underwent percutaneous nephrolithotomy (PCNL). During this period, we retrospectively reviewed the data of 46 patients with 50 (1...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2009.08.054
更新日期:2010-05-01 00:00:00
abstract:INTRODUCTION:Efforts continue to develop techniques that maintain the neurovascular bundles and minimize trauma for robotic laparoscopic radical prostatectomy. We evaluated the feasibility of preserving the nerve bundles without cautery or surgical clips. TECHNICAL CONSIDERATIONS:The seminal vesicles were dissected us...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2004.11.023
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVES:To examine the prevalence, characteristics, and impact of sexual dysfunction in our primary care referral population. METHODS:Participants seeking treatment for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) were recruited from general urology clinics. The subjects completed the National Institu...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2007.08.043
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the practical application and limitation of ultrasonography and retrograde urethrography in detecting prostatic utricle associated with hypospadias. METHODS:Between 1995 and 1999, 80 patients with hypospadias, 1 month to 16 years of age (mean age 3 years, 6 months), underwent ultrasonography and...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(01)00954-2
更新日期:2001-06-01 00:00:00
abstract::MicroRNAs (miRNA) are a class of naturally occurring, small, noncoding RNAs that function as specific repressors of protein-encoding genes, being pivotal regulators of development and cellular homeostasis. They have been functionally classified as proto-oncogenes or tumor suppressors and are aberrantly expressed in di...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/j.urology.2010.03.012
更新日期:2010-09-01 00:00:00
abstract::Epidermal growth factor (EGF), a potent mitogen and tumor promoter, is excreted in urine permitting it to incubate with urothelial cells. We have previously shown that the distribution of receptors for EGF (EGF-Rs) on malignant urothelium changes to favor contact between EGF-Rs and intraluminal EGF. OBJECTIVES. To det...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(94)80047-2
更新日期:1994-10-01 00:00:00
abstract:OBJECTIVE:To compare pressure, dilation, and histology in a porcine model after stenting with a pigtail suture stent (PSS)-where the ureteral and bladder component consists of a suture and a double J (DJ) stent. METHODS:Twelve pigs were studied with a PSS (4.8F/MiniJFil®) and DJ stent (4.8F/RocaJJ Soft) inserted in bo...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2020.11.031
更新日期:2020-11-27 00:00:00
abstract::Human semen containing normal number of sperm was exposed to concentrations of Escherichia coli varying from 500 to 10-8 colonies per cubic centimeter. A significant decrease in motility was abserved at 10-6 colonies per cubic centimeter. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(75)90116-8
更新日期:1975-05-01 00:00:00
abstract:OBJECTIVE:To quantify the effective radiation dose associated with the evaluation and follow-up of patients with urolithiasis. METHODS:Retrospective review was performed for consecutive patients presenting to a tertiary stone clinic with acute stone episodes between November 2007 and December 2008, and had at least 2 ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2011.07.1387
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVES:To identify a population of patients within the group with positive surgical margins after radical prostatectomy who would benefit in terms of improved local control of disease by the administration of adjuvant radiation therapy to the prostate bed. METHODS:Postoperative prostate-specific antigen (PSA) valu...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(99)80422-1
更新日期:1996-02-01 00:00:00
abstract::This is the first reported case of recurrent stress urinary incontinence secondary to dislodged bone-anchoring screws. A 71-year-old man who had undergone successful bone-anchored sling placement for post-prostatectomy incontinence, presented with recurrent stress urinary incontinence after a bout of coughing. Pelvic ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2008.01.030
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVES:To identify the patient demographic factors, comorbidities, and concomitant medications associated with a change in the likelihood of tadalafil-associated adverse events (AEs) in men with erectile dysfunction. METHODS:Pooled safety data were analyzed from 3488 tadalafil-treated men who participated in 21 pl...
journal_title:Urology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.urology.2008.10.058
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To describe and compare the management of WT and oncologic outcomes by patient age using a large national database. METHODS:The National Cancer Database was queried for patients with WT diagnosis from 2004 to 2013. Patients were grouped by age and compared: pediatric (<16 years), young adults (16-35 years) a...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2019.10.007
更新日期:2020-01-01 00:00:00
abstract::Alveolar rhabdomyosarcoma is an aggressive cancer that can metastasize to a variety of organs. We present what we believe to be the first reported case of metastatic intratesticular rhabdomyosarcoma in a patient presenting with testicular pain shortly after the induction of systemic chemotherapy. The published data re...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2007.02.023
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVE:To describe a novel technique for localizing small testicular mass during testicular-sparing surgery (TSS). METHODS AND RESULTS:A 20-year-old man presented with bilateral testicular masses. Both alpha-fetoprotein (AFP) and beta-human chorionic gonadotropin (BHCG) levels were raised. Clinical and imaging stud...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2012.10.077
更新日期:2013-04-01 00:00:00
abstract::The choice of anesthesia during thermal therapy of the prostate plays a significant role in the morbidity profile, patient convenience, and cost. We report 39 men with symptomatic benign prostatic hyperplasia who underwent transurethral needle ablation of the prostate under transperineal prostatic block. This method o...
journal_title:Urology
pub_type: 杂志文章,多中心研究
doi:10.1016/s0090-4295(00)00836-0
更新日期:2000-12-20 00:00:00
abstract::In patients with complete disruption of the membranous urethra treated initially with placement of a suprapubic cystostomy, delayed synchronous retrograde and voiding cystourethrograms failed to demonstrate accurately the distance between the two urethral ends. Radiographic exposure obtained during synchronous instrum...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(87)90500-0
更新日期:1987-04-01 00:00:00
abstract::A subfertile male with a history of left cryptorchism underwent scrotal ultrasound that revealed stippled calcifications, without associated mass, in the right testicle. Six months later, while on a regimen of clomiphene citrate, a testicular tumor became palpable. This was sonographically confirmed to be surrounding ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(90)80202-x
更新日期:1990-12-01 00:00:00
abstract:OBJECTIVE:To report an alternative form of management of a persistent lymphocele that was unresponsive to percutaneous drainage and ethanol sclerotherapy. METHODS:Herein is described the technique of dilating the previously established percutaneous drainage tract to facilitate insertion of a flexible ureteroscope. Thr...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(94)90091-4
更新日期:1994-03-01 00:00:00
abstract:OBJECTIVE:To highlight the feasibility and technical details of performing simultaneous ipsilateral pyeloplasty and ureteric re-implantation for simultaneous proximal and distal obstruction of the ureter. METHODS:Two patients with preoperative diagnosis of proximal and distal ureteric obstruction underwent robot-assis...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2020.01.020
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:Up to 10% of patients who have undergone the Bricker ileal conduit urinary diversion may develop ureteroileal anastomotic complications that are more frequently associated with the left side ureter. We have therefore modified the standard Bricker ileal conduit technique to minimize the anastomotic complicatio...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2011.07.001
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:To present the results of a new technique for abdominoplasty in patients with the Prune Belly syndrome (PBS). METHODS:Since 1985, 46 children with PBS underwent surgical treatment that included urinary tract reconstruction (UTR), orchidopexy, and abdominoplasty. In 41 patients, we performed the abdominoplast...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2013.09.031
更新日期:2014-02-01 00:00:00
abstract::One hundred patients with surgical Stage D1 (TXN + M0) adenocarcinoma of the prostate underwent pelvic lymphadenectomy and radical retropubic prostatectomy and were followed up for one-half to fifteen and one-half years. Forty-eight patients received "adjuvant" hormonal or radiation (or both) treatment; all patients w...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(84)90415-1
更新日期:1984-08-01 00:00:00
abstract:OBJECTIVE:To define how the learning curve for success in ultrasound-guided percutaneous nephrolithotomy (PCNL) is impacted by body mass index (BMI). Previous research has shown ultrasound-guided PCNL to be an effective method of nephrolithiasis treatment comparable to fluoroscopy-guided PCNL. A common concern for the ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2018.07.033
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:To determine if prostatic inflammation at the time of radical prostatectomy (RP) was associated with the International Prostate Symptom Score (IPSS). METHODS:We performed a proof of principle analytic case control study of patients who underwent RP between January 2005 and August 2008 for lower urinary tract...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2013.07.080
更新日期:2014-01-01 00:00:00
abstract::Urinary incontinence in pediatric and adolescent patients has been successfully managed with the artificial urinary sphincter for several decades. Placement of the sphincter can be difficult in the preadolescent girl due to poorly developed vaginal tissue that can result in difficulty establishing the surgical plane b...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(99)00277-0
更新日期:1999-11-01 00:00:00