Abstract：
OBJECTIVES:To investigate the impact of health status on androgen levels in men and to assess the age-related changes in androgen levels. METHODS:Sera were obtained from 526 men (age 20 to 89 years) participating in a health screening project and 35 men selected according to the SENIEUR protocol, which excludes those with underlying disease. The health screening project participants were divided into two groups: healthy men (n = 133; group 1) and the remainder (n = 393; group 2). The total testosterone and sex hormone-binding globulin levels were quantified, and the amount of free testosterone (cfT) was calculated. RESULTS:The lowest annual declines in androgen level were observed in group 3 (testosterone 0.2%; cfT 0.4%), followed by group 1 (testosterone 0.4%; cfT 0.8%) and group 2 (testosterone 0.8%; cfT 0.9%). Body mass index and levels of cholesterol, triglycerides, and glucose correlated negatively (P <0.01) with testosterone and cfT. Decade-adjusted reference values (mean +/- 2 standard deviations) for testosterone and cfT were defined. The proposed lower testosterone reference value declined gradually from 3.1 ng/mL (20 to 29 years) to 1.7 ng/mL (70 years or older). CONCLUSIONS:In this cross-sectional study, serum androgens declined in aging men, and the extent of this decrease correlated with health status. A fixed, non-age-adjusted reference value does not adequately reflect this and might lead to a false diagnosis of androgen deficiency, particularly in elderly men. The clinical value of age-related reference values, however, needs to be determined in prospective studies.
journal_name
Urologyjournal_title
Urologyauthors
Schatzl G,Madersbacher S,Temml C,Krenn-Schinkel K,Nader A,Sregi G,Lapin A,Hermann M,Berger P,Marberger Mdoi
10.1016/s0090-4295(02)02252-5subject
Has Abstractpub_date
2003-03-01 00:00:00pages
629-33issue
3eissn
0090-4295issn
1527-9995pii
S0090429502022525journal_volume
61pub_type
杂志文章相关文献
UROLOGY文献大全abstract：OBJECTIVE:To determine whether African Americans (AAs) with intermediate- to high-risk prostate cancer (PCa) receive similar treatment as white patients and whether any observed disparities are narrowing with time. METHODS:We used Surveillance, Epidemiology, and End Results to identify 128,189 men with localized inter...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2014.05.009
更新日期：2014-08-01 00:00:00
abstract：OBJECTIVE:To investigate the role of contemporary minilaparoscopy (ML; 3 mm instruments and laparoscope) and to identify predictive factors for complications in a prospective multicenter series for renal and adrenal surgeries. MATERIALS AND METHODS:From July 2013 to December 2014, 110 patients from 6 laparoscopic Span...
journal_title：Urology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.urology.2016.02.048
更新日期：2016-06-01 00:00:00
abstract：:A simple technique for performing the vascular anastomoses in renal transplantation is presented. It utilizes ipsilateral side-to-end vascular anastomoses using the external iliac arteries and punch anastomoses. Using this method, transplantation of kidneys is simplified despite short, multiple, or unequal caliber of ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(84)90205-x
更新日期：1984-10-01 00:00:00
abstract：:Lymphoepithelioma-like carcinoma is an undifferentiated epithelial tumor with a prominent lymphocytic infiltrate and is rarely seen in the upper urinary tract. Only 3 and 2 cases involving the ureter and renal pelvis, respectively, have been reported. We report the fourth documented case of lymphoepithelioma-like carc...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/j.urology.2005.05.038
更新日期：2005-11-01 00:00:00
abstract：:Vesicourethral suspension operations fail (1) when preoperative evaluation is insuffcient, leading to improper selection of patients; and (2) for technical reasons when anatomy is uncorrected (suture malplacement, suture breakage, and failure to release adhesions) or when anatomy is corrected (periurethral fibrosis, f...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(79)90149-3
更新日期：1979-08-01 00:00:00
abstract：OBJECTIVES:To evaluate the efficacy and safety of phosphodiesterase-5 (PDE-5) inhibitors for treating lower urinary tract symptoms secondary to benign prostatic hyperplasia. METHODS:Randomized controlled trials were identified and extracted from MEDLINE, Embase, Cochrane Central, and relevant reference lists. The data...
journal_title：Urology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.urology.2010.07.508
更新日期：2011-01-01 00:00:00
abstract：OBJECTIVES:Tissue-specific expression is of key importance in gene therapy and can be achieved by using tissue-specific promoters to drive therapeutic gene expression. The uroplakin (UP) promoter is a powerful tool for bladder cancer gene therapy, but the role of UP protein in the bladder remains unknown. This study ai...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2007.11.128
更新日期：2008-08-01 00:00:00
abstract：OBJECTIVES:Delay in treatment of testis cancer (TC) has a proven negative impact on disease stage, treatment outcome, and mortality. Poor public awareness of the disease and lack of testis self-examination (TSE) may account for late presentation. The aim of this study was to examine the knowledge of TC and performance ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2010.03.022
更新日期：2010-10-01 00:00:00
abstract：OBJECTIVE:To give a retrospective analysis of factors affecting outcome of tubularized incised plate (TIP) repair for penoscrotal hypospadias. METHODS:Data of all patients who underwent TIP repair for penoscrotal hypospadias by a single surgeon were retrieved. Follow-up was carried out every 3 months within the first ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2011.10.033
更新日期：2012-02-01 00:00:00
abstract：OBJECTIVES:To study the values of the renal resistive index (RI) before and at different points after relief of obstructive anuria and to correlate these values with the corresponding values of serum creatinine and with the recovery of renal function after release of obstruction. METHODS:A total of 32 consecutive pati...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(01)01623-5
更新日期：2002-04-01 00:00:00
abstract：:We review the literature about the impact of shock wave lithotripsy (SWL) on male reproduction. Studies investigating the in vitro effect of shock waves on semen samples indicate that spermatozoa are vulnerable to SWL. According to animal studies, intratesticular bleeding is common, but pregnancy rates are not affecte...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/j.urology.2011.12.003
更新日期：2012-03-01 00:00:00
abstract：OBJECTIVES:To explore the roles of pain and urgency in the nocturia of patients with interstitial cystitis/painful bladder syndrome (IC/PBS). METHODS:In a longitudinal study of incident IC/PBS cases, we assessed the associations of the presence and severity of nocturia with the presence and severity of pain and urgenc...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2011.02.012
更新日期：2011-06-01 00:00:00
abstract：:We report the case of a 56-year-old man who in a motor vehicle collision developed a pelvic fracture and complete urethra rupture. Sudden onset of intermittent severe urethral bleeding occurred and it led to life-threatening blood pressure drop and dyspnea. An angiography of internal iliac artery showed a pseudoaneury...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2013.08.016
更新日期：2013-12-01 00:00:00
abstract：:Metastasis of gastric carcinoma to the ureter is very rare. In most published cases, the diagnosis is only made at postmortem examination or when gross metastasis is present. This report presents a case in which the metastasis occluded the ureteral lumen from inside, and the diagnosis was made by histopathologic exami...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(99)00169-7
更新日期：1999-09-01 00:00:00
abstract：OBJECTIVE:To report survival for patients who undergo urinary diversion for benign indications and to identify risk factors for morbidity at 90 days. METHODS:This is a retrospective review of consecutive urinary diversions with or without cystectomy for non-oncological indications at a single institution. The indicati...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2017.05.061
更新日期：2018-01-01 00:00:00
abstract：:To plan the treatment of carcinoma of the bladder correctly accurate knowledge of the morphology and degree of infiltration of the tumor is essential. Double contrast cystography and polycystography are radiologic techniques that can provide such information. Hitherto, these two procedures have been performed separate...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(77)90201-1
更新日期：1977-02-01 00:00:00
abstract：OBJECTIVES:To correlate the clinical outcomes of 148 patients with clear cell renal carcinoma treated at a single institution with a variety of other factors. METHODS:Cases were derived from a consecutive series of nephrectomy specimens obtained from 1980 to 1994. A retrospective review of clinical records was perform...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(99)00408-2
更新日期：2000-01-01 00:00:00
abstract：OBJECTIVES:To describe the normal values for nocturnal urine production and its determinants, as well as the relation between nocturnal urine production and voiding frequency. METHODS:Data were collected from 1688 men aged 50 to 78 years without bladder or prostate cancer, radical prostatectomy, neurogenic bladder dys...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(02)01818-6
更新日期：2002-10-01 00:00:00
abstract：OBJECTIVE:To analyze differences in length of stay, opioid use, and other perioperative outcomes in patients undergoing radical cystectomy with urinary diversion who received either liposomal bupivacaine (LB) or epidural analgesia. METHODS:This was a single center, retrospective cohort study of patients undergoing ope...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2020.11.036
更新日期：2020-12-03 00:00:00
abstract：OBJECTIVE:To examine hospital-level variation in outcomes following benign urologic surgeries given that hospital-level variation in surgical outcomes can portend quality and appropriateness of care concerns and identify quality improvement opportunities in perioperative care. MATERIALS AND METHODS:Using the Washingto...
journal_title：Urology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.urology.2015.07.067
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVES:To investigate the expression of endothelin-1 (ET-1) and adrenomedullin (ADM) in the renal pelvis, stenotic ureteropelvic junction, and ureter of 20 male Wistar rats with congenital unilateral ureteropelvic junction obstruction; the normal contralateral kidneys served as controls. The molecular pathophysiolo...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2003.07.019
更新日期：2004-01-01 00:00:00
abstract：:We carried out an analysis of the United States Renal Data System to determine the incidence, risk factors and prognosis of renal cell carcinoma (RCC) in a national population of patients receiving incident long-term dialysis. In Cox regression, male gender, older age, end-stage renal disease caused by obstruction, tu...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/j.urology.2011.01.007
更新日期：2011-06-01 00:00:00
abstract：:The efficacy of treating carcinoma of the prostate with levodopa (L-dopa), a known inhibitor of prolactin secretion, has been tested in 11 Stage D patients who were refractory to conventional modalities. Relief of bone pain and recovery of mobility was excellent in 6, fair in 2, questionable in 1, and nonexistent in 2...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(77)90034-6
更新日期：1977-07-01 00:00:00
abstract：:The management of clinically localized renal masses suspicious for renal cell carcinoma varies, partially because of gaps in the evidence base. We conducted a systematic review to summarize research gaps for the evaluation of composite models for predicting malignancy; use of percutaneous renal sampling for diagnosis;...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/j.urology.2016.08.013
更新日期：2016-12-01 00:00:00
abstract：:Divided, or so-called kissing nevi of the penis, which are separated during embryogenesis, are very rare, with only seven studies reported to date. We present a case of a 30-year-old patient with a divided nevus located at the penis that rapidly changed in size and color within 4 months. These clinical features and th...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2006.11.015
更新日期：2007-02-01 00:00:00
abstract：OBJECTIVE:To report the functional results of continent cutaneous ileal urinary diversion using modified W-pouch with non-isolated extra limb for continence. PATIENTS AND METHODS:From January 2013 to January 2016, 21 patients with muscle-invasive bladder cancer with median (interquartile range) of 59 (56.5-62.5) years...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2017.04.006
更新日期：2017-07-01 00:00:00
abstract：:In this study, the cytologic diagnosis obtained by transrectal fine needle prostatic aspiration was compared to the histologic diagnosis obtained by prostatic needle biopsy or transurethral prostatic resection. Confirmation of all diagnoses occurred 91 per cent of the time: 96 per cent with benign prostatic hyperplasi...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(82)90044-9
更新日期：1982-01-01 00:00:00
abstract：:Prostate-specific antigen (PSA) testing could be used to identify men who are at higher future risk of developing clinical prostate cancer or to diagnose prostate cancer earlier in high-risk groups, such as black men or those with a family history of the disease. These cohorts then could be offered chemopreventive cli...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(00)00967-5
更新日期：2001-04-01 00:00:00
abstract：:We report a case of testicular teratocarcinoma involving the inferior vena cava with extension to the right atrium and metastases to the tricuspid valve. We believe this to be the first such reported case. ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(92)90392-a
更新日期：1992-10-01 00:00:00
abstract：OBJECTIVE:To improve the understanding of the epidemiology of renal cortical neoplasms through pretreatment biopsy, we evaluated a facilitated ultrasound targeting (FUT) technology. The technology allows a needle to be passed through the transducer probe and guided along a virtual dotted line on the monitor. We compare...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2013.05.029
更新日期：2013-09-01 00:00:00
