当前位置： SCI文献检索 > UROLOGY期刊下所有文献 > Congenital unilateral ureteropelvic junction obstruction of the rat: a useful animal model for human ureteropelvic junction obstruction?

Congenital unilateral ureteropelvic junction obstruction of the rat: a useful animal model for human ureteropelvic junction obstruction?

Abstract：

OBJECTIVES:To investigate the expression of endothelin-1 (ET-1) and adrenomedullin (ADM) in the renal pelvis, stenotic ureteropelvic junction, and ureter of 20 male Wistar rats with congenital unilateral ureteropelvic junction obstruction; the normal contralateral kidneys served as controls. The molecular pathophysiology of congenital ureteropelvic junction obstruction is still unclear. The implication of altered peptidergic innervation is under discussion. Our study group has recently been able to demonstrate a significant increase in ET-1 and a significant decrease in ADM in prestenotic and stenotic tissue, but not in the remainder of the ureter, compared with controls. METHODS:Twenty animals were killed, and samples of the renal pelvis, ureteropelvic junction, upper ureter, middle part of the ureter, and lower ureter were immediately snap-frozen and stored in liquid nitrogen. Total RNA was extracted, and subsequently 1 microg of RNA was reversely transcribed. mRNA expression of ET-1 and ADM was determined semiquantitatively using on-line polymerase chain reaction. The expression of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was determined to relate the specific mRNA expression to the expression of a housekeeping gene. RESULTS:We found a significant increase in the expression of ET-1 in the obstructed junctions related to GAPDH (P <0.001). The expression of ADM, however, revealed no statistically significant differences. No differences at all could be detected in the tissue samples from the rest of the ureter. CONCLUSIONS:Alterations in the local production of peptidergic neurotransmitters, especially ET-1, may contribute to the molecular pathogenesis of ureteropelvic junction obstruction. Results previously obtained in the stenotic tissue from children were confirmed in the stenotic tissue from the rat model. We hypothesize that the alterations are disease-, but not age-specific.

journal_name

Urology

journal_title

Urology

authors

Miller J,Hesse M,Diemer T,Haenze J,Knerr I,Rascher W,Weidner W

doi

10.1016/j.urology.2003.07.019

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

190-4

issue

1

eissn

0090-4295

issn

1527-9995

pii

S0090429503008835

journal_volume

63

pub_type

杂志文章

相关文献

UROLOGY文献大全
  • Urinary diversion in patients with spinal cord injury in the United States.

    abstract：OBJECTIVE:To describe the patterns in the use of bladder augmentation and urinary diversion to manage urologic sequelae among patients with spinal cord injury in the United States. MATERIALS AND METHODS:Discharge estimates were derived from the Nationwide Inpatient Sample. All patients underwent bladder augmentation o...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2012.06.063

    authors： Peterson AC,Curtis LH,Shea AM,Borawski KM,Schulman KA,Scales CD Jr

    更新日期：2012-12-01 00:00:00

  • Incidence of high-grade prostatic intraepithelial neoplasia in sextant needle biopsy specimens.

    abstract：OBJECTIVES:There is scant literature on the frequency of high-grade prostatic intraepithelial neoplasia (PIN) in needle biopsy specimens. These data have implications as to how often pathologists should be expected to diagnose these lesions on needle biopsy and impact on the feasibility of cancer chemoprevention trials...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/S0090-4295(96)00622-X

    authors： Wills ML,Hamper UM,Partin AW,Epstein JI

    更新日期：1997-03-01 00:00:00

  • Preclinical evaluation of PDS (polydioxanone) synthetic absorbable suture vs chromic surgical gut in urologic surgery.

    abstract：:A variety of suture materials are available for use in urologic surgery. Urologists have relied on absorbable suture materials which provide transient strength in anticipation that healing will occur before the suture is absorbed. Absorbable sutures thus decrease the chance of stone formation, known to occur on suture...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/0090-4295(87)90303-7

    authors： Cohen EL,Kirschenbaum A,Glenn JF

    更新日期：1987-10-01 00:00:00

  • Urological Surveillance and Medical Complications after Spinal Cord Injury in the United States.

    abstract：OBJECTIVE:To evaluate the national patterns of urologic follow up after spinal cord injury (SCI) and the occurrence and predictors of urological complications. MATERIALS AND METHODS:This retrospective cohort study used a 5% sample of Medicare data 2007-2010. The minimum adequate urologic surveillance was defined as a ...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2015.06.005

    authors： Cameron AP,Lai J,Saigal CS,Clemens JQ,NIDDK Urological Diseases in America Project.

    更新日期：2015-09-01 00:00:00

  • Incidence and level of seminal reactive oxygen species in normal men.

    abstract：OBJECTIVES:Excessive formation of reactive oxygen species (ROS) in human semen has been associated with impaired sperm function and fertility potential. The presence of ROS in semen specimens from normal fertile men emphasizes the importance of defining a normal range of ROS formation. The purpose of this study was to ...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/s0090-4295(95)97088-6

    authors： Shekarriz M,Thomas AJ Jr,Agarwal A

    更新日期：1995-01-01 00:00:00

  • Saw palmetto (Serenoa repens) in men with lower urinary tract symptoms: effects on urodynamic parameters and voiding symptoms.

    abstract：OBJECTIVES:To assess the effects of saw palmetto on voiding symptoms and urodynamic parameters in men with lower urinary tract symptoms (LUTS) presumed secondary to benign prostatic hyperplasia (BPH). METHODS:Fifty men with previously untreated LUTS and a minimum International Prostate Symptom Score (IPSS) of 10 or gr...

    journal_title：Urology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0090-4295(98)00143-5

    authors： Gerber GS,Zagaja GP,Bales GT,Chodak GW,Contreras BA

    更新日期：1998-06-01 00:00:00

  • Urinary calculous disease in Southeast Asian immigrants.

    abstract：:Recent immigrants from Southeast Asia accounted for 39 of 149 hospital admissions for treatment of urinary tract stones. Presumptive diagnosis of a urinary calculus was possible in only 19 per cent of the refugees compared with 60 per cent of other patients treated at the same hospital (p less than 0.005). Calculi in ...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/0090-4295(86)90041-5

    authors： Ireton RC,Krieger JN,Mason JT,Ansell JS

    更新日期：1986-09-01 00:00:00

  • Nonclosure Versus Closure of Buccal Mucosal Graft Harvest Site: A Systematic Review and Meta-Analysis of Patient-Reported Outcomes.

    abstract：OBJECTIVE:To compare the postprocedural oral pain scale and other patient reported oral morbidities for nonclosure vs closure of buccal mucosal graft (BMG) harvest sites through systematic review and meta-analysis of comparative studies. METHODS:A systematic literature search was performed in September 2018. Nonrandom...

    journal_title：Urology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.urology.2018.12.008

    authors： Chua ME,Silangcruz JMA,Ming JM,Sarino EM,DeLong J,Virasoro R,Tonkin J,McCammon KA

    更新日期：2019-03-01 00:00:00

  • Transurethral resection in saline vaporization: evaluation of clinical efficacy and prostate volume.

    abstract：OBJECTIVE:To assess the efficacy and safety of transurethral resection in saline vaporization for symptomatic bladder outlet obstruction and the change in prostate volume. METHODS:A total of 106 patients with symptomatic bladder outlet obstruction underwent transurethral resection in saline vaporization. The effective...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2011.09.044

    authors： Otsuki H,Kuwahara Y,Kosaka T,Tsukamoto T,Nakamura K,Shiroki R,Hoshinaga K

    更新日期：2012-03-01 00:00:00

  • Incidence of local recurrence and port site metastasis after laparoscopic radical nephroureterectomy.

    abstract：OBJECTIVES:To address the incidence of local recurrence and port site metastasis in patients who underwent laparoscopic radical nephroureterectomy (RNU) for upper tract transitional cell carcinoma (TCC). METHODS:Between August 1993 and February 2006 116 laparoscopic RNU were performed in 115 patients at our institutio...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2007.07.027

    authors： Muntener M,Schaeffer EM,Romero FR,Nielsen ME,Allaf ME,Brito FA,Pavlovich CP,Kavoussi LR,Jarrett TW

    更新日期：2007-11-01 00:00:00

  • Natural history of prostatism: high American Urological Association Symptom scores among community-dwelling men and women with urinary incontinence.

    abstract：OBJECTIVES:The American Urological Association Symptom Index (AUASI) has been reported to be nonspecific for benign prostatic hyperplasia. Comparable scores occur in patients with lower urinary tract symptoms of varying etiology, and even among women. The purpose of this study was to determine the association between t...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/s0090-4295(97)00505-0

    authors： Roberts RO,Jacobsen SJ,Jacobson DJ,Reilly WT,Talley NJ,Lieber MM

    更新日期：1998-02-01 00:00:00

  • Single system ectopic ureter to rectum subtending solitary kidney and bladder agenesis in newborn male.

    abstract：:We report a case of a single system solitary ectopic ureter to the rectum with bladder agenesis in a viable newborn male. Only 2 cases of ectopic ureter to the rectum and 18 cases of bladder agenesis have been reported in viable newborns. To our knowledge, this case constitutes the first reported combination of these ...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2006.09.048

    authors： Weight CJ,Chand D,Ross JH

    更新日期：2006-12-01 00:00:00

  • Influence of patient age on biochemical freedom from disease in patients undergoing conformal proton radiotherapy of organ-confined prostate cancer.

    abstract：OBJECTIVES:To examine a large, single-institution series of patients to test the perception among clinicians that radiotherapy is preferred for "older" patients and surgery should be indicated for "younger" men. Both radiotherapy and surgery are used to control prostate cancer, and both yield similar results in terms o...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2004.04.043

    authors： Rossi CJ Jr,Slater JD,Yonemoto LT,Jabola BR,Bush DA,Levy RP,Grove R,Slater JM

    更新日期：2004-10-01 00:00:00

  • Ureteral stenosis as the sole manifestation of Wegener's granulomatosis.

    abstract：:In Wegener's granulomatosis, necrotizing lesions are typically located in the upper and lower respiratory tract and kidneys, and ureteral involvement is uncommon. We report 2 cases in which intrinsic ureteral stenosis was the sole manifestation of this small-vessel vasculitis. Excisional surgery evidenced characterist...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/s0090-4295(03)00368-6

    authors： Kamar N,Malavaud B,Alric L,le Mao G,Mazerolles C,Duffaut M,Sarramon JP,Pourrat J

    更新日期：2003-08-01 00:00:00

  • Impact of the MyProstateScore (MPS) Test on the Clinical Decision to Undergo Prostate Biopsy: Results From a Contemporary Academic Practice.

    abstract：OBJECTIVE:To evaluate the association of the MyProstateScore (MPS) urine test on the decision to undergo biopsy in men referred for prostate biopsy in urology practice. METHODS:MPS testing was offered as an alternative to immediate biopsy in men referred to the University of Michigan for prostate biopsy from October 2...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2020.07.042

    authors： Lebastchi AH,Russell CM,Niknafs YS,Eyrich NW,Chopra Z,Botbyl R,Kabeer R,Osawa T,Siddiqui J,Siddiqui R,Davenport MS,Mehra R,Tomlins SA,Kunju LP,Chinnaiyan AM,Wei JT,Tosoian JJ,Morgan TM

    更新日期：2020-11-01 00:00:00

  • Enzymatic dissolution of calcium and struvite crystals: in vitro evaluation of biochemical requirements.

    abstract：OBJECTIVE:To evaluate the factors that affect the enzymatic dissolution rate of calcium oxalate monohydrate (COM), calcium phosphate (brushite), and magnesium ammonium phosphate (struvite) crystals as enzymatic digestion of kidney stones could enhance lithotripsy or provide alternatives to surgical removal. METHODS:At...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2011.04.046

    authors： Thalji NK,Richards NG,Peck AB,Canales BK

    更新日期：2011-09-01 00:00:00

  • Prospective evaluation of laparoscopic assisted cystectomy and ileal conduit in advanced multiple sclerosis.

    abstract：OBJECTIVE:To assess the morbidity, mortality, and impact on quality of life and renal function after laparoscopic cystectomy and ileal conduit in patients with multiple sclerosis with lower urinary tract symptom refractory to conservative management. MATERIALS AND METHODS:A prospective study was conducted between Febr...

    journal_title：Urology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.urology.2012.06.039

    authors： Guillotreau J,Panicker JN,Castel-Lacanal E,Viala F,Roumiguié M,Malavaud B,Marque P,Clanet M,Rischmann P,Gamé X

    更新日期：2012-10-01 00:00:00

  • Ulcerative balanoposthitis of the foreskin as a manifestation of chronic lymphocytic leukemia: case report and review of the literature.

    abstract：:Ulcerative lesions of the penis have many possible etiologies, including infectious, neoplastic, traumatic, drug-induced, and autoimmune. Although the most frequent neoplasm presenting as an ulcerative penile lesion is squamous cell carcinoma, it may rarely be a manifestation of other malignancies, including those of ...

    journal_title：Urology

    pub_type： 杂志文章,评审

    doi：10.1016/s0090-4295(00)00735-4

    authors： Gatto-Weis C,Topolsky D,Sloane B,Hou JS,Qu H,Fyfe BS

    更新日期：2000-10-01 00:00:00

  • Rho-kinase levels in testicular ischemia-reperfusion injury and effects of its inhibitor, Y-27632, on oxidative stress, spermatogenesis, and apoptosis.

    abstract：OBJECTIVE:To investigate testicular Rho-kinase levels and the effects of its inhibitor, Y-27632, on oxidative stress, spermatogenesis, and apoptosis in testicular ischemia-reperfusion rat model. METHODS:The study included 29 adult Wistar-Albino male rats weighing 150-200 g. The rats were divided into 3 groups. Group 1...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2013.11.032

    authors： Çayan S,Saylam B,Tiftik N,Ünal ND,Apa DD,Efesoy O,Çimen B,Bozlu M,Akbay E,Büyükafşar K

    更新日期：2014-03-01 00:00:00

  • Compartment syndrome: an unusual complication of the lithotomy position.

    abstract：:The compartment syndrome is a rare complication of surgery in the lithotomy position, but one that may result in neurovascular damage and permanent disability. Herein, we present a case of bilateral three-compartment syndrome following urethroplasty in the dorsolithotomy position, with review of the literature and dis...

    journal_title：Urology

    pub_type： 杂志文章,评审

    doi：10.1016/0090-4295(94)90204-6

    authors： Moses TA,Kreder KJ,Thrasher JB

    更新日期：1994-05-01 00:00:00

  • Detection of residual prostate cancer after radical prostatectomy with the Abbott IMx PSA assay.

    abstract：OBJECTIVES:This analysis was performed to define the level of serum prostate-specific antigen (PSA) measured with the Abbott IMx assay that indicates residual or progressive prostate cancer after radical retropubic prostatectomy (RRP). METHODS:Since March 1992, we have used the Abbott IMx assay to determine PSA levels...

    journal_title：Urology

    pub_type： 临床试验,杂志文章

    doi：10.1016/S0090-4295(96)00050-7

    authors： Schild SE,Wong WW,Novicki DE,Ferrigni RG,Swanson SK

    更新日期：1996-06-01 00:00:00

  • Closure of laparoscopic trocar sites using a spring-loaded needle.

    abstract：:Closure of laparoscopic trocar sites can be difficult, particularly in the obese patient. We have begun using a spring-loaded needle to facilitate closure of these sites. We have found that the device allows for accurate suture placement, the potential of decreased closure time, reduced risk for trocar site dehiscence...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/0090-4295(95)80023-9

    authors： Garzotto MG,Newman RC,Cohen MS,Rout R,Grice OD

    更新日期：1995-02-01 00:00:00

  • Phase II study evaluating oral triamcinolone in patients with androgen-independent prostate cancer.

    abstract：OBJECTIVES:To assess the effect of triamcinolone administration on the serum prostate-specific antigen (PSA) response and the time to progression in patients with androgen-independent prostate cancer (AIPC). METHODS:Patients with AIPC were prospectively treated with oral triamcinolone 4 mg twice daily, and their serum...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2005.11.004

    authors： Srinivas S,Krishnan AV,Colocci N,Feldman D

    更新日期：2006-05-01 00:00:00

  • Prognostic significance of Gleason score 3+4 versus Gleason score 4+3 tumor at radical prostatectomy.

    abstract：OBJECTIVES:To determine the clinical significance of Gleason score 3+4 versus 4+3 on radical prostatectomy. METHODS:Of 2390 men who underwent radical prostatectomy by a single surgeon, 570 had Gleason score 7 tumors without lymph node metastasis, seminal vesicle invasion, or tertiary Gleason pattern 5. Patients were e...

    journal_title：Urology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0090-4295(00)00753-6

    authors： Chan TY,Partin AW,Walsh PC,Epstein JI

    更新日期：2000-11-01 00:00:00

  • Excision and Circumferential Buccal Graft for Severe Meatus and Fossa Navicularis Strictures.

    abstract：OBJECTIVE:To demonstrate our technique for glans sparing transurethral excision and circumferential buccal graft for severe strictures of the meatus and fossa navicularis. MATERIALS AND METHODS:Key steps of the procedure are use of a fixed retractor and stay sutures to retract the glans skin laterally, preplacing uret...

    journal_title：Urology

    pub_type：

    doi：10.1016/j.urology.2020.09.008

    authors： Ehlers M,Figler BD

    更新日期：2020-12-01 00:00:00

  • Potentiation of drug-induced erection with audiovisual sexual stimulation.

    abstract：:Twenty-five patients underwent audiovisual sexual stimulation (AVSS) after pharmacologically-induced erection. Grade of erection and cavernosal blood flow were assessed after intracorporeal (IC) injection of TRI-MIX or prostaglandin E1, and then after AVSS, using pulsed Doppler ultrasonography (PDUS). After IC injecti...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/0090-4295(93)90502-2

    authors： Katlowitz NM,Albano GJ,Morales P,Golimbu M

    更新日期：1993-05-01 00:00:00

  • Phenacetin-induced renal papillary necrosis: pyonephros, anuria, and bilateral ureteral obstruction.

    abstract：:A fifty-five-year-old man was seen with anuria. Retrograde pyelograms demonstrated bilateral ureteral obstruction subsequently shown to have resulted from sloughed renal papillae. A twenty-year history of phenacetin was obtained. Treatment included bilateral ureteral intubation, then ureterotomy on one side. ...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/0090-4295(75)90353-2

    authors： Strimer RM,Morin LJ

    更新日期：1975-06-01 00:00:00

  • Does shock wave lithotripsy of renal stones cause cardiac muscle injury? A troponin I-based study.

    abstract：OBJECTIVES:To investigate whether shock wave lithotripsy (SWL) causes cardiac muscle injury that alters the levels of troponin I plasma, a cardio-specific enzyme shown to be useful in diagnosing cardiac muscle injury because of its high specificity. METHODS:Patients treated by SWL for renal stones participated in the ...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/s0090-4295(03)00002-5

    authors： Greenstein A,Sofer M,Lidawi G,Matzkin H

    更新日期：2003-05-01 00:00:00

  • Adverse impact of sexual dysfunction in chronic prostatitis/chronic pelvic pain syndrome.

    abstract：OBJECTIVES:To examine the prevalence, characteristics, and impact of sexual dysfunction in our primary care referral population. METHODS:Participants seeking treatment for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) were recruited from general urology clinics. The subjects completed the National Institu...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2007.08.043

    authors： Lee SW,Liong ML,Yuen KH,Leong WS,Cheah PY,Khan NA,Krieger JN

    更新日期：2008-01-01 00:00:00

  • Successful treatment of propofol-induced priapism with distal glans to corporal cavernosal shunt.

    abstract：:We report a case of postoperative pediatric priapism in a boy without a hematologic disorder after a propofol-based general anesthetic. Our case underscores the importance of the early diagnosis and treatment to lessen the risk of complications. Given the wide use of propofol for sedation and anesthesia, clinicians sh...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2008.12.066

    authors： Fuentes EJ,Garcia S,Garrido M,Lorenzo C,Iglesias JM,Sola JE

    更新日期：2009-07-01 00:00:00