Abstract：
OBJECTIVES:There is scant literature on the frequency of high-grade prostatic intraepithelial neoplasia (PIN) in needle biopsy specimens. These data have implications as to how often pathologists should be expected to diagnose these lesions on needle biopsy and impact on the feasibility of cancer chemoprevention trials for prostate cancer. METHODS:We reviewed 439 consecutive 18-gauge sextant needle biopsy specimens from the Johns Hopkins Hospital. RESULTS:Based on the pathology reports, high-grade PIN was recorded in 12 (2.7%) of the cases and was confirmed upon review. Following review of the slides, unequivocal high-grade PIN was found in an additional 6 cases. There were 6 other cases where the findings were borderline between high- and low-grade PIN, but which were believed to be more consistent with high-grade PIN. Considering these latter cases in conjunction with the unequivocal cases of high-grade PIN, the incidence of high-grade PIN was 5.5% (24 of 439). CONCLUSIONS:Recognizing that approximately 50% of men with high-grade PIN on needle biopsy will be found to have carcinoma on repeat biopsy, the management of high-grade PIN on biopsy will only apply to 50% of the men initially discovered with this finding. If only 2.75% of men who are biopsied eventually need therapy for high-grade PIN on needle biopsy, the number of cases needed to study the decrease of high-grade PIN following chemoprevention might be prohibitively high. If the incidence of high-grade PIN on needle biopsy requiring therapy is only 2.75%, it may also not be worthwhile developing large trials to investigate various treatment regimens for high-grade PIN found on biopsy.
journal_name
Urologyjournal_title
Urologyauthors
Wills ML,Hamper UM,Partin AW,Epstein JIdoi
10.1016/S0090-4295(96)00622-Xsubject
Has Abstractpub_date
1997-03-01 00:00:00pages
367-73issue
3eissn
0090-4295issn
1527-9995pii
S0090-4295(96)00622-Xjournal_volume
49pub_type
杂志文章相关文献
UROLOGY文献大全abstract：OBJECTIVES:To determine whether an association exists between C-reactive protein (CRP) levels and lower urinary tract symptoms (LUTS) as assessed by the American Urological Association Symptom Index (AUA-SI) among both men and women, and to determine the association of CRP levels with the individual urologic symptoms c...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2008.12.012
更新日期：2009-05-01 00:00:00
abstract：OBJECTIVES:To compare the stone-free rate and complications between horseshoe and normal kidneys. METHODS:Between December 1997 and June 2008, a total of 2401 patients with 2618 renal units underwent percutaneous nephrolithotomy (PCNL). During this period, we retrospectively reviewed the data of 46 patients with 50 (1...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2009.08.054
更新日期：2010-05-01 00:00:00
abstract：:The incidence and etiology of horseshoe kidneys and their structural abnormalities are discussed. Previously, patients with horseshoe kidneys have been considered undesirable donors for renal transplantation. Two cases of horseshoe kidney transplantation are presented, apparently, the first reported utilization of suc...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(75)90767-0
更新日期：1975-09-01 00:00:00
abstract：OBJECTIVES:To assess the effect of ileal bladder substitutes with preservation of the ileocecal valve and distal 25 cm of ileum on nephrolithiasis. METHODS:We reviewed a consecutive series of 518 patients (44 women and 474 men) with ileal orthotopic bladder substitution in whom 55 to 65 cm of ileum was resected but wi...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2007.08.058
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVE:To evaluate the trends in the American diet over the last 40 years (1974-2010), during which time the National Health and Nutrition Examination Survey data set has documented an increase in stone prevalence from 3.8% to 8.8%. MATERIALS AND METHODS:We used the National Health and Nutrition Examination Survey ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2014.06.037
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVE:To compare the efficacy and safety of mirabegron and onabotulinumtoxinA in the management of treatment-experienced patients with overactive bladder. METHODS:The network meta-analysis was based on evidence from a systematic literature review of randomized controlled trials and a post-hoc analysis of treatment...
journal_title：Urology
pub_type： 杂志文章,meta分析
doi：10.1016/j.urology.2019.02.005
更新日期：2019-05-01 00:00:00
abstract：OBJECTIVE:To examine the relationship between the body mass index and the size of renal stones in a group of patients with urolithiasis. METHODS:One-hundred seventy-three patients with renal stones were enrolled. Body mass index was calculated on the basis of height and weight measurements, and stone size was either m...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2012.07.027
更新日期：2012-11-01 00:00:00
abstract：OBJECTIVE:To assess whether the stone composition affects the operative time of ureteroscopic holmium:yttrium-aluminum-garnet laser lithotripsy (ULL) with active fragment retrieval. The chemical composition of a calculus is known to affect the efficacy with which it is fragmented by a device, such as pneumatic, laser, ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2012.05.040
更新日期：2012-10-01 00:00:00
abstract：:Mesoblastic nephroma is the most common solid renal neoplasm in the first few months of life. It has been recognized only recently as a distinct entity, having been classified previously as Wilms tumor. There are relatively few ultrasonic descriptions of this entity in the literature. We present an additional case fea...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(82)90590-8
更新日期：1982-02-01 00:00:00
abstract：OBJECTIVE:To assess patients' perceived causes of prostate cancer (PCa) and relation to treatment satisfaction, an Internet-based survey study was designed. PCa is a profoundly personal disease, considering the location and common sequelae of treatment. Deeply held patient self-perceptions regarding the etiology of a p...
journal_title：Urology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.urology.2016.09.046
更新日期：2017-01-01 00:00:00
abstract：:The effects of serotonergic drugs on the central nervous system control of the lower urinary tract have revealed possible approaches for the treatment of detrusor overactivity and urinary incontinence. Studies in animals of the distribution of serotonergic nerves and receptors and the changes in voiding function induc...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(01)01636-3
更新日期：2002-05-01 00:00:00
abstract：:Congenital anorchism is a rare condition. Bilateral impa-pable undescended testes are relatively common by comparison. Surgical exploration has been regarded as the final arbiter between anorchism and bilateral cryptorchism. Exploration has not proved completely reliable in making this differentiation. Endocrine studi...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(78)90192-9
更新日期：1978-01-01 00:00:00
abstract：OBJECTIVE:To describe the different ultrasound (US) findings of mature testicular hamartomas in children. MATERIALS AND METHODS:This is a retrospective study from January 2000 to July 2012 that reviewed the clinical, laboratory, and US findings of 7 children with a pathologic diagnosis of mature teratoma of the testis...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2013.07.046
更新日期：2014-01-01 00:00:00
abstract：:We report a case of a man with a testicular mixed germ cell tumor in whom the first symptom was severe anemia secondary to upper gastrointestinal bleeding from a metastatic pure choriocarcinoma. He underwent ileal enterectomy, radical orchiectomy, and several cycles of chemotherapy (cisplatin, etoposide, and bleomycin...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2005.06.102
更新日期：2005-12-01 00:00:00
abstract：:Acute renal failure and a syndrome characteristic of acute renal vein thrombosis developed in a patient with sickle trait and gram-negative bacteremia. It is suggested that intrarenal vaso-occlusion by sickled erythrocytes produced signs and symptoms typical of renal vein thrombosis and contributed to the severity of ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(75)90716-5
更新日期：1975-08-01 00:00:00
abstract：:A successful percutaneous reanastomosis of a transplanted kidney is reported. The kidney already had been operated on several times. The kidney-ureter anastomosis was occluded. Using a combination of ureteroscopy and the percutaneous technique, the old anastomosis was bypassed, and a new one was made. ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(88)90448-7
更新日期：1988-07-01 00:00:00
abstract：OBJECTIVES:To present the results of repairing congenital or acquired penile torsion by means of a simple surgical procedure that does not involve resection of corporeal tissue. METHODS:Forty-six circumcised patients (mean age 27 months, range 6 to 119) presented with isolated penile torsion of a greater than 30 degre...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2007.01.014
更新日期：2007-02-01 00:00:00
abstract：:To study the effects of incontinence surgery on detrusor contractility, a group of 24 women who preoperatively voided without a detrusor contraction during voiding urethrocystometry were re-evaluated for detrusor contractility three months after surgery for stress urinary incontinence. Twelve women regained detrusor c...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(88)90101-x
更新日期：1988-04-01 00:00:00
abstract：:We herein describe a case of adrenal hemorrhage on the right side in a forty-five-year-old woman. Her medical history did not show any evidence of an acute bleeding. The hematoma was removed and adrenalectomy performed. A veinectasis and a localized vasculitis are discussed as causes of bleeding. ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(88)90320-2
更新日期：1988-08-01 00:00:00
abstract：:Our patient was a 61-year-old man with hormone-refractory prostate cancer and a rapidly rising serum prostate-specific antigen level. During the course of therapy for prostate cancer, abnormal blood counts and subsequent bone marrow biopsy led to a diagnosis of acute lymphoblastic leukemia. He was treated with a chemo...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2004.05.042
更新日期：2004-10-01 00:00:00
abstract：:Leiomyomas account for less than 0.43% of all bladder tumors. To date only about 250 cases have been reported in the literature. Pulmonary lymphangioleiomyomatosis (LAM) is a rare lung disease featuring abnormal proliferation of atypical smooth muscle cells around bronchovascular structures. We describe a woman with L...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2007.11.031
更新日期：2008-04-01 00:00:00
abstract：OBJECTIVES:Frequently, statistically significant prognostic factors are reported in published studies with suggestions that disease management should be modified. However, the clinical relevance of such factors is rarely quantified. We evaluated the accuracy of predicting the need for invasive treatment among patients ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2005.11.049
更新日期：2006-05-01 00:00:00
abstract：:Benign prostatic hyperplasia (BPH) is very common in older men, causing symptoms that can markedly impair quality of life. Surgical treatment, typically transurethral resection of the prostate (TURP), is highly effective but can be costly and is associated with the risk for significant morbidity. Medical treatments fo...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/s0090-4295(98)00140-x
更新日期：1998-06-01 00:00:00
abstract：:Urinary retention and the possible consequence of infection after total joint replacement is an important subject to urologists and orthopedic surgeons. A prospective, randomized study was performed in 77 elderly female patients with total joint replacement to test whether twenty-four-hour catheterization perioperativ...
journal_title：Urology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0090-4295(88)90381-0
更新日期：1988-09-01 00:00:00
abstract：OBJECTIVES:To investigate the financial and educational costs of the urology residency interview process, we performed a survey of the applicants to the 2006 urology match. METHODS:All applicants registered for the 2006 urology match were invited to participate. In January 2006 prior to the match, an anonymous online ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2007.11.102
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVE:To present and validate a new technique for biobanking fresh-frozen prostate cancer tissue based on MRI-transrectal ultrasound fusion biopsy. MATERIALS AND METHODS:From August 2014 to August 2016, patients with elevated levels of PSA and at least 1 suspicious lesion on MRI were invited to this study. Each MR...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2019.08.029
更新日期：2019-12-01 00:00:00
abstract：:Twenty-five patients with renal cell carcinoma were treated with a lipophilic macromolecular drug, poly(stylene-co-maleic acid)-conjugated neocarzinostatin (SMANCS) dissolved in lipid contrast medium (Lipiodol). The drug was injected by catheterizing the renal artery and another feeding artery in 24 patients, and in t...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(91)80308-t
更新日期：1991-03-01 00:00:00
abstract：OBJECTIVE:To study the correlation between a new visual tool (ANalogical UroFlowmetry (ANUF)) and uroflowmetry (UF) parameters when performed to assess male lower urinary tract symptoms (MLUTS). METHODS:We configured an original pictogram composed of 4 different urine streams. In the setting of a University Hospital b...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2020.08.027
更新日期：2020-12-01 00:00:00
abstract：:A case is reported of complete obstruction of a solitary kidney induced by epsilon-aminocaproic acid used to treat significant idiopathic bleeding. The pharmacology and complications of epsilon-aminocaproic acid are also reviewed. ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(84)90390-x
更新日期：1984-07-01 00:00:00
abstract：:Urinary incontinence occurring during orgasm in women is an infrequently volunteered symptom. We studied 3 such patients to understand the mechanism behind such leakage. Urodynamic studies were performed prior to and during orgasm. It was found that during orgasm, there was involuntary bladder contraction with simulta...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(88)90160-4
更新日期：1988-03-01 00:00:00
