Abstract:
OBJECTIVE:To compare the efficacy and safety of mirabegron and onabotulinumtoxinA in the management of treatment-experienced patients with overactive bladder. METHODS:The network meta-analysis was based on evidence from a systematic literature review of randomized controlled trials and a post-hoc analysis of treatment-experienced subpopulations from mirabegron studies. RESULTS:Nineteen trials described in 21 publications were included. CONCLUSION:Overall, compared to mirabegron, there was some evidence that onabotulinumtoxinA was associated with improved outcomes, including reductions in the number of micturitions in a 24-hour period, and the number of incontinence episodes. However, mirabegron was associated with a lower risk of urinary tract infections compared with onabotulinumtoxinA.
journal_name
Urologyjournal_title
Urologyauthors
Lozano-Ortega G,Walker D,Rogula B,Deighton A,Johnston K,Hawkins N,Dmochowski Rdoi
10.1016/j.urology.2019.02.005subject
Has Abstractpub_date
2019-05-01 00:00:00pages
1-8eissn
0090-4295issn
1527-9995pii
S0090-4295(19)30153-0journal_volume
127pub_type
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