The Relative Efficacy and Safety of Mirabegron and OnabotulinumtoxinA in Patients With Overactive Bladder who Have Previously Been Managed With an Antimuscarinic: A Network Meta-analysis.

Abstract:

OBJECTIVE:To compare the efficacy and safety of mirabegron and onabotulinumtoxinA in the management of treatment-experienced patients with overactive bladder. METHODS:The network meta-analysis was based on evidence from a systematic literature review of randomized controlled trials and a post-hoc analysis of treatment-experienced subpopulations from mirabegron studies. RESULTS:Nineteen trials described in 21 publications were included. CONCLUSION:Overall, compared to mirabegron, there was some evidence that onabotulinumtoxinA was associated with improved outcomes, including reductions in the number of micturitions in a 24-hour period, and the number of incontinence episodes. However, mirabegron was associated with a lower risk of urinary tract infections compared with onabotulinumtoxinA.

journal_name

Urology

journal_title

Urology

authors

Lozano-Ortega G,Walker D,Rogula B,Deighton A,Johnston K,Hawkins N,Dmochowski R

doi

10.1016/j.urology.2019.02.005

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

1-8

eissn

0090-4295

issn

1527-9995

pii

S0090-4295(19)30153-0

journal_volume

127

pub_type

杂志文章,meta分析

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