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Histopathologic and biologic characteristics of a transitional cell carcinoma with inverted papilloma-like endophytic growth pattern.

Abstract：

:To evaluate histopathologic and biologic characteristics in a patient with transitional cell carcinoma (TCC) with an endophytic growth pattern similar to that seen in an inverted papilloma. Although the tumor surface was mostly covered with normal-looking urothelium, the covering layer was thicker in parts than in those of benign papillomas. The widths of the trabeculae were irregular, and cytologic atypia with remarkable mitosis was seen. High expression of p53, Ki67, and cytoplasmic cyclin D1 was demonstrated by immunohistochemical staining. To clarify the biologic activities of tumors with inverted papilloma-like growth pattern, even when it appears as benign lesions by routine pathologic examination, analyses of immunoreactivity for proliferation markers might be critical.

journal_name

Urology

journal_title

Urology

authors

Sudo T,Irie A,Ishii D,Satoh E,Mitomi H,Baba S

doi

10.1016/s0090-4295(02)02521-9

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

837

issue

4

eissn

0090-4295

issn

1527-9995

pii

S0090429502025219

journal_volume

61

pub_type

杂志文章

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