Abstract：
OBJECTIVES:Cryptorchidism is associated with infertility, even in those patients with unilateral undescended testes. The mechanism for this infertility is not understood. We demonstrated recently that in mice, a stable nuclear matrix, a structural component of the nucleus that organizes DNA, is necessary for proper embryogenesis. We tested the hypothesis that spermatozoa from cryptorchid patients had unstable nuclear matrices. METHODS:Semen samples from 7 patients with a history of undescended testes and decreased fertility were tested for sperm nuclear matrix stability using our halo assay. RESULTS:All 7 patients were found to have unstable nuclear matrices, as compared with controls. CONCLUSIONS:This preliminary study suggests that one factor in the decreased fertility of cryptorchid patients may be unstable sperm nuclear matrices.
journal_name
Urologyjournal_title
Urologyauthors
Barone JG,Christiano AP,Ward WSdoi
10.1016/s0090-4295(00)00788-3subject
Has Abstractpub_date
2000-12-20 00:00:00pages
1068-70issue
6eissn
0090-4295issn
1527-9995pii
S0090-4295(00)00788-3journal_volume
56pub_type
杂志文章相关文献
UROLOGY文献大全abstract：OBJECTIVES:Recent improvements in socioeconomic conditions have changed the clinical picture of urinary stones, including bladder calculi. With the ongoing changes in these predisposing factors, it is possible that the clinical picture of bladder calculi will show additional changes. Nevertheless, few contemporary seri...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2005.12.038
更新日期：2006-06-01 00:00:00
abstract：:Sympathetic nervous innervation of the canine urethra was studied using catecholamine histofluorescent straining and the in vitro muscle bath. Morphologically, adrenergic nerves were found terminating on the urethral smooth muscle. Pharmacologically, urethral strips responded like muscle strips from the bladder base t...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(76)90476-3
更新日期：1976-03-01 00:00:00
abstract：OBJECTIVES:An association between prostatitis and male infertility has been suspected, yet is poorly understood. Prostatitis is often associated with granulocytes in the prostatic fluid that generate reactive oxygen species (ROS), known to impair male fertility. We compared ROS, the total antioxidant capacity (TAC), an...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(99)00613-5
更新日期：2000-06-01 00:00:00
abstract：OBJECTIVE:To report our 5-year experience with a modified single-port, double-needle, minilaparoscopic technique for patent processus vaginalis with multiple peritoneal folds in the hydrocele sac orifice. METHODS:A total of 125 consecutive cases of boys with unilateral pediatric hydrocele underwent minilaparoscopic re...
journal_title：Urology
pub_type： 临床试验,杂志文章
doi：10.1016/j.urology.2015.01.053
更新日期：2015-06-01 00:00:00
abstract：:The ultrasonographic characteristics of an epidermoid cyst of the testicle are presented. Since these findings are similar to other published case reports, preoperative sonographic diagnosis of this lesion may be possible. ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(90)80104-u
更新日期：1990-06-01 00:00:00
abstract：:Several articles describing the natural history of Peyronie disease have shown that untreated patients seem to have spontaneous improvement. It has been suggested that this could be the reason for the success of so many different methods. A review of the literature and of our previous experience has been done, trying ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(80)90320-9
更新日期：1980-07-01 00:00:00
abstract：:Three cases of pelvic lipomatosis are presented. Excretory urogram revealed characteristic elevation and elongation of urinary bladder base and relative hyperlucency of pelvic cavity. Associated varying degrees of hydronephrosis and hydroureters are seen secondary to distal ureteral obstruction. Barium enema showed el...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(76)90578-1
更新日期：1976-01-01 00:00:00
abstract：OBJECTIVES:To review a single surgeon's experience with the development of postoperative deep venous thrombosis after urologic reconstruction in the myelomeningocele population. This complication is rarely reported in this population, despite the multiple risk factors. We reviewed the risk factors for the development o...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2005.01.052
更新日期：2005-07-01 00:00:00
abstract：:A rare developmental disorder, cystic dysplasia of the testis, encountered in a newborn infant, is described. The relationship to renal dysplasia and the recent literature are reviewed. ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(87)90597-8
更新日期：1987-01-01 00:00:00
abstract：OBJECTIVES:To determine whether an increased body mass index (BMI) is a predictor of advanced pathologic findings in European men undergoing radical prostatectomy (RP). The relationship between obesity and prostate cancer is controversial. Studies, predominantly derived from the United States, have suggested that an in...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2008.09.038
更新日期：2009-03-01 00:00:00
abstract：OBJECTIVES:To analyze the feasibility of neurovascular bundle (NVB) preservation and peripheral nerve grafting during salvage radical prostatectomy (RP) for radiorecurrent prostate cancer and analyze their effect on the recovery of potency. METHODS:Of 100 patients who underwent salvage RP with curative intent from 198...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2005.04.002
更新日期：2005-09-01 00:00:00
abstract：OBJECTIVES:To investigate the associations between benign prostatic hyperplasia (BPH) and polymorphisms in genes that encode growth factors, cytokines, and vitamin D and their receptors. METHODS:A total of 510 white men (median age 60 years) randomly selected from the Olmsted County, Minnesota community participated i...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2005.08.061
更新日期：2006-02-01 00:00:00
abstract：OBJECTIVES:To report our experience in the management of vaginal extrusion after the tension-free vaginal tape (TVT) procedure for urodynamic stress incontinence. METHODS:Five patients diagnosed with vaginal extrusion after a TVT procedure performed at our institution were identified. We reviewed the patients' records...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2007.02.009
更新日期：2007-06-01 00:00:00
abstract：OBJECTIVE:To evaluate variation in neoadjuvant chemotherapy (NAC) use among patients with ≥ clinical T2 (cT2) bladder cancer and determine changes in staging at radical cystectomy (RC) associated with therapy. METHODS:Using the National Cancer Database (NCDB), we identified all patients diagnosed with organ-confined, ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2013.07.072
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVES:To evaluate the process of soft-tissue electrovaporization and to study variables that affect tissue clearance rates in a laboratory setting, in order to identify parameters that can optimize transurethral electrovaporization of the prostate. METHODS:Fresh bovine skeletal muscle, equivalent in impedance and...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(97)00092-7
更新日期：1997-06-01 00:00:00
abstract：OBJECTIVE:To determine if partial nephrectomy (PN) confers a renal functional benefit compared to radical nephrectomy (RN) for clinical T2 renal masses (T2RM) when adjusting for tumor complexity characterized by the RENAL nephrometry score. METHODS:A 2-center study of 202 patients with T2RM undergoing RN (122) or PN (...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2015.02.067
更新日期：2015-08-01 00:00:00
abstract：OBJECTIVES:To assess the effects of finasteride on angiogenetic and hypoxia markers in benign prostatic hyperplasia. METHODS:A total of 178 patients aged 51 to 85 years (mean 68.7) with benign prostatic hyperplasia and awaiting transurethral prostate resection were prospectively randomized into a group of patients rec...
journal_title：Urology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.urology.2006.03.038
更新日期：2006-08-01 00:00:00
abstract：OBJECTIVES:To evaluate, in two randomized, multicenter trials, levofloxacin compared with ciprofloxacin and lomefloxacin for efficacy and safety in treating acute pyelonephritis. METHODS:We enrolled a total of 186 patients with bacteriologically proved infection. Of these, 89 patients in both trials combined received ...
journal_title：Urology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0090-4295(98)00160-5
更新日期：1998-07-01 00:00:00
abstract：:A total of 311 patients who underwent consecutive transurethral resection of prostate (TURP) for obstructive voiding symptoms were reviewed. All patients had benign prostate glands by digital rectal examination. Results of preoperative ultrasound screening of the prostate in 65 of 311 patients showed 41 with nonmalign...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(93)90113-o
更新日期：1993-06-01 00:00:00
abstract：OBJECTIVES:Ureteral access sheaths (UASs) are used to facilitate ureteroscopic procedures. Difficulties with use have been reported. Manufacturers have redesigned these devices to ameliorate these problems, including reinforcement of the sheath wall. This study compared reinforced (RUASs) and nonreinforced UASs (NRUASs...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2008.07.055
更新日期：2009-02-01 00:00:00
abstract：OBJECTIVES:To determine the response to sildenafil citrate (Viagra) in patients with erectile dysfunction after radiation therapy for localized prostate cancer. METHODS:Baseline and follow-up data from 21 patients presenting with erectile dysfunction after radiation treatment for clinical T1-2 prostate cancer were obt...
journal_title：Urology
pub_type： 临床试验,杂志文章
doi：10.1016/s0090-4295(99)00146-6
更新日期：1999-08-01 00:00:00
abstract：OBJECTIVE:To determine whether the ratio of dietary calcium and oxalate consumption at mealtime affects gastrointestinal oxalate absorption and urinary oxalate excretion. METHODS:A study was conducted with 10 non-stone-forming adults placed on controlled diets with daily calcium and oxalate contents of 1000 and 750 mg...
journal_title：Urology
pub_type： 临床试验,杂志文章
doi：10.1016/j.urology.2012.01.053
更新日期：2012-06-01 00:00:00
abstract：OBJECTIVES:To evaluate the efficacy of sildenafil for the treatment of erectile dysfunction after radical prostatectomy and to determine whether age, preservation of the neurovascular bundles (NVBs), or the interval between surgery and the initiation of sildenafil therapy influences the response to sildenafil. METHODS...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(00)00659-2
更新日期：2000-10-01 00:00:00
abstract：OBJECTIVES:To investigate the pattern of anti-Dysport antibody (ADA) formation after Dysport injection in patients with neuropathic bladder. Antibody formation may lead to failure or allergic reactions in patients undergoing Dysport injection. METHODS:Forty-four children with neuropathic bladder were enrolled and clas...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2010.03.023
更新日期：2010-07-01 00:00:00
abstract：OBJECTIVE:To evaluate whether the addition of a single dose of an aminoglycoside to a fluoroquinolone-based prophylaxis regime would decrease septic complications associated with transrectal prostate biopsy. METHODS:A retrospective survey of all patients undergoing transrectal ultrasound guided prostate biopsy (TRUS-P...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2013.01.074
更新日期：2013-11-01 00:00:00
abstract：:Peyronie's disease (PD) is a penile wound-healing disorder resulting in fibrotic plaque in the tunica albuginea, likely resulting from micro trauma. Due to variable disease presentations, a myriad of proposed treatment options, physician misconceptions about the disorder, and severe psychological distress in afflicted...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/j.urology.2016.02.009
更新日期：2016-09-01 00:00:00
abstract：:Four patients with protracted benign hematuria underwent silver nitrate instillation of the upper collecting system. The doses varied from 10 ml. of 0.25 per cent silver nitrate to 14 ml. of 1 per cent silver nitrate. In all 4 cases the hematuria resolved within four days without significant complications. At follow-u...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(81)90384-8
更新日期：1981-10-01 00:00:00
abstract：OBJECTIVES:To examine whether treatment with continuous positive airway pressure (CPAP) reduces nocturia in patients with obstructive sleep apnea (OSA). METHODS:This prospective clinical study recruited patients referred to the Rambam Sleep Laboratory with suspected OSA. After polysomnography, those found to have no O...
journal_title：Urology
pub_type： 临床试验,杂志文章
doi：10.1016/j.urology.2005.11.054
更新日期：2006-05-01 00:00:00
abstract：:A wealth of clinical evidence supports the view that muscarinic receptor antagonists are effective in the treatment of overactive bladder. However, treatment-limiting adverse effects such as dry mouth, constipation, and blurred vision have restricted the usefulness of previously available agents, such as oxybutynin. A...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/s0090-4295(99)00492-6
更新日期：2000-05-01 00:00:00
abstract：OBJECTIVES:To describe the epidemiology of urinary tract infections caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli. METHODS:We performed three studies: a trend study (1999 to 2004) to assess the evolution and origin of ESBL-producing E. coli isolates from urine samples; a comparison of th...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2006.08.1075
更新日期：2006-12-01 00:00:00
