Abstract:
OBJECTIVES:Pyruvate kinase type M2 (TuM2-PK) and thymidine kinase 1 (TK1) are the key enzymes involved in tumor cells metabolism and proliferation. We explored the association of their preoperative circulating levels with disease recurrence in patients with renal cell carcinoma (RCC). METHODS:We measured the plasma levels of TuM2-PK levels and serum TK1 activity preoperatively in patients with RCC, using a quantitative ELISA, and correlated the results with clinicopathological parameters. RESULTS:Significantly higher levels of TuM2-PK and TK1 were found in 116 patients with RCC compared with 20 healthy participants (P < .001 and P = .03), but not compared with 27 patients with benign kidney tumors (P = .13 and P = .72). There was a significant association between the level of TuM2-PK and of TK1 activity with T stage (P = .01 and P = .04). Of 2 markers only TuM2-PK was significantly associated with tumor grade (P = .001). The presence of extensive tumor necrosis (> 50%) was associated with high TuM2-PK (P = .001) and low TK1 (P = .03). The 5-year recurrence-free survival for patients with elevated TuM2-PK or TK1 was significantly lower compared with those for patients with normal marker levels (55% vs 94%, P < .001 and 21% vs 90%, P = .002). Multivariate Cox Proportional Hazard analysis demonstrated that TuM2-PK and TK1, adjusted for stage, grade and tumor necrosis were retained as independent predictors of disease recurrence (HR = 7.3, P = .04 and HR = 3.8, P = .03). CONCLUSIONS:The measurements of 2 circulating biomarkers, TuM2-PK and TK1, in RCC patients before nephrectomy can be useful for predicting recurrence and stratifying the patients into risk groups for possible adjuvant treatment.
journal_name
Urologyjournal_title
Urologyauthors
Nisman B,Yutkin V,Nechushtan H,Gofrit ON,Peretz T,Gronowitz S,Pode Ddoi
10.1016/j.urology.2010.04.034subject
Has Abstractpub_date
2010-08-01 00:00:00pages
513.e1-6issue
2eissn
0090-4295issn
1527-9995pii
S0090-4295(10)00595-9journal_volume
76pub_type
杂志文章相关文献
UROLOGY文献大全abstract:OBJECTIVES:To determine the effect of discontinuation of alpha-blockade and continuation of finasteride in men with lower urinary tract symptoms and enlarged prostates receiving combination treatment and to determine whether the alpha-blocker dose influences the ability to discontinue it. METHODS:We treated 272 consec...
journal_title:Urology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0090-4295(01)01201-8
更新日期:2001-08-01 00:00:00
abstract::Late relapses of nonseminomatous germ cell tumors of the testicle are unusual. In such cases, chemotherapy is reported to have only modest success and surgery may be the preferred treatment modality. We report a patient who experienced relapse 11 years after the initial diagnosis of advanced testicular cancer and who ...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/S0090-4295(96)00495-5
更新日期:1997-03-01 00:00:00
abstract:OBJECTIVE:To investigate whether antitumor activity of sunitinib is enhanced by silencing Akt1 in a human castration-resistant prostate cancer PC3 model. MATERIALS AND METHODS:We initially established PC3 in which the expression vector containing a short hairpin ribonucleic acid targeting Akt1 was introduced (PC3/sh-A...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2015.02.016
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVES:To determine whether an increased body mass index (BMI) is a predictor of advanced pathologic findings in European men undergoing radical prostatectomy (RP). The relationship between obesity and prostate cancer is controversial. Studies, predominantly derived from the United States, have suggested that an in...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2008.09.038
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVES:To evaluate the effectiveness and safety of retroperitoneal laparoscopic adrenalectomy for pheochromocytoma and report our experience in adrenalectomy without previous control of the adrenal vein. METHODS:From January 2000 to December 2005, 56 patients underwent 58 retroperitoneal laparoscopic adrenalectomy...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2007.01.078
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVE:To determine whether the additional benefits of improved prostate cancer detection associated with 5α-reductase inhibitors are sufficient to warrant chemoprevention in the case where the degree of prostate cancer risk reduction is deemed inadequate. METHODS:We reanalyzed data from REDUCE, a randomized trial ...
journal_title:Urology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.urology.2014.08.048
更新日期:2015-02-01 00:00:00
abstract::Partial segment priapism or segmental thrombosis of the corpus cavernosum is a rare urologic condition reported 23 times in the world literature. We present the clinical and radiologic findings of a 22-year-old man who presented 7 days after the onset of symptoms in whom the diagnosis was confirmed with magnetic reson...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2008.06.040
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVES:Percutaneous perineal cryoablation of the prostate is a promising technique in the treatment armamentarium for clinically localized prostate carcinoma. We report our initial experience using a transrectal ultrasound-guided, third-generation, argon/helium cryosurgical system. METHODS:From January 2002 to Jul...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2007.03.027
更新日期:2007-07-01 00:00:00
abstract::We describe a case of an unusual variation of the double retroaortic left renal vein discovered during routine donor examination of the abdomen by multidetector computed tomography. A 53-year-old man underwent evaluation in our department as a potential renal donor for his brother who had end-stage renal failure. Mult...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2009.01.050
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVES:To describe 6 cases of rectourethral fistula in patients treated with brachytherapy plus external beam radiotherapy for localized prostate cancer and subsequent rectal biopsies or rectal surgery. METHODS:A retrospective chart review was undertaken of patients with prostate cancer treated with brachytherapy ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2007.01.044
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVES:To report on five serious intraoperative damages to nonprocedure-related organs during 10 years of experience with the Bookwalter device. Self-retaining retractors are helpful devices, particularly during major transperitoneal and retroperitoneal operations. Various retractors are available and allow the use...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(02)01946-5
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVES:To evaluate the utility of using Internet search trends data to estimate kidney stone occurrence and understand the priorities of patients with kidney stones. Internet search trends data represent a unique resource for monitoring population self-reported illness and health information-seeking behavior. METH...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2011.04.024
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVES:To estimate the rates of rectal bleeding after dose-escalated three-dimensional conformal radiation therapy (3D-CRT) on a prospective, Phase II study in which a modified intrarectal balloon was used for prostate gland localization and immobilization. METHODS:The study cohort comprised 100 men with biopsy-pr...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2005.10.008
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVE:To analyze the outcomes of emphysematous pyelonephritis (EPN), the impact of different treatment modalities, and to determine risk factors associated with mortality. METHODS:We retrospectively reviewed cases of EPN from 3 tertiary care institutions in Mexico. The diagnosis was confirmed with computed tomogra...
journal_title:Urology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.urology.2014.02.010
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVES:Laparoscopic examination of the contralateral inguinal ring has recently been advocated to exclude contralateral hernia in young children. We report a modification using nondisposable cystoscopic equipment, which is quick and reliable. METHODS:Either an 8 or 10 F soft straight catheter or a cystoscope sheat...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(99)80497-x
更新日期:1996-04-01 00:00:00
abstract:OBJECTIVE:To compare modified autologous transobturator-tape (a-TOT) and transobtrator-tape (TOT) surgeries in terms of effectivity and complications. MATERIALS AND METHODS:Prospectively 117 patients (a-TOT:36,TOT:81) were enrolled in this study. A-TOT was performed with autologous fascia elongated with nonabsorbable ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2020.09.018
更新日期:2020-12-01 00:00:00
abstract::Positive surgical margins after radical prostatectomy are associated with an increased risk of cancer recurrence. Depending on the patient's clinical presentation and the amount of residual prostatic tissue, this could be described as a surgical complication or as treatment failure. Endorectal magnetic resonance (MR) ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2009.12.009
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVES:To define the likelihood of nitrate users wishing to use sildenafil citrate being permitted by their nitrate-prescribing physicians to cease nitrate use, and to attempt to derive predictors of a "no" response to this request. METHODS:A total of 248 patients with erectile dysfunction were included in this st...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2007.01.029
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of 3-dimensionally (3D) printed physical renal models with enhancing masses on medical trainee characterization, localization, and understanding of renal malignancy. METHODS:Proprietary software was used to import standard computed tomography (CT) cross-sectional imaging into 3D printe...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2015.02.053
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVES:The presence of metastatic lesions is the only acceptable fact to confirm malignant pheochromocytoma. Patients with malignant pheochromocytomas, however, have a very poor survival rate. The aim of our study was to postulate predictive values for malignant pheochromocytomas. METHODS:We evaluated symptoms, di...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(98)00612-8
更新日期:1999-04-01 00:00:00
abstract:OBJECTIVES:To report on the safety of radical retropubic prostatectomy (RRP) in patients with a penile prosthesis presenting with clinically localized prostate cancer. METHODS:From January 1990 to December 1997, 8 consecutive men with a penile prosthesis underwent RRP for clinically localized prostate cancer. Retrospe...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/s0090-4295(98)00372-0
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVE:To provide contemporary gestational age-specific recommendations for management, a retrospective series of patients with renal or bladder cancer during pregnancy is reported. METHODS:Obstetric and oncological data of pregnant patients with a diagnosis of renal or bladder cancer were selected from the worldwi...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2020.08.084
更新日期:2020-10-22 00:00:00
abstract:OBJECTIVES:To assess the effects of saw palmetto on voiding symptoms and urodynamic parameters in men with lower urinary tract symptoms (LUTS) presumed secondary to benign prostatic hyperplasia (BPH). METHODS:Fifty men with previously untreated LUTS and a minimum International Prostate Symptom Score (IPSS) of 10 or gr...
journal_title:Urology
pub_type: 临床试验,杂志文章
doi:10.1016/s0090-4295(98)00143-5
更新日期:1998-06-01 00:00:00
abstract::A case in which sonography demonstrated that calculi may arise in female urethral diverticula is presented. The diagnosis of female urethral diverticula is reviewed. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(93)90549-p
更新日期:1993-12-01 00:00:00
abstract:OBJECTIVE:To present our experience of vaginal reconstruction in female cloacal exstrophy patients. PATIENTS AND METHODS:The records of 7 postpubertal female cloacal exstrophy patients (median age, 17 years; range, 11-26 years) were retrospectively reviewed. Complete duplication of the uterus and vagina was noted in a...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2014.05.042
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVES:To evaluate fluorescence in situ hybridization (FISH) in voided urine specimens and selective upper urinary tract washings obtained from patients with suspected transitional cell cancer of the upper urinary tract (UT-TCC). METHODS:A total of 16 patients with suspected UT-TCC were included in the study. All ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2007.06.1103
更新日期:2007-10-01 00:00:00
abstract::A nephrogenic adenoma located within a urethral diverticulum of a female was found incidental to a diverticulectomy. Cases of this apparently benign lesion have been reported previously, but the lesions were located in the bladder, particularly in older males with a history of chronic cystitis. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(78)90109-7
更新日期:1978-02-01 00:00:00
abstract:OBJECTIVES:To investigate the clinical and pathologic characteristics of prostate cancer in Korean men to determine how ethnic differences affect clinical outcome. METHODS:The clinical and pathologic data of 604 Korean men who underwent radical prostatectomy from 1994 to 2003 were reviewed. Biochemical failure was def...
journal_title:Urology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.urology.2006.04.029
更新日期:2006-10-01 00:00:00
abstract:OBJECTIVE:To assess the relative contributions of patient and surgeon factors for predicting selection of ileal conduit (IC), neobladder (NB), or continent pouch (CP) urinary diversions (UD) for patients diagnosed with muscle-invasive/high-risk nonmuscle invasive bladder cancer. This information is needed to enhance re...
journal_title:Urology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.urology.2018.09.037
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:It has been suggested that prostatic neuroendocrine (NE) cells play an important role in the growth and differentiation of the prostate by secreting various neuropeptides and serotonin. However, the mechanism by which NE cells themselves are regulated is virtually unknown. In the present study we evaluated th...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(94)90146-5
更新日期:1994-06-01 00:00:00