Decision analysis of dutasteride use for patients with negative prostate biopsy.

Abstract:

OBJECTIVE:To determine whether the additional benefits of improved prostate cancer detection associated with 5α-reductase inhibitors are sufficient to warrant chemoprevention in the case where the degree of prostate cancer risk reduction is deemed inadequate. METHODS:We reanalyzed data from REDUCE, a randomized trial of dutasteride for prostate cancer chemoprevention in men with prior negative biopsy. We evaluated whether statistical models using prostate-specific antigen (PSA) and PSA velocity could help predict the result of repeat prostate biopsy separately for dutasteride and placebo groups. Area under the curve was evaluated by 10-fold cross-validation. RESULTS:PSA velocity improved discrimination at 4 years in the dutasteride group but not at 2 years nor in the placebo group. At 2 years, dutasteride improved discrimination of PSA slightly (0.616 vs. 0.603 for any grade cancer; 0.681 vs. 0.676 for high-grade disease). Between-group differences in cancer rates at 4 years were small. CONCLUSION:Clinicians who are willing to treat at least 23 patients with dutasteride for 2 years to avoid 1 prostate cancer diagnosis should offer dutasteride after initial negative biopsy. Clinicians not willing to do so might consider dutasteride for its additional benefit of reducing unnecessary biopsy, although this benefit is apparent only under very restrictive conditions. It is difficult to justify extending treatment with dutasteride for >2 years.

journal_name

Urology

journal_title

Urology

authors

Vickers AJ,Sjoberg DD

doi

10.1016/j.urology.2014.08.048

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

337-41

issue

2

eissn

0090-4295

issn

1527-9995

pii

S0090-4295(14)01101-7

journal_volume

85

pub_type

杂志文章,随机对照试验

相关文献

UROLOGY文献大全
  • Primary granulocytic sarcoma of the urinary bladder: case report and review of the literature.

    abstract::We report a case of granulocytic sarcoma of the urinary bladder, with no evidence of hematologic involvement. The patient was initially misdiagnosed and was treated with chemotherapy for transitional carcinoma grade 3. Despite this treatment, the clinical features of the patient progressed, and a repeated biopsy yield...

    journal_title:Urology

    pub_type: 杂志文章,评审

    doi:10.1016/s0090-4295(02)01750-8

    authors: Aki H,Baslar Z,Uygun N,Ozguroglu M,Tuzuner N

    更新日期:2002-08-01 00:00:00

  • Combined intravesical and oral oxybutynin chloride in adult patients with spinal cord injury.

    abstract:OBJECTIVES:Detrusor hyperreflexia with elevated storage pressures presents a major risk factor for renal damage in patients with neurogenic lower urinary tract dysfunction. If standard anticholinergic treatment is unsuccessful, surgical treatment must be considered. We evaluated the effects of intravesical oxybutynin t...

    journal_title:Urology

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0090-4295(99)00540-3

    authors: Pannek J,Sommerfeld HJ,Bötel U,Senge T

    更新日期:2000-03-01 00:00:00

  • Immunologic response and proviral load in human T-lymphotropic virus type 1 infected individuals with erectile dysfunction.

    abstract:OBJECTIVE:To evaluate the immune response and proviral load in individuals with human T-lymphotropic virus type 1 (HTLV-1) and erectile dysfunction (ED) compared with those in the controls. MATERIALS AND METHODS:We performed a cross-sectional study of 102 men aged 18-70 years with positive serology for HTLV-1, who wer...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2013.02.014

    authors: Tannus M,Costa DT,Castro NM,Oliveira P,Carvalho N,Andrade R,Santos S,Carvalho EM

    更新日期:2013-06-01 00:00:00

  • Predicting Short-term Outcomes After Radical Cystectomy Based on Frailty.

    abstract:OBJECTIVE:To evaluate the impact of frailty on adverse perioperative outcomes in patients treated with radical cystectomy for bladder cancer. MATERIAL AND METHODS:We identified 9459 adults (age ≥18) in the Nationwide Readmission Database who underwent radical cystectomy in 2014 for bladder cancer. We defined patients'...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2019.04.057

    authors: Michel J,Goel AN,Golla V,Lenis AT,Johnson DC,Chamie K,Litwin MS

    更新日期:2019-11-01 00:00:00

  • Constipation associated with vesicoureteral reflux.

    abstract::Seventeen children who had vesicoureteral reflux underwent urodynamic and rectal manometric studies. All had uninhibited bladder contractions. All had rectal dilatation confirming the presence of constipation by rectal balloon manometry. The recurrent association of constipation with ureteral reflux suggests the possi...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/0090-4295(86)90070-1

    authors: O'Regan S,Schick E,Hamburger B,Yazbeck S

    更新日期:1986-11-01 00:00:00

  • Vasectomy reversal outcomes among patients with vasal obstructive intervals greater than 10 years.

    abstract:OBJECTIVE:To analyze the vasectomy reversal (VR) outcomes specifically among patients with vasal obstructive intervals (VOIs) of >10 years. The VOI has been shown to be a significant predictor of outcome after VR. Although no strict cutoff exists, couples have frequently been discouraged from considering a VR strictly ...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2013.09.016

    authors: Grober ED,Karpman E,Fanipour M

    更新日期:2014-02-01 00:00:00

  • Prostate-specific antigen doubling time predicts response to deferred antiandrogen therapy in men with androgen-independent prostate cancer.

    abstract:OBJECTIVES:To identify the pretreatment variables that are predictive of response and the duration of response to deferred antiandrogen therapy in men with androgen-independent prostate cancer (AIPC). METHODS:A total of 375 patients receiving androgen deprivation therapy for advanced prostate cancer between 1977 and 2...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2003.11.016

    authors: Shulman MJ,Karam JA,Benaim EA

    更新日期:2004-04-01 00:00:00

  • Complete eversion and prolapse of bladder.

    abstract::Complete eversion and prolapse of the urinary bladder is rare. We report a case occurring in an eighty-two-year-old female. We believe only 3 previous cases have been reported, and only 1 of these occurred in an adult. ...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/0090-4295(83)90310-2

    authors: Underhill TR,Altaffer LF 3rd

    更新日期:1983-12-01 00:00:00

  • Radiographic Kinetics of Sarcomatoid Renal Cell Carcinoma.

    abstract::Renal cell carcinoma is a common entity often managed surgically with excellent survival benefits. We report a rare case of sarcomatoid renal cell carcinoma with aggressive growth kinetics after palliative resection captured radiographically. ...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2016.03.027

    authors: Syed A,Raval A,Pridjian A,Birbe R,Trabulsi EJ

    更新日期:2016-07-01 00:00:00

  • Sacral Neuromodulation in Urological Practice.

    abstract::Sacral neuromodulation (SNM) is a minimally invasive, restorative treatment to improve voiding and elimination functions. We give a historical perspective of SNM and explore the evidence for the use of this therapy for Food and Drug Administration-approved pathologies as well as disease processes that are being treate...

    journal_title:Urology

    pub_type: 杂志文章,评审

    doi:10.1016/j.urology.2016.06.004

    authors: Liberman D,Ehlert MJ,Siegel SW

    更新日期:2017-01-01 00:00:00

  • Unicentric Castleman's disease associated with hydronephrosis.

    abstract::We describe a patient with an unusual case of unicentric Castleman's disease, which bore a malignant appearance and was located in the pararenal space. She initially presented with hydronephrosis. Two years after surgical removal of the tumor, no recurrence was evident. To our knowledge, only 2 additional cases of thi...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/s0090-4295(00)00783-4

    authors: Hsu HH,Chen YC,Fang JT,Huang CC,Shih LY,Ghuang CK

    更新日期:2000-11-01 00:00:00

  • Regression of large pelvic desmoid tumor by tamoxifen and sulindac.

    abstract::A 54-year-old man was evaluated for symptoms of bladder outlet obstruction. Evaluation revealed a 10 by 9.8-cm tumor composed of bland, fibroblastic, poorly cellular material adjacent to the prostate. Administration of a course of antiestrogen (tamoxifen) and a nonsteroidal anti-inflammatory agent (sulindac) resulted ...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/s0090-4295(96)00026-x

    authors: Izes JK,Zinman LN,Larsen CR

    更新日期:1996-05-01 00:00:00

  • Percutaneous nephrolithotomy: nephrostomy or tubeless or totally tubeless?

    abstract:OBJECTIVES:To compare the feasibility and morbidity of tubeless, totally tubeless, and standard percutaneous nephrolithotomy (PNL) with nephrostomy tube in a single center with selected patient population. METHODS:Between July 2006 and February 2008, PNL was performed in 176 patients in this retrospective study. Patie...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2009.06.104

    authors: Istanbulluoglu MO,Cicek T,Ozturk B,Gonen M,Ozkardes H

    更新日期:2010-05-01 00:00:00

  • Influence of estradiol pretreatment on antimuscarinic action of oxybutynin in rat detrusor muscle.

    abstract:OBJECTIVES:To investigate the antimuscarinic effect of oxybutynin in the rat detrusor muscle after estrogen pretreatment because, to our knowledge, no study has been done on the interaction of estrogen with antimuscarinic drugs. Estrogen has been shown to affect muscarinic receptors in the detrusor muscle of animals. I...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2004.10.069

    authors: Yildiz O,Ozgok Y,Seyrek M,Un I,Kilciler M,Tuncer M

    更新日期:2005-04-01 00:00:00

  • Congenital unilateral ureteropelvic junction obstruction of the rat: a useful animal model for human ureteropelvic junction obstruction?

    abstract:OBJECTIVES:To investigate the expression of endothelin-1 (ET-1) and adrenomedullin (ADM) in the renal pelvis, stenotic ureteropelvic junction, and ureter of 20 male Wistar rats with congenital unilateral ureteropelvic junction obstruction; the normal contralateral kidneys served as controls. The molecular pathophysiolo...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2003.07.019

    authors: Miller J,Hesse M,Diemer T,Haenze J,Knerr I,Rascher W,Weidner W

    更新日期:2004-01-01 00:00:00

  • Ureteroscopic diagnosis of intraluminal metastatic rectal carcinoma.

    abstract::Ureteral obstruction resulting from metastatic adenocarcinoma is almost always extrinsic in nature. In contrast, true intraluminal metastases are extremely rare. With this report, we document the videoendoscopic appearance of true intraluminal ureteral metastases from metastatic rectal cancer confirmed with histopatho...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/s0090-4295(97)00072-1

    authors: Fazeli-Matin S,Levin HS,Streem SB

    更新日期:1997-06-01 00:00:00

  • Nephrolithiasis and Elevated Urinary Ammonium: A Matched Comparative Study.

    abstract:OBJECTIVE:To describe the associations between elevated urinary ammonium and clinical characteristics of kidney stone formers. A 24-hour urine test is recommended in high-risk patients to identify urinary abnormalities and select interventions to reduce the recurrence risk. While elevations in urine ammonium may be see...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2020.05.063

    authors: Sui W,Hancock J,Asplin JR,Gould ER,Hsi RS

    更新日期:2020-10-01 00:00:00

  • Correlation of ureteroscopic appearance with histologic grade of upper tract transitional cell carcinoma.

    abstract:OBJECTIVES:To correlate urologists' impressions of the tumor grade of upper tract tumors at ureteroscopy with the histologic findings after biopsy or resection. METHODS:A retrospective review of all patients who underwent diagnostic or therapeutic ureteroscopy for upper tract transitional cell carcinoma (TCC) between ...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2003.10.076

    authors: El-Hakim A,Weiss GH,Lee BR,Smith AD

    更新日期:2004-04-01 00:00:00

  • Vaginal reconstruction in female cloacal exstrophy patients.

    abstract:OBJECTIVE:To present our experience of vaginal reconstruction in female cloacal exstrophy patients. PATIENTS AND METHODS:The records of 7 postpubertal female cloacal exstrophy patients (median age, 17 years; range, 11-26 years) were retrospectively reviewed. Complete duplication of the uterus and vagina was noted in a...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2014.05.042

    authors: Hisamatsu E,Nakagawa Y,Sugita Y

    更新日期:2014-09-01 00:00:00

  • Loss of expression of von Hippel-Lindau tumor suppressor protein associated with improved survival in patients with early-stage clear cell renal cell carcinoma.

    abstract:OBJECTIVES:To determine whether actual expression of the von Hippel-Lindau (VHL) protein product itself (pVHL) is associated with clear cell renal cell carcinoma (CC-RCC) survival. Recent data have suggested that somatic mutations of the VHL tumor suppressor gene are associated with better cancer-specific survival in p...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2004.12.040

    authors: Parker AS,Cheville JC,Lohse CM,Igel T,Leibovich BC,Blute ML

    更新日期:2005-06-01 00:00:00

  • Urothelial cell platelet-activating factor production mediated by calcium-independent phospholipase A2γ.

    abstract:OBJECTIVES:To determine the effect of phospholipase A(2) (PLA(2)) inhibitors on urothelial cell platelet-activating factor (PAF) production in response to tryptase stimulation. METHODS:Urothelial cells isolated from normal human ureters were immortalized with the human papillomavirus type 16E6E7 cell line (TEU-2 cells...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2010.08.032

    authors: Rastogi P,Rickard A,Klumpp DJ,McHowat J

    更新日期:2011-01-01 00:00:00

  • Microsurgical two-layer vasovasostomy: word of caution.

    abstract::Microsurgical technique, with separate mucosal and muscular layer anastomosis, recently has been advocated as the most successful method of vasovasostomy. Unexpected difficulties may be encountered using this method; moreover, considerable practice in the microsurgical laboratory is mandatory before actual performance...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/0090-4295(78)90015-8

    authors: Belker AM,Acland RD,Juhala CA

    更新日期:1978-06-01 00:00:00

  • Levels of nitric oxide metabolites do not increase during penile erection.

    abstract::Cavernosal smooth muscle relaxation, one of the primary events in penile erection, is initiated by the synthesis and release of nitric oxide (NO) from the neurons of the cavernosa. The present study was undertaken to determine whether or not serum levels of NO metabolites rise during an erection. Since NO is rapidly c...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/0090-4295(93)90271-b

    authors: Moriel EZ,Gonzalez-Cadavid N,Ignarro LJ,Byrns R,Rajfer J

    更新日期:1993-11-01 00:00:00

  • Hand port use for extraction during laparoscopic donor nephrectomy.

    abstract:OBJECTIVES:To report our technique of laparoscopic donor nephrectomy using the hand port for specimen extraction. In 1999, our institution began a kidney transplant program. Donor nephrectomies have since been exclusively performed laparoscopically. Early in our experience, we used a specimen extraction bag to assist i...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2005.10.065

    authors: Lallas CD,Castle EP,Andrews PE

    更新日期:2006-04-01 00:00:00

  • Seminal oxidative stress in patients with chronic prostatitis.

    abstract:OBJECTIVES:An association between prostatitis and male infertility has been suspected, yet is poorly understood. Prostatitis is often associated with granulocytes in the prostatic fluid that generate reactive oxygen species (ROS), known to impair male fertility. We compared ROS, the total antioxidant capacity (TAC), an...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/s0090-4295(99)00613-5

    authors: Pasqualotto FF,Sharma RK,Potts JM,Nelson DR,Thomas AJ,Agarwal A

    更新日期:2000-06-01 00:00:00

  • Radioisotopic transit parameters in obstruction of pelviureteral junction.

    abstract::Cortical and whole kidney radionuclide transit parameters were studied in 16 patients who underwent a pyeloplasty for unilateral pelviureteral junction (PUJ) obstruction. As expected, the whole kidney mean transit time was found to be very sensitive but, due to the low specificity, not very helpful in the distinction ...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/0090-4295(88)90249-x

    authors: Verboven M,Achten R,Keuppens F,Jonckheer M,Piepsz A

    更新日期:1988-10-01 00:00:00

  • Extensive, obstructing sodium urate deposition on wall of isolated ileum for replacement of entire ureter.

    abstract::We report a rare case of obstructing sodium urate stones occurring in the form of extensive deposition on the wall of isolated ileum for replacement of the entire ureter. The stones were disintegrated and removed with a rigid ureteroscope and an electrohydraulic lithotriptor. Hyperuriaciduria, excessive alkalization o...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/0090-4295(93)90349-f

    authors: Naito S,Iwabuchi N,Kumazawa J

    更新日期:1993-07-01 00:00:00

  • Heat/burning sensation induced by topical application of capsaicin on perineal cutaneous area: new approach in diagnosis and treatment of chronic prostatitis/chronic pelvic pain syndrome?

    abstract:OBJECTIVES:To investigate the feasibility, safety, and efficacy of perineal cutaneous application of capsaicin as a test for the diagnosis, as well as a potential therapeutic tool, in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). METHODS:We recruited 22 patients (mean age 34.5 years, range ...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2005.11.028

    authors: Turini D,Beneforti P,Spinelli M,Malagutti S,Lazzeri M

    更新日期:2006-05-01 00:00:00

  • Urinary bladder leiomyoma associated with pulmonary lymphangioleiomyomatosis.

    abstract::Leiomyomas account for less than 0.43% of all bladder tumors. To date only about 250 cases have been reported in the literature. Pulmonary lymphangioleiomyomatosis (LAM) is a rare lung disease featuring abnormal proliferation of atypical smooth muscle cells around bronchovascular structures. We describe a woman with L...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2007.11.031

    authors: Metzdorf MM,Schmidt JD

    更新日期:2008-04-01 00:00:00

  • Renal and Bladder Cancer During Pregnancy: A Review of 47 Cases and Literature-based Recommendations for Management.

    abstract:OBJECTIVE:To provide contemporary gestational age-specific recommendations for management, a retrospective series of patients with renal or bladder cancer during pregnancy is reported. METHODS:Obstetric and oncological data of pregnant patients with a diagnosis of renal or bladder cancer were selected from the worldwi...

    journal_title:Urology

    pub_type: 杂志文章

    doi:10.1016/j.urology.2020.08.084

    authors: Maggen C,Linssen J,Gziri MM,Zola P,Cardonick E,de Groot CJM,Garcia AC,Fruscio R,Drochytek V,Van Calsteren K,Albersen M,Amant F,International Network on Cancer, Infertility and Pregnancy (INCIP).

    更新日期:2020-10-22 00:00:00