Abstract：
OBJECTIVES:Detrusor hyperreflexia with elevated storage pressures presents a major risk factor for renal damage in patients with neurogenic lower urinary tract dysfunction. If standard anticholinergic treatment is unsuccessful, surgical treatment must be considered. We evaluated the effects of intravesical oxybutynin treatment on detrusor hyperreflexia in patients in whom standard oral treatment had failed. METHODS:Twenty-five patients (mean age 36. 7 years) with storage pressures greater than 40 cm H(2)O despite standard anticholinergic treatment received intravesical (15 mg three times daily) and oral oxybutynin chloride treatment. The follow-up evaluations included urodynamic testing, renal ultrasound, urine examination (urinalysis and urine culture), and evaluation of side effects. RESULTS:The mean follow-up was 6 months. Intravesical treatment led to an increase in bladder storage volume from 349 to 420 mL. The mean maximum storage pressure was significantly reduced from 54 to 26.5 cm H(2)O. Detrusor storage pressures returned to values less than 40 cm H(2)O in 21 of 25 patients. Dysreflexia was treated successfully in 3 of 5 patients. No patient developed renal damage. No severe side effects or drug-related discontinuation of treatment were observed. CONCLUSIONS:Intravesical oxybutynin therapy seems to be a safe and effective treatment option for detrusor hyperreflexia in adults and avoids surgical treatment in most patients. Long-term observations concerning side effects, acceptance, and efficacy are needed.
journal_name
Urologyjournal_title
Urologyauthors
Pannek J,Sommerfeld HJ,Bötel U,Senge Tdoi
10.1016/s0090-4295(99)00540-3subject
Has Abstractpub_date
2000-03-01 00:00:00pages
358-62issue
3eissn
0090-4295issn
1527-9995pii
S0090-4295(99)00540-3journal_volume
55pub_type
临床试验,杂志文章相关文献
UROLOGY文献大全abstract：OBJECTIVE:To evaluate the specific contribution of ilioinguinal (II) and iliohypogastric (IH) nerve injury and referred pain to interstitial cystitis/bladder pain syndrome and patient-reported chronic pelvic pain, and to enumerate the effects of II and IH nerve resection on the pain and voiding symptoms in patients wit...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2020.11.034
更新日期：2020-12-03 00:00:00
abstract：OBJECTIVES:We evaluated 11 currently available biopsy devices using a standard and a novel renal biopsy technique in a porcine model. We then applied our laboratory findings to clinical practice to improve our biopsy results during laparoscopic renal cryoablation procedures. METHODS:A total of 11 biopsy devices were a...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2007.04.028
更新日期：2007-09-01 00:00:00
abstract：OBJECTIVES:To examine the correlation of biopsy Gleason scores with radical prostatectomy specimens from a laboratory that uses protocols designed to minimize observer variability. This protocol mandates consensus case review of all nonbenign cases. METHODS:Between August 24, 1993 and June 26, 1997, 106 patients who u...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/s0090-4295(98)00002-8
更新日期：1998-04-01 00:00:00
abstract：OBJECTIVES:To determine whether platelet-derived growth factor receptor (PDGFR) plays a role in the tumorigenicity of prostate cancer cells. METHODS:PC3 prostate cancer cells were transfected with small interfering (si)PDGFR-α and siPDGFR-β, constructed according to the conventional small interfering RNA design standa...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2011.01.050
更新日期：2011-06-01 00:00:00
abstract：OBJECTIVE:To evaluate the effects of different degrees of intratesticular hematoma (ITH), a major consequence of blunt testis trauma, on testis microstructure and function. We determined a cutoff point for significant vs nonsignificant ITH. METHODS:Seventy male rats were divided into 7 equal groups. The control group ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2018.05.005
更新日期：2018-08-01 00:00:00
abstract：OBJECTIVE:To develop a noninvasive and real-time dual-wavelengths optic system to detect testicular torsion in an animal model. Diagnosis of testicular torsion is challenging in emergency conditions and frequently ends with surgical exploration. MATERIALS AND METHODS:In this study, 9 male 8-month-old Wistar albino rat...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2011.12.005
更新日期：2012-04-01 00:00:00
abstract：OBJECTIVE:To determine factors associated with performance and quality of lymph node dissection during radical nephrectomy. MATERIALS AND METHODS:Using an International Data Registry, we performed multilevel logistic regression to determine the association of surgical approach (open surgery vs minimally invasive surge...
journal_title：Urology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.urology.2019.01.068
更新日期：2019-07-01 00:00:00
abstract：:Forty-three patients with benign prostatic hypertrophy with marked urinary distress, which I believed warranted surgical treatment, were selected from private practice. These patients were treated with long-term conservative therapy to determine the efficacy of candicidin for this condition. Patients receiving candici...
journal_title：Urology
pub_type： 临床试验,杂志文章
doi：10.1016/0090-4295(74)90113-7
更新日期：1974-07-01 00:00:00
abstract：OBJECTIVES:To determine whether needle biopsy of the posterolateral aspects of the prostate aids in prostate cancer detection. In the routine sextant biopsy strategy, the posterolateral aspects of the prostate are not sampled. METHODS:Using an 18-gauge biopsy gun, we performed sextant biopsies and an additional nine n...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(01)00979-7
更新日期：2001-06-01 00:00:00
abstract：:We report a case of granulocytic sarcoma of the urinary bladder, with no evidence of hematologic involvement. The patient was initially misdiagnosed and was treated with chemotherapy for transitional carcinoma grade 3. Despite this treatment, the clinical features of the patient progressed, and a repeated biopsy yield...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/s0090-4295(02)01750-8
更新日期：2002-08-01 00:00:00
abstract：OBJECTIVES:To determine the clinical implication of the loss of transforming growth factor-beta (TGF-beta) receptor (TbetaR) expression for the pathologic features in renal cell carcinoma (RCC) and the prognosis of 62 patients (Stage I, 4; Stage II, 28; Stage III, 11; and Stage IV, 19) who underwent radical nephrectomy...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(02)02553-0
更新日期：2003-05-01 00:00:00
abstract：OBJECTIVE:To investigate the effect of chronic daily administration of different doses of tadalafil on the structure of the seminiferous tubules and on spermatogenesis. MATERIALS AND METHODS:Sixty adult male Wistar rats were included; they were divided into four groups: a control group (group I) and groups II, III, an...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2015.12.038
更新日期：2016-04-01 00:00:00
abstract：OBJECTIVE:To provide an anatomical atlas made of serially sectioned images of a female cadaver that clearly demonstrated the pudendal nerve. MATERIALS AND METHODS:The courses of the pudendal nerve, internal pudendal artery, and internal pudendal vein were observed on the sectioned images of a female cadaver. The spati...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2020.05.007
更新日期：2020-08-01 00:00:00
abstract：:A fifty-year-old male patient with bilateral cryptorchidism and abdominal mass due to a large seminoma was found to have persistent müllerian duct derivatives: uterus and fallopian tubes. The patient underwent total hysterosalpingectomy and bilateral intra-abdominal orchidectomy of a seminoma and testes. He was given ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(84)90391-1
更新日期：1984-07-01 00:00:00
abstract：OBJECTIVES:To determine whether atherosclerosis-induced chronic pelvic ischemia plays a role in the pathogenesis of aging bladder dysfunction. METHODS:Old (70 weeks of age), apolipoprotein E gene knockout (APOEKO) mice, known to develop atherosclerosis spontaneously were used. A group of 70-week-old C57B mice were use...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2004.08.055
更新日期：2005-01-01 00:00:00
abstract：:As with other drugs, new drug applications for marketing approval of chemopreventive drugs must include data from adequate and well-controlled clinical trials that demonstrate effectiveness and safety for the intended use. This article summarizes the regulatory requirements for traditional marketing approval, as well ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(00)00977-8
更新日期：2001-04-01 00:00:00
abstract：OBJECTIVE:To describe distinctive morphologic variations of the prostate associated with the prostatic urethra, and to determine whether structural changes of the urethra within the prostate resulting from gland enlargement, rather than prostrate volume itself, lead to male lower urinary tract symptom (LUTS). MATERIAL...
journal_title：Urology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.urology.2017.03.014
更新日期：2017-06-01 00:00:00
abstract：:A technique is described wherein chordee which persists after resection of all evident fibrous tissue may be corrected. This technique involves a ventral midline incision and transverse dorsal plicating sutures which rotate the corporeal bodies to allow a straight erection. ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(89)90442-1
更新日期：1989-12-01 00:00:00
abstract：:In 1981, the National Prostatic Cancer Treatment Group began an open survey of available A1, B1 prostatic adenocarcinomas to determine outcome and clinical characteristics. Their report as of September, 1985, summarizes the outcome and important features of the survey. The majority of A1 cases had a low tumor grade I ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(87)90065-3
更新日期：1987-03-01 00:00:00
abstract：:From 1962 to 1978, 56 patients underwent transrenal endarterectomy as surgical treatment for renovascular hypertension. Over-all results were 39 per cent cured, 36 per cent improved, and 25 per cent failed. Criteria for selecting patients with atherosclerotic renal artery disease for surgical treatment are reviewed. T...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(79)90181-x
更新日期：1979-11-01 00:00:00
abstract：OBJECTIVE:To evaluate the feasibility of routine outpatient management after robotic-assisted radical prostatectomy (RARP). Prostate cancer is indeed the second most common cancer in men. Surgical technics have evolved from open surgery to robot-assisted surgery with a reduction of postoperative complications. Such tec...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2019.01.050
更新日期：2019-06-01 00:00:00
abstract：:We present 2 cases of prenatal hydroureteronephrosis and bladder outlet obstruction due to an obstructing ureterocele. Both neonates were stabilized and managed with early endoscopic decompression. Neither infant demonstrated significant function in the kidney ipsilateral to the ureterocele either before or after uret...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(98)00337-9
更新日期：1998-12-01 00:00:00
abstract：OBJECTIVES:Epididymovasostomy is commonly performed at the most distal site of the epididymis where whole sperm are present within the lumen, regardless of their motility status. Although more fresh and motile sperm can be found more proximally within the epididymis, it is believed that the outcome of epididymovasostom...
journal_title：Urology
pub_type： 临床试验,杂志文章
doi：10.1016/s0090-4295(97)80001-5
更新日期：1997-04-01 00:00:00
abstract：OBJECTIVE:To investigate the effect of low-intensity pulsed ultrasound (LIPUS) as a treatment for erectile dysfunction (ED) in a rat model of type I diabetes mellitus (DM) induced by streptozotocin (STZ). MATERIALS AND METHODS:Seventy male Sprague-Dawley rats were randomly assigned to 2 cohorts: a normal control (NC) ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2015.07.026
更新日期：2015-12-01 00:00:00
abstract：:We report the case of Kock pouch incontinence resulting from perforation of the efferent nipple valve by an unsuccessful catheterization attempt in a patient with a spinal cord injury. Continence was reestablished by surgical revision. ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2007.03.066
更新日期：2007-07-01 00:00:00
abstract：:A papilloma in the renal pelvis of a five-year-old girl is reported. The transitional cell tumors of the renal pelvis in the pediatric age group are reviewed, and this is found to be the first case of a benign papilloma in childhood. We believe this pathologic entity should be included in the differential diagnosis of...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(90)80108-y
更新日期：1990-06-01 00:00:00
abstract：OBJECTIVE:To analyze the vasectomy reversal (VR) outcomes specifically among patients with vasal obstructive intervals (VOIs) of >10 years. The VOI has been shown to be a significant predictor of outcome after VR. Although no strict cutoff exists, couples have frequently been discouraged from considering a VR strictly ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2013.09.016
更新日期：2014-02-01 00:00:00
abstract：OBJECTIVE:To evaluate the effect of 3-dimensionally (3D) printed physical renal models with enhancing masses on medical trainee characterization, localization, and understanding of renal malignancy. METHODS:Proprietary software was used to import standard computed tomography (CT) cross-sectional imaging into 3D printe...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2015.02.053
更新日期：2015-06-01 00:00:00
abstract：:Urinary stone disease (USD) is an important healthcare problem in the US affecting both adults and children, and costs $10 billion to the nation. Prevalence of USD has nearly doubled during the last 15 years in parallel to the obesity and type 2 diabetes epidemic. Despite the advances in the management of an acute epi...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/j.urology.2015.07.006
更新日期：2015-10-01 00:00:00
abstract：OBJECTIVES:To evaluate a selected population of 50 consecutive patients with primary T1, G3 bladder transitional cell carcinoma in the absence of carcinoma in situ (Tis) treated with a bladder-sparing approach. METHODS:Between January 1983 and December 1992, all patients were treated by transurethral resection (TUR) p...
journal_title：Urology
pub_type： 临床试验,杂志文章
doi：10.1016/s0090-4295(96)00007-6
更新日期：1996-05-01 00:00:00
