Abstract：
OBJECTIVES:To determine the clinical implication of the loss of transforming growth factor-beta (TGF-beta) receptor (TbetaR) expression for the pathologic features in renal cell carcinoma (RCC) and the prognosis of 62 patients (Stage I, 4; Stage II, 28; Stage III, 11; and Stage IV, 19) who underwent radical nephrectomy for RCC. Loss of expression in TbetaR could result in escape from the growth inhibitory effect of TGF-beta in TGF-beta-secreting cancer. METHODS:TbetaR and apoptosis in the tumor were detected by immunohistochemistry using samples from 62 patients. We statistically investigated the relationship among the TbetaR expression pattern, pathologic features, and the prognosis of patients with RCC. RESULTS:A loss of expression of TbetaR-I and TbetaR-II was identified in 29 patients (46.7%) and 31 patients (50.0%), respectively. Although the loss of TbetaR-I was not associated with clinical stage, the loss of TbetaR-II was associated with clinical stage (P <0.01). Univariate analysis of all patients demonstrated that Stage T3 or greater, clinical Stage III or greater, loss of TbetaR-II, and a tumor apoptotic index of less than 35 were associated with a significantly lower survival rate than their respective counterparts. Multivariate analysis showed that the only two significant prognostic factors were clinical stage and loss of TbetaR-II. In addition, TbetaR-negative RCC had significantly lower apoptosis than did TbetaR-positive RCC. CONCLUSIONS:These results suggest that a loss of TbetaR-II expression in the primary tumor is a significant prognostic factor in patients with RCC.
journal_name
Urologyjournal_title
Urologyauthors
Miyajima A,Asano T,Seta K,Asano T,Kakoi N,Hayakawa Mdoi
10.1016/s0090-4295(02)02553-0subject
Has Abstractpub_date
2003-05-01 00:00:00pages
1072-7issue
5eissn
0090-4295issn
1527-9995pii
S0090429502025530journal_volume
61pub_type
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