Abstract:
OBJECTIVE:To evaluate the immune response and proviral load in individuals with human T-lymphotropic virus type 1 (HTLV-1) and erectile dysfunction (ED) compared with those in the controls. MATERIALS AND METHODS:We performed a cross-sectional study of 102 men aged 18-70 years with positive serology for HTLV-1, who were interviewed from 2004 to 2010. The study sample was divided into 2 groups: group 1, 42 HTLV-1-infected men with ED, as determined by the International Index of Erectile Function-5 score; and group 2, 60 HTLV-1-infected men without ED. The cytokines interferon-γ and tumor necrosis factor-α, and the proviral load were analyzed between the 2 groups. RESULTS:Compared with those without ED, the men with ED had greater levels of tumor necrosis factor-α (545.37 ± 877.06 vs 509.39 ± 724.70 pg/mL) and interferon-γ (1154.35 ± 1282.98 vs 1122.78 ± 1573.16 pg/mL), but this difference was not significant (P = .69 and P = .57, respectively). The proviral load was 135,695 ± 190,113 copies/10(5) cells in the ED group and 47,607 ± 83,129 copies/10(5) cells in the non-ED patients, with a statistically significant difference (P = .02). When ED was stratified as mild, moderate, and severe, no difference was found in the proviral load among the ED groups (P = .09); however, the levels were greater in the severe forms. CONCLUSION:The association of a greater proviral load in men with ED with HTLV-1 gives support to the idea that ED is part of the autonomic syndrome related to viral infection and should be investigated for early identification of the syndrome.
journal_name
Urologyjournal_title
Urologyauthors
Tannus M,Costa DT,Castro NM,Oliveira P,Carvalho N,Andrade R,Santos S,Carvalho EMdoi
10.1016/j.urology.2013.02.014subject
Has Abstractpub_date
2013-06-01 00:00:00pages
1261-4issue
6eissn
0090-4295issn
1527-9995pii
S0090-4295(13)00212-4journal_volume
81pub_type
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