Abstract：
OBJECTIVES:To investigate the associations between benign prostatic hyperplasia (BPH) and polymorphisms in genes that encode growth factors, cytokines, and vitamin D and their receptors. METHODS:A total of 510 white men (median age 60 years) randomly selected from the Olmsted County, Minnesota community participated in a study of BPH from 1990 to 2000. Biennial measurements were made to assess the International Prostate Symptom Score, peak urinary flow rate, and prostate volume. Genotyping of genes that encode transforming growth factor, interleukin-10, tumor necrosis factor, and vitamin D receptor, among others, was performed. RESULTS:The CC genotype of the transforming growth factor-beta 1 gene was inversely associated with treatment for BPH (hazard ratio [HR] 0.38, 95% confidence interval [CI] 0.15 to 0.98). The presence of at least one allele with 17 or more CA repeats of the epidermal growth factor receptor gene was positively associated with an International Prostate Symptom Score greater than 7 (HR 1.32, 95% CI 1.01 to 1.73). The AA genotype of tumor necrosis factor-alpha was inversely associated with peak urinary flow rate (HR 0.33, 95% CI 0.12 to 0.90). For the vitamin D receptor gene, positive associations were found between prostate volume and the CC genotype of the T_C (Taq 1) polymorphism (HR 1.39, 95% CI 1.0 to 1.92) and the AA genotype of the G_A (Bsm 1) polymorphism (HR 1.36, 95% CI 1.06 to 1.74). CONCLUSIONS:These findings suggest that transforming growth factor-beta 1, tumor necrosis factor-alpha, epidermal growth factor receptor, and vitamin D receptor polymorphisms may be involved in the pathogenesis of BPH.
journal_name
Urologyjournal_title
Urologyauthors
Mullan RJ,Bergstralh EJ,Farmer SA,Jacobson DJ,Hebbring SJ,Cunningham JM,Thibodeau SN,Lieber MM,Jacobsen SJ,Roberts ROdoi
10.1016/j.urology.2005.08.061subject
Has Abstractpub_date
2006-02-01 00:00:00pages
300-5issue
2eissn
0090-4295issn
1527-9995pii
S0090-4295(05)01305-1journal_volume
67pub_type
杂志文章相关文献
UROLOGY文献大全abstract：:The presentation, diagnosis, and management of a patient with an ileovesical fistula is discussed, this being the second reported case in the literature. ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(89)90135-0
更新日期：1989-06-01 00:00:00
abstract：OBJECTIVES:To study the values of the renal resistive index (RI) before and at different points after relief of obstructive anuria and to correlate these values with the corresponding values of serum creatinine and with the recovery of renal function after release of obstruction. METHODS:A total of 32 consecutive pati...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(01)01623-5
更新日期：2002-04-01 00:00:00
abstract：:Overactive bladder (OAB) is a common, disabling condition associated with considerable negative impact on quality of life, quality of sleep, and mental health. The age-specific prevalence of OAB is similar among men and women. Urge incontinence affects only a portion of the OAB population: 33% of patients have OAB wit...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/j.urology.2004.10.047
更新日期：2004-12-01 00:00:00
abstract：OBJECTIVES:To determine why the incidence of pediatric urolithiasis is less than that of adult urolithiasis, we investigated the difference in inhibition of calcium oxalate (CaOX) crystallization between pediatric and adult urinary macromolecules (UMMs). METHODS:Urinary parameters in relation to urolithiasis, the inhi...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(99)00004-7
更新日期：1999-06-01 00:00:00
abstract：OBJECTIVES:Transitional cell carcinoma of the urinary bladder is associated with occupational exposure to 4,4'-methylenebis(2-chloroaniline) (MBOCA). A program to monitor MBOCA levels in the work environment and to screen for bladder cancer was performed at four MBOCA manufacturing factories. METHODS:The U.S. Occupati...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2005.02.031
更新日期：2005-08-01 00:00:00
abstract：OBJECTIVE:To evaluate the association between fruit/vegetable consumption and erectile dysfunction (ED) among Canadian men with diabetes. METHODS:Data from the 2011 Survey on Living with Chronic Diseases in Canada - Diabetes Component were analyzed using Statistical Analysis System Enterprise Guide (SAS EG). Responden...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2013.07.061
更新日期：2013-12-01 00:00:00
abstract：OBJECTIVES:To compare the stone-free rate and complications between horseshoe and normal kidneys. METHODS:Between December 1997 and June 2008, a total of 2401 patients with 2618 renal units underwent percutaneous nephrolithotomy (PCNL). During this period, we retrospectively reviewed the data of 46 patients with 50 (1...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2009.08.054
更新日期：2010-05-01 00:00:00
abstract：OBJECTIVE:To determine anatomical variations between the prone, supine, and supine oblique positions that are likely to affect percutaneous renal access. MATERIAL AND METHODS:Twenty patients underwent computed tomography urograms in the supine and prone positions. Twenty patients underwent supine oblique and prone sca...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2011.06.019
更新日期：2012-01-01 00:00:00
abstract：:Prostate carcinoma presenting initially as multiple pulmonary nodules in an asymptomatic patient without previous prostate carcinoma is unusual. Whether the incidence of prostate carcinoma is significantly increased in patients treated previously for germ cell tumors is unclear. We report such a patient, who responded...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(03)00568-5
更新日期：2003-10-01 00:00:00
abstract：:Urinary stones are a well-established complication of lower urinary tract reconstruction in children and can be managed through an open, percutaneous, or transurethral endoscopic approach for their surgical removal. For children with no urethral access, it is not generally advised to pursue an endoscopic approach thro...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2014.02.012
更新日期：2014-06-01 00:00:00
abstract：OBJECTIVES:We determined the value of clinical and radiological findings in diagnosis of false penile fracture. Also, the long-term outcome of conservative and surgical treatment of such patients was evaluated. METHODS:Seventeen patients with false penile fracture were treated conservatively (3 patients) and surgicall...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2009.11.086
更新日期：2010-06-01 00:00:00
abstract：:We report a case of a critically ill patient who had a ureterocutaneous fistula develop after placement of a Dacron bypass graft from the aorta to the right popliteal artery and the left femoral artery. We describe a successful nonsurgical method to terminate renal function in this patient, who was a poor operative ri...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(79)90295-4
更新日期：1979-02-01 00:00:00
abstract：OBJECTIVE:To evaluate the statistical association between routine home health use after prostatectomy, short-term surgical outcomes, and payments. METHODS:We identified all men who underwent a robotic radical prostatectomy from April 1, 2014, to October 31, 2015, in the Michigan Urological Surgery Improvement Collabor...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2017.11.004
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVE:To investigate the effect of hyperglycemia on the expression of the aquaporin (AQP) isoforms in the diabetic rat vagina. METHODS:Female Sprague-Dawley rats (230-240 g, n = 45) were divided into control (n = 10) and experimental (n = 35) groups. Diabetes in the experimental group was induced by intraperitonea...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2012.03.026
更新日期：2012-09-01 00:00:00
abstract：OBJECTIVES:The Radiation Therapy Oncology Group 9413 trial has shown an improvement in progression-free survival (PFS) with external beam radiotherapy that included the pelvic nodes. In clinical practice, two pelvic field size designs are in use. We examined the effect of differences in the level of pelvic nodal covera...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2007.08.037
更新日期：2008-02-01 00:00:00
abstract：:The cases of 57 patients who underwent implantation of a Kaufman prosthesis for urinary incontinence at this center are reviewed. All except one of the patients were incontinent following prostatic surgery. Although many of the patients required revision or adjustments after the initial implantation, 55 percent of the...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(91)80145-w
更新日期：1991-10-01 00:00:00
abstract：:This article will discuss the advantages and disadvantages of the various types of optical magnification currently available. The instruments necessary for performing most operations will also be presented. Attention will be focused on the physical properties and technical considerations of microvascular anastomosis. ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(84)80013-8
更新日期：1984-05-01 00:00:00
abstract：:Urethral pressure profiles have been a useful adjunct in the study of continence. Caffeine, a known smooth muscle inhibitor and skeletal muscle stimulator, is shown to decrease the urethral pressure profile in anesthetized dogs. This would lead one to believe that the smooth muscle component of urethral tonus is the d...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(77)90159-5
更新日期：1977-10-01 00:00:00
abstract：OBJECTIVES:To develop a method for assessing absolute renal function (as well as morphology) in children, using gamma camera imaging of intravenously injected technetium-99m (99mTc) dimercaptosuccinic acid (DMSA). METHODS:Forty-five children (ages 1 week to 10 years; mean, 2.0 years) were imaged using a planar techniq...
journal_title：Urology
pub_type： 临床试验,杂志文章
doi：10.1016/s0090-4295(99)80461-0
更新日期：1996-03-01 00:00:00
abstract：OBJECTIVE:Gender-affirming vaginectomy treats gender dysphoria associated with the presence of a vagina in transgender males.1,2 Prior reported approaches include transperineal vaginectomy, mucosal fulguration, and robotic-assisted. We present key steps in transperineal gender-affirming vaginectomy in a 39-year-old tra...
journal_title：Urology
pub_type：
doi：10.1016/j.urology.2020.05.084
更新日期：2020-10-01 00:00:00
abstract：:Urachal xanthogranuloma is rare. In this case, the patient presented with a lower abdominal mass and elevated inflammatory markers. The computed tomography findings of xanthogranulomatous urachitis resemble those of urachal carcinoma and, although rare, this entity should be included in the differential diagnosis of u...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2008.02.045
更新日期：2009-02-01 00:00:00
abstract：:Adult Wilms tumor is still considered a rarity. Approximately 170 adult Wilms tumors have been reported. The final diagnosis is usually established with surgery. There is no specific radiologic diagnosis of adult Wilms tumor. We report on a case of Wilms tumor in a twenty-two-year-old black man. The tumor was removed ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(87)90182-8
更新日期：1987-08-01 00:00:00
abstract：:To evaluate histopathologic and biologic characteristics in a patient with transitional cell carcinoma (TCC) with an endophytic growth pattern similar to that seen in an inverted papilloma. Although the tumor surface was mostly covered with normal-looking urothelium, the covering layer was thicker in parts than in tho...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(02)02521-9
更新日期：2003-04-01 00:00:00
abstract：OBJECTIVES:Perineal urethrostomy is a well-accepted reconstructive option for complex anterior urethral stricture disease. We present a novel technique for the construction of a perineal urethrostomy that allows the surgeon greater control when managing all levels of anterior urethral stricture disease. METHODS:A peri...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2010.10.053
更新日期：2011-06-01 00:00:00
abstract：INTRODUCTION:Remote robotic telemanipulators have been recently used in performing laparoscopic urologic procedures, both in the laboratory and in clinical practice. We present, to our knowledge, the initial 2 cases of robotic-assisted laparoscopic adrenalectomy in humans. TECHNICAL CONSIDERATIONS:Robotic-assisted lap...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(02)02011-3
更新日期：2002-12-01 00:00:00
abstract：OBJECTIVES:To introduce a modified technique for urethral anastomosis in orthotopic neobladder reconstruction. METHODS:Between January 2002 and August 2008, about 141 consecutive patients (130 men and 11 women) underwent total cystectomy and orthotopic neobladder reconstruction in which a modified technique was used t...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2009.06.082
更新日期：2009-11-01 00:00:00
abstract：:Reconstructive surgery for salvage of giant hydronephrosis is associated with unique challenges. We introduce the surgical technique of laparoscopic ureterocalicostomy for giant hydronephrosis. A transperitoneal five-port access was created and, after reflecting the colon, the lower pole of the hydronephrotic sac was ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2007.06.1088
更新日期：2007-09-01 00:00:00
abstract：OBJECTIVE:To treat mild-to-moderate apical compartment prolapse while preserving the uterus, our extraperitoneal uterosacral ligament hysteropexy repair technique was developed. Hysterectomy for prolapse accounted for 13% of all benign hysterectomies, which is the third most common reason.1 Although concomitant hystere...
journal_title：Urology
pub_type：
doi：10.1016/j.urology.2020.02.026
更新日期：2020-06-01 00:00:00
abstract：:A patient with spontaneous ureteral rupture in the absence of obstruction or calculus disease is presented. In addition to ureteral rupture this patient also had a penile squamous cell carcinoma and infected inguinal lymph nodes. A review of the literature discloses that all reported cases with spontaneous rupture of ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(87)90078-1
更新日期：1987-03-01 00:00:00
abstract：OBJECTIVES:To assess whether the age at which the initial hypospadias repair is performed influences the complication rate of hypospadias repair. METHODS:The records of 325 consecutive patients who underwent initial hypospadias repair were reviewed. The patients with glanular and coronal hypospadias underwent repair w...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2006.03.079
更新日期：2006-09-01 00:00:00
