Abstract：
OBJECTIVES:To investigate the effects of Uro-Vaxom, an oral vaccine against Escherichia coli urinary tract infections, on human monocyte-derived dendritic cells (moDCs). Dendritic cells (DCs) are important antigen-presenting cells of the immune system. DCs are considered promising cellular adjuvants for inducing immunity against cancer or infectious diseases. METHODS:moDCs were generated in the presence of granulocyte-macrophage colony-stimulating factor and interleukin-4. Flow cytometric phenotyping, as well as the ability to stimulate T cells in an allogeneic mixed leukocyte reaction, was used to assess the effects of Uro-Vaxom on human moDCs. In addition, interferon-gamma and interleukin-4 production by T cells stimulated with Uro-Vaxom-activated moDCs were measured by intracellular fluorescence-activated cell sorter-staining at the single-cell level. RESULTS:Uro-Vaxom induced the terminal maturation of CD83+ moDCs in a dose-dependent manner. Phenotypic analyses revealed that Uro-Vaxom-activated moDCs displayed a phenotype of mature DCs with high levels of MHC molecules and increased levels of co-stimulatory molecules (CD80, CD86). Consistent with these findings, Uro-Vaxom-activated moDCs potently stimulated T-cell proliferation and interferon-gamma production in the allogeneic mixed leukocyte reaction. CONCLUSIONS:In DC-based immunotherapy, Uro-Vaxom could be used as a stimulant of DC maturation, which meets the standards of good manufacturing practice. In future preclinical studies, we will evaluate the effectiveness of a vaccination with Uro-Vaxom-activated moDCs. It could be an attractive treatment option in preventing recurrent E. coli urinary tract infections in predisposed individuals.
journal_name
Urologyjournal_title
Urologyauthors
Schmidhammer S,Ramoner R,Höltl L,Bartsch G,Thurnher M,Zelle-Rieser Cdoi
10.1016/s0090-4295(02)01767-3subject
Has Abstractpub_date
2002-09-01 00:00:00pages
521-6issue
3eissn
0090-4295issn
1527-9995pii
S0090429502017673journal_volume
60pub_type
杂志文章相关文献
UROLOGY文献大全abstract：OBJECTIVES:Urologists routinely use the systematic sextant needle biopsy technique to detect prostate cancer. However, recent evidence suggests that this technique has a significant sampling error. We developed a novel three-dimensional (3D) computer-assisted prostate biopsy simulator based on whole-mounted step-sectio...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(99)00068-0
更新日期：1999-05-01 00:00:00
abstract：OBJECTIVES:Shorter CAG repeat lengths in exon 1 of the androgen receptor (AR) gene are associated with a stronger transcriptional activity of the AR and with a higher risk of prostate cancer. Because benign prostatic hyperplasia (BPH) is an androgen-dependent condition, we examined the hypothesis that men with shorter ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(98)00468-3
更新日期：1999-01-01 00:00:00
abstract：:Pseudoaneurysms are rare in urology and typically have a delayed presention with intermittent episodes of bleeding. We report a patient who presented with delayed and recurent hemoperitoneum following robotic assisted laparoscopic salvage radical prostatectomy and was found to have a pseudoaneurysm in the corona morti...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2020.04.017
更新日期：2020-07-01 00:00:00
abstract：OBJECTIVES:To evaluate, in a screening population, the impact of tumor volume and prostate volume on prostate-specific antigen (PSA) velocity (PSAV) and to find predictors of biochemical failure after radical prostatectomy. Longitudinal PSA changes in men with prostate cancer have been reported to be significantly diff...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2006.06.020
更新日期：2006-11-01 00:00:00
abstract：OBJECTIVES:To evaluate the location of interstitial cells of Cajal-like cells and the ureteral aspect using histopathologic studies of obstructive and refluxing megaureters to reveal the different pathogenesis of megaureters in the human urinary tract. The underlying pathophysiology of obstructive megaureter and reflux...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2009.02.062
更新日期：2009-08-01 00:00:00
abstract：OBJECTIVE:To investigate the role of contemporary minilaparoscopy (ML; 3 mm instruments and laparoscope) and to identify predictive factors for complications in a prospective multicenter series for renal and adrenal surgeries. MATERIALS AND METHODS:From July 2013 to December 2014, 110 patients from 6 laparoscopic Span...
journal_title：Urology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.urology.2016.02.048
更新日期：2016-06-01 00:00:00
abstract：OBJECTIVES:To present our initial experience with laparoscopic ureteroneocystostomy in patients with traumatic disruption of the distal ureter owing to gynecologic procedures. Reconstructive laparoscopic procedures are still evolving. METHODS:Six patients with ureterovaginal fistula in whom endoscopic management had f...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2005.04.048
更新日期：2005-10-01 00:00:00
abstract：:A new modification of transvaginal technique of bladder neck suspension is described. Its main merit is its safety. The ligature-carrying needles are inserted from below rather than above. It virtually eliminates bladder injury. Our experience with 29 cases and a follow-up of six to thirty months shows that this techn...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(90)80258-o
更新日期：1990-09-01 00:00:00
abstract：:Despite the emergence of different devices in the treatment of postprostatectomy urinary incontinence, the AMS 800 (American Medical Systems, Minnetonka, MN) remains the gold standard for the treatment of stress urinary incontinence in men. We reviewed the current literature regarding the indications, surgical princip...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/j.urology.2016.01.016
更新日期：2016-06-01 00:00:00
abstract：OBJECTIVE:To identify risk factors for recurrent urinary tract infection (UTI) in patients who perform clean intermittent catheterization (CIC). METHODS:A 6-year retrospective chart review of patients with spina bifida or tethered cord who perform clean intermittent catheterization (8 months to 58 years) was conducted...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2016.12.049
更新日期：2017-04-01 00:00:00
abstract：OBJECTIVES:Intracavernous needle injection is an effective delivery method for pharmacotherapy of erectile dysfunction. Needle phobia, pain, and concern about local tissue injury have stimulated the search for new, less invasive means of inducing penile erection. In this preliminary communication, we evaluate a jet inj...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/S0090-4295(97)00541-4
更新日期：1997-12-01 00:00:00
abstract：:Two cases of Kaposi sarcoma are presented. In each case the lesion had a bluish discoloration and was painless. Excision of lesions with wider margins was adequate therapy. ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(85)90055-x
更新日期：1985-08-01 00:00:00
abstract：OBJECTIVES:To evaluate the efficacy of transvaginal tape mobilization as a method of treating urinary retention after tension-free vaginal tape (TVT) procedures, and secondly to evaluate the time to resumption of voiding function after TVT procedures. METHODS:Postoperative voiding function and the 1-year continence st...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2005.03.055
更新日期：2005-09-01 00:00:00
abstract：OBJECTIVES:To present patterns of failure and hazard rates for failure that support the concept of cure for patients with prostate cancer treated with external beam radiation (RT). METHODS:Two patient groups are reported: 408 patients treated with RT alone and 63 patients treated with RT and short-term androgen depriv...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(99)00605-6
更新日期：2000-05-01 00:00:00
abstract：:Fifty-four female patients with persistent or recurrent stress urinary incontinence who underwent between 1 and 9 previously unsuccessful operative procedures were treated with transvaginal mobilization of the urethra and anterior vaginal wall with subsequent modified Pereyra bladder neck suspension. The important poi...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(84)90140-7
更新日期：1984-04-01 00:00:00
abstract：OBJECTIVES:To obtain accurate spatial information on cancer distribution with a novel prostate biopsy regimen. METHODS:From 2003 to 2005, 265 patients underwent a three fan-shaped biopsy (3FSB) technique of 12 to 14 cores and sextant biopsy (SB) simultaneously. When both techniques had positive findings, and radical p...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2006.08.1065
更新日期：2006-12-01 00:00:00
abstract：OBJECTIVES:To evaluate the efficacy and toxicity of three-dimensional conformal radiotherapy (3D-CRT) in the adjuvant and salvage setting after radical prostatectomy (RP). METHODS:From 1986 to 1997, 38 patients received adjuvant 3D-CRT, with a median time from RP to 3D-CRT of 2.8 months, and 57 patients were treated w...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(03)00127-4
更新日期：2003-07-01 00:00:00
abstract：OBJECTIVE:To characterize the associations between diabetes mellitus (DM) and lower urinary tract symptoms (LUTS). This study focuses on the relationships between specific diabetic characteristics (eg, severity, biomarkers) and the prevalence of LUTS. MATERIALS AND METHODS:The 2005-2008 cycles of the National Health a...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2017.03.040
更新日期：2017-07-01 00:00:00
abstract：OBJECTIVE:To determine, via a randomized comparison study, whether robotic simulator-acquired skills transfer to performance of a urethrovesical anastomosis (UVA) on a 3-dimensional-printed bladder model using the da Vinci Robot. MATERIALS AND METHODS:Medical students, surgical residents, and fellows were recruited an...
journal_title：Urology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.urology.2017.09.023
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:To study the prevalence of fluoroquinolone-resistant Escherichia coli before transrectal ultrasound (TRUS)-guided prostate biopsy and prospectively analyze the rates of infective complications after biopsy in patients receiving fluoroquinolone prophylaxis. E. coli is the pathogen most commonly associated with...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2011.07.1392
更新日期：2011-12-01 00:00:00
abstract：OBJECTIVES:To measure the renal parenchymal volume (RPV) before and after unilateral nephrectomy and investigate the relationship between the RPV and single kidney glomerular filtration rate (GFR). METHODS:From November 2003 to August 2009, 183 patients who had undergone unilateral nephrectomy were enrolled in the pre...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2010.03.063
更新日期：2011-06-01 00:00:00
abstract：OBJECTIVE:To characterize the contemporary management of prostate cancer patients in large community practices. The optimal management of incident prostate cancer has changed in the last decades to include active surveillance for a large number of men. At the same time, many community practices have merged into larger ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2019.01.061
更新日期：2019-07-01 00:00:00
abstract：OBJECTIVES:To evaluate the process of soft-tissue electrovaporization and to study variables that affect tissue clearance rates in a laboratory setting, in order to identify parameters that can optimize transurethral electrovaporization of the prostate. METHODS:Fresh bovine skeletal muscle, equivalent in impedance and...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(97)00092-7
更新日期：1997-06-01 00:00:00
abstract：OBJECTIVES:Xanthogranulomatous pyelonephritis (XGP) is an atypical form of chronic renal infection. The treatment of choice is open nephrectomy, which is challenging, given the extent of the disease and the not uncommon involvement of the renal hilum and contiguous structures. We compared our experience with laparoscop...
journal_title：Urology
pub_type： 临床试验,杂志文章
doi：10.1016/s0090-4295(99)00261-7
更新日期：1999-09-01 00:00:00
abstract：OBJECTIVES:To compare the outcomes of those patients who underwent laparoscopic versus open cytoreductive nephrectomy. Cytoreductive nephrectomy before systemic therapy has been shown to offer a survival advantage compared with systemic therapy alone for metastatic renal cell carcinoma. METHODS:We reviewed the outcome...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2004.06.052
更新日期：2004-11-01 00:00:00
abstract：OBJECTIVE:To assess the feasibility and safety of a novel flexible mini-nephroscope in minimally invasive percutaneous nephrolithotomy (PCNL). Presumably, limiting the size and number of tracts during PCNL has the potential of decreasing the morbidity of the procedure. We present our experience with this new technique....
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2017.01.009
更新日期：2017-05-01 00:00:00
abstract：OBJECTIVES:To evaluate, in a cross-sectional study, the relationships among physical activity, sexual functioning, and treatment type for 111 men who had undergone radiotherapy for localized prostate cancer within the past 18 months. Physical activity preserves the sexual functioning capacity of older men. However, lit...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2004.11.029
更新日期：2005-05-01 00:00:00
abstract：OBJECTIVE:To provide an update on SpaceOAR System, a Food and Drug Administration-approved hydrogel indicated to create distance between the prostate and the rectum which has been studied in phase 2 and 3 clinical trials. Here, we review and summarize these clinical results including the safety of prostate-rectum space...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/j.urology.2017.11.016
更新日期：2018-05-01 00:00:00
abstract：OBJECTIVE:To evaluate sexual dysfunction and enlargement of seminal vesicles in sexually active men who were treated by α1-blockers for benign prostatic hyperplasia and its possible clinical application. MATERIALS AND METHODS:This is a prospective cohort study from January 2015 to December 2016. We enrolled sexually a...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2017.08.025
更新日期：2018-08-01 00:00:00
abstract：OBJECTIVES:Transformation of normal epithelium into cancer cells involves epigenetic and genetic changes and modifications in nuclear structure and tissue architecture. To evaluate nuclear morphometric alterations and clinicopathologic features for organ- vs nonorgan-confined prostate carcinoma (PCa) prediction. METHO...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2008.09.060
更新日期：2009-05-01 00:00:00
