Abstract:
OBJECTIVES:To evaluate the location of interstitial cells of Cajal-like cells and the ureteral aspect using histopathologic studies of obstructive and refluxing megaureters to reveal the different pathogenesis of megaureters in the human urinary tract. The underlying pathophysiology of obstructive megaureter and refluxing megaureter is poorly understood. METHODS:The data from 14 patients with obstructive megaureter (7 boys and 7 girls), with a mean age of 12 months (range 2-84), and 9 patients with refluxing megaureter (7 boys and 2 girls), with a mean age of 11 months (range 4-24), were compared. We investigated the difference in the histopathologic aspects using Masson's trichrome, terminal uridine deoxynucleotidyl transferase dUTP nick end labeling (for apoptosis), and human c-kit antibody (CD117 for interstitial cells of Cajal-like cells) between the obstructive and refluxing megaureters. RESULTS:The proportion of smooth muscle was significantly lower in segments of refluxing megaureter (32.04% +/- 4.96%) than in the segments of obstructive megaureter (52.48% +/- 3.46%; P < .01). The number of apoptotic cells was significantly increased in the obstructive megaureter (mean 1661 +/- 135.1 cells) compared with the refluxing megaureter (mean 375.2 +/- 65.14 cells; P < .0001). The number of c-kit positive cells was significantly lower in the refluxing megaureter (mean 83.60 +/- 48.84 cells) than in the obstructive megaureter (mean 463.6 +/- 100.4 cells; P < .05). CONCLUSIONS:The differences in the histopathologic aspects can provide information on the possible pathophysiology of obstructive and refluxing megaureters. Ureteral peristalsis can be affected by the increased myocyte apoptosis in the obstructive megaureter and by the decreased number of interstitial cells of Cajal-like cells and smooth muscle content in refluxing megaureters. Additional research is warranted to elucidate the exact pathophysiology.
journal_name
Urologyjournal_title
Urologyauthors
Kang HJ,Lee HY,Jin MH,Jeong HJ,Han SWdoi
10.1016/j.urology.2009.02.062subject
Has Abstractpub_date
2009-08-01 00:00:00pages
318-23issue
2eissn
0090-4295issn
1527-9995pii
S0090-4295(09)00334-3journal_volume
74pub_type
杂志文章相关文献
UROLOGY文献大全abstract:OBJECTIVE:To evaluate the association between the Prostate Health Index (PHI) and adverse pathology in a cohort of African American (AA) men undergoing radical prostatectomy. MATERIALS AND METHODS:Eighty AA men with prostate-specific antigen (PSA) of 2-10 ng/mL underwent measurement of PSA, free PSA (fPSA), and p2PSA ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2015.12.004
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVES:Pyruvate kinase type M2 (TuM2-PK) and thymidine kinase 1 (TK1) are the key enzymes involved in tumor cells metabolism and proliferation. We explored the association of their preoperative circulating levels with disease recurrence in patients with renal cell carcinoma (RCC). METHODS:We measured the plasma le...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2010.04.034
更新日期:2010-08-01 00:00:00
abstract::We present our experience with inferior vena cava (IVC) reconstruction in patients undergoing post-chemotherapy retroperitoneal lymph node dissection (PC-RPLND) due to metastatic germ cell tumor. Four patients underwent IVC reconstruction with a prosthetic graft. Early postoperative leg edema was prevented in all 4. L...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2008.02.054
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVES:To determine whether Zuidex using a non-cystoscopy mid-urethral injection technique produces as good a result (i.e. was not inferior) as Contigen injected endoscopically at the bladder neck in the treatment of urinary stress incontinence secondary to intrinsic sphincter deficiency in adult women. METHODS:A ...
journal_title:Urology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.urology.2009.05.034
更新日期:2009-10-01 00:00:00
abstract::Lack of tumescence of the glans penis during normal penile erection may represent a handicap to sexual intercourse. The pharmacodynamic spongiosography for the evaluation of venous drainage of the corpus spongiosum is described, demonstrating a pathologic venous outflow. The patient was successfully treated by resecti...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(90)80151-c
更新日期:1990-04-01 00:00:00
abstract::Two cases are reported of combined renal and hepatic failure following exposure to halothane anesthesia. Both patients presented with postoperative fever and rapidly deteriorating liver and kidney function. Both required peritoneal dialysis. Both patients died, and in both cases this was the second exposure to halotha...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(81)90255-7
更新日期:1981-04-01 00:00:00
abstract::Complete eversion and prolapse of the urinary bladder is rare. We report a case occurring in an eighty-two-year-old female. We believe only 3 previous cases have been reported, and only 1 of these occurred in an adult. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(83)90310-2
更新日期:1983-12-01 00:00:00
abstract:OBJECTIVE:To describe the associations between elevated urinary ammonium and clinical characteristics of kidney stone formers. A 24-hour urine test is recommended in high-risk patients to identify urinary abnormalities and select interventions to reduce the recurrence risk. While elevations in urine ammonium may be see...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2020.05.063
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVES:Nephrolithiasis is a recurrent condition with significant associated morbidity and economic impact. Although urologic intervention addresses symptomatic stone episodes, prevention of recurrences with proven medical therapy is indicated. METHODS:This retrospective study examined 97 patients who presented in ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(00)00822-0
更新日期:2000-12-20 00:00:00
abstract::Medical management of clinical BPH is a reality. The only effective nonsurgical treatment now recommended is aimed at relieving the dynamic component of clinical BPH. Pharmacologic treatment using alpha-adrenoceptor antagonists may be used appropriately to manage patients with prostatism who are poor surgical risks bu...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/0090-4295(90)80176-n
更新日期:1990-11-01 00:00:00
abstract:OBJECTIVES:To evaluate the safety, tolerance, protocol completion rate, tumor response rate, and patient survival of chemoradiotherapy for patients with muscle-invasive operable bladder cancer. METHODS:After transurethral resection of the tumor in patients with Stage T2-T4a bladder cancer, twice-daily radiotherapy wit...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2008.09.036
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To develop and evaluate a diagnostic algorithm based on the alteration of mast cell and nerve fiber observed in bladder tissue of patients with interstitial cystitis (IC). MATERIALS AND METHODS:Non-IC samples from 6 control groups (N = 10, 10, 13, 2, 11, and 3, respectively) and nonclassic interstitial cysti...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(99)80330-6
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVES:To identify the pretreatment variables that are predictive of response and the duration of response to deferred antiandrogen therapy in men with androgen-independent prostate cancer (AIPC). METHODS:A total of 375 patients receiving androgen deprivation therapy for advanced prostate cancer between 1977 and 2...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2003.11.016
更新日期:2004-04-01 00:00:00
abstract:OBJECTIVE:To describe pelvic bone osteomyelitis in the prostate cancer survivor, to report on clinical presentation and treatment, and to suggest an algorithmic approach to managing this syndrome complex. MATERIALS AND METHODS:A retrospective chart review from January 2011 to June 2014 was performed to identify prosta...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2014.11.020
更新日期:2015-03-01 00:00:00
abstract::The natural history of renal cell carcinoma is often unpredictable and even bizarre. We report a case of solitary late recurrence of renal cell carcinoma presenting as a duodenal ulcer and review the relevant literature. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(92)90248-u
更新日期:1992-05-01 00:00:00
abstract::Five hundred girls with recurrent urinary tract infections and documented reflux were seen in our private practice during the last twenty years. All patients received medical treatment for three to forty-eight months (an average of fifteen months) after which the 250 who were not cured were submitted to corrective sur...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(80)90329-5
更新日期:1980-07-01 00:00:00
abstract:OBJECTIVES:The American Urological Association Symptom Index (AUASI) has been reported to be nonspecific for benign prostatic hyperplasia. Comparable scores occur in patients with lower urinary tract symptoms of varying etiology, and even among women. The purpose of this study was to determine the association between t...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(97)00505-0
更新日期:1998-02-01 00:00:00
abstract:OBJECTIVES:To investigate the association between the length of time-to-ejaculation and semen parameters. METHODS:Ejaculates from 142 men under infertility assessment were analyzed according to the World Health Organization guidelines. Seminal neutral alpha-glucosidase (NAG), prostate-specific antigen (PSA), zinc, and...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2007.12.009
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:To find clinical or radiographic factors that are associated with angioembolization failure after high-grade renal trauma. MATERIAL AND METHODS:Patients were selected from the Multi-institutional Genito-Urinary Trauma Study. Included were patients who initially received renal angioembolization after high-gra...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2020.10.027
更新日期:2020-10-28 00:00:00
abstract::We present 2 cases of prenatal hydroureteronephrosis and bladder outlet obstruction due to an obstructing ureterocele. Both neonates were stabilized and managed with early endoscopic decompression. Neither infant demonstrated significant function in the kidney ipsilateral to the ureterocele either before or after uret...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(98)00337-9
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVE:To determine whether measurement of telomere DNA content (TC) in prostate biopsy tissue predicts prostate-specific antigen (PSA) recurrence in men after undergoing radical prostatectomy for prostate cancer. METHODS:Slot blot titration assay was used to quantitate TC in archived diagnostic prostate needle bio...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2009.04.032
更新日期:2010-03-01 00:00:00
abstract::Although metastatic renal cell carcinoma (RCC) is not uncommon, dissemination to the gallbladder or prostate is very rare. We present 1 case of RCC with synchronous metastasis to the gallbladder and 1 case of RCC with metachronous metastasis to the prostate. These cases illustrate the propensity of RCC for unpredictab...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/S0090-4295(99)80310-0
更新日期:1995-11-01 00:00:00
abstract:OBJECTIVE:To describe the long-term outcomes of robot-assisted laparoscopic pyeloplasty (RALP) for the correction of ureteropelvic junction (UPJ) obstruction. METHODS:A retrospective electronic medical record review of RALPs from October 2002 to July 2014 was performed, with additional follow-up for patients released ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2015.12.050
更新日期:2016-04-01 00:00:00
abstract::Ureteral rejection has been studied in the dog utilizing the isolated transplanted ureter technique. While on adequate immunosuppressive therapy, the allograft ureter remains functionally and histologically normal. When the drugs are discontinued, progressive destructive changes occur within the ureteral wall. As the ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(74)90104-6
更新日期:1974-07-01 00:00:00
abstract:OBJECTIVES:To investigate mitochondrial DNA (mtDNA) mutations in human detrusor after partial bladder outlet obstruction (BOO) and correlate the findings with the results of urodynamic studies. METHODS:Sixty-two male patients with and without BOO were recruited and assessed by the International Prostate Symptom Score,...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(99)00609-3
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVES:To determine the best preventive strategies for bladder calculi in children with an augmented bladder, the risk factors and prevention strategies for urolithiasis were evaluated. METHODS:The records of 89 patients following augmentation cystoplasty were reviewed to assess the results of augmentation cystopl...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(00)00663-4
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVES:To define and discuss the characteristics of all-terrain vehicle (ATV)-related pediatric (<16 years) genitourinary (GU) trauma. ATV collisions represent a significant and growing portion of trauma cases in rural America. ATV-related renal injuries have been reported in adults but a comprehensive review of AT...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2009.08.068
更新日期:2010-05-01 00:00:00
abstract::Divided, or so-called kissing nevi of the penis, which are separated during embryogenesis, are very rare, with only seven studies reported to date. We present a case of a 30-year-old patient with a divided nevus located at the penis that rapidly changed in size and color within 4 months. These clinical features and th...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2006.11.015
更新日期:2007-02-01 00:00:00
abstract::Percutaneous drainage has rapidly become the initial procedure of choice in the treatment of most intra-abdominal abscesses. The retroperitoneal location of the urinary tract facilitates a percutaneous approach and has been found to be highly effective, with surgical intervention required in a minority of cases. Nonin...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(84)90242-5
更新日期:1984-05-01 00:00:00
abstract:OBJECTIVES:To investigate whether there is an oxytocinergic neurotransmission at the hippocampus involved in the central regulation of penile erection in the rat. METHODS:Male adult Sprague-Dawley (n = 27) rats anesthetized with pentobarbital were used. A 26-gauge needle was inserted into the corpus cavernosum to meas...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(01)01000-7
更新日期:2001-07-01 00:00:00