当前位置： SCI文献检索 > UROLOGY期刊下所有文献 > Mitochondrial DNA deletion of the human detrusor after partial bladder outlet obstruction-correlation with urodynamic analysis.

Mitochondrial DNA deletion of the human detrusor after partial bladder outlet obstruction-correlation with urodynamic analysis.

Abstract：

OBJECTIVES:To investigate mitochondrial DNA (mtDNA) mutations in human detrusor after partial bladder outlet obstruction (BOO) and correlate the findings with the results of urodynamic studies. METHODS:Sixty-two male patients with and without BOO were recruited and assessed by the International Prostate Symptom Score, a quality-of-life assessment index, and sonography. The severity of partial BOO was determined by pressure-flow study with an International Continence Society (ICS) nomogram. Random detrusor biopsies obtained cystoscopically were analyzed by polymerase chain reaction (PCR) techniques to detect possible mtDNA deletions. Primer-shift PCR and DNA sequencing were then performed to characterize specific mtDNA deletions. A semiquantitative PCR method was used to determine the proportion of the deleted mtDNA in detrusor. Finally, the mtDNA deletion and the urodynamic results were compared statistically. RESULTS:A 4977-bp mtDNA deletion was identified in the human detrusor. Its incidence and proportion were found to increase after partial BOO (P = 0.005 and 0.012, respectively). The incidence of the mtDNA deletion was 4.2% (1 of 24) in the unobstructed group, 27.8% (5 of 18) in the equivocal group, and 40% (8 of 20) in the obstructed group. The mean proportion of the 4977-bp deleted mtDNA was 23.7 and 12.7 times higher in the obstructed and equivocal groups, respectively, compared with that of the unobstructed group. CONCLUSIONS:We found mtDNA with the 4977-bp deletion in human detrusor and an increase of this deletion after partial BOO. This molecular change might account for the previous observations of mitochondrial functional impairment and voiding dysfunction after partial BOO.

journal_name

Urology

journal_title

Urology

authors

Lu SH,Chang LS,Yang AH,Lin AT,Chen KK,Wei YH

doi

10.1016/s0090-4295(99)00609-3

subject

Has Abstract

pub_date

2000-04-01 00:00:00

pages

603-7

issue

4

eissn

0090-4295

issn

1527-9995

pii

S0090-4295(99)00609-3

journal_volume

55

pub_type

杂志文章

相关文献

UROLOGY文献大全
  • Histopathologic evaluation of neurovascular bundles and periprostatic tissue in interfascial and intrafascial nerve-sparing radical prostatectomy technique: a cadaveric anatomic study.

    abstract：OBJECTIVE:To compare interfascial (IEF) or intrafascial (IAF) periprostatic nerve dissection technique in prostate tissue using immunohistochemical methods in fresh cadavers. MATERIALS AND METHODS:Prostate tissues of 25 fresh cadavers were removed from rectum and other surrounding structures. IEF nerve dissection (n =...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2013.06.012

    authors： Rifaioglu MM,Davarci M,Ozgur T,Ozkanli S,Ozdes T,Inci M,Onem K,Balbay MD

    更新日期：2013-10-01 00:00:00

  • The impact of dietary calcium and oxalate ratios on stone risk.

    abstract：OBJECTIVE:To determine whether the ratio of dietary calcium and oxalate consumption at mealtime affects gastrointestinal oxalate absorption and urinary oxalate excretion. METHODS:A study was conducted with 10 non-stone-forming adults placed on controlled diets with daily calcium and oxalate contents of 1000 and 750 mg...

    journal_title：Urology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.urology.2012.01.053

    authors： Lange JN,Wood KD,Mufarrij PW,Callahan MF,Easter L,Knight J,Holmes RP,Assimos DG

    更新日期：2012-06-01 00:00:00

  • Acute kidney injuries induced by various irrigation pressures in rat models of mild and severe hydronephrosis.

    abstract：OBJECTIVE:To clarify whether tolerance to irrigation pressure could be modified over varying degrees of kidney obstruction during the endoscopic treatment of kidney stones in a rat model. METHODS:A total of 126 rats were randomly allocated into 2 experimental groups and a control group. The experimental groups underwe...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2013.08.024

    authors： Cao Z,Yu W,Li W,Cheng F,Xia Y,Rao T,Yao X,Zhang X,Larré S

    更新日期：2013-12-01 00:00:00

  • A Fatal Case of Massive Incarcerated Genital Prolapse.

    abstract：:Genital prolapse is usually seen as a benign condition warranting treatment only when bothersome. We report the case of a 77-year-old woman who presented with massive incarcerated pelvic organ prolapse, which led to bladder necrosis, cystectomy with bilateral cutaneous ureterostomy, and death from medical complication...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2016.09.010

    authors： Peyronnet B,Berquet G,Lefevre M,Khene Z,Bensalah K,Manunta A

    更新日期：2017-01-01 00:00:00

  • Short-term outcomes of Chait Trapdoor for antegrade continence enema in adults.

    abstract：OBJECTIVE:To examine our short-term experience of antegrade continence enema (ACE) delivered via a Chait Trapdoor (Cook Medical, Bloomington, IN) in adults with intractable neurogenic bowel. METHODS:We performed a retrospective review at the Universities of Utah and Minnesota of 15 patients with Chait Trapdoor placed ...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2014.01.023

    authors： Myers JB,Hu EM,Elliott SP,Nguyen A,Hovert P,Brant WO,Hamilton BD,Wallis MC,Redshaw JD

    更新日期：2014-06-01 00:00:00

  • Weak correlation between bladder outlet obstruction and probability to void to completion.

    abstract：OBJECTIVES:To investigate the weak correlation between bladder outlet obstruction (BOO), as diagnosed using the provisional International Continence Society nomogram for the definition of BOO in men, and postvoid residual urine volume. METHODS:The relationship between voiding to completion and several indexes for blad...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/s0090-4295(03)00575-2

    authors： Kranse R,van Mastrigt R

    更新日期：2003-10-01 00:00:00

  • Upper gastrointestinal bleeding following renal transplantation.

    abstract：:Upper gastrointestinal bleeding has been shown to be a common complication of renal transplantation and one which carries a significant risk of mortality. In a retrospective review of 200 consecutive renal transplants in 194 patients, we found an incidence of only 6 per cent and a mortality rate of 8.3 per cent. Allog...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/0090-4295(85)90181-5

    authors： Sarosdy MF,Saylor R,Dittman W,Cruz AB Jr,Gaskill HV 3rd,Banowsky LH

    更新日期：1985-10-01 00:00:00

  • Transurethral electrovaporization of the prostate: one-year experience.

    abstract：OBJECTIVES:To determine the safety and efficacy of transurethral electrovaporization of the prostate (TVP) in men with lower urinary tract symptoms. METHODS:A prospective trial of 114 consecutive patients who underwent TVP since August 1994 was conducted. The mean follow-up period was 12.3 months. Parameters evaluated...

    journal_title：Urology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0090-4295(96)00487-6

    authors： Kaplan SA,Santarosa RP,Te AE

    更新日期：1996-12-01 00:00:00

  • Gallbladder and pancreatic metastases from bilateral renal carcinoma presenting with hematobilia and anemia.

    abstract：:A case of bilateral metachronous renal cell carcinoma with gallbladder and pancreatic metastases, presenting with hematobilia and anemia is presented. The presentation of metastatic renal cell carcinoma with hematobilia and anemia is previously unreported. This case illustrates (1) the occasionally very long interval ...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/s0090-4295(05)80084-6

    authors： Fullarton GM,Burgoyne M

    更新日期：1991-08-01 00:00:00

  • Prevalence of ST131 among fluoroquinolone-resistant Escherichia coli obtained from rectal swabs before transrectal prostate biopsy.

    abstract：OBJECTIVE:To identify the prevalence and characteristics of fluoroquinolone-resistant (FQ-R) Escherichia coli ST131 isolates in men undergoing ultrasound-guided transrectal prostate biopsy (TPB). MATERIALS AND METHODS:Twenty-seven FQ-R E coli isolates from rectal swabs from 136 men undergoing TPB at 3 institutions in ...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2012.10.056

    authors： Liss MA,Peterson EM,Johnston B,Osann K,Johnson JR

    更新日期：2013-03-01 00:00:00

  • Correlation of cytology and cystoscopy.

    abstract：:A total of 152 patients had cytology and cystoscopy performed for either initial or recurrent bladder tumors and postoperative control examinations. Positive cytology was found in 97 per cent of patients with pathologically proved bladder tumors. However, 23 per cent of the patients with negative cytology had positive...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/0090-4295(79)90024-4

    authors： Sutton AP,Hajdu E,Ganz M,Buchbinder M,Abrams HJ

    更新日期：1979-01-01 00:00:00

  • Pleomorphic leiomyosarcoma of the adrenal gland: case report and review of the literature.

    abstract：:Primary adrenal leiomyosarcomas (LMS) are extremely rare mesenchymal tumors. To the best of our knowledge only 12 cases (9 cases of conventional and 2 cases of pleomorphic LMS) have been reported in the literature until the present date. Herein we report a case of pleomorphic LMS in a 47-year-old woman who presented w...

    journal_title：Urology

    pub_type： 杂志文章,评审

    doi：10.1016/j.urology.2007.07.029

    authors： Mohanty SK,Balani JP,Parwani AV

    更新日期：2007-09-01 00:00:00

  • Intravesical prostatic protrusion can be a predicting factor for the treatment outcome in patients with lower urinary tract symptoms due to benign prostatic obstruction treated with tamsulosin.

    abstract：OBJECTIVE:To assess the effect of the intravesical protrusion of the prostate (IPP) on the response to medical treatment with tamsulosin for a 3 month period. MATERIALS AND METHODS:The study, which was conducted between 2009 and 2011 in the ambulatory clinic of an academic hospital, divided 183 patients with lower uri...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2012.12.007

    authors： Cumpanas AA,Botoca M,Minciu R,Bucuras V

    更新日期：2013-04-01 00:00:00

  • Identifying Prevalence and Risk Factors for Mild Cognitive Impairment in Adults Presenting for Urological Evaluation.

    abstract：OBJECTIVE:To examine mild cognitive impairment (MCI) in a young and older adult urology population, and which external factors were associated with diminished cognitive status at baseline. METHODS:We enrolled patients >18 years of age presenting to a large, urban tertiary care center for a wide variety of urologic com...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2016.03.040

    authors： Roberge G,Stortz SK,Frankel WC,Greene KL,Deng DY

    更新日期：2016-08-01 00:00:00

  • An endoscopic study of the lacuna magna and reappraisal of its clinical significance in contemporary urological practice.

    abstract：OBJECTIVE:To endoscopically study the Lacuna Magna (LM) and attempt to explain some of the anatomical, clinical and embryological issues pertaining to it. The LM, stated to be present in 30 to 50 percent of males and linked to congenital distal urethral obstructions, post-void bloody-spotting and dysuria in young boys,...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2011.05.013

    authors： Shenoy SP,Marla PK,Venugopal P,Adappa KK,Tantry TP,Shankar M,Rai GD

    更新日期：2011-11-01 00:00:00

  • Seminal vesicle cyst presenting as rectal obstruction.

    abstract：:We report an unusual case of a pelvic mass arising from the seminal vesicle. A 45-year-old man presented with difficulty voiding and difficult bowel movements. Computed tomography demonstrated a large 14 x 10 x 15-cm cystic pelvic mass displacing the bladder anteriorly and the rectum posteriorly. Magnetic resonance im...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2003.10.052

    authors： Altunrende F,Kim ED,Klein FA,Waters WB

    更新日期：2004-03-01 00:00:00

  • Cytomegalovirus infection of the native ureter after liver-kidney transplantation.

    abstract：:We report a case of invasive cytomegalovirus (CMV) infection in the native ureter of a patient 7 years after liver-kidney transplantation. Previous reports of CMV ureteritis in transplant patients have involved only the allograft ureter, usually within 3 months of transplantation. The common characteristics of these p...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/s0090-4295(99)00084-9

    authors： Mateo R,Vivas C,Shapiro R,Rhandawa P,Kusne S,Scantlebury V,Udupa D,Jordan M

    更新日期：1999-08-01 00:00:00

  • Morphologic changes in detrusor muscles of patients with chronic obstruction of lower urinary tract. Electronmicroscopic and immunohistochemical findings.

    abstract：:The anterior bladder wall and actin- and myosin-like immunoreactivities within the detrusor muscles in patients with chronic obstruction of the lower urinary tract were examined by means of a MOP Videoplan image-processing system, electronmicroscopy, and light microscopic immunohistochemistry. The image-processing sys...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/0090-4295(91)80333-3

    authors： Hongoh Y,Sakanaka M,Kitagawa Y,Magari S,Miyazaki S

    更新日期：1991-06-01 00:00:00

  • Congenital posterior urethral perineal fistulae: a unique form of urethral duplication.

    abstract：:Three unique cases of urethral duplication, often referred to as congenital posterior urethral perineal fistulae, are presented. Presenting signs and symptoms, evaluation, and treatment are discussed, and the literature is reviewed. Although labeled as a fistula in the literature, this entity most likely represents a ...

    journal_title：Urology

    pub_type： 杂志文章,评审

    doi：10.1016/s0090-4295(96)00171-9

    authors： Wagner JR,Carr MC,Bauer SB,Colodny AH,Retik AB,Hendren WH

    更新日期：1996-08-01 00:00:00

  • Polyclonal and monoclonal antibodies to prostate-specific antigen can cross-react with human kallikrein 2 and human kallikrein 1.

    abstract：OBJECTIVES:The human tissue kallikrein family contains three closely related proteases: human kallikrein 1 (hK1), human kallikrein 2 (hK2), and prostate-specific antigen (PSA). The structural homology between these three proteins suggests potential cross-reactivity interference when different immunologic techniques are...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/s0090-4295(98)00573-1

    authors： Finlay JA,Day JR,Rittenhouse HG

    更新日期：1999-04-01 00:00:00

  • Testicular seminoma originating in an undescended testis in a renal allograft recipient.

    abstract：:Immunosuppressed transplant recipients are at significantly increased risk for developing neoplasms than are nonimmunosuppressed individuals. However, only six cases of pure testicular seminoma following renal transplantation have been reported in the English literature. This case report represents the first descripti...

    journal_title：Urology

    pub_type： 杂志文章,评审

    doi：10.1016/s0090-4295(96)00104-5

    authors： Modlin CS,Flechner SM,Penn I

    更新日期：1996-07-01 00:00:00

  • Late urologic effects after adjuvant irradiation in stage I endometrial carcinoma.

    abstract：OBJECTIVES:To evaluate the incidence and type of incontinence after external beam radiotherapy (RT) and brachytherapy. Distinct late effects on the urinary bladder can occur and are frequently mild after adjuvant RT for Stage I endometrial carcinoma. Not all side effects that impair quality of life (eg, urinary inconti...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2003.09.040

    authors： Herwig R,Bruns F,Strasser H,Pinggera GM,Micke O,Rehder P,Gozzi C,Willich N,Hertle L

    更新日期：2004-02-01 00:00:00

  • Prenatal bladder outlet obstruction secondary to ureterocele.

    abstract：:We present 2 cases of prenatal hydroureteronephrosis and bladder outlet obstruction due to an obstructing ureterocele. Both neonates were stabilized and managed with early endoscopic decompression. Neither infant demonstrated significant function in the kidney ipsilateral to the ureterocele either before or after uret...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/s0090-4295(98)00337-9

    authors： Austin PF,Cain MP,Casale AJ,Hiett AK,Rink RC

    更新日期：1998-12-01 00:00:00

  • Congenital unilateral ureteropelvic junction obstruction of the rat: a useful animal model for human ureteropelvic junction obstruction?

    abstract：OBJECTIVES:To investigate the expression of endothelin-1 (ET-1) and adrenomedullin (ADM) in the renal pelvis, stenotic ureteropelvic junction, and ureter of 20 male Wistar rats with congenital unilateral ureteropelvic junction obstruction; the normal contralateral kidneys served as controls. The molecular pathophysiolo...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2003.07.019

    authors： Miller J,Hesse M,Diemer T,Haenze J,Knerr I,Rascher W,Weidner W

    更新日期：2004-01-01 00:00:00

  • Adrenocortical oncocytoma: two case reports and review of literature.

    abstract：:Oncocytomas of the adrenal gland are rare; only 9 cases are reported in the world literature. We report 2 new cases in which benign adrenal masses were detected during evaluation for microhematuria or flank pain. Subsequent to extirpation of the mass, pathologic examination established the diagnosis of adrenocortical ...

    journal_title：Urology

    pub_type： 杂志文章,评审

    doi：10.1016/s0090-4295(96)00543-2

    authors： Waters PR,Haselhuhn GD,Gunning WT 3rd,Phillips ER,Selman SH

    更新日期：1997-04-01 00:00:00

  • Sensitivity to Change of Subdomain Question 6 of the Urogenital Distress Inventory Short Form After Sling Removal for Pain.

    abstract：OBJECTIVE:To determine the sensitivity to change of question 6 (Q6) of the modified short form version of the Urogenital Distress Inventory (UDI-6) before and after synthetic sling removal (SSR). METHODS:Following IRB approval, a prospectively maintained database of mid-urethral sling (MUS) complications identified wo...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2020.10.029

    authors： Wang CN,Christie AL,Zimmern PE

    更新日期：2021-01-01 00:00:00

  • Bone alterations in patients with idiopathic hypercalciuria and calcium nephrolithiasis.

    abstract：OBJECTIVES:To verify whether alterations in bone density and turnover in patients with calcium nephrolithiasis and hypercalciuria are observable in various subgroups of patients divided according to the pathogenesis of the hypercalciuria. METHODS:Seventy patients with calcium nephrolithiasis and idiopathic hypercalciu...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/s0090-4295(02)01626-6

    authors： Tasca A,Cacciola A,Ferrarese P,Ioverno E,Visonà E,Bernardi C,Nobile M,Giannini S

    更新日期：2002-06-01 00:00:00

  • Laser tissue soldering in urinary tract reconstruction: first human experience.

    abstract：OBJECTIVES:Laser tissue soldering (LTS) in the urinary tract provides an immediate leak-free seal and may avoid complications seen with conventional repair (such as fistula and stricture). We have begun a Phase I clinical trial investigating the use of LTS in performing urologic reconstructive surgery. METHODS:Ten pat...

    journal_title：Urology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0090-4295(99)80206-4

    authors： Kirsch AJ,Miller MI,Hensle TW,Chang DT,Shabsigh R,Olsson CA,Connor JP

    更新日期：1995-08-01 00:00:00

  • Enterocystoplasty after cystoprostatectomy for bladder cancer. Time-saving technical modifications.

    abstract：:Enterocystoplasty, to construct a functional and continent bladder in male patients following cystoprostatectomy, can be simplified and shortened by some modifications. Partial pubectomy will allow a precise and bloodless section of the membranous urethra preserving the external sphincter and a watertight anastomosis ...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/0090-4295(86)90096-8

    authors： De Sy WA,Verbaeys A,Oosterlinck W

    更新日期：1986-08-01 00:00:00

  • Cost effective analysis of prenephrectomy radioisotope scans in renal cell carcinoma.

    abstract：:To evaluate the cost-effectiveness of liver and bone isotope scans, results of scans were reviewed in 60 patients with renal cell carcinoma. In no patient did the results of the scans influence or change the treatment plan. Routine utilization of radioisotope scans as part of the preoperative evaluation of patients wi...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/0090-4295(83)90491-0

    authors： Lindner A,Goldman DG,deKernion JB

    更新日期：1983-08-01 00:00:00