Abstract:
OBJECTIVES:Laser tissue soldering (LTS) in the urinary tract provides an immediate leak-free seal and may avoid complications seen with conventional repair (such as fistula and stricture). We have begun a Phase I clinical trial investigating the use of LTS in performing urologic reconstructive surgery. METHODS:Ten patients (aged 3 months to 38 years) underwent urologic reconstruction using LTS with a protein solder composed of human albumin (42%) and indocyanine green dye. In each case standard microsuture repair preceded laser-soldered suture line reinforcement. Anastomotic closure time and immediate leak pressure were measured. Postoperatively, all patients were evaluated for evidence of complications, including stricture, fistula formation, or impaired healing. RESULTS:Using LTS as an adjunct to suturing added an average of 7.9 +/- 3.0 minutes (28%) to the overall mean anastomotic time of 28.3 +/- 9.4 minutes. Intraoperative leak pressure measurements for laser-soldered anastomoses (> or = 94.2 +/- 24.2 mm Hg) were significantly higher (P < 0.001) than primarily sutured anastomoses (20 +/- 2.9 mm Hg). Two instances of suture disruption (20%) occurred during laser activation, neither of which were repaired with sutures. Average follow-up for all patients was 7.1 + - 2.2 months. There were no intraoperative or postoperative complications, including the 2 patients with suture disruption. CONCLUSIONS:These initial clinical results indicate that LTS is safe, easy to perform, and, contrary to conventional suturing, provides an immediate leak-free closure. Follow-up in these and other patients, as well as those undergoing sutureless and stent-free procedures, will determine whether our method of LTS benefits patients undergoing urologic reconstruction.
journal_name
Urologyjournal_title
Urologyauthors
Kirsch AJ,Miller MI,Hensle TW,Chang DT,Shabsigh R,Olsson CA,Connor JPdoi
10.1016/s0090-4295(99)80206-4subject
Has Abstractpub_date
1995-08-01 00:00:00pages
261-6issue
2eissn
0090-4295issn
1527-9995pii
S0090429599802064journal_volume
46pub_type
临床试验,杂志文章相关文献
UROLOGY文献大全abstract:OBJECTIVE:This study reviews the incidence and management of cyclophosphamide-induced hemorrhagic cystitis in a group of patients who received high-dose chemotherapy and bone marrow transplantation. METHODS:The records of 217 consecutive patients undergoing bone marrow transplantation were reviewed. The incidence, deg...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(94)90079-5
更新日期:1994-03-01 00:00:00
abstract::Postoperative ileal-ileal intussusception is an unusual and uncommonly cited complication of bladder augmentation. The preoperative diagnosis is difficult due to the vague clinical findings. We report a case of ileal-ileal intussusception that occurred following gastrocystoplasty in a child. Computed tomography accura...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(99)80401-4
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVES:To investigate the factors affecting desmopressin response and relapse rates in an adult male population with monosymptomatic nocturnal enuresis (MNE). Nocturnal enuresis is a frequent heterogeneous condition, which is genetically complex in nature. METHODS:Between September 2007 and January 2009, a total o...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2009.05.033
更新日期:2009-10-01 00:00:00
abstract::Infants born with imperforate anus have a high incidence of genitourinary anomalies. Vesicoureteral reflux was the most common abnormality in this series. Since these patients often have bacteriuria, this is an important finding. An intravenous pyelogram and voiding cystourethrogram should be part of the evaluation of...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(79)90380-7
更新日期:1979-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the impact of extended warm ischemia on incidence of acute kidney injury (AKI) and ultimate functional recovery after partial nephrectomy (PN), incorporating rigorous control for loss of parenchymal mass, and embedded within comparison to cohorts of patients managed with hypothermia or limited war...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2015.08.034
更新日期:2016-01-01 00:00:00
abstract::Ureteral obstruction resulting from metastatic adenocarcinoma is almost always extrinsic in nature. In contrast, true intraluminal metastases are extremely rare. With this report, we document the videoendoscopic appearance of true intraluminal ureteral metastases from metastatic rectal cancer confirmed with histopatho...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(97)00072-1
更新日期:1997-06-01 00:00:00
abstract:OBJECTIVES:To evaluate the body mass index (BMI) and lower urinary tract symptom (LUTS) severity on treatment response to sildenafil in men with erectile dysfunction (ED) and moderate to severe LUTS associated with benign prostatic hyperplasia. METHODS:A post hoc analysis of data from a 12-week, double-blind, placebo-...
journal_title:Urology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.urology.2008.04.020
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:To determine, via a randomized comparison study, whether robotic simulator-acquired skills transfer to performance of a urethrovesical anastomosis (UVA) on a 3-dimensional-printed bladder model using the da Vinci Robot. MATERIALS AND METHODS:Medical students, surgical residents, and fellows were recruited an...
journal_title:Urology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.urology.2017.09.023
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:To report the long-term clinical outcomes and durability of response after treatment with induction intravesical docetaxel. Most novel agents used to treat bacillus Calmette-Guerin refractory high-grade non-muscle-invasive (NMI) bladder cancer are evaluated only after short follow-up periods. Our previously ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2009.06.112
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVES:To determine whether nadir prostate-specific antigen (PSA) levels within 12 months (nadir PSA12) after completion of radiotherapy (RT) can be used as an early marker of recurrence risk. METHODS:A total of 4839 patients were treated with RT and without hormonal therapy from 1986 to 1995 for Stage T1-T2 prost...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2006.08.1056
更新日期:2006-12-01 00:00:00
abstract::A seven-year-old body with diurnal and nocturnal incontinence was found to have a dysplastic left kidney and an associated ectopic ureter in a single, system which opened beside the verumontanum. An intravesical bulge was identified which resembled a ureterocele but was, in fact, a dilated ectatic lower ureter proxima...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(81)90014-5
更新日期:1981-01-01 00:00:00
abstract::Two patients presented with synchronous Hodgkin's disease and testicular germ cell neoplasms. Both patients are in complete remission following treatment with multidrug chemotherapy and radiation therapy. Despite epidemiologic similarities between Hodgkin's disease and testicular cancer, only 13 cases of their associa...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/0090-4295(91)80208-o
更新日期:1991-02-01 00:00:00
abstract::Sacral neuromodulation (SNM) is a minimally invasive, restorative treatment to improve voiding and elimination functions. We give a historical perspective of SNM and explore the evidence for the use of this therapy for Food and Drug Administration-approved pathologies as well as disease processes that are being treate...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/j.urology.2016.06.004
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:To evaluate periurethral silicone injection in the treatment of female stress urinary incontinence due to intrinsic sphincter deficiency (ISD) and assess whether coexisting urethral hypermobility has an impact on treatment outcome. METHODS:A total of 29 female patients with stress urinary incontinence under...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(02)01996-9
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVE:To determine the efficacy of computed tomography of the chest (CTC) and plain radiograph (CXR) in the initial staging process of testicular germ cell tumors. METHODS:The medical records of 362 patients with testicular germ cell tumor treated at our center between January 1980 and August 1993 were reviewed wi...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(94)80139-8
更新日期:1994-08-01 00:00:00
abstract::Using cultured HeLa S3 cells an ID50 of 2.5 micrograms/ml was found after a twenty-four-hour incubation with estradiol-17 beta- 3N -bis-(2-chloroethyl) carbamate (estramustine). Similar ID90 values were found in two Walker 256 rat carcinoma cell lines which were either sensitive or resistant to nitrogen mustards. Alka...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(84)80094-1
更新日期:1984-06-01 00:00:00
abstract:OBJECTIVES:To evaluate prospectively the success of scrotal incision orchiopexy (Bianchi technique) with or without inguinal hernia in patients with an undescended testis within the inguinal canal or beyond the external inguinal ring. METHODS:A total of 72 orchiopexies were performed in 56 patients with a primary unde...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2004.06.069
更新日期:2004-12-01 00:00:00
abstract::We report a case of symptomatic hypercalcemia in a patient with muscle-invasive, resectable squamous cell carcinoma of the bladder. Serum parathyroid hormone was consistent with secretion of parathyroid hormone-related protein. After radical cystoprostatectomy, calcium levels returned to normal. Patients with squamous...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(97)00638-9
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVES:To evaluate the anticancer effects of a lipophilic macromolecular anticancer agent, poly(styrene-co-maleic acid)-conjugated neocarzinostatin (SMANCS), dissolved in a lipid contrast medium (Lipiodol) given via the renal artery to patients with renal cell carcinoma. METHODS:Among 467 patients with renal cell ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(99)00537-3
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVES:Laser tissue soldering (LTS) with the diode laser and human albumin-hyaluronate-indocyanine green solder is a safe and effective method of providing an immediate leak-free closure during hypospadias repair. In this report, we compare the physiology, histology, and immunohistochemistry of wound healing follow...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/S0090-4295(97)00278-1
更新日期:1997-08-01 00:00:00
abstract::The use of percutaneous nephrostomy to evaluate the recoverability of function of the obstructed kidney is described and examined as a practical clinical method. Long-term drainage was used to assess the functional status of four kidneys and found to be of great value. The use of percutaneous nephrostomy to evaluate f...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(82)90603-3
更新日期:1982-05-01 00:00:00
abstract:OBJECTIVES:To investigate the protective effect of epigallocatechin gallate (EGCG), a green tea extract, on partial bladder outlet obstruction (pBOO)-induced bladder injury in a rat model. METHODS:The female Sprague-Dawley rats underwent sham or BOO procedures, and were divided into several groups (sham with saline in...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2015.12.020
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVES:To assess the general health-related quality of life (GHQOL) of patients with superficial bladder cancer who underwent transurethral resection (TUR). METHODS:We assessed the GHQOL a total of 178 times for 133 patients with superficial bladder cancer before multiple TURs. The GHQOL was assessed using the Med...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2004.09.050
更新日期:2005-02-01 00:00:00
abstract::The ureteral crossover method for the correction of bilateral vesicoureteral reflux, characterized by ureteral overlapping in the submucosal space and directing the submucosal tunnels toward a point other than the bladder neck, has been tested in 10 dogs. The operation was successful in 18 of 20 ureters (90%). This te...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(88)90420-7
更新日期:1988-11-01 00:00:00
abstract:OBJECTIVE:To describe pelvic bone osteomyelitis in the prostate cancer survivor, to report on clinical presentation and treatment, and to suggest an algorithmic approach to managing this syndrome complex. MATERIALS AND METHODS:A retrospective chart review from January 2011 to June 2014 was performed to identify prosta...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2014.11.020
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVES:Unusually high incidences of upper urinary tract urothelial carcinoma (UUT-UC) have been reported from the endemic area for "blackfoot disease" of southern Taiwan, and the arsenic-contaminated water was considered to be the reason for this prevalence. In this study, we determined the ratio of UC in different...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(02)01529-7
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVES:To examine the effect of 5-aza-2'-deoxycytidine (DAC), a DNA methyltransferase inhibitor, on the growth of renal cell carcinoma (RCC) and examine the synergistic growth suppression by DAC and chemotherapeutic agents. METHODS:The synergy of DAC and chemotherapeutic agents against RCC cell lines was analyzed ...
journal_title:Urology
pub_type: 历史文章,杂志文章
doi:10.1016/j.urology.2007.02.026
更新日期:2007-05-01 00:00:00
abstract::Urachal xanthogranuloma is rare. In this case, the patient presented with a lower abdominal mass and elevated inflammatory markers. The computed tomography findings of xanthogranulomatous urachitis resemble those of urachal carcinoma and, although rare, this entity should be included in the differential diagnosis of u...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2008.02.045
更新日期:2009-02-01 00:00:00
abstract::The identification of the decapeptide luteinizing hormone-releasing hormone (LHRH) has led to the development of LHRH agonists, which are a new class of drugs for the treatment of advanced prostate cancer. These peptides have a modified amino acid structure that makes them more potent than LHRH. Prolonged administrati...
journal_title:Urology
pub_type: 临床试验,杂志文章,评审
doi:10.1016/0090-4295(89)90105-2
更新日期:1989-05-01 00:00:00
abstract:OBJECTIVES:To determine the prevalence rates of erectile and ejaculatory dysfunction, associated bother, and their relation to sexual activity in a population-based sample of elderly men.Methods. Data were collected from 1688 men by way of self-administered questionnaires (including the International Continence Society...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(00)01091-8
更新日期:2001-04-01 00:00:00