Abstract:
:The identification of the decapeptide luteinizing hormone-releasing hormone (LHRH) has led to the development of LHRH agonists, which are a new class of drugs for the treatment of advanced prostate cancer. These peptides have a modified amino acid structure that makes them more potent than LHRH. Prolonged administration of LHRH agonists results in down-regulation of the LHRH receptors in the pituitary and decreased secretion of luteinizing hormone. The result is decreased production of testosterone by Leydig cells, which is the basis for the use of LHRH agonists to treat prostate cancer. The effectiveness of LHRH agonists has been demonstrated in the United States in several randomized, controlled clinical trials. Daily administration of leuprolide produced equivalent results compared with diethylstilbestrol (DES). More recently, in two separate, randomized studies, the long-acting LHRH agonist Zoladex (ICI Pharma, Wilmington, Delaware) produced the same objective response rate as DES or bilateral orchiectomy. The equivalent response rates obtained with LHRH agonists indicate that these drugs can now be considered a reasonable treatment option for patients with metastatic prostatic cancer.
journal_name
Urologyjournal_title
Urologyauthors
Chodak GWdoi
10.1016/0090-4295(89)90105-2subject
Has Abstractpub_date
1989-05-01 00:00:00pages
42-4issue
5 Suppleissn
0090-4295issn
1527-9995journal_volume
33pub_type
临床试验,杂志文章,评审相关文献
UROLOGY文献大全abstract::The inflammatory myofibroblastic tumor (IMT) is a rare benign tumor, known by several names and found in several locations throughout the body, including the lungs and genitourinary system (mostly the bladder). We report a case of a paratesticular IMT in a 17-year-old boy. Although the initial clinical diagnosis was r...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/j.urology.2010.09.027
更新日期:2011-07-01 00:00:00
abstract::We report on a new endoscopic approach to the removal of a migrated urethral stent following hypospadias repair. A flexible balloon-tipped guide wire allows the effective cystoscopic retrieval of a urethral stent, suggesting potential applications to the removal of other foreign bodies in the urinary tract. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/S0090-4295(96)00052-0
更新日期:1996-06-01 00:00:00
abstract:OBJECTIVES:The CD40 antigen is expressed by antigen-presenting cells, many kinds of epithelium, and carcinomas. As signaling through CD40 modulates the differentiation state of CD40-expressing cells, we wanted to investigate whether benign or malignant prostate epithelium expressed CD40. METHODS:Twenty-two paraffin-em...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(00)01005-0
更新日期:2001-03-01 00:00:00
abstract::Urethral dilatation has long been the standard treatment for patients with urethral stricture. However, in many patients such dilatations may be difficult, painful, or have to be done at frequent intervals. The alternative techniques of direct vision urethrotomy or urethroplasty have been considered in 101 patients ov...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(81)90461-1
更新日期:1981-12-01 00:00:00
abstract::Although the radiologic characteristics and endoscopic appearance of aberrant renal papillae have been described, a tissue diagnosis is the only way to exclude a low-grade urothelial malignancy. We report on three caliceal filling defects managed percutaneously in which biopsy findings confirmed aberrant papillae. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(94)80280-7
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVES:To assess sexual dysfunction in sexually active men after radical cystectomy (RC) and to determine whether sildenafil citrate can improve erectile dysfunction after surgery. METHODS:The baseline and follow-up data from 49 sexually active male patients (mean age 57.8 +/- 9.1 years) undergoing RC (1995 to 200...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2004.05.056
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy of imidafenacin for nocturia and nocturnal polyuria in patients with overactive bladder. MATERIALS AND METHODS:A stratified analysis was conducted on data from a phase III randomized, double-blind, controlled trial of imidafenacin performed at 158 centers in Japan. The subjects recei...
journal_title:Urology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.urology.2013.05.017
更新日期:2013-09-01 00:00:00
abstract::The presentation, diagnosis, and management of a patient with an ileovesical fistula is discussed, this being the second reported case in the literature. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(89)90135-0
更新日期:1989-06-01 00:00:00
abstract:OBJECTIVE:To determine the sensitivity to change of question 6 (Q6) of the modified short form version of the Urogenital Distress Inventory (UDI-6) before and after synthetic sling removal (SSR). METHODS:Following IRB approval, a prospectively maintained database of mid-urethral sling (MUS) complications identified wo...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2020.10.029
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVES:Prostate-specific antigen (PSA) is a widely used serum marker for human prostate cancer (PCa). The majority of PSA in serum is present as a complex with alpha-1-antichymotrypsin (ACT). In recent years, the ratio of free (uncomplexed) to total PSA has shown improved discrimination of PCa from benign prostatic...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/S0090-4295(97)00449-4
更新日期:1997-11-01 00:00:00
abstract:OBJECTIVES:To determine the value of mid-infrared spectroscopy (MIRS) of ureteral stent encrustations in predicting urinary stone composition. METHODS:A retrospective study analyzed the composition of stent encrustations and urinary stones by MIRS in patients who had had a stent for ureteral obstruction between 2001 a...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2005.03.054
更新日期:2005-08-01 00:00:00
abstract::Minimally invasive laparoscopic techniques have been applied to the staging and treatment of testicular cancer during the performance of retroperitoneal lymph node dissection. The da Vinci Surgical System potentially improves the safety and accuracy of this approach. We present what we believe to be the first publishe...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2005.07.022
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:To describe the patterns in the use of bladder augmentation and urinary diversion to manage urologic sequelae among patients with spinal cord injury in the United States. MATERIALS AND METHODS:Discharge estimates were derived from the Nationwide Inpatient Sample. All patients underwent bladder augmentation o...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2012.06.063
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVES:To compare postoperative morbidity and mortality in a concurrent and contemporary series of patients who underwent radical cystectomy with ileal conduit versus orthotopic neobladder. METHODS:The data of 198 patients were reviewed, 117 with orthotopic reconstruction and 81 with ileal conduit during a 5-year ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(99)00619-6
更新日期:2000-06-01 00:00:00
abstract:OBJECTIVE:To describe the associations between elevated urinary ammonium and clinical characteristics of kidney stone formers. A 24-hour urine test is recommended in high-risk patients to identify urinary abnormalities and select interventions to reduce the recurrence risk. While elevations in urine ammonium may be see...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2020.05.063
更新日期:2020-10-01 00:00:00
abstract::We evaluated the role of lymphadenectomy (LND) in the prevention of local recurrence following radical nephrectomy for renal cell carcinoma (RCC) by two retrospective studies. In one, the relative importance of various tumor characteristics to the subsequent development of local recurrence was investigated in 37 patie...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(93)90234-2
更新日期:1993-01-01 00:00:00
abstract::Inguinal ureteral and concomitant urinary bladder hernia is an exceptionally rare phenomenon. It is reported that diagnosis of urinary bladder involvement in inguinal hernias are extremely difficult to make with about only 7% of such cases being identified preoperatively. We present a case of a 70-year old man with su...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2020.03.031
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVES:To review the experience of 40 consecutive patients who underwent radical retropubic prostatectomy and to determine if and how the procedure could be performed safely on an ambulatory basis. METHODS:Between June 20, 1994 and November 26, 1996, 40 consecutive men with clinically localized prostate carcinoma ...
journal_title:Urology
pub_type: 临床试验,杂志文章
doi:10.1016/s0090-4295(97)00716-4
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVES:Peripheral primitive neuroectodermal tumor (PNET) is a highly aggressive neoplasm belonging to the Ewing family of tumors. It is characterized by the expression of MIC2 and neural markers (eg, neuron-specific enolase, synaptophysin, S-100, vimentin, Leu-7), and the presence of the EWS-FLI1 translocation. ME...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/j.urology.2006.02.037
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVES:To analyze the self-learning curve of a single surgeon with holmium laser enucleation of the prostate and to evaluate the safety, effectiveness, and outcome of the procedure after 2 years of experience. METHODS:The data from the first 125 patients who underwent holmium laser enucleation of the prostate were...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2008.12.052
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVES:To evaluate the efficacy of transvaginal tape mobilization as a method of treating urinary retention after tension-free vaginal tape (TVT) procedures, and secondly to evaluate the time to resumption of voiding function after TVT procedures. METHODS:Postoperative voiding function and the 1-year continence st...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2005.03.055
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVES:To estimate the declining benefits of screening for prostate cancer as patient age at screening increases. The benefits of prostate cancer screening decline with age because of the long natural history of prostate cancer and competing causes of death among older men. METHODS:We used a previously described M...
journal_title:Urology
pub_type: 历史文章,杂志文章
doi:10.1016/j.urology.2005.05.030
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of penile cancer in patients with adult acquired buried penis (AABP). Penile cancer is a rare but aggressive cancer. Several case reports have recently been published that indicate that AABP may increase the risk of penile cancer. MATERIALS AND METHODS:A retrospective review was c...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2019.07.019
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVES:To determine the clinical significance of Gleason score 3+4 versus 4+3 on radical prostatectomy. METHODS:Of 2390 men who underwent radical prostatectomy by a single surgeon, 570 had Gleason score 7 tumors without lymph node metastasis, seminal vesicle invasion, or tertiary Gleason pattern 5. Patients were e...
journal_title:Urology
pub_type: 临床试验,杂志文章
doi:10.1016/s0090-4295(00)00753-6
更新日期:2000-11-01 00:00:00
abstract::Discussion, diagnosis, and management of fibroepithelial polyps in a newborn female. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2019.06.026
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVES:To evaluate the process of soft-tissue electrovaporization and to study variables that affect tissue clearance rates in a laboratory setting, in order to identify parameters that can optimize transurethral electrovaporization of the prostate. METHODS:Fresh bovine skeletal muscle, equivalent in impedance and...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(97)00092-7
更新日期:1997-06-01 00:00:00
abstract:OBJECTIVES:There is little objective information on what is designated as being the prostate capsule. We have quantified objectively with computerized image analysis the percentage of smooth muscle fibers (SMFs) surrounding the surgical specimens of radical prostatectomies. METHODS:Ten radical prostatectomy specimens ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(99)80190-3
更新日期:1995-08-01 00:00:00
abstract:OBJECTIVES:To study the role of urethral sonography and color Doppler imaging in the evaluation of patients with urethral strictures and associated abnormalities. METHODS:We reviewed our experience with 41 urethral sonographic studies in 35 patients and compared them to 33 retrograde urethrograms. For 6 recent cases, ...
journal_title:Urology
pub_type: 临床试验,杂志文章
doi:10.1016/s0090-4295(99)80391-4
更新日期:1996-01-01 00:00:00
abstract::Chromaffin cell tumors are derived from neural crest cells and can produce and secrete catecholamines. Classic symptoms include headache, palpitations, diaphoresis, and hypertension. Diagnosis is typically in adulthood, and metastatic disease is rarely found. Genetic testing is suggested with young age, extra-adrenal ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2016.05.028
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVES:To verify whether in patients with biochemical progression after radical prostatectomy (RRP), the administration of a cyclooxygenase-2 (COX-2) inhibitor during the off-phases of intermittent androgen deprivation (IAD) may increase the effectiveness and off-therapy time of intermittent therapy. METHODS:This ...
journal_title:Urology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.urology.2007.09.033
更新日期:2008-05-01 00:00:00