Abstract:
OBJECTIVES:To verify whether in patients with biochemical progression after radical prostatectomy (RRP), the administration of a cyclooxygenase-2 (COX-2) inhibitor during the off-phases of intermittent androgen deprivation (IAD) may increase the effectiveness and off-therapy time of intermittent therapy. METHODS:This is a comparative, prospective study. A total of 44 patients with biochemical progression after RRP were included in a clinical protocol for IAD once prostate-specific antigen (PSA) levels progressed over 0.4 ng/mL. The 44 cases were randomly assigned to receive two different treatment strategies: group A received IAD therapy using bicalutamide 150 mg once daily in the on-phases and no therapy in the off-phases; group B received IAD therapy using bicalutamide 150 mg once daily in the on-phases and etoricoxib 60 mg once daily in the off-phases. RESULTS:Median follow-up was 62 weeks. In group A 5 of 22 (22.7%) cases and in group B 2 of 22 (9.1%) cases failed to respond to IAD (P >0.05). Comparing the two groups, in all three cycles of IAD the time of the cycles and the time of the off-phases were significantly (P <0.0001) longer in group B than in group A. The highest PSA value reached during the off-phases in each cycle was significantly (P <0.001) lower in group B than in group A. Withdrawal from treatment owing to side effects was not necessary in any of the 44 patients. CONCLUSIONS:In patients with biochemical progression after RRP, we showed that the use of a COX-2 inhibitor in the off-phases of IAD is able to increase the off-treatment time significantly.
journal_name
Urologyjournal_title
Urologyauthors
Di Silverio F,Sciarra A,Gentile Vdoi
10.1016/j.urology.2007.09.033subject
Has Abstractpub_date
2008-05-01 00:00:00pages
947-51issue
5eissn
0090-4295issn
1527-9995pii
S0090-4295(07)02167-Xjournal_volume
71pub_type
杂志文章,随机对照试验相关文献
UROLOGY文献大全abstract:OBJECTIVE:To provide an anatomical atlas made of serially sectioned images of a female cadaver that clearly demonstrated the pudendal nerve. MATERIALS AND METHODS:The courses of the pudendal nerve, internal pudendal artery, and internal pudendal vein were observed on the sectioned images of a female cadaver. The spati...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2020.05.007
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:To present our results for repair of unilateral vesicoureteral reflux in 76 children using a modified technique of detrusorrhaphy. METHODS:A retrospective chart review was performed for 76 children who underwent repair of unilateral vesicoureteral reflux by a modified technique of detrusorrhaphy. Of the 76 r...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(98)00072-7
更新日期:1998-05-01 00:00:00
abstract:OBJECTIVE:To evaluate clinical and patient-reported urinary and sexual outcomes after a long-segment stricture repair using the 1-sided urethral dissection, penile invagination, and dorsal buccal mucosa graft onlay technique described by Kulkarni et al. METHODS:Patients from 4 institutions after single-stage repairs f...
journal_title:Urology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.urology.2017.08.029
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:To determine the hormonal (luteinizing hormone [LH] and testosterone) and biochemical (serum prostate-specific antigen [PSA]) response to withdrawal of luteinizing hormone-releasing hormone (LHRH) agonists in patients who received more than 2 years of LHRH therapy for advanced prostate cancer. METHODS:Fourt...
journal_title:Urology
pub_type: 临床试验,杂志文章
doi:10.1016/s0090-4295(99)00061-8
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVES:This study sought to characterize the postoperative prostate-specific antigen (PSA) doubling time and time to biochemical recurrence in patients who have failed radical prostatectomy. METHODS:Of 539 consecutive patients who underwent radical prostatectomy between 1984 and 1992, postoperative PSA levels in 8...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/S0090-4295(97)00231-8
更新日期:1997-05-01 00:00:00
abstract::Multiple modalities are used for hemostasis during laparoscopic radical prostatectomy. We report an instance of migration of a hemostatic clip into the bladder leading to stone formation. As such, these devices should be used with caution in the region of the vesicourethral anastomosis. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2007.10.014
更新日期:2008-02-01 00:00:00
abstract::Although cystitis glandularis has been considered a premalignant lesion, the instance of cystitis glandularis progression to adenocarcinoma or cystitis glandularis associated with adenocarcinomatous change is rare. This article includes 4 cases of neurogenic bladder with urinary diversion for different periods of time...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(80)90484-7
更新日期:1980-04-01 00:00:00
abstract::The lymphatic spread of prostate adenocarcinoma most often involves the iliac, obturator, and hypogastric nodes. Inguinal lymphadenopathy is very rare during the early stages of this disease, especially in the absence of pelvic lymphadenopathy or other metastases. We present a case of prostate adenocarcinoma with ingu...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(02)02269-0
更新日期:2003-02-01 00:00:00
abstract::A rare case of a fifty-six-year-old female with neuroblastoma is presented. Possible implications as to etiology are discussed, and the radiographic similarities between renal cell carcinoma and neuroblastoma are presented. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(75)90774-8
更新日期:1975-09-01 00:00:00
abstract:OBJECTIVES:To evaluate the relationship between low prostate-specific antigen (PSA) levels that are considered normal and the long-term risk of prostate cancer. METHODS:The relative risk of, and cumulative probability of freedom from, prostate cancer by PSA level and age decade was evaluated in male participants of a ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(01)01304-8
更新日期:2001-09-01 00:00:00
abstract::A retrospective study to evaluate the relationship of blood groups of 96 patients with transitional cell carcinoma of the bladder in Israeli population, reports that patients with blood group O had higher grade tumors and higher recurrence rates than the other blood groups, without a difference in the mortality rates....
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(87)90379-7
更新日期:1987-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the effectiveness of cystoscopic lithotripsy, we performed Amplatz sheath technique using Ho: YAG laser. Maheshwari first reported the use of an Amplatz sheath in the female urethra in 1998, and Okeke et al reported the use of an Amplatz sheath for male patients during cystolithotripsy in 2004. Th...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2012.07.046
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVES:To define the responses of stretched penile length (PL) to intramuscular testosterone enanthate (TE) treatment in prepubertal boys with hypospadias. METHODS:We examined 17 Japanese boys with hypospadias at 1.4 +/- 1.3 (mean +/- SD) years of age. Their PLs were 2.79 +/- 0.37 cm and -1.16 +/- 0.88 SD of the m...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2009.12.065
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVES:To study the values of the renal resistive index (RI) before and at different points after relief of obstructive anuria and to correlate these values with the corresponding values of serum creatinine and with the recovery of renal function after release of obstruction. METHODS:A total of 32 consecutive pati...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(01)01623-5
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the renal function outcomes after selective trans-arterial embolization (SAE) of iatrogenic vascular lesions (IVL), including pseudoaneurysm and arteriovenous fistula, following partial nephrectomy (PN). MATERIALS AND METHODS:A multi-institutional study was conducted including consecutive patient...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2020.03.036
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVE:To study the use of a baseline prostate-specific antigen (PSA) and digital rectal examination in men (aged 40-49 years) in predicting long-term prostate cancer risk in a prospectively followed, representative population cohort. PATIENTS AND METHODS:Since 1990, a random sample of men in Olmsted County (aged 4...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2013.06.074
更新日期:2013-12-01 00:00:00
abstract::Percutaneous nephrostomy is a well-recognized procedure utilized by the radiologist both as a temporary drainage method for urinary tract obstruction and as the elective therapeutic modality in selected pathologies of the urinary tract. We report a complication not previously mentioned in the literature, urinoma forma...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(79)90478-3
更新日期:1979-05-01 00:00:00
abstract::We believe this is the first reported case of symptomatic contralateral retroperitoneal hematoma secondary to percutaneous ultrasonic lithotripsy. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(87)90105-1
更新日期:1987-06-01 00:00:00
abstract::A supratesticular intrascrotal mass clinically mimicking a spermatocele was found to be a scrotal neoplasm histologically identified as a schwannoma. We herein present the first case of intrascrotal schwannoma to our knowledge. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(85)90135-9
更新日期:1985-09-01 00:00:00
abstract::Dog ureters were anastomosed end to end using either chromic catgut, polyglycolic acid (PGA), polyglactin-910, or polypropylene sutures. Analysis of luminal diameters, fibrosis, scar vascularity, and inflammatory reaction four and seven months later indicated that in ureters of the uninfected dog the best results were...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(83)90087-0
更新日期:1983-03-01 00:00:00
abstract::Five hundred girls with recurrent urinary tract infections and documented reflux were seen in our private practice during the last twenty years. All patients received medical treatment for three to forty-eight months (an average of fifteen months) after which the 250 who were not cured were submitted to corrective sur...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(80)90329-5
更新日期:1980-07-01 00:00:00
abstract:OBJECTIVES:Establishing realistic health-related quality-of-life (HRQOL) expectations before the choice of cancer treatment is made is an important goal of patient counseling. We prospectively studied the pretreatment expectations of prostate cancer-specific HRQOL with an adapted Expanded Prostate Cancer Index Composit...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2006.08.1092
更新日期:2006-12-01 00:00:00
abstract::Although metastatic renal cell carcinoma (RCC) is not uncommon, dissemination to the gallbladder or prostate is very rare. We present 1 case of RCC with synchronous metastasis to the gallbladder and 1 case of RCC with metachronous metastasis to the prostate. These cases illustrate the propensity of RCC for unpredictab...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/S0090-4295(99)80310-0
更新日期:1995-11-01 00:00:00
abstract:OBJECTIVES:To assess the practice preferences among urologists treating superficial bladder cancer in the United States. METHODS:We surveyed 226 urologists using a specially designed survey instrument. The type of practice, number of urologists in group practice, annual volume of patients with bladder cancer, and thos...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(03)00765-9
更新日期:2003-12-01 00:00:00
abstract:INTRODUCTION:Retroperitoneal lymphadenectomy (RPLND) is indicated in patients with testicular cancer of all stages for staging, prognostic, and therapeutic purposes. Modification of the classic RPLND to incorporate nerve sparing has reduced the morbidity associated with this procedure with respect to ejaculation and fe...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(99)00378-7
更新日期:2000-01-01 00:00:00
abstract::The diagnosis of metastatic testicular carcinoma in a thirty-three-year-old man and his nineteen-year-old brother is reported. Histologically, the tumor of the older brother consisted predominantly of embryonal carcinoma with minor components of seminoma and adult teratoma; the tumor of the younger brother consisted e...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(88)90233-6
更新日期:1988-10-01 00:00:00
abstract:OBJECTIVE:To review the incidence of defunctionalized bladder-related complications in patients who have had a supravesical urinary diversion for intractable urinary incontinence without concomitant cystectomy. MATERIALS AND METHODS:We retrospectively analyzed the records of patients requiring urinary diversion for in...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2013.06.037
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:To develop an evidence-based approach to the diagnostic workup of suspicious upper urinary tract lesions. METHODS:The PubMed database was searched using the following terms with a filter for English language: "upper tract urothelial carcinoma" and "upper tract transitional cell carcinoma," along with the fol...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/j.urology.2015.08.046
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVES:To determine the efficacy and cost-effectiveness of routine antimicrobial prophylaxis prior to shock wave lithotripsy (SWL) in patients with a sterile pretreatment urine culture. METHODS:A structured MedLine search revealed eight prospective, randomized, controlled trials (RCTs) of active treatment versus p...
journal_title:Urology
pub_type: 杂志文章,meta分析
doi:10.1016/S0090-4295(96)00626-7
更新日期:1997-05-01 00:00:00
abstract::The compartment syndrome is a rare complication of surgery in the lithotomy position, but one that may result in neurovascular damage and permanent disability. Herein, we present a case of bilateral three-compartment syndrome following urethroplasty in the dorsolithotomy position, with review of the literature and dis...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/0090-4295(94)90204-6
更新日期:1994-05-01 00:00:00