Abstract:
OBJECTIVE:To study the use of a baseline prostate-specific antigen (PSA) and digital rectal examination in men (aged 40-49 years) in predicting long-term prostate cancer risk in a prospectively followed, representative population cohort. PATIENTS AND METHODS:Since 1990, a random sample of men in Olmsted County (aged 40-49 years) has been followed up prospectively (n = 268), with biennial visits, including a urologic questionnaire, PSA screening, and physical examination. The ensuing risk of prostate cancer (CaP) was compared using survival analyses. RESULTS:Median follow-up was 16.3 years (interquartile range 14.0-17.3, max 19.1). For men with a baseline PSA <1.0 ng/mL (n = 195), the risk of subsequent Gleason 6 CaP diagnosis by 55 years was 0.6% (95% confidence interval [CI] 0%-1.7%) and 15.7% (95% CI 6.5%-24.9%) for men with a baseline PSA ≥ 1.0 ng/mL. No man with a low baseline PSA developed an intermediate or high risk CaP, whereas 2.6% of men with a higher baseline PSA did (95% CI 0.58%-4.6%). CONCLUSION:Men (aged 40-49 years) can be stratified with a baseline PSA. If it is below 1.0 ng/mL, there is very little risk for developing a lethal CaP, and as many as 75% of men might be able to avoid additional PSA screening until 55 years. Conversely, men aged 40-49 years with a baseline PSA level >1.0 ng/mL had a significant risk of CaP diagnosis and should be monitored more closely.
journal_name
Urologyjournal_title
Urologyauthors
Weight CJ,Kim SP,Jacobson DJ,McGree ME,Karnes RJ,St Sauver Jdoi
10.1016/j.urology.2013.06.074subject
Has Abstractpub_date
2013-12-01 00:00:00pages
1211-7issue
6eissn
0090-4295issn
1527-9995pii
S0090-4295(13)01061-3journal_volume
82pub_type
杂志文章相关文献
UROLOGY文献大全abstract:OBJECTIVES:To determine the incidence of calcified Peyronie's disease plaque that cannot be cut with a blade in a 100-case series and to describe the use of a soft tissue-protecting bone saw for plaque incision. METHODS:Chart reviews were done of all surgically treated Peyronie's disease patients at our center between...
journal_title:Urology
pub_type: 临床试验,杂志文章
doi:10.1016/j.urology.2015.04.027
更新日期:2015-08-01 00:00:00
abstract::A case is described of the onset of acute renal failure due to renal artery occlusion in a solitary kidney of a sixty-six-year-old woman. She had been treated for severe hypertension due to renal artery stenosis. An aortorenal bypass to revascularized the kidney was combined with repair of an abdominal aortic aneurysm...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(88)90577-8
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:To investigate the relationship of lower urinary tract symptoms (LUTS) to urinary tract infection, prostatitis, sexually transmitted infection, lifetime sexual partner count, and recreational drug use in a population of men who have sex with men. LUTS in men are a source of considerable morbidity, distress, a...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2011.07.1412
更新日期:2012-01-01 00:00:00
abstract::Treatment of a series of 194 patients with T3 (B2/C) tumors by radical radiotherapy, 5,000 to 5,500 rad in four weeks, produced a five-year survival of 40 per cent. Patients whose tumor completely disappeared after treatment (N = 97) had a five-year survival of 69 per cent. These results raise doubts about the necessi...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(84)90199-7
更新日期:1984-10-01 00:00:00
abstract::A 64-year-old woman had been diagnosed with uterine prolapse (UP), with a postvoid residual urine volume 4 years previously. In addition, she had had moderate renal dysfunction diagnosed 2 years before presentation. Her serum creatinine was 10.1 mg/dL, and she underwent right double-J stenting and insertion of an intr...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2005.09.025
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVES:To describe our initial experience with the laparoscopic technique of sliding-clip renorrhaphy applied to open surgery for small renal masses. METHODS:Knotless renorrhaphy with the sliding-clip technique is performed by securing suture with Hem-o-lok clips slid under tension against the renal capsule and lo...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2010.10.025
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVES:To report experience with 100 robot-assisted partial nephrectomy (RAPN) operations performed at our institution. Nephron-sparing surgery is an established treatment for patients with small renal masses. The laparoscopic approach has emerged as an alternative to open nephron-sparing surgery, but it is recogni...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2009.10.040
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVES:In 2001, we reported a novel technique for pediatric circumcision that has proved to be fast, reliable, and safe during the past 4 years, with good cosmetic results. Inspired by our success with this technique, we have created a similar device to be used for adults. METHODS:We conducted a prospective, rando...
journal_title:Urology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.urology.2010.02.021
更新日期:2010-10-01 00:00:00
abstract::Emphysematous pyelonephritis is a severe infection found almost exclusively in diabetics, characterized by the presence of gas within the renal parenchyma. The diagnosis is established radiographically. An additional case is added to the 52 cases reported in the literature; we believe this is the fifth reported case w...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(85)90332-2
更新日期:1985-03-01 00:00:00
abstract::A total of 7 patients with high grade, T3a (Stage B2) bladder cancer were treated with external radiation therapy and interstitial iridium implantation from May 1986 through March 1988. Follow-up has ranged from nineteen to sixty-one months with a median of forty months. One patient has required a cystectomy and is cu...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(93)90559-s
更新日期:1993-03-01 00:00:00
abstract:OBJECTIVES:To evaluate the effectiveness and safety of a new purified collagen gel with specific properties for renal artery embolization in an experimental model in dogs. METHODS:The new gel was prepared from type I bovine tendon collagen, highly purified to eliminate immunogenicity, and reconstituted through extensi...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2005.10.043
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVE:To analyze whether strains positive for extended-spectrum β-lactamase (ESBL) affected the clinical course and progression to chronic prostatitis in patients with postbiopsy acute prostatitis. METHODS:From 2002 to 2011, 3657 patients underwent transrectal ultrasound-guided biopsy of the prostate, and 33 patie...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2013.02.040
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVES:To evaluate the prevalence, clinical correlates, and severity of sexual dysfunction in combat veterans with and without post-traumatic stress disorder (PTSD) using a validated instrument for assessing sexual function. The results of recent studies have suggested that combat veterans with PTSD experience a hi...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(02)01899-x
更新日期:2002-11-01 00:00:00
abstract::A case of cavernous hemangioma of the bladder is presented and its endoscopic appearance is illustrated. A scan utilizing technetium-99-labeled albumin has been found valuable in determining the extent of the lesion. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(79)90425-4
更新日期:1979-03-01 00:00:00
abstract:OBJECTIVES:To examine populations with diagnosed clinical interstitial cystitis (IC) and urethral syndrome and normal controls using the potassium sensitivity test (PST), to determine the incidence of PST-provoked pain and/or urgency, and to document the type and location of IC and urethral syndrome pain, association o...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(00)01110-9
更新日期:2001-03-01 00:00:00
abstract:OBJECTIVE:To evaluate our 5-year experience with deep lateral transurethral incisions of bladder neck contracture (TUIBNC), identify risk factors associated with failure of procedure, and assess outcomes of men subsequently treated for concomitant or de novo stress urinary incontinence (SUI). MATERIALS AND METHODS:We ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2013.08.018
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVES:There is scant literature on the frequency of high-grade prostatic intraepithelial neoplasia (PIN) in needle biopsy specimens. These data have implications as to how often pathologists should be expected to diagnose these lesions on needle biopsy and impact on the feasibility of cancer chemoprevention trials...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/S0090-4295(96)00622-X
更新日期:1997-03-01 00:00:00
abstract:OBJECTIVE:To investigate the cognitive and physical workload experienced by each operating room team member for different types of urologic procedures. METHODS:Surgeons, anesthesiologists, surgical fellows, bedside assistants, circulating nurses, and scrub nurses completed the National Aeronautics and Space Administra...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2017.05.012
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVES:To assess the feasibility of telerobotic assisted surgery. METHODS:In a laboratory model, a cholecystectomy, splenectomy, and nephrectomy were performed by an inexperienced surgeon who was being mentored by an experienced surgeon stationed at a remote site. The remote surgeon controlled the laparoscopic cam...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(94)80003-0
更新日期:1994-07-01 00:00:00
abstract:OBJECTIVES:Prostate-specific antigen (PSA) levels, transrectal ultrasound, and systematic sextant biopsies have each shown limited ability to predict prostate cancer volume. In combination, these studies may allow more accurate estimation of volume and prognosis. METHODS:One hundred twenty-four patients were evaluated...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(95)96858-x
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVES:To conduct a trial using three different doses of bacillus Calmette-Guérin (BCG) to determine whether lowering the dose of BCG could reduce toxicity without compromising its efficacy in the treatment of superficial bladder cancer. METHODS:From July 2002 to June 2005, 152 patients with superficial bladder ca...
journal_title:Urology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.urology.2007.07.017
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVE:To examine the association between kidney size and renal cell carcinoma (RCC) death among patients with Stage pT1 clear cell RCC undergoing surgery. METHODS:We used a case-cohort design and evaluated 191 patients from our Nephrectomy Registry who had undergone open radical nephrectomy for unilateral, sporadi...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2012.04.013
更新日期:2012-07-01 00:00:00
abstract::Perinephric urinomas commonly arise following traumatic injury or high-grade obstruction from kidney stones or lower urinary tract disorders. Not only are spontaneous urinomas rare in the pediatric population, but malignancy presenting with perinephric urinomas have only been described in the adult population. In this...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2018.04.003
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVES:Previous studies have observed higher age-specific serum prostate-specific antigen (PSA) values in African-American (AA) men without prostate cancer compared to white men, leading some to recommend race-specific PSA reference ranges for the early detection of prostate cancer. The primary objective of the Fli...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/s0090-4295(00)00873-6
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVES:The importance of the expression of granin A (GRN-A, chromogranin-A) has become appreciated in the neuroendocrine differentiation of prostate cancer. We studied the expression of GRN-A in prostate cancer using serum immunoassay and tissue immunohistology procedures for this protein in order to define the cli...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/s0090-4295(98)00062-4
更新日期:1998-05-01 00:00:00
abstract::Previous studies performed in our laboratory indicated that the primary antibacterial defense mechanism of the rabbit bladder is the antiadsorptive action of the surface mucopolysaccharide. The increased bacterial adsorption that occurs when the bladder is denuded of this layer was prevented by the instillation of hep...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(78)90291-1
更新日期:1978-10-01 00:00:00
abstract:OBJECTIVE:To analyze the impact of gender on the clinicopathologic features and survival of patients with surgically treated papillary renal cell carcinoma (papRCC) using a comprehensive international multicenter database. MATERIALS AND METHODS:Data of 2325 patients undergoing surgery for unilateral papRCC between 198...
journal_title:Urology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.urology.2017.06.042
更新日期:2017-11-01 00:00:00
abstract::We report an unusual case of an accessory or duplicated urethra. This case is unique because of its association with multiple urologic anomalies which made management and diagnosis of this condition unusual. The unusual combination of right ectopic ureter and left renal and ureteral agenesis in association with the ac...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(75)90633-0
更新日期:1975-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy and safety of elocalcitol in the treatment of women with overactive bladder and idiopathic detrusor overactivity. METHODS:The study was a multicenter, double-blind, randomized, placebo-controlled, parallel-group trial of women with overactive bladder symptoms recruited from 48 Europe...
journal_title:Urology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.urology.2012.03.035
更新日期:2012-07-01 00:00:00
abstract::Nocturia is a bothersome, multifactorial condition with many underlying causes and contributing factors. Nocturnal polyuria (NP; overproduction of urine at night) is a frequent component. The prevalence of nocturia increases with age; specific estimates of prevalence are influenced by frequency thresholds used to defi...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/j.urology.2019.07.005
更新日期:2019-11-01 00:00:00