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Heparin as antibacterial agent in rabbit bladder.

Abstract：

:Previous studies performed in our laboratory indicated that the primary antibacterial defense mechanism of the rabbit bladder is the antiadsorptive action of the surface mucopolysaccharide. The increased bacterial adsorption that occurs when the bladder is denuded of this layer was prevented by the instillation of heparin. Additional studies showed that the protective effect of heparin is inhibited by protamine, a further indication that the bladder's "antiadherence factor" is a mucopolysaccharide. Small amounts of heparin, applied directly to the mucoprotein-deficient bladder or to the surface of the inoculated bacteria, produced a statistically significant reduction in bacterial adsorption.

journal_name

Urology

journal_title

Urology

authors

Hanno PM,Fritz R,Wein AJ,Mulholland SG

doi

10.1016/0090-4295(78)90291-1

subject

Has Abstract

pub_date

1978-10-01 00:00:00

pages

411-5

issue

4

eissn

0090-4295

issn

1527-9995

journal_volume

12

pub_type

杂志文章

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