Abstract:
OBJECTIVE:To compare the predictive performance of a logistic regression model developed with contemporary data from a diverse group of urology practices to that of the Prostate Cancer Prevention Trial (PCPT) Risk Calculator version 2.0. MATERIALS AND METHODS:With data from all first-time prostate biopsies performed between January 2012 and March 2015 across the Michigan Urological Surgery Improvement Collaborative (MUSIC), we developed a multinomial logistic regression model to predict the likelihood of finding high-grade cancer (Gleason score ≥7), low-grade cancer (Gleason score ≤6), or no cancer on prostate biopsy. The performance of the MUSIC model was evaluated in out-of-sample data using 10-fold cross-validation. Discrimination and calibration statistics were used to compare the performance of the MUSIC model to that of the PCPT risk calculator in the MUSIC cohort. RESULTS:Of the 11,809 biopsies included, 4289 (36.3%) revealed high-grade cancer; 2027 (17.2%) revealed low-grade cancer; and the remaining 5493 (46.5%) were negative. In the MUSIC model, prostate-specific antigen level, rectal examination findings, age, race, and family history of prostate cancer were significant predictors of finding high-grade cancer on biopsy. The 2 models, based on similar predictors, had comparable discrimination (multiclass area under the curve = 0.63 for the MUSIC model and 0.62 for the PCPT calculator). Calibration analyses demonstrated that the MUSIC model more accurately predicted observed outcomes, whereas the PCPT risk calculator substantively overestimated the likelihood of finding no cancer while underestimating the risk of high-grade cancer in this population. CONCLUSION:The PCPT risk calculator may not be a good predictor of individual biopsy outcomes for patients seen in contemporary urology practices.
journal_name
Urologyjournal_title
Urologyauthors
Auffenberg GB,Merdan S,Miller DC,Singh K,Stockton BR,Ghani KR,Denton BTdoi
10.1016/j.urology.2017.01.039subject
Has Abstractpub_date
2017-06-01 00:00:00pages
137-142eissn
0090-4295issn
1527-9995pii
S0090-4295(17)30165-6journal_volume
104pub_type
杂志文章相关文献
UROLOGY文献大全abstract:OBJECTIVES:To determine why the incidence of pediatric urolithiasis is less than that of adult urolithiasis, we investigated the difference in inhibition of calcium oxalate (CaOX) crystallization between pediatric and adult urinary macromolecules (UMMs). METHODS:Urinary parameters in relation to urolithiasis, the inhi...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(99)00004-7
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVES:To evaluate the efficacy of laparoscopic radical nephrectomy for patients with small renal cell carcinoma by comparing the clinical results of patients treated laparoscopically with those of patients treated with traditional open radical nephrectomy. METHODS:Of 100 patients with localized, small (less than ...
journal_title:Urology
pub_type: 临床试验,杂志文章
doi:10.1016/s0090-4295(98)00505-6
更新日期:1999-02-01 00:00:00
abstract::We report the case of a 56-year-old man who in a motor vehicle collision developed a pelvic fracture and complete urethra rupture. Sudden onset of intermittent severe urethral bleeding occurred and it led to life-threatening blood pressure drop and dyspnea. An angiography of internal iliac artery showed a pseudoaneury...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2013.08.016
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVES:To report the long-term clinical outcomes and durability of response after treatment with induction intravesical docetaxel. Most novel agents used to treat bacillus Calmette-Guerin refractory high-grade non-muscle-invasive (NMI) bladder cancer are evaluated only after short follow-up periods. Our previously ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2009.06.112
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVES:To investigate the effectiveness and morbidity of percutaneous laser endoureterotomy in the management of ureterointestinal anastomotic strictures after radical cystectomy and urinary diversion. METHODS:Between May 1997 and August 2000, 19 percutaneous endoureterotomy incisions, including 3 repeated incisio...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(01)01396-6
更新日期:2001-12-01 00:00:00
abstract:OBJECTIVES:Numerous techniques have been described for supporting the vaginal vault after enterocele repair and hysterectomy. We describe a transvaginal culdosuspension that obliterates the cul-de-sac and supports the vaginal cuff high on the levator plate. The normal vaginal axis is restored, and adequate vaginal dept...
journal_title:Urology
pub_type: 临床试验,杂志文章
doi:10.1016/s0090-4295(99)00266-6
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVES:To examine the ability of the urinary prostate cancer gene 3 (PCA3) assay to predict biopsy-detected cancers in men receiving dutasteride in the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) study cohort. METHODS:Urine and serum samples from 930 men in the active arm were acquired at years 2 a...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2011.03.033
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVES:Access to complex urinary tract pathology may require supracostal access placing patients at risk for intrathoracic complications. Our objective was to retrospectively review our experience with percutaneous renal surgery with a particular emphasis on identifying the incidence of nephropleural fistula and ma...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/j.urology.2004.03.031
更新日期:2004-08-01 00:00:00
abstract::Ochronosis is the clinical manifestation of alkaptonuria, a rare inborn error of metabolism. It is characterized by widespread pigmentation of the fibroconnective tissues, arthritis, and passage of dark urine. Prostatic involvement is usually limited to the incidental finding of calculi within the gland. Herein, we re...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(83)90502-2
更新日期:1983-08-01 00:00:00
abstract:OBJECTIVE:To accurately measure the correction obtained by the release of the skin and dartos fascia and that obtained by mobilization of the urethral plate and resection of the underlying fibrous tissue (according to Koyanagi and Mollard), in the release of chordee. METHODS:From February 1996 to February 2011, 234 pa...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2012.06.050
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVES:To determine whether an increased body mass index (BMI) is a predictor of advanced pathologic findings in European men undergoing radical prostatectomy (RP). The relationship between obesity and prostate cancer is controversial. Studies, predominantly derived from the United States, have suggested that an in...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2008.09.038
更新日期:2009-03-01 00:00:00
abstract::A growing number of studies have described an apparent synergy between systemic chemotherapy administration and the intratumoral injection of dendritic cells (DCs) in the successful treatment of murine tumors. A review of several of these studies is undertaken here and possible combinations of DC therapy and conventio...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/j.urology.2007.06.1127
更新日期:2007-12-01 00:00:00
abstract::Computed tomography (CT) and ultrasound are emerging as useful diagnostic adjuvants in the confirmation of pelvic lipomatosis. A case of pelvic lipomatosis studied by CT and sonography is presented. These two techniques offer greater precision in the demonstration of fatty tissue density within the true pelvis. The fi...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(79)90543-0
更新日期:1979-12-01 00:00:00
abstract::Although currently available antimuscarinic agents are the standard of care for overactive bladder (OAB), they are limited by certain side effects, particularly dry mouth and constipation. Research aimed at discovering new therapies for OAB has resulted in the identification of some promising drugs. Investigations of ...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/j.urology.2003.10.005
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVE:To assess efficacy and safety of liposomal bupivacaine (LB) infiltration of the buccal mucosal graft (BMG) harvest site in alleviating pain by evaluating the postoperative narcotic usage, pain score, and morbidities. PATIENTS AND METHODS:Single-blinded randomized controlled trial of 43 adult patients for BMG...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2020.06.067
更新日期:2020-11-01 00:00:00
abstract::A case is presented of vesical endometriosis treated surgically in a thirty-one-year-old woman who presented with hypogastric pain and a pelvic mass. Echography showed an intravesical tumor, and cystoscopy led to a presumptive diagnosis of bladder endometriosis. The clinical features, diagnosis, and management are dis...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(84)90358-3
更新日期:1984-09-01 00:00:00
abstract:OBJECTIVES:In 1998, D'Amico et al. suggested a model stratifying patients with prostate cancer into those with low, intermediate, or high-risk of biochemical recurrence after surgery according to the clinical TNM stage, biopsy Gleason score, and preoperative prostate-specific antigen level. We studied the performance a...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2007.08.055
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVE:To present the results of Koyanagi-Snow-Hayashi urethroplasty in severe hypospadias repair. METHODS:From June 2015 to December 2019, 43 patients with severe hypospadias associated with curvature underwent Koyanagi- Snow-Hayashi urethroplasty. All patients were treated for the first time and by a single surge...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2020.11.058
更新日期:2021-01-08 00:00:00
abstract:OBJECTIVES:To test the effect of nephron-sparing surgery (NSS) vs radical nephrectomy (RN) on cancer-specific mortality (CSM) in patients with T1bN0M0 renal cell carcinoma (RCC) in a population-based cohort. To date, only few series from tertiary care centers supported the use of NSS for T1bN0M0 (range 4-7 cm) RCC. ME...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2009.04.098
更新日期:2010-02-01 00:00:00
abstract::There is a vast amount of evidence linking the presence of genitourinary infection with infertility. Infection in either partner can result in specific effects on sperm function, accessory sexual gland dysfunction, and the induction of immunologic responses in either partner. Careful investigation for infection should...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/0090-4295(78)90395-3
更新日期:1978-09-01 00:00:00
abstract:OBJECTIVE:To describe the diagnostic criteria and outcome of fetal megacystis according to the gestational age at diagnosis. METHODS:A 7-year retrospective study was carried out from 2004 to 2011, including cases of megacystis referred to 2 prenatal fetal medicine units. The following data were collected and analyzed:...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2014.02.018
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVES:To study the efficacy and safety of dutasteride, a dual inhibitor of the 5-alpha-reductase isoenzymes types I and II. METHODS:A total of 4325 men (2951 completed) with clinical benign prostatic hyperplasia, moderate to severe symptoms (American Urological Association-Symptom Index score of 12 points or grea...
journal_title:Urology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0090-4295(02)01905-2
更新日期:2002-09-01 00:00:00
abstract:OBJECTIVES:To examine the contributions of fear of recurrence and the more commonly examined treatment-related symptoms to the health-related quality of life (HRQOL) of men treated for localized prostate cancer. METHODS:A total of 730 men with localized disease were identified from the Cancer of the Prostate Strategic...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2007.12.084
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVES:A survey to determine prostate cancer-related knowledge, beliefs, and prior screening behavior was administered to men participating in prostate cancer screening events at nine major sites in the southeast. Since prostate cancer disproportionately affects blacks, a primary focus of the analysis was to determ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/S0090-4295(99)80218-0
更新日期:1995-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the feasibility of routine outpatient management after robotic-assisted radical prostatectomy (RARP). Prostate cancer is indeed the second most common cancer in men. Surgical technics have evolved from open surgery to robot-assisted surgery with a reduction of postoperative complications. Such tec...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2019.01.050
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:To report 3-year outcomes of a prospective, multicenter, randomized, blinded control trial after treatment with convective radiofrequency (RF) water vapor thermal therapy for moderate to severe lower urinary tract symptoms due to benign prostatic hyperplasia (BPH). MATERIALS AND METHODS:Fifteen centers enrol...
journal_title:Urology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.urology.2017.10.023
更新日期:2018-01-01 00:00:00
abstract::Positive surgical margins after radical prostatectomy are associated with an increased risk of cancer recurrence. Depending on the patient's clinical presentation and the amount of residual prostatic tissue, this could be described as a surgical complication or as treatment failure. Endorectal magnetic resonance (MR) ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2009.12.009
更新日期:2010-11-01 00:00:00
abstract::In this study, a model system was designed to investigate the metastatic potential of intramuscularly implanted bladder tumor cells in mice. Of the 4 FANFT-induced murine bladder tumors investigated, MBT-2 and -8 metastasized to the lung. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(83)90235-2
更新日期:1983-11-01 00:00:00
abstract::Eighty-three children with a chief complaint of nocturnal enuresis and no history of urinary tract infection (UTI) were prospectively evaluated with a contrast voiding cystourethrogram (VCUG). The following four historical details of presentation were noted: primary vs. secondary enuresis, daytime wetting, urgency, an...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(05)80074-3
更新日期:1991-08-01 00:00:00
abstract:OBJECTIVES:To evaluate the efficacy of transvaginal tape mobilization as a method of treating urinary retention after tension-free vaginal tape (TVT) procedures, and secondly to evaluate the time to resumption of voiding function after TVT procedures. METHODS:Postoperative voiding function and the 1-year continence st...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2005.03.055
更新日期:2005-09-01 00:00:00