Abstract：
OBJECTIVES:In 1998, D'Amico et al. suggested a model stratifying patients with prostate cancer into those with low, intermediate, or high-risk of biochemical recurrence after surgery according to the clinical TNM stage, biopsy Gleason score, and preoperative prostate-specific antigen level. We studied the performance and clinical relevance of this classification system over time, in the context of the stage migration seen in the contemporary era, using data from a high-volume, tertiary referral center. METHOD:From 1984 to 2005, 6652 men underwent radical prostatectomy at our institution for clinically localized prostate cancer (clinical Stage T1c-T2c) with follow-up information available and no neoadjuvant or adjuvant therapy before biochemical recurrence. Biochemical recurrence-free survival (BRFS) was estimated using the Kaplan-Meier method, and the BRFS rates between the D'Amico risk groups and by era were compared using the log-rank statistic. Finally, the distribution of patients among the three groups was compared over time. RESULTS:The 5-year BRFS rate was 84.6% overall and 94.5%, 76.6%, and 54.6% for the low, intermediate, and high-risk groups, respectively (P <0.0001). In the contemporary era, a very small fraction (4.9%) of patients undergoing radical prostatectomy at our institution were in the high-risk group, with most (67.7%) in the low-risk group (P <0.001). CONCLUSIONS:The D'Amico classification system continues to stratify men into risk groups with statistically significant differences in BRFS. However, the major shift in the distribution of patients among the three risk groups over time suggests that the clinical relevance of this classification scheme may be limited and diminishing in the contemporary era.
journal_name
Urologyjournal_title
Urologyauthors
Hernandez DJ,Nielsen ME,Han M,Partin AWdoi
10.1016/j.urology.2007.08.055subject
Has Abstractpub_date
2007-11-01 00:00:00pages
931-5issue
5eissn
0090-4295issn
1527-9995pii
S0090-4295(07)02097-3journal_volume
70pub_type
杂志文章相关文献
UROLOGY文献大全abstract：:Cystinuria is an inherited disorder of the dibasic amino acid transport system in the proximal tubule and the small intestine. Two responsible genes have been identified, the SLC3A1 on chromosome 2 and the SLC7A9 on chromosome 19. The inability of renal tubules to reabsorb cystine and the relative insolubility of cyst...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/j.urology.2013.10.013
更新日期：2014-04-01 00:00:00
abstract：OBJECTIVES:To study the role of urethral sonography and color Doppler imaging in the evaluation of patients with urethral strictures and associated abnormalities. METHODS:We reviewed our experience with 41 urethral sonographic studies in 35 patients and compared them to 33 retrograde urethrograms. For 6 recent cases, ...
journal_title：Urology
pub_type： 临床试验,杂志文章
doi：10.1016/s0090-4295(99)80391-4
更新日期：1996-01-01 00:00:00
abstract：:Diethylstilbestrol diphosphate (DES-P) has shown effective symptomatic relief in patients with metastatic carcinoma of the prostate. Although there is little known about its role in soft tissue metastasis, our experience in 3 patients with advanced carcinoma of the prostate infiltrating the trigone and ureterovesical ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(76)90084-4
更新日期：1976-06-01 00:00:00
abstract：OBJECTIVE:To compare the results of polymerase chain reaction (PCR) and immunologic methods for the detection of nanobacteria (NB) in the expressed prostatic secretions (EPSs) of patients with type-III prostatitis. METHODS:In total, 150 patients with type-III prostatitis for whom conventional clinical treatment had fa...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2014.05.038
更新日期：2014-09-01 00:00:00
abstract：OBJECTIVE:To examine the association between kidney size and renal cell carcinoma (RCC) death among patients with Stage pT1 clear cell RCC undergoing surgery. METHODS:We used a case-cohort design and evaluated 191 patients from our Nephrectomy Registry who had undergone open radical nephrectomy for unilateral, sporadi...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2012.04.013
更新日期：2012-07-01 00:00:00
abstract：:Some guidelines for the use of lasers in renal surgery are presented. The carbon dioxide laser was successfully used in 9 patients with diverse renal pathology (staghorn calculus, 4 patients; renal tumor, 3 patients; congenital arteriovenous (A-V) fistula, 1 patient; segmental chronic atrophic pyelonephritis, 1 patien...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(87)90141-5
更新日期：1987-02-01 00:00:00
abstract：OBJECTIVES:To determine whether the antiandrogen withdrawal syndrome occurs with the steroidal antiandrogen cyproterone acetate. METHODS:Cyproterone acetate was withheld in 12 patients with progressing androgen-independent metastatic prostate cancer. Eight patients had been receiving cyproterone acetate concomitant wi...
journal_title：Urology
pub_type： 临床试验,杂志文章
doi：10.1016/s0090-4295(98)00354-9
更新日期：1998-12-01 00:00:00
abstract：:Two infants who had obstructive uropathy accompanied by renal failure and sepsis are reported herein. Diagnostic and therapeutic techniques used to treat this type of surgical emergency are discussed in the order they were performed, as follows: (1) resuscitation for severe fluid and electrolyte disturbances; (2) gath...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(80)90594-4
更新日期：1980-11-01 00:00:00
abstract：OBJECTIVES:To determine whether nadir prostate-specific antigen (PSA) levels within 12 months (nadir PSA12) after completion of radiotherapy (RT) can be used as an early marker of recurrence risk. METHODS:A total of 4839 patients were treated with RT and without hormonal therapy from 1986 to 1995 for Stage T1-T2 prost...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2006.08.1056
更新日期：2006-12-01 00:00:00
abstract：OBJECTIVES:To analyze the relationships among socioeconomic status (SES), race, and the clinical parameters of patients undergoing radical prostatectomy (RP) in an equal access health care system. METHODS:The Department of Defense Center for Prostate Disease Research longitudinal prostate cancer database from multiple...
journal_title：Urology
pub_type： 杂志文章,多中心研究
doi：10.1016/s0090-4295(00)00808-6
更新日期：2000-12-20 00:00:00
abstract：OBJECTIVES:To assess the safety and efficacy of a suprapubic prostatectomy technique performed in a rural hospital in Asia. METHODS:A retrospective study of 200 consecutive suprapubic transvesical prostatectomies with a removable bladder neck partition suture for benign prostatic hyperplasia from 1995 to 1998 in a rur...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(99)00307-6
更新日期：1999-12-01 00:00:00
abstract：:In an attempt to solve the problem of chemosensitivity testing of renal cell carcinoma in vitro, a modified short-term culture technique was developed. The kinetic study of hypernephroma cells and normal renal cells showed that the uptake of H3-uridine and H3-thymidine is at its maximum after eighty hours. The effect ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(88)90150-1
更新日期：1988-03-01 00:00:00
abstract：:The effectiveness of metallic stents in the management of malignant ureteric obstruction is unclear. This systematic review evaluates the use of 4 commercially available metallic stents (Resonance, Memokath 051, Uventa, and Allium URS). Twenty-one studies met eligibility criteria. Overall success rates ranged from 88%...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/j.urology.2018.01.019
更新日期：2018-08-01 00:00:00
abstract：OBJECTIVES:To evaluate the incidence and type of incontinence after external beam radiotherapy (RT) and brachytherapy. Distinct late effects on the urinary bladder can occur and are frequently mild after adjuvant RT for Stage I endometrial carcinoma. Not all side effects that impair quality of life (eg, urinary inconti...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2003.09.040
更新日期：2004-02-01 00:00:00
abstract：OBJECTIVE:To present our experience of vaginal reconstruction in female cloacal exstrophy patients. PATIENTS AND METHODS:The records of 7 postpubertal female cloacal exstrophy patients (median age, 17 years; range, 11-26 years) were retrospectively reviewed. Complete duplication of the uterus and vagina was noted in a...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2014.05.042
更新日期：2014-09-01 00:00:00
abstract：OBJECTIVES:To examine the correlation of biopsy Gleason scores with radical prostatectomy specimens from a laboratory that uses protocols designed to minimize observer variability. This protocol mandates consensus case review of all nonbenign cases. METHODS:Between August 24, 1993 and June 26, 1997, 106 patients who u...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/s0090-4295(98)00002-8
更新日期：1998-04-01 00:00:00
abstract：OBJECTIVES:To investigate the effects of morphine on reperfusion injury due to testicular torsion-detorsion (T/D). METHODS:We divided 36 adult male Sprague-Dawley rats into six groups. Testicular ischemia was achieved by twisting the right testis 720 degrees counterclockwise for 1 hour, and reperfusion was allowed for...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2005.06.101
更新日期：2005-12-01 00:00:00
abstract：OBJECTIVE:To assess the perioperative complications and functional midterm outcomes after pyeloplasty for poorly functioning kidneys due to ureteropelvic junction obstruction. PATIENTS AND METHODS:We retrospectively analyzed patients who underwent pyeloplasty for primary ureteropelvic junction obstruction in very poor...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2016.02.045
更新日期：2016-06-01 00:00:00
abstract：OBJECTIVE:To systematically review prospective trials aimed at the role of restaging transurethral resection (reTUR) to define the group of patients with bladder cancer who would benefit. MATERIALS AND METHODS:A systematic review of the literature in accordance with the Preferred Reporting Items for Systematic Reviews...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/j.urology.2014.06.005
更新日期：2014-10-01 00:00:00
abstract：:Aztreonam, the first monobactam antibiotic, represents a significant evolutionary advance in antimicrobial therapy. Aztreonam is stable in the presence of the hydrolytic beta-lactamase enzymes; as such, it is effective against most Gram-negative aerobes, including Pseudomonas aeruginosa, Escherichia coli, Klebsiella, ...
journal_title：Urology
pub_type： 杂志文章,评审
doi：
更新日期：1988-06-01 00:00:00
abstract：OBJECTIVES:To compare surgical and functional results of both surgical approaches to endoscopic partial nephrectomy. It is currently performed either by the transperitoneal (t) or the retroperitoneal (r) approach. METHODS:This was a retrospective, matched-pair comparison of 105 patients who underwent either transperit...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2010.02.057
更新日期：2011-01-01 00:00:00
abstract：OBJECTIVES:To investigate clinical features of Chinese patients with severe primary erectile dysfunction (S-PED) and to identify the ideal treatment options for this population. METHODS:Patients with PED were screened for enrollment in our study. Sexual history, marital status, and erectile function were evaluated by ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2009.12.008
更新日期：2010-08-01 00:00:00
abstract：:Eighty-three children with a chief complaint of nocturnal enuresis and no history of urinary tract infection (UTI) were prospectively evaluated with a contrast voiding cystourethrogram (VCUG). The following four historical details of presentation were noted: primary vs. secondary enuresis, daytime wetting, urgency, an...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(05)80074-3
更新日期：1991-08-01 00:00:00
abstract：OBJECTIVES:An association between prostatitis and male infertility has been suspected, yet is poorly understood. Prostatitis is often associated with granulocytes in the prostatic fluid that generate reactive oxygen species (ROS), known to impair male fertility. We compared ROS, the total antioxidant capacity (TAC), an...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(99)00613-5
更新日期：2000-06-01 00:00:00
abstract：OBJECTIVE:To evaluate stone diameter and ureteral dilation using computerized tomography as a predictor of ureteral stone expulsion after medical expulsive therapy. MATERIALS AND METHODS:We retrospectively reviewed the records of 328 patients with symptomatic ureteral stones <10 mm on axial computerized tomography ima...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2012.06.032
更新日期：2012-10-01 00:00:00
abstract：INTRODUCTION:To describe the otherwise heretical technique of "blind" nonureteroscopic extraction of calculi from the intramural ureter using a 7-mm-diameter tapered coil called the "Stone Cone." TECHNICAL CONSIDERATIONS:After bypassing the stone and deploying the Stone Cone, slow traction was exerted. The Stone Cone'...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2007.02.007
更新日期：2007-04-01 00:00:00
abstract：:Late relapses of nonseminomatous germ cell tumors of the testicle are unusual. In such cases, chemotherapy is reported to have only modest success and surgery may be the preferred treatment modality. We report a patient who experienced relapse 11 years after the initial diagnosis of advanced testicular cancer and who ...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/S0090-4295(96)00495-5
更新日期：1997-03-01 00:00:00
abstract：:Serial carcinoembryonic antigen (CEA) assays were conducted in patients with endocrine-unresponsive prostatic adenocarcinoma who were being treated with multidrug chemotherapy. Changes in CEA correlated with the clinical status of the patient in 70 per cent of the determinations and were more accurate than acid phosph...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(76)90517-3
更新日期：1976-12-01 00:00:00
abstract：OBJECTIVE:To characterize the clinical and metabolic abnormalities of patients presenting with multiple stones and determine their risk of new stone formation. MATERIALS AND METHODS:This retrospective case-controlled study consisted of 911 patients who had ureter stones for the first time and 107 age- and sex-matched ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2014.02.029
更新日期：2014-08-01 00:00:00
abstract：OBJECTIVE:To describe the technique and report outcomes of laparoscopic radical cystectomy using 2 ports (2-port LRC) for muscle-invasive bladder cancer. PATIENTS AND METHODS:Prospective study was performed between November 2011 and October 2012 to standardize 2-port LRC, lymph node dissection, and urinary diversion. ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2014.07.024
更新日期：2014-11-01 00:00:00
