Late urologic effects after adjuvant irradiation in stage I endometrial carcinoma.

Abstract:

OBJECTIVES:To evaluate the incidence and type of incontinence after external beam radiotherapy (RT) and brachytherapy. Distinct late effects on the urinary bladder can occur and are frequently mild after adjuvant RT for Stage I endometrial carcinoma. Not all side effects that impair quality of life (eg, urinary incontinence) are classified in the commonly used grading system. METHODS:Forty-one patients were evaluated for newly occurred urinary incontinence after adjuvant RT. The mean follow-up was 64.8 months, and the mean age was 62.1 years. The validated incontinence score from Gaudenz was used. Additionally, quality-of-life questions were asked. RESULTS:Overall, 22 (53.7%) of 41 patients complained of urinary incontinence. Urge incontinence was classified in 45.5% (10 of 22 patients) and stress urinary incontinence in 54.5% (12 of 22 patients). CONCLUSIONS:The onset of stress urinary incontinence after brachytherapy can be explained by anatomic findings, such as adverse affects to the nerve supply of the rhabdosphincter. According to our results, the exposure to additional external beam RT can cause urge incontinence. Patients and doctors must be aware that urinary incontinence, with an occurrence rate of more than 50%, represents the most common side effect after surgery and RT for Stage I endometrial carcinoma. We conclude that, depending on the type of RT, a stress incontinence rate of 24.4% and an urge incontinence rate of 29.2% is possible.

journal_name

Urology

journal_title

Urology

authors

Herwig R,Bruns F,Strasser H,Pinggera GM,Micke O,Rehder P,Gozzi C,Willich N,Hertle L

doi

10.1016/j.urology.2003.09.040

subject

Has Abstract

pub_date

2004-02-01 00:00:00

pages

354-8

issue

2

eissn

0090-4295

issn

1527-9995

pii

S0090429503010288

journal_volume

63

pub_type

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