Prostate Cancer Genomic Classifier Relates More Strongly to Gleason Grade Group Than Prostate Imaging Reporting and Data System Score in Multiparametric Prostate Magnetic Resonance Imaging-ultrasound Fusion Targeted Biopsies.


OBJECTIVE:To assess the association between Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) score, the Decipher score, and histologic grade of carcinoma in biopsy tissue among low- to intermediate-risk prostate cancer patients. METHODS:MRI-ultrasound targeted biopsy of regions of interest and concurrent 12-core systematic biopsy was performed on men with Gleason grade group (GG) 1 and 2. We compared Decipher score with PI-RADS scores and biopsy Gleason GG. Subgroup analyses were performed to evaluate patients who underwent radical prostatectomy (RP), and men with Decipher testing from a targeted biopsy core. RESULTS:One hundred two patients with GG1 and GG2 had biopsy Decipher testing. There was no significant difference in the median Decipher scores among the 3 multiparametric magnetic resonance imaging categories. Patients with GG2 vs GG1 in the setting of PI-RADS 4-5 had higher genomic scores (P = .01), but no significant difference was noted in patients with PI-RADS ≤3. The rate of genomic higher-risk disease on a targeted biopsy from PI-RADS5 was higher in GG2 (75%) vs GG1 (11.1%; P = .01). On multivariable logistic regression analysis, the Decipher score ≥0.45, (odds ratio (OR) 2.71; P = .02), and age (OR 1.11; P = .004) remained significant factors associated with Gleason GG2 on biopsy. CONCLUSION:High-risk genomic classification can be seen across all combinations of PI-RADS categories and Gleason GG1 and GG2, confirming a potential utility for Decipher testing in men with low- to favorable intermediate-risk prostate cancer. The Decipher biopsy genomic test related to Gleason GG independent of PI-RADSv2 score. Confirmatory genomic testing for patients undergoing active surveillance appears more valuable than PI-RADSv2 score.






Martin DT,Ghabili K,Levi A,Humphrey PA,Sprenkle PC




Has Abstract


2019-03-01 00:00:00














  • A novel technique to prevent inadvertent sheath migration.

    abstract::Inadvertent trocar-sheath migration is annoying to the surgeon and may result in serious visceral injury. Herein is described a novel technique to prevent such migration. A 0.25-in. Penrose drain is wrapped around the trocar-sheath unit as a collar to prevent sheath migration. ...


    pub_type: 杂志文章


    authors: Nguyen TT,Wang DS,Winfield HN

    更新日期:2003-08-01 00:00:00

  • Use of a Novel Flexible Mini-nephroscope in Minimally Invasive Percutaneous Nephrolithotomy.

    abstract:OBJECTIVE:To assess the feasibility and safety of a novel flexible mini-nephroscope in minimally invasive percutaneous nephrolithotomy (PCNL). Presumably, limiting the size and number of tracts during PCNL has the potential of decreasing the morbidity of the procedure. We present our experience with this new technique....


    pub_type: 杂志文章


    authors: Mishra DK,Agrawal MS

    更新日期:2017-05-01 00:00:00

  • Treatment of unstable bladder.

    abstract::We present our experience with 2 spinal-injury patients tested for urinary incontinence via implanted sacral nerve electrodes. In each patient, spinal injury occurred at the T-12 level, with presentation of spontaneous detrusor activity. Associated weakness of the voluntary sphincter mechanism was evident urodynamical...


    pub_type: 杂志文章


    authors: Schmidt RA

    更新日期:1991-01-01 00:00:00

  • Unilateral adrenal hemorrhage in forty-five-year-old woman.

    abstract::We herein describe a case of adrenal hemorrhage on the right side in a forty-five-year-old woman. Her medical history did not show any evidence of an acute bleeding. The hematoma was removed and adrenalectomy performed. A veinectasis and a localized vasculitis are discussed as causes of bleeding. ...


    pub_type: 杂志文章


    authors: Friedrichs R,Dohrenbusch J,Heinrichs B,Rübben H

    更新日期:1988-08-01 00:00:00

  • Advantages and risks of ileovesicostomy for the management of neuropathic bladder.

    abstract:OBJECTIVES:To evaluate the efficacy and complications of ileovesicostomy in patients with neurogenic bladder dysfunction. METHODS:Fifteen consecutive neurologically impaired patients (8 from multiple sclerosis, 4 from spinal cord injury, 3 from other causes) with complications of previous bladder management underwent ...


    pub_type: 临床试验,杂志文章


    authors: Atan A,Konety BR,Nangia A,Chancellor MB

    更新日期:1999-10-01 00:00:00

  • A review of contemporary data on surgically resected renal masses--benign or malignant?

    abstract:OBJECTIVE:To clearly define the proportions of benign vs malignant histologic findings in resected renal masses through an in-depth review of the contemporary medical data to assist in preoperative risk assessment. MATERIALS AND METHODS:PubMed and select oncology congresses were searched for publications that identify...


    pub_type: 杂志文章,评审


    authors: Corcoran AT,Russo P,Lowrance WT,Asnis-Alibozek A,Libertino JA,Pryma DA,Divgi CR,Uzzo RG

    更新日期:2013-04-01 00:00:00

  • False penile fracture: value of different diagnostic approaches and long-term outcome of conservative and surgical management.

    abstract:OBJECTIVES:We determined the value of clinical and radiological findings in diagnosis of false penile fracture. Also, the long-term outcome of conservative and surgical treatment of such patients was evaluated. METHODS:Seventeen patients with false penile fracture were treated conservatively (3 patients) and surgicall...


    pub_type: 杂志文章


    authors: El-Assmy A,El-Tholoth HS,Abou-El-Ghar ME,Mohsen T,Ibrahiem el HI

    更新日期:2010-06-01 00:00:00

  • Carcinoma of prostate presenting as intracranial tumor with multiple cranial nerve palsies.

    abstract::Carcinoma of the prostate is one of the commonest of cancers occurring in men over the age of fifty years. A small focus of cancer in the prostate can be active biologically and give rise to metastases without producing any symptoms of bladder neck obstruction. In such cases, the attention may be directed away from th...


    pub_type: 杂志文章


    authors: Rao KG

    更新日期:1982-04-01 00:00:00

  • Development and Validity of a Silicone Renal Tumor Model for Robotic Partial Nephrectomy Training.

    abstract:OBJECTIVE:To provide a training tool to address the technical challenges of robot-assisted laparoscopic partial nephrectomy, we created silicone renal tumor models using 3-dimensional printed molds of a patient's kidney with a mass. In this study, we assessed the face, content, and construct validity of these models. ...


    pub_type: 杂志文章


    authors: Monda SM,Weese JR,Anderson BG,Vetter JM,Venkatesh R,Du K,Andriole GL,Figenshau RS

    更新日期:2018-04-01 00:00:00

  • Prevalence, Risk Factors, and Treatment for Overactive Bladder in a Racially Diverse Population.

    abstract:OBJECTIVE:To evaluate differences in prevalence, overactive bladder (OAB) risk factors, and OAB treatment in a diverse population of underrepresented racial/ethnic groups. METHODS:This is a retrospective cohort study of women ≥ 18 years who had an OAB diagnosis code from June 1, 2013 to June 30, 2016. Women who had ne...


    pub_type: 杂志文章


    authors: Mckellar K,Bellin E,Schoenbaum E,Abraham N

    更新日期:2019-04-01 00:00:00

  • Robot-assisted Partial Nephrectomy: Is Routine Urinary Catheterization Still Mandatory in the Era of Enhanced Recovery?

    abstract:OBJECTIVE:To assess the benefits and safety of noncatheterization during robot-assisted partial nephrectomy within an enhanced recovery protocol. MATERIALS AND METHODS:A single-center retrospective comparative study was carried out of consecutive patients who underwent a robot-assisted partial nephrectomy between Febr...


    pub_type: 杂志文章


    authors: Tremblais B,Dominique I,Terrier JE,Ecochard R,Hacquard H,Ruffion A,Paparel P

    更新日期:2019-02-01 00:00:00

  • Analysis of G/A polymorphism in the androgen response element I of the PSA gene and its interactions with the androgen receptor polymorphisms.

    abstract:OBJECTIVES:To compare the in vitro functional activity of the prostate-specific antigen (PSA) androgen response element (ARE) I alleles alone or in combination with androgen receptor (AR) polymorphisms and to determine the association of ARE I alleles with serum PSA in men without clinical prostatic disease. Data are c...


    pub_type: 杂志文章


    authors: Rao A,Chang BL,Hawkins G,Hu JJ,Rosser CJ,Hall MC,Meyers DA,Xu J,Cramer SD

    更新日期:2003-04-01 00:00:00

  • Prostate cancer presenting with malignant ascites: signet-ring cell variant of prostatic adenocarcinoma.

    abstract::A case of prostate cancer presenting with malignant ascites as the sole clinical manifestation is reported. The clinical course simulated occult gastrointestinal malignancy. At the histologic level, the tumor had a signet-ring morphology. Detailed immunocytochemical and ultrastructural studies, however, confirmed the ...


    pub_type: 杂志文章


    authors: Catton PA,Hartwick RW,Srigley JR

    更新日期:1992-05-01 00:00:00

  • Resident-Driven Holistic Lean Daily Management System to Enhance Care Experience at a Safety Net Hospital.

    abstract:OBJECTIVE:To describe the use of Lean in urology at Zuckerberg San Francisco General, a community safety-net and trauma hospital that serves as a major teaching site for the University of California San Francisco. METHODS:We examined our process improvement activities from 2016 to 2018. Our Lean Daily Management Syste...


    pub_type: 杂志文章


    authors: Tresh A,Cohen AJ,Mmonu NA,Berdy S,Barnas K,Krombach J,Breyer BN

    更新日期:2020-06-01 00:00:00

  • An Escherichia coli-based oral vaccine against urinary tract infections potently activates human dendritic cells.

    abstract:OBJECTIVES:To investigate the effects of Uro-Vaxom, an oral vaccine against Escherichia coli urinary tract infections, on human monocyte-derived dendritic cells (moDCs). Dendritic cells (DCs) are important antigen-presenting cells of the immune system. DCs are considered promising cellular adjuvants for inducing immuni...


    pub_type: 杂志文章


    authors: Schmidhammer S,Ramoner R,Höltl L,Bartsch G,Thurnher M,Zelle-Rieser C

    更新日期:2002-09-01 00:00:00

  • Elevation of testicular temperature predicts testicular catch-up growth and hypotrophy after varicocelectomy and observation in adolescent varicocele.

    abstract:OBJECTIVE:To predict testicular catch-up growth after varicocelectomy, we investigated the usefulness of testicular temperature (TT) measurements for adolescent varicocele. MATERIALS AND METHODS:The present study included 110 patients with left varicocele patients (age 9-17 years, mean ± standard deviation 12.5 ± 2.4)...


    pub_type: 杂志文章


    authors: Shiraishi K,Matsuyama H

    更新日期:2013-07-01 00:00:00

  • Factors That Influence Selectionof Urinary Diversion Among Bladder Cancer Patients in 3 Community-based Integrated Health Care Systems.

    abstract:OBJECTIVE:To assess the relative contributions of patient and surgeon factors for predicting selection of ileal conduit (IC), neobladder (NB), or continent pouch (CP) urinary diversions (UD) for patients diagnosed with muscle-invasive/high-risk nonmuscle invasive bladder cancer. This information is needed to enhance re...


    pub_type: 杂志文章,多中心研究


    authors: Kwan ML,Leo MC,Danforth KN,Weinmann S,Lee VS,Munneke JR,Bulkley JE,Rosetti MO,Yi DK,Banegas MP,Wagner MD,Williams SG,Aaronson DS,Grant M,Krouse RS,Gilbert SM,McMullen CK

    更新日期:2019-03-01 00:00:00

  • A single-center experience of symptomatic male urethral diverticula.

    abstract:OBJECTIVES:To describe our experience of the etiology, presentation, management and outcomes of male urethral diverticula, which are uncommon, with few reports of large series published. METHODS:Twenty-one patients with male urethral diverticula were treated at a single institution during a 7-year period. Their case n...


    pub_type: 杂志文章


    authors: Allen D,Mishra V,Pepper W,Shah S,Motiwala H

    更新日期:2007-10-01 00:00:00

  • Ambulatory surgery centers and outpatient urologic surgery among Medicare beneficiaries.

    abstract:OBJECTIVE:To determine the effect of an ambulatory surgery center (ASC) opening in a healthcare market on utilization and quality of outpatient urologic surgery. METHODS:This is a retrospective cohort study of Medicare beneficiaries undergoing outpatient urologic surgery from 2001 to 2010. Markets were classified into...


    pub_type: 杂志文章


    authors: Suskind AM,Dunn RL,Zhang Y,Hollingsworth JM,Hollenbeck BK

    更新日期:2014-07-01 00:00:00

  • Management of neonates with large abdominal wall defects and undescended testis.

    abstract:OBJECTIVES:To assess, in a retrospective study, the outcome of different treatment modalities in newborns with undescended testes secondary to large abdominal wall or diaphragmatic defects. Large abdominal and diaphragmatic defects are known to be associated with cryptorchidism, yet the reported incidence varies widely...


    pub_type: 杂志文章


    authors: Berger AP,Hager J

    更新日期:2006-07-01 00:00:00

  • Calcifying Fibrous Tumor of the Tunica Vaginalis Testis: A Report of 2 Cases.

    abstract:OBJECTIVE:To improve the clinical diagnosis and treatment of calcifying fibrous tumor (CFT) of the tunica vaginalis testis, we discussed clinical manifestations and pathologic features of CFT. MATERIALS AND METHODS:A retrospective analysis of 2 cases of CFT that occurred in our hospital was performed, and we also revi...


    pub_type: 杂志文章


    authors: Kang W,Cui Z,Li X,Sun P,Jin X

    更新日期:2017-02-01 00:00:00

  • Growth factors in urologic tissues: detection, characterization, and clinical applications.

    abstract::During the last two decades, enormous strides have been made in understanding cellular and molecular biology. The direction of treatment of many neoplasms and other diseases are starting at the microscopic level. Growth factors are polypeptides that play a part in the development and maintenance of living tissues. We,...


    pub_type: 杂志文章,评审


    authors: Mydlo JH,Macchia RJ

    更新日期:1992-12-01 00:00:00

  • 7-Nitroindazole: a selective inhibitor of penile erection: an in vivo study in a rat animal model.

    abstract:OBJECTIVES:The neuronal isoform of nitric oxide synthase (nNOS) has been localized in neurons innervating the penis and is believed to be an important mediator of erection. Using the selective inhibitor 7-nitroindazole (7-NI), we evaluated the possible role of nNOS in penile erection using a rat animal model. METHODS:...


    pub_type: 杂志文章


    authors: Spiess PE,Dion SB,Zvara P,Merlin SL,Chan PT,Brock GB

    更新日期:1996-01-01 00:00:00

  • Phase I-II RTOG study (99-06) of patients with muscle-invasive bladder cancer undergoing transurethral surgery, paclitaxel, cisplatin, and twice-daily radiotherapy followed by selective bladder preservation or radical cystectomy and adjuvant chemotherapy.

    abstract:OBJECTIVES:To evaluate the safety, tolerance, protocol completion rate, tumor response rate, and patient survival of chemoradiotherapy for patients with muscle-invasive operable bladder cancer. METHODS:After transurethral resection of the tumor in patients with Stage T2-T4a bladder cancer, twice-daily radiotherapy wit...


    pub_type: 杂志文章


    authors: Kaufman DS,Winter KA,Shipley WU,Heney NM,Wallace HJ 3rd,Toonkel LM,Zietman AL,Tanguay S,Sandler HM

    更新日期:2009-04-01 00:00:00

  • Association Between Exstrophy-epispadias Complex And Congenital Anomalies: A German Multicenter Study.

    abstract:OBJECTIVE:To further investigate associated anomalies in exstrophy-epispadias complex (EEC) patients congenital uro-rectal malformations network (CURE-Net) database was systematically screened. In literature the EEC comprises a spectrum of anomalies, mainly occurring "isolated" without additional congenital defects. Ne...


    pub_type: 杂志文章,多中心研究


    authors: Ebert AK,Zwink N,Jenetzky E,Stein R,Boemers TM,Lacher M,Fortmann C,Obermayr F,Fisch M,Mortazawi K,Schmiedeke E,Eisenschmidt V,Schäfer M,Hirsch K,Rösch WH,Reutter H

    更新日期:2019-01-01 00:00:00

  • Tumor-targeted chemotherapy with lipid contrast medium and macromolecular anticancer drug (SMANCS) for renal cell carcinoma.

    abstract::Twenty-five patients with renal cell carcinoma were treated with a lipophilic macromolecular drug, poly(stylene-co-maleic acid)-conjugated neocarzinostatin (SMANCS) dissolved in lipid contrast medium (Lipiodol). The drug was injected by catheterizing the renal artery and another feeding artery in 24 patients, and in t...


    pub_type: 杂志文章


    authors: Kobayashi M,Imai K,Sugihara S,Maeda H,Konno T,Yamanaka H

    更新日期:1991-03-01 00:00:00

  • Urachal carcinoma during pregnancy.

    abstract::We report a case of Stage T4aN2M0 urachal carcinoma that was diagnosed early in pregnancy. Because positive pelvic lymph nodes and uterine involvement were present, surgical resection, including hysterectomy with termination of the pregnancy, and postoperative radiotherapy were performed. The treatment options, which ...


    pub_type: 杂志文章


    authors: Van Calsteren K,Van Mensel K,Joniau S,Oyen R,Hanssens M,Amant F,Van Poppel H

    更新日期:2006-06-01 00:00:00

  • Medical management of benign prostatic hyperplasia.

    abstract::Medical management of clinical BPH is a reality. The only effective nonsurgical treatment now recommended is aimed at relieving the dynamic component of clinical BPH. Pharmacologic treatment using alpha-adrenoceptor antagonists may be used appropriately to manage patients with prostatism who are poor surgical risks bu...


    pub_type: 杂志文章,评审


    authors: Kane MM,Fields DW,Vaughan ED Jr

    更新日期:1990-11-01 00:00:00

  • Bloodless partial nephrectomy with a new high-intensity collimated ultrasonic coagulating applicator in the porcine model.

    abstract:OBJECTIVES:To evaluate the long-term hemostatic efficacy of a new high-intensity collimated ultrasonic (HICU) applicator for open subhilar partial nephrectomy (PN) in the porcine model. METHODS:An applicator was designed with a planar 3.78-MHz HICU transducer and a reflector to optimize the delivery of acoustic energy...


    pub_type: 杂志文章


    authors: Murat FJ,Lafon C,Cathignol D,Theillère Y,Gelet A,Chapelon JY,Martin X

    更新日期:2006-07-01 00:00:00

  • Intraoperative Onabotulinumtoxin-A Reduces Postoperative Narcotic and Anticholinergic Requirements After Continent Bladder Reconstruction.

    abstract:OBJECTIVE:To determine if intradetrusor injection of onabotulinumtoxin-A (BTX-A) would reduce postoperative narcotic and anticholinergic requirements in children undergoing open continent bladder reconstruction. MATERIALS AND METHODS:After institutional review board approval, we retrospectively reviewed all bladder re...


    pub_type: 杂志文章


    authors: Fuchs ME,Beecroft N,McLeod DJ,Dajusta DG,Ching CB

    更新日期:2018-08-01 00:00:00