Abstract：
:Although currently available antimuscarinic agents are the standard of care for overactive bladder (OAB), they are limited by certain side effects, particularly dry mouth and constipation. Research aimed at discovering new therapies for OAB has resulted in the identification of some promising drugs. Investigations of pharmacologic targets in the central nervous system (CNS) have yielded encouraging results with several agents, including tramadol and gabapentin. Further investigation may show that drugs acting at serotonergic and noradrenergic CNS sites are clinically useful as therapies for OAB. Some peripherally acting drugs, such as resiniferatoxin and botulinum toxin, have already been proved to be of clinical value. However, development of other agents that block afferent or efferent nerve impulses in the bladder through activity at vanilloid, purinergic, or opioid-like receptor sites may result in clinically useful drugs.
journal_name
Urologyjournal_title
Urologyauthors
Andersson KEdoi
10.1016/j.urology.2003.10.005subject
Has Abstractpub_date
2004-03-01 00:00:00pages
32-41issue
3 Suppl 1eissn
0090-4295issn
1527-9995pii
S0090429503010963journal_volume
63pub_type
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