Abstract：
OBJECTIVE:To explore the roles of stem cell factor (SCF) on the loss of interstitial cells (ICCs) in the bladder of diabetic rats, which have not been investigated. METHODS:The rats were assigned to 3 groups: normal control rats, diabetic rats, and SCF-treated diabetic rats. The diabetic rat model was created using a streptozotocin (60 mg/kg) intraperitoneal injection. The SCF and c-kit levels in bladder tissue were determined using reverse transcriptase-polymerase chain reaction and Western blot analysis. The quantity of ICCs as represented by c-kit-positive cells was examined by image analysis of immunofluorescence staining. RESULTS:Compared with the control rats, the diabetic rats exhibited a significant decrease in the SCF levels and c-kit expression and number of ICCs in the bladder tissues. All these impaired parameters were effectively restored to the control level after exogenous SCF treatment. CONCLUSION:These findings suggest that the loss of ICCs in the bladder tissue of diabetic rats can be attributed to a deficiency in endogenous SCF. The beneficial effect of exogenous SCF on diabetic depletion of ICCs could provide a theoretical rationale for the use of SCF as a potential therapeutic drug in treating patients with diabetes-related voiding dysfunction.
journal_name
Urologyjournal_title
Urologyauthors
Chen W,Jiang C,Jin X,Shen W,Song B,Li Ldoi
10.1016/j.urology.2011.08.019subject
Has Abstractpub_date
2011-12-01 00:00:00pages
1443.e1-6issue
6eissn
0090-4295issn
1527-9995pii
S0090-4295(11)02261-8journal_volume
78pub_type
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