Abstract：
OBJECTIVES:To examine the effects of vitamin C (VC) on androgen receptor (AR)-mediated functions in a human prostate cancer cell line, Los Angeles prostate cancer (LAPC-4). VC is an essential dietary substance in the maintenance and preservation of vital functions in humans. However, the role of VC in prostate cancer remains to be elucidated. METHODS:Cell proliferation and the expression of two well-known androgen regulated proteins, prostate-specific antigen and human glandular kallikrein-2, were studied in the presence of VC. RESULTS:In the presence of androgen and VC, both cell growth and the expression of prostate-specific antigen and human glandular kallikrein-2 proteins were decreased. Moreover, AR-mediated transcription activity of the prostate-specific antigen gene was suppressed with VC, similar to the phenomenon observed when cells were treated with hydrogen peroxide. These effects were reversed with catalase. However, additional studies did not reveal changes in the expression level of AR protein or its androgen-binding activity with the addition of VC. CONCLUSIONS:The results of our study suggest that the pro-oxidant property of VC might be one of the mechanisms by which it modulates AR-mediated function in LAPC-4 cells.
journal_name
Urologyjournal_title
Urologyauthors
Wang MH,Abreu-Delgado Y,Young CYdoi
10.1016/s0090-4295(03)00136-5subject
Has Abstractpub_date
2003-07-01 00:00:00pages
167-71issue
1eissn
0090-4295issn
1527-9995pii
S0090429503001365journal_volume
62pub_type
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