Abstract:
OBJECTIVE:To analyze the impact of gender on the clinicopathologic features and survival of patients with surgically treated papillary renal cell carcinoma (papRCC) using a comprehensive international multicenter database. MATERIALS AND METHODS:Data of 2325 patients undergoing surgery for unilateral papRCC between 1984 and 2015 in 17 European and North American centers were retrospectively collated. The impact of clinicopathologic features on the likelihood of nephron-sparing surgery (NSS) was evaluated using a multivariable logistic regression model. The influence on cancer-specific mortality (CSM) and other-cause mortality was analyzed by multivariable competing-risk regression models. Finally, subgroup analyses were conducted for organ-confined (n = 2075) and non-organ-confined tumors (n = 250). The median follow-up was 47 months. RESULTS:The study cohort included 1782 (77%) male patients (male-to-female ratio 3.3:1.0). Considering age, symptoms at presentation, performance status, pathologic tumor size, stage, and grade, we observed that there were no significant gender-specific differences. In contrast, female patients underwent NSS significantly less frequently (P <.001). On multivariable analysis, the likelihood of NSS was 72% higher in male patients after adjusting for all relevant cofactors (P <.001). No significant gender-specific differences in terms of CSM and other-cause mortality were demonstrated, but CSM was 59% lower in female patients in the subgroup of organ-confined tumors (P = .001). CONCLUSION:No impact of gender on survival was found analyzing this large cohort of patients undergoing surgery for papRCC. However, CSM appears to be lower in female patients with organ-confined disease. In this context, it is interesting that the likelihood of NSS seems to be significantly higher in male patients.
journal_name
Urologyjournal_title
Urologyauthors
Wolff I,Scavuzzo A,Capitanio U,Klatte T,Shariat SF,Wagener N,Zastrow S,Borgmann H,Krabbe LM,Hutterer G,May M,Brookman-May SD,Collaborative Research On Renal Neoplasms Association (CORONA) and the European Association of Urology (doi
10.1016/j.urology.2017.06.042subject
Has Abstractpub_date
2017-11-01 00:00:00pages
107-114eissn
0090-4295issn
1527-9995pii
S0090-4295(17)30714-8journal_volume
109pub_type
杂志文章,多中心研究相关文献
UROLOGY文献大全abstract::We herein describe a case of adrenal hemorrhage on the right side in a forty-five-year-old woman. Her medical history did not show any evidence of an acute bleeding. The hematoma was removed and adrenalectomy performed. A veinectasis and a localized vasculitis are discussed as causes of bleeding. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(88)90320-2
更新日期:1988-08-01 00:00:00
abstract:OBJECTIVES:To update continence results and present fluorourodynamic data in 17 female patients undergoing orthotopic lower urinary tract reconstruction with the Kock ileal urethrostomy following cystectomy. METHODS:Continence results, voiding pattern, and overall patient satisfaction were evaluated by means of patien...
journal_title:Urology
pub_type: 临床试验,杂志文章
doi:10.1016/S0090-4295(96)00165-3
更新日期:1996-09-01 00:00:00
abstract:OBJECTIVES:To investigate the holding strength and slippage of Lapra-Ty clips on various suture types and sizes. METHODS:Using an automated materials testing system with the Lapra-Ty in a fixed position, Lapra-Ty holding strength and displacement were determined with 0, 2-0, 3-0, and 4-0 Vicryl, Monocryl, and polydiox...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2007.08.061
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:To determine the effect irrigation fluid temperature has on core body temperature changes in patients undergoing transurethral resection of the prostate (TURP). METHODS:Fifty-six male patients (mean age 71.2 +/- 8.2 years) scheduled for TURP were enrolled in the study. Patients were randomized to one of two...
journal_title:Urology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0090-4295(01)00993-1
更新日期:2001-06-01 00:00:00
abstract::Internal ureteral stents have become an integral part of urologic practice to relieve intrinsic as well as extrinsic upper urinary tract obstruction. Missed internal ureteral stents is a serious potential complication that is associated with increased patient morbidity and is especially a problem in developing countri...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2020.04.048
更新日期:2020-07-01 00:00:00
abstract::During the past decade, our understanding of the epidemiology and natural history of benign prostatic hyperplasia (BPH) has improved considerably. Population-based studies confirm that lower urinary tract symptoms (LUTS) are very common among aging men. These studies have confirmed that men with moderate-to-severe sym...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/s0090-4295(01)01346-2
更新日期:2001-12-01 00:00:00
abstract:OBJECTIVE:To compare the clinical outcomes of transumbilical multiport laparoscopic orchiopexy (TMLO) vs standard laparoscopic orchiopexy (SLO) for 1-stage management of impalpable testes in children. MATERIALS AND METHODS:A total of 30 patients underwent primary TMLO from January 2010 to December 2011. An additional ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2012.07.076
更新日期:2012-12-01 00:00:00
abstract::Large-burden bladder stones often require percutaneous cystolithotomy or an open procedure. These approaches may not be feasible in certain patients who are at increased risk of operative complications. We present a novel technique for transurethral cystolitholapaxy using Amplatz sheath in the male urethra. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2004.07.022
更新日期:2004-11-01 00:00:00
abstract::We report on 2 patients with neurologic symptoms secondary to intracranial metastases from carcinoma of the prostate. In one of these patients, the intracranial lesion was the only clinically detectable metastasis. We have found only three other such cases reported in the English-language literature. ...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/S0090-4295(96)00238-5
更新日期:1996-11-01 00:00:00
abstract:OBJECTIVES:To exploit the favorable dose intensity and safety profile of weekly paclitaxel, we conducted a Phase I trial of paclitaxel by 3-hour infusion in combination with estramustine phosphate (EM) in men with hormone-refractory prostate cancer (HRPC). The antimicrotubule drug combination of paclitaxel by 96-hour i...
journal_title:Urology
pub_type: 临床试验,杂志文章
doi:10.1016/s0090-4295(01)01011-1
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVES:To evaluate the efficacy of laparoscopic radical nephrectomy for patients with small renal cell carcinoma by comparing the clinical results of patients treated laparoscopically with those of patients treated with traditional open radical nephrectomy. METHODS:Of 100 patients with localized, small (less than ...
journal_title:Urology
pub_type: 临床试验,杂志文章
doi:10.1016/s0090-4295(98)00505-6
更新日期:1999-02-01 00:00:00
abstract::In the evaluation of 116 renal masses 91 (80%) were interpreted as cystic and 25 (20%) as solid. Additional evaluation by arteriography and finally surgery showed that 3 of the 25 initially believed to be solid proved to be cystic. These three renal masses with internal echoes on ultrasound were found at surgery to be...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(77)90367-3
更新日期:1977-03-01 00:00:00
abstract:OBJECTIVES:To examine estrogen receptor-beta (ERbeta) expression in prostate cancer (CaP) metastases, thereby providing a basis for conducting estrogen therapy studies in patients with metastatic CaP. Advanced androgen-independent CaP is a serious health problem with no effective treatment at present. Estrogens have be...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2004.05.036
更新日期:2004-10-01 00:00:00
abstract::Carcinoma of the prostate is one of the commonest of cancers occurring in men over the age of fifty years. A small focus of cancer in the prostate can be active biologically and give rise to metastases without producing any symptoms of bladder neck obstruction. In such cases, the attention may be directed away from th...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(82)90208-4
更新日期:1982-04-01 00:00:00
abstract:OBJECTIVES:To determine whether easily measurable prostate biopsy features could complement Gleason score, prostate-specific antigen (PSA), or clinical stage in predicting recurrence-free survival after prostatectomy. Information relating preoperative parameters to recurrence-free survival is needed to counsel patients...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(02)01654-0
更新日期:2002-05-01 00:00:00
abstract::We report an important and unusual cause of an enhancing retroperitoneal paracaval mass. Ten years after vena cava filter (VCF) placement, a 3.5-cm mass was found juxtaposed to the right kidney and vena cava. Open exploration demonstrated a venous variceal mass with perforation of the VCF through the wall of the vena ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2011.06.042
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:To compare the PERC-tic technique, described as placement of dual wires under fluoroscopic guidance adjacent to the stone within the obstructed calyx, to standard percutaneous nephrolithotomy (PCNL) with working wires secured down the ureter. MATERIALS AND METHODS:This is a retrospective cohort study of pati...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2019.12.040
更新日期:2020-06-01 00:00:00
abstract::Hemangiomas of the genitalia are extremely rare. A hemangioma is self-limited and usually resolves spontaneously, therefore conservative treatment is generally recommended. However, genital hemangiomas may require surgical treatment if they become symptomatic. Herein we report a case of hemangioma of the penis and scr...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(93)90649-u
更新日期:1993-08-01 00:00:00
abstract:OBJECTIVES:There is little objective information on what is designated as being the prostate capsule. We have quantified objectively with computerized image analysis the percentage of smooth muscle fibers (SMFs) surrounding the surgical specimens of radical prostatectomies. METHODS:Ten radical prostatectomy specimens ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(99)80190-3
更新日期:1995-08-01 00:00:00
abstract:OBJECTIVE:To describe our ultrasound technique for confirming intraoperative, antegrade-placed ureteral stent position during laparoscopic pyeloplasty. BACKGROUND:Disadvantages of retrograde stent placement include the need to reposition the patient into and out of the lithotomy position. Antegrade stent placement can...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2017.12.019
更新日期:2018-04-01 00:00:00
abstract::Hemorrhagic cystitis is a recognized acute complication of cyclophosphamide (Cytoxan) therapy in the treatment of malignant disease. More recently, lower dose, long-term cyclophosphamide therapy has been used in the treatment of autoimmune diseases including rheumatoid arthritis. In 3 patients hemorrhagic cystitis dev...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(79)90526-0
更新日期:1979-12-01 00:00:00
abstract:OBJECTIVES:This analysis was performed to define the level of serum prostate-specific antigen (PSA) measured with the Abbott IMx assay that indicates residual or progressive prostate cancer after radical retropubic prostatectomy (RRP). METHODS:Since March 1992, we have used the Abbott IMx assay to determine PSA levels...
journal_title:Urology
pub_type: 临床试验,杂志文章
doi:10.1016/S0090-4295(96)00050-7
更新日期:1996-06-01 00:00:00
abstract:OBJECTIVES:To evaluate, in two randomized, multicenter trials, levofloxacin compared with ciprofloxacin and lomefloxacin for efficacy and safety in treating acute pyelonephritis. METHODS:We enrolled a total of 186 patients with bacteriologically proved infection. Of these, 89 patients in both trials combined received ...
journal_title:Urology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s0090-4295(98)00160-5
更新日期:1998-07-01 00:00:00
abstract:OBJECTIVES:To evaluate the oncologic outcomes of hand-assisted retroperitoneoscopic nephroureterectomy (HARNU) for upper urinary tract urothelial carcinoma and compare them with the data from conventional open surgery. METHODS:We collected the data from 25 patients who underwent HARNU at our institution from January 1...
journal_title:Urology
pub_type: 临床试验,杂志文章
doi:10.1016/j.urology.2007.01.088
更新日期:2007-06-01 00:00:00
abstract::Leiomyosarcomas arising from the renal vein are rare tumors: only 13 cases are found in the literature. We report a case in a sixty-one-year-old woman who presented with back pain and hematuria. She underwent resection of the tumor and an ipsilateral nephrectomy. The tumor recurred locally, and the patient died thirty...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/s0090-4295(91)80358-e
更新日期:1991-09-01 00:00:00
abstract::We report a case of a man with a testicular mixed germ cell tumor in whom the first symptom was severe anemia secondary to upper gastrointestinal bleeding from a metastatic pure choriocarcinoma. He underwent ileal enterectomy, radical orchiectomy, and several cycles of chemotherapy (cisplatin, etoposide, and bleomycin...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2005.06.102
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVES:To determine the effect of discontinuation of alpha-blockade and continuation of finasteride in men with lower urinary tract symptoms and enlarged prostates receiving combination treatment and to determine whether the alpha-blocker dose influences the ability to discontinue it. METHODS:We treated 272 consec...
journal_title:Urology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0090-4295(01)01201-8
更新日期:2001-08-01 00:00:00
abstract:OBJECTIVES:To compare the accuracy of testicular volume measurements with the Prader orchidometer versus ultrasonography. METHODS:The volume of 938 testes in 469 men with infertility (mean age 35.8 years) was measured using a Prader orchidometer and by ultrasonography. The ultrasound testicular volumes were calculated...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2006.09.013
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To develop an evidence-based approach to the diagnostic workup of suspicious upper urinary tract lesions. METHODS:The PubMed database was searched using the following terms with a filter for English language: "upper tract urothelial carcinoma" and "upper tract transitional cell carcinoma," along with the fol...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/j.urology.2015.08.046
更新日期:2016-02-01 00:00:00
abstract::To determine whether serum beta 2 microglobulin could be useful as a tumor marker in patients with testicular cancers, sera stored in our serum bank from 23 patients were assayed by radioimmunoassay for beta 2 microglobulin levels. Sera were selected from 12 preorchiectomy patients, 8 patients who had undergone orchie...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(80)90614-7
更新日期:1980-11-01 00:00:00