Abstract：
OBJECTIVE:To evaluate the efficacy of imidafenacin for nocturia and nocturnal polyuria in patients with overactive bladder. MATERIALS AND METHODS:A stratified analysis was conducted on data from a phase III randomized, double-blind, controlled trial of imidafenacin performed at 158 centers in Japan. The subjects received imidafenacin (0.1 mg) twice daily (group I) or placebo twice daily (group P). The 24-hour urine volume, daytime and nighttime voiding frequency, and volume voided/micturition were evaluated from 3-day voiding diaries recorded every 4 weeks during the 12-week study period. Longitudinal data analysis was performed, with all values expressed as the least squares mean ± standard error. RESULTS:A total of 46 patients (mean age 66.54 ± 9.38 years, 9 men and 37 women) with nocturia and nocturnal polyuria (>33% of urine production at night) were enrolled. Group I (n = 35) and group P (n = 11) showed no baseline differences in the daily voided volume, concomitant diseases, age, or body weight. However, the average daily number of micturitions differed (11.22 ± 2.17 vs 14.45 ± 2.85). Therefore, longitudinal data analysis was performed for each micturition pattern. After 12 weeks of treatment, nighttime micturition was significantly less frequent in group I than in group P (P = .0292), and the nocturnal percentage of 24-hour production was significantly smaller (P = .0053). The interval to the first nighttime void was significantly longer in group I than in group P, but no difference was found in the first nighttime voided volume. CONCLUSION:The novel antimuscarinic agent, imidafenacin, decreases the number of urinations and reduces nocturnal urine production, thereby improving both nocturia and nocturnal polyuria.
journal_name
Urologyjournal_title
Urologyauthors
Yokoyama O,Homma Y,Yamaguchi Odoi
10.1016/j.urology.2013.05.017subject
Has Abstractpub_date
2013-09-01 00:00:00pages
515-20issue
3eissn
0090-4295issn
1527-9995pii
S0090-4295(13)00628-6journal_volume
82pub_type
杂志文章,随机对照试验相关文献
UROLOGY文献大全abstract：OBJECTIVES:Several studies have shown that 5-aminolevulinic acid (5-ALA)-induced fluorescence cystoscopy improves the detection of superficial bladder cancer. The results have suggested a reduced rate of recurrent tumors with the use of 5-ALA fluorescence before bladder tumor resection. We performed a prospective, rand...
journal_title：Urology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.urology.2006.12.023
更新日期：2007-04-01 00:00:00
abstract：OBJECTIVES:We evaluated 11 currently available biopsy devices using a standard and a novel renal biopsy technique in a porcine model. We then applied our laboratory findings to clinical practice to improve our biopsy results during laparoscopic renal cryoablation procedures. METHODS:A total of 11 biopsy devices were a...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2007.04.028
更新日期：2007-09-01 00:00:00
abstract：:Splenogonadal fusion is a rare condition wherein splenic tissue is found attached to or within the testis. There are two anatomic types: continuous and discontinuous. We report a case of splenogonadal fusion that presented in an adult man with bilateral cryptorchid testes. ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(94)80027-8
更新日期：1994-07-01 00:00:00
abstract：OBJECTIVE:To evaluate the agreement between radiologic staging of bladder cancer using multidetector row computed tomography (CT) and histopathologic staging and estimate the influence of interobserver variability of the CT findings as a potential limitation of this imaging modality. The available data on the value of ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2012.01.040
更新日期：2012-06-01 00:00:00
abstract：OBJECTIVE:To evaluate the effectiveness and tolerance of the AdVance Male Sling System for the treatment of male stress urinary incontinence in patients after prostatic surgery. METHODS:An international, observational, prospective, multicenter study was conducted on male patients with urinary incontinence after prosta...
journal_title：Urology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.urology.2018.06.035
更新日期：2018-10-01 00:00:00
abstract：OBJECTIVE:To evaluate in more detail the effectiveness of a new designed more efficient ultrasonic propulsion for large stones and specific stone compositions in a tissue phantom model. In the first clinical trial of noninvasive ultrasonic propulsion, urinary stones of unknown compositions and sizes up to 10 mm were su...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2017.09.013
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:To give a retrospective analysis of factors affecting outcome of tubularized incised plate (TIP) repair for penoscrotal hypospadias. METHODS:Data of all patients who underwent TIP repair for penoscrotal hypospadias by a single surgeon were retrieved. Follow-up was carried out every 3 months within the first ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2011.10.033
更新日期：2012-02-01 00:00:00
abstract：OBJECTIVES:To investigate clinical features of Chinese patients with severe primary erectile dysfunction (S-PED) and to identify the ideal treatment options for this population. METHODS:Patients with PED were screened for enrollment in our study. Sexual history, marital status, and erectile function were evaluated by ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2009.12.008
更新日期：2010-08-01 00:00:00
abstract：OBJECTIVES:The extent of the required preoperative workup of patients who are candidates for radical prostatectomy is still controversial. Traditionally, cystoscopy has been reserved only for those patients who present with hematuria. However, several investigators have reported significant incidental cystoscopic findi...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(01)00936-0
更新日期：2001-05-01 00:00:00
abstract：:A family in which transitional cell carcinoma (TCC) of the renal pelvis and upper ureter developed in three siblings is presented. A description of these patients and their relatives together with a survey of the literature is presented. ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(86)90400-0
更新日期：1986-05-01 00:00:00
abstract：OBJECTIVE:To determine whether the ratio of dietary calcium and oxalate consumption at mealtime affects gastrointestinal oxalate absorption and urinary oxalate excretion. METHODS:A study was conducted with 10 non-stone-forming adults placed on controlled diets with daily calcium and oxalate contents of 1000 and 750 mg...
journal_title：Urology
pub_type： 临床试验,杂志文章
doi：10.1016/j.urology.2012.01.053
更新日期：2012-06-01 00:00:00
abstract：OBJECTIVES:To compare aspiration and sclerotherapy using sodium tetradecylsulfate (STDS) with open hydrocelectomy in the treatment of hydroceles with regard to safety, efficacy, and cost-effectiveness. METHODS:Patients with symptomatic hydroceles were prospectively enrolled in an aspiration and sclerotherapy protocol ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(02)02430-5
更新日期：2003-04-01 00:00:00
abstract：:We investigated the effectiveness of intravesically administered drugs on the tumor incidence and tumor size in a FANFT-induced animal model for bladder cancer. In the first experiment 106 C3H/He mice were divided into a control and three treatment groups. Therapy consisted of either cis-diamminedichloroplatinum (II) ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(82)90574-x
更新日期：1982-02-01 00:00:00
abstract：OBJECTIVE:To determine the outcomes of pregnancy and cesarean delivery (CD) in women with neuropathic bladder (NB) and pediatric lower urinary tract reconstruction (LUTR) as these women often have normal fertility and may become pregnant. METHODS:We reviewed consecutive patients with NB due to spinal dysraphism who un...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2017.11.052
更新日期：2018-04-01 00:00:00
abstract：:In 83 patients with non-neurologic, nonoperated vesicoureteral reflux the relation between enuresis and nephropathy was analyzed. The material showed that in spite of identical age, sex distribution, previous history of recurrent urinary tract infections, and the number of refluxing units, patients with enuresis showe...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(85)90156-6
更新日期：1985-11-01 00:00:00
abstract：OBJECTIVES:To evaluate the analgesic effect and utility of prilocaine infiltration alone for minimal morbidity during extracorporeal shock wave lithotripsy. METHODS:A total of 114 patients with kidney stones, aged 18 to 69 years, were randomly separated into two groups. The 58 patients in group 1 received intramuscula...
journal_title：Urology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.urology.2006.01.047
更新日期：2006-07-01 00:00:00
abstract：OBJECTIVES:To analyze the feasibility of neurovascular bundle (NVB) preservation and peripheral nerve grafting during salvage radical prostatectomy (RP) for radiorecurrent prostate cancer and analyze their effect on the recovery of potency. METHODS:Of 100 patients who underwent salvage RP with curative intent from 198...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2005.04.002
更新日期：2005-09-01 00:00:00
abstract：:We report a rare case of primary epithelial bladder tumor in a thirteen-year-old boy. Histologically, the tumor was that of a solitary and papillary transitional cell carcinoma, grade 1. This tumor was detectable at cystoscopic examination, and cytologic procedures were without benefit for a diagnosis. ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(92)90274-z
更新日期：1992-02-01 00:00:00
abstract：OBJECTIVE:To characterize the changes in urine composition associated with increasing severity of diabetes, we analyzed urine composition relative to glycated hemoglobin (HbA1c) and treatment strategy in a largely minority population. METHODS:Patients treated for kidney stones between 2001 and 2013 at a single tertiar...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2015.10.013
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVES:Using an athermal technique for nerve preservation we noted that approximately 40% are potent compared with approximately 60% who are not at 3 months after robot-assisted laparoscopic prostatectomy (RLP). In an attempt to understand this difference, we examine factors potentially influencing potency at 3 mon...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2008.05.055
更新日期：2008-12-01 00:00:00
abstract：:We report a case of traumatic testicular injury resulting in significant loss of both tunica albuginea and seminiferous tubules. Secondary to the substantial tissue loss, our approach to surgical reconstruction required a certain degree of creativity. The injury was managed by creating a single midline testis with two...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2006.05.003
更新日期：2006-10-01 00:00:00
abstract：OBJECTIVE:To evaluate our 5-year experience with deep lateral transurethral incisions of bladder neck contracture (TUIBNC), identify risk factors associated with failure of procedure, and assess outcomes of men subsequently treated for concomitant or de novo stress urinary incontinence (SUI). MATERIALS AND METHODS:We ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2013.08.018
更新日期：2013-12-01 00:00:00
abstract：OBJECTIVE:To identify the prevalence and characteristics of fluoroquinolone-resistant (FQ-R) Escherichia coli ST131 isolates in men undergoing ultrasound-guided transrectal prostate biopsy (TPB). MATERIALS AND METHODS:Twenty-seven FQ-R E coli isolates from rectal swabs from 136 men undergoing TPB at 3 institutions in ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2012.10.056
更新日期：2013-03-01 00:00:00
abstract：OBJECTIVE:To investigate the impact of the expression profile of E-cadherin and N-cadherin in urothelial carcinoma of the upper urinary tract (UC-UUT) on the probability of intra- and extravesical disease recurrence in patients undergoing nephroureterectomy. METHODS:This study included 59 consecutive patients diagnose...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2011.07.1388
更新日期：2011-12-01 00:00:00
abstract：OBJECTIVE:To determine the efficacy of computed tomography of the chest (CTC) and plain radiograph (CXR) in the initial staging process of testicular germ cell tumors. METHODS:The medical records of 362 patients with testicular germ cell tumor treated at our center between January 1980 and August 1993 were reviewed wi...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(94)80139-8
更新日期：1994-08-01 00:00:00
abstract：:We report 2 cases of concordant prune belly syndrome occurring in monozygotic twins. In addition to suggesting a genetic basis for this disease, our 12-year follow-up of these cases illustrates that these patients with an otherwise poor prognosis can have normal growth, development, and renal function with appropriate...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(00)00452-0
更新日期：2000-06-01 00:00:00
abstract：OBJECTIVE:To assess national and regional practice patterns and rates of pathologic specimen identification sent at time of pyeloplasty, as well as project associated costs, we used a national administrative database. The rate at which the excised ureteropelvic junction obstruction (UPJO) is sent for pathologic identif...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2018.08.036
更新日期：2018-12-01 00:00:00
abstract：:Treatment of high-flow priapism varies and has included transcatheter embolization when conservative approaches fail. We present the case of an 8-year-old boy with high-flow priapism, who was treated with ultrasound-guided thrombin injection because of encouraging experience with the method obtained when treating aneu...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2007.02.012
更新日期：2007-04-01 00:00:00
abstract：OBJECTIVES:To describe the use of an innovative 5-part Percutaneous Access Needle with Glidewire (5-PANG), a novel technique in an attempt to make percutaneous nephrolithotomy (PCNL-a routinely performed procedure) tract establishment a fast, safe, and less cumbersome procedure. METHODS:An access needle (5-PANG needle...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2009.11.027
更新日期：2010-05-01 00:00:00
abstract：OBJECTIVE:To examine mild cognitive impairment (MCI) in a young and older adult urology population, and which external factors were associated with diminished cognitive status at baseline. METHODS:We enrolled patients >18 years of age presenting to a large, urban tertiary care center for a wide variety of urologic com...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2016.03.040
更新日期：2016-08-01 00:00:00
