当前位置： SCI文献检索 > UROLOGY期刊下所有文献 > Evaluation of the effect of spinal cord injury on serum PSA levels.

Evaluation of the effect of spinal cord injury on serum PSA levels.

Abstract：

OBJECTIVES:Prostatic structure and secretory activity are thought to be influenced by autonomic innervation of the prostate. Prostatic denervation is especially likely in patients with spinal cord injury (SCI) at the level of the cauda equina or the conus medullaris, where the peripheral nerve supply to the prostate may be specifically damaged. This may result in changes in serum prostate-specific antigen (PSA) levels, either directly or indirectly. Therefore, we measured serum PSA levels and also studied the influence of factors such as age, catheterization, duration of SCI, urinary tract infection, and history of cystitis on serum PSA values in men with SCI. METHODS:Serum PSA levels were determined in 79 men with SCI (age older than 40 years) using banked sera by the Abbott MEIA PSA assay. Variables such as age, catheterization, duration of SCI, urine culture results, and history of cystitis were obtained from a review of patient records. Comparisons were made with a randomly selected, non-SCI control population of 501 men, 40 to 89 years old, who underwent serum PSA determination at our institution. Statistical comparisons were performed using the Mann-Whitney U test (nonparametric), since the populations were not normally distributed. Multivariate logistic regression analysis was used to assess the correlation between the various factors and the serum PSA levels in men with SCI. RESULTS:No statistically significant differences were found in the median serum PSA values between the SCI group and the non-SCI control population. The age-specific PSA values obtained in the SCI group were also comparable to those reported for the general population at large. Age (P <0.03) and the presence of a catheter (P <0.0002) were the only two factors that were correlated with higher serum PSA values in the SCI group by regression analysis. CONCLUSIONS:Men with SCI tended to have serum PSA value distributions that were similar to those of the general population. However, those in the SCI group who had indwelling catheters were more likely to have higher PSA values at baseline, as were older men with SCI.

journal_name

Urology

journal_title

Urology

authors

Konety BR,Nguyen TT,Brenes G,Lewis N,Saul M,Nelson JB,Getzenberg RH

doi

10.1016/s0090-4295(00)00548-3

subject

Has Abstract

pub_date

2000-07-01 00:00:00

pages

82-6

issue

eissn

0090-4295

issn

1527-9995

pii

S0090429500005483

journal_volume

pub_type

杂志文章,评审

在线工具

Evaluation of the effect of spinal cord injury on serum PSA levels.