Abstract:
:Life-threatening infections caused by the encapsulated fungal pathogen Cryptococcus neoformans have been increasing steadily over the past 10 years because of the onset of AIDS and the expanded use of immunosuppressive drugs. Intricate host-organism interactions make the full understanding of pathogenicity and virulence of C. neoformans difficult. We discuss the current knowledge of the characteristics C. neoformans must possess to enter the host and establish progressive disease: basic growth requirements and virulence factors, such as the polysaccharide capsule; shed products of the organism; melanin production; mannitol secretion; superoxide dismutase; proteases; and phospholipases.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Buchanan KL,Murphy JWdoi
10.3201/eid0401.980109subject
Has Abstractpub_date
1998-01-01 00:00:00pages
71-83issue
1eissn
1080-6040issn
1080-6059journal_volume
4pub_type
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