Abstract：
:The aim of the work was to evaluate effect of CoQ10 on the lactate level in the rat brain after administration of Et-1. Fifty-three male Wistar rats (approximately 220-250 g) were used in the experiment. The animals were divided into four groups. 1. control; 2-4 under chloride hydrate anaesthesia, the rats were subjected to stereotaxic injection into right cerebral lateral ventricle: 2. 1 microliter Ringer's solution (control) and i.p. 0.5 ml of soybean oil, 3. 10 pmoles Et-1 diluted in 1 microliter Ringer's solution and i.p. 0.5 ml soybean oil, 4. 10 pmoles Et-1 diluted in 1 microliter Ringer's solution and i.p. 10 mg/kg of the body weight CoQ1O (Sigma). Right and left hemispheres were taken after one hour, 4 and 24 hours and the lactate level was assayed by an enzymatic method. Et-1 evoked a significant increase of lactate level at all experimental time intervals. CoQ10 reduced lactate acidosis after 24 hours from the administration of Et-1. The above phenomenon can be explained among other by an improvement of the cellular respiratory activity. CoQ10 represents very important electron transporter from flavins to cytochromes in the respiratory chain. Therefore CoQ10 can be used for prevention and treatment of ischaemic insult in human cases.
journal_name
Neurol Neurochir Poljournal_title
Neurologia i neurochirurgia polskaauthors
Piotrowski P,Ostrowski RP,Pańkowska T,Smiałek Msubject
Has Abstractpub_date
1998-11-01 00:00:00pages
1397-404issue
6eissn
0028-3843issn
1897-4260journal_volume
32pub_type
杂志文章abstract：BACKGROUND:The epilepsy treatment during pregnancy represents a balance between teratogenic hazard and seizure control. The aim of the study was to evaluate the safety and efficacy of lacosamide (LCS) during pregnancy and breastfeeding. METHODS:Patients referred to our Epilepsy Center for pregnancy planning who became...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：10.1016/j.pjnns.2017.03.003
更新日期：2017-01-01 00:00:00
abstract：:Forty-five cases of pituitary adenomas with clinical characteristics of acromegaly treated surgically from an approach through the nose and sphenoid sinus are presented. After the operation the somatic features of acromegaly decreased in 66% of cases, headaches regressed in 88%, visual field defects disappeared in 20%...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1982-07-01 00:00:00
abstract：:From a group of 248 cases of epilepsy observed in the last five years 69 (28%) children, 32 boys and 37 girls, were isolated (aged from several months to 14 years) in whom the first epileptic seizures appeared at the age of 3 years or less. The subgroups were subjected to detailed psychiatric-psychological analysis fo...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1984-11-01 00:00:00
abstract：:Peripheral facial paresis is a serious clinical and social problem. The effect of physical therapy in 44 patients aged 13-80 was studied. Idiopathic peripheral facial paresis was the cause of mimic muscles dysfunction in 75% of our patients. Medical treatment was conducted according to the established program, consist...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：:Fourteen patients with chronic glomerulonephritis and with Alport's syndrome were treated. Haemodialysis was performed 2--3 times weekly. The duration of treatment was from 10 months to 9 years. Serum levels of electrolytes, urea and creatinine were determined, the neurological condition was examined and nerve conduct...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1979-11-01 00:00:00
abstract：:Benign spinal neoplasm (b.s.n.) represented 11% (8 cases) of all histopathologically verified spinal neoplasm in 85 patients operated on between 1975 and 1990. Local back or neck pain were first clinical symptoms of b.s.n. On admission all the patients presented with bone lesions on X-ray plain radiograms of the spine...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1993-07-01 00:00:00
abstract：:In 21 epileptic patients (11 females and 10 males) aged 18-55 years on carbamazepine (CBZ) therapy the serum levels of vitamin B12 were measured. Mean serum level of vitamin B12 in epileptic patients was in the same range as compared to the values in healthy subjects. However, there were differences depending on the d...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1993-09-01 00:00:00
abstract：:The purpose of the study was to establish the influence exerted by a supratentorial brain tumour on the EEG correlates of sleep, and to compare the results before and after operation. Five patients were studied (aged 38 to 59 years) who were treated surgically for supratentorial expanding lesions: two cases of meningi...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：BACKGROUND AND PURPOSE:The aim of the study was to present the results of our management of frontal sinus fractures. MATERIALS AND METHODS:We analyzed records of 101 patients treated between 1996 and 2002, who sustained frontal sinus fractures. 7 patients were women and 94 were men. The average age of patients was 34 ...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：2006-09-01 00:00:00
abstract：:Spinal muscular atrophy (SMA) is a hereditary neuromuscular disorder, which causes progressive muscle weakness and in severe cases respiratory failure and death. Although the majority of the SMA cases are autosomal recessive, there is an autosomal dominant variant of SMA that primarily affects the lower extremities, k...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：10.1016/j.pjnns.2017.12.004
更新日期：2018-03-01 00:00:00
abstract：:This study was conducted to analyse the prevalence and features of headache in patients with SLE. 44 patients with SLE were reviewed retrospectively. The mean age of the patients was 43.8 +/- 11.5 years (r: 22-68), mean time of evolution of SLE was 11.8 +/- 9.0 years (r: 1-30). 28 patients (27 woman and 1 man) had cli...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:The authors conducted periodic electroencephalographic (chrono-EEG) investigations in 64 subjects including 48 with various vasomotor headaches and 16 healthy ones. Chrono-EEG investigations carried out at different times of the day during wakefulness in healthy subjects and patients with Horton's (cluster) headaches ...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:The reported case was observed in a patient aged 54 years with disseminated lesions in the central nervous system. The history of the disease covered 18 years with periods of exacerbations and remissions. Seven years after the appearance of neurological signs involvement of the internal organs and skin was noted. In t...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1984-09-01 00:00:00
abstract：:The paper contains a clinical analysis of 23 cases of dorsomedial intervertebral disc prolapse in the lumbar spine treated surgically with stress laid on late results, which were evaluated in follow up. The results were compared with the rate of increase of clinical manifestations, clinical conditions of the patients,...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1981-05-01 00:00:00
abstract：BACKGROUND AND PURPOSE:The essential stage of Dolenc's approach to the cavernous sinus is the incision of the meningo-orbital fold (MOF) without damaging nervous structures in the superior orbital fissure. The goal of the research is to perform a topographic and morphometric study of the meningo-orbital fold. MATERIAL...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:Leigh syndrome (subacute necrotizing encephalomyopathy, MIM 256,000) is a progressive neurodegenerative disorder of infancy and childhood, with characteristic pathological hallmarks including symmetric necrotizing lesions in the brainstem, basal ganglia, thalamus and spinal cord. It may result from several defects of ...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章,评审
doi：
更新日期：2008-05-01 00:00:00
abstract：:Neuromyelitis optica spectrum disorders (NMOSD) are inflammatory demyelinating diseases of the central nervous system (CNS) that cause optic neuritis, transverse myelitis, and some other CNS syndromes. Recently, diagnosis and understanding of these diseases has been markedly enhanced by the discovery that serum autoan...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：10.5603/PJNNS.a2019.0049
更新日期：2019-01-01 00:00:00
abstract：:Vertebral haemangioma is a slowly growing benign tumour arising from blood vessels. Haemangioma of the vertebrae is usually asymptomatic. Neurological symptoms occur when haemangioma causes compression of nerve roots or spinal cord. In this paper a case of a 59 year-old woman with, vertebral body L2 haemangioma is rep...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1999-03-01 00:00:00
abstract：:A case of giant saccular aneurysm of basilar artery successfully treated by endovascular balloon occlusion is presented. The authors stress the effectiveness of this method in the treatment of an aneurysm which was considered inaccessible for direct surgery due to its localization. Endovascular procedure afforded prot...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1991-11-01 00:00:00
abstract：BACKGROUND AND PURPOSE:The aim of this study was to assess cognitive impairment in patients with relapsing-remitting multiple sclerosis (RR-MS) and to evaluate the correlation of cognitive impairment with physical disability and MRI lesion volume. MATERIAL AND METHODS:Sixty patients with RR-MS and 50 healthy controls ...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：2008-09-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Ongoing evaluation of the results of thrombolytic therapy in patients with ischaemic stroke (IS) in regions with different health care organization is absolutely crucial for making this method of treatment safer and efficient. The aim of this study was to analyse the efficacy and safety of treatm...
journal_title：Neurologia i neurochirurgia polska
pub_type： 临床试验,杂志文章
doi：10.5114/ninp.2013.36755
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Synovial cysts of the spine occur most frequently in the lumbosacral region. Methods of treatment vary, but in cases of chronic pain or neurological deficits surgical intervention is undertaken. The aim of this paper is to present indications, surgical technique and efficacy of surgical treatment...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：10.5114/ninp.2012.31356
更新日期：2012-09-01 00:00:00
abstract：:The authors determined peripheral-blood ammonia level in patients with cerebral strokes. The determinations were done by the method of Konitzer et al. on the 1st, 3rd and 7th days of the disease. The results of determinations were subjected to statistical analysis with the t test of Student. It was found that the mean...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:Time course of vasospasm in man has a big impact on clinical pisture, it also has an influence on the decision of surgery. The presence of acute stage of vasospasm is still under discussion. Many authors deny its existence. It is well known that positive decision about early operating has a crucial role in case of vas...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章,评审
doi：
更新日期：2001-03-01 00:00:00
abstract：:Every year several thousands of operations on the cervical spine from anterior approach are performed in the world for decompression of spinal cord and nerve roots. It is estimated that in 0.2 to 12% of the operations serious intraoperative and postoperative complications occur. Such cases have been reported in the wo...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章,评审
doi：
更新日期：1997-01-01 00:00:00
abstract：:We present a 43-year-old man with recurrent episodes of Hashimoto's encephalopathy who was diagnosed with autoimmune thyroiditis in childhood. Encephalopathy started with subacute dementia followed by extrapyramidal and psychiatric symptoms of insidious onset. He had also status epilepticus which occurred within the f...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章,评审
doi：
更新日期：2004-01-01 00:00:00
abstract：:The authors present the results of surgical treatment of 48 aneurysms situated on the anterior communicating artery operated upon by the classic and microsurgical methods. The latter method has made it possible to raise the proportion of very good and good results from 23% in the classic method to 70%, and to reduce t...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:The role of blood brain barrier (BBB) is to preserve a precisely regulated environment for proper neuronal signaling. In many of the central nervous system (CNS) pathologies, the function of BBB is altered. Thus, there is a necessity to evaluate a fast, noninvasive and reliable method for monitoring of BBB condition. ...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章,评审
doi：10.1016/j.pjnns.2018.02.002
更新日期：2018-01-01 00:00:00
abstract：:The paper presents the results obtained by 53 investigators implementing the first Polish multicentre study of the effectiveness and safety of tiagabine (Gabitril). The study included 81 patients with refractory epilepsy with partial seizures. The duration of the study was 16 weeks. For the initial 6 weeks, Gabitril w...
journal_title：Neurologia i neurochirurgia polska
pub_type： 临床试验,杂志文章,多中心研究
doi：
更新日期：2000-01-01 00:00:00
abstract：INTRODUCTION:The absence of patient's cooperation when it comes to his/her treatment ("noncompliance") is typical to chronic diseases and it is significant problem in medical practice. The term "compliance" means patient's capability of strictly adhering to the recommendations concerning the prescribed treatment. The n...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：10.1016/j.pjnns.2017.10.005
更新日期：2018-03-01 00:00:00
