Abstract：
:The role of blood brain barrier (BBB) is to preserve a precisely regulated environment for proper neuronal signaling. In many of the central nervous system (CNS) pathologies, the function of BBB is altered. Thus, there is a necessity to evaluate a fast, noninvasive and reliable method for monitoring of BBB condition. It seems that revealing the peripheral diagnostic biomarker whose release pattern (concentration, dynamics) will be correlated with clinical symptoms of neurological disorders offers significant hope. It could help with faster diagnosis and efficient treatment monitoring. In this review we summarize the recent data concerning exploration of potential new serum biomarkers appearing in the peripheral circulation following BBB disintegration, with an emphasis on epilepsy, traumatic brain injury (TBI) and stroke. We consider the application of well-known proteins (S100β and GFAP) as serum indicators in the light of recently obtained results. Furthermore, the utility of molecules like MMP-9, UCHL-1, neurofilaments, BDNF, and miRNA, which are newly recognized as a potential serum biomarkers, will also be discussed.
journal_name
Neurol Neurochir Poljournal_title
Neurologia i neurochirurgia polskaauthors
Chmielewska N,Szyndler J,Makowska K,Wojtyna D,Maciejak P,Płaźnik Adoi
10.1016/j.pjnns.2018.02.002subject
Has Abstractpub_date
2018-01-01 00:00:00pages
318-325issue
3eissn
0028-3843issn
1897-4260pii
S0028-3843(17)30445-0journal_volume
52pub_type
杂志文章,评审abstract：BACKGROUND AND PURPOSE:The objective of the study was to assess bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) for patients with advanced Parkinson disease (PD). MATERIAL AND METHODS:The study population included 5 patients with bilateral STN DBS who completed a 5-year postoperative follow-up period....
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：10.1016/s0028-3843(14)60401-1
更新日期：2010-01-01 00:00:00
abstract：:The purpose of the study was an attempt at evaluation of therapeutic results in 10 cases of tumours situated in the pineal region. The diagnosis was based on clinical and neuroradiological findings. Treatment included neurosurgical decompressing procedures (by the methods of Torkildsen, Pudenz Stookey-Scarf) followed ...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1977-07-01 00:00:00
abstract：BACKGROUND AND PURPOSE:DYT1 dystonia is the most common form of inherited primary dystonia. The aim of the study was: 1) to evaluate the prevalence of the DYT1 mutation in a population of Polish patients with early-onset generalized dystonia and with other forms of familial dystonia, 2) to evaluate the frequency of the...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：2007-11-01 00:00:00
abstract：:In 62 women the course of epilepsy was analysed at the age of puberty from 11 to 15 years of life. In 19 cases the course of the disease remained unchanged at that time, in 20 cases the seizures disappeared or became less frequent, in 20 cases the frequency of seizures increased, other types of seizures developed, or ...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1975-09-01 00:00:00
abstract：OBJECTIVE:White matter hyperintensities (WMHs) were often found in migraine patients. The aim of study was to characterize WMHs, assess their prevalence, determine relationship to clinical symptoms and homocysteine levels in migraine females. METHODS:69 women 38 with migraine without aura (MO), 31 with migraine with a...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：10.1016/j.pjnns.2018.09.007
更新日期：2018-01-01 00:00:00
abstract：:The aim of the study was to evaluate the relation between heart diseases and ischemic cerebral stroke. In addition to routine tests, echocardiographic examinations were performed in 70 patients with ischemic cerebral stroke and in 30 persons constituting the control group. It was found that heart diseases occurred in ...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:A group of 69 patients aged 60-80 years with brain tumours were analysed, estimating the surgical risk at the time of qualification for operations. Surgical treatment was given to 36 patients limiting it to lobectomy of the part of the brain containing the greater part of the tumour. The peri-operational mortality was...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1993-11-01 00:00:00
abstract：:A case of an extensive arterial anomaly in the vertebral canal (Th5-S5) in a boy aged 3 years is described. Sudden onset of the disease with massive subarachnoid haemorrhage, loss of consciousness and signs of raised intracranial pressure suggested rather a lesion in the cranial cavity. The final diagnosis was made af...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND AND PURPOSE:The aim was to conduct a pilot study of selected epidemiological aspects of multiple sclerosis (MS) in Poland. MATERIAL AND METHODS:Cross-sectional data were collected in 21 centres providing MS treatment. The demographic profile of the patients, medical history of MS, disability status, comorbi...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章,多中心研究
doi：10.1016/s0028-3843(14)60134-1
更新日期：2010-09-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Cerebral artery fenestrations (CAF) are rare congenital variations usually diagnosed by digital subtraction angiography (DSA). The aim of this study was to examine the frequency of occurrence of fenestrations in cerebral arteries and their coexistence with cerebral aneurysms in computed tomograph...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：10.5114/ninp.2012.29132
更新日期：2012-05-01 00:00:00
abstract：:Arteriovenous malformations (AVMs) are the most dangerous congenital vascular malformations. Intracranial AVMs occur in about 0.1 percent of the population and account for 1 to 2 percent of all strokes. The angioarchitecture of AVMs consists of direct arterial to venous connections without an intervening capillary net...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：2005-11-01 00:00:00
abstract：:In the recent years the number of diagnosed cases of Lyme Disease has tended to increase. This is due to the possibility of serological examinations. Between 1992-95 at the Neurological Department of 2nd Chair of Pediatrics Silesian Medical Academy in Katowice 7 children with Lyme Disease were hospitalized. The author...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1998-05-01 00:00:00
abstract：INTRODUCTION:Tremor is the most prevalent movement disorder, defined as rhythmic oscillations of a body part, caused by alternating or synchronic contractions of agonistic or antagonistic muscles. The aim of the study was to assess prevalence and to characterize parameters of tremor accompanying de-generative ataxias, ...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：10.5114/ninp.2013.35585
更新日期：2013-05-01 00:00:00
abstract：:A man aged 51 developed signs of damage to the inferior part of the thoracic cord and lumbosacral cord due to a dissecting aneurysm of the abdominal aorta. The aneurysm was demonstrated by USG and CT investigations of the abdomen. ...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1991-03-01 00:00:00
abstract：:The authors determined peripheral-blood ammonia level in patients with cerebral strokes. The determinations were done by the method of Konitzer et al. on the 1st, 3rd and 7th days of the disease. The results of determinations were subjected to statistical analysis with the t test of Student. It was found that the mean...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:The authors discuss the problem of recurrent haemorrhage in neurosurgical practice on the basis of a material of 36 cases out of a groups of 401 treated surgically for arterial aneurysms in the years 1971--1975. They describe the methods of prevention of recurrent haemorrhage by administration of pharmacological agent...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1977-11-01 00:00:00
abstract：:Metachromatic leukodystrophy is a genetic metabolic disease which generally occurs in childhood, surprisingly it can also occur during adulthood. Adult forms have very often characteristic presentations with progressive dementia. The authors presented a case of metachromatic leukodystrophy in an adult, differential di...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:A case of pinealoma is described in a patient aged 16 years who had been treated initially conservatively with ventriculoperitoneal shunting and cobalt irradiation of the whole brain. The spine was not irradiated because of absence of histological examination. After 6 months the patient returned to hospital with parap...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1986-09-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Bradykinesia, which is commonly defined as slowness of movements, is one of the cardinal signs of Parkinson's disease (PD) and parkinsonian syndromes. Simple clinical rating scales are used commonly to measure bradykinesia in routine clinical practice although this kind of assessment is biased. T...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：2009-01-01 00:00:00
abstract：:The authors analysed the effectiveness of Lipanthyl treatment in 38 patients after stroke undergoing rehabilitation treatment. The effects of the drug were evaluated on the general condition, neurological and psychic status, progression of motor rehabilitation, and on lipid metabolism parameters. A statistically signi...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:Motor neglect is characterized by underutilization of one side of the body when this failure cannot be attributed to primary sensory and motor defects. Impaired motor activity manifests itself in disturbance of using spontaneously contralesional limbs in the absence of severe hemiplegia (motor neglect) or in reduced r...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章,评审
doi：
更新日期：2005-03-01 00:00:00
abstract：:Contemporary experience and results of clinical trials concerning dopamine agonist application in the treatment of many different diseases (apart from Parkinson's disease) are presented in the paper. A basic clinical recommendation for agonists is restless legs syndrome. In this syndrome almost all agonists give a con...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章,评审
doi：
更新日期：2007-03-01 00:00:00
abstract：AIM:Sialorrhea is one of the main problems of patients with Parkinson's disease (PD). Most of the medications used for the treatment of it are ineffective. We decided to try in such patients local injections of botulinum toxin, type A, into both parotid glands. MATERIAL:11 patients with clinical diagnosis of idiopathi...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：INTRODUCTION:One of the leading causes of death in Poland is stroke. Cardiogenic stroke is known to be one of the most important reasons for acute ischaemic stroke (AIS), comprising 25-30% of all AISs. AIM OF STUDY:Assessment of the prevalence of different risk factors of cardiogenic causes of AIS using transthoracic ...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：10.5603/PJNNS.a2019.0016
更新日期：2019-01-01 00:00:00
abstract：:The authors report the results of EEG monitoring lasting many hours with cassette recording and with interpretation after reproduction on monitor screen. The Medilog 9000 System Oxford was used for that purpose. The group comprised 32 verified cases of epilepsy and 19 cases of seizures with unestablished aetiology. In...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Disturbances of glucose metabolism in epilepsy and other neurodegenerative diseases. Impairment of glucose and acetyl-CoA metabolism is a characteristic feature of several degenerative brain diseases. Presented paper provides experimental evidences that NO, aluminum and thiamine deficiency result in concordant disturb...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章,评审
doi：
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Diabetes mellitus (DM) is an in-dependent risk factor for cardiovascular diseases. The origin of diabetic microangiopathy is multifactorial; it affects all layers of the artery wall, causing endothelial and vasoreactivity impairment. The incidence of cerebral vasoreactivity failure in diabetic pa...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：10.5114/ninp.2012.32175
更新日期：2012-11-01 00:00:00
abstract：AIM OF THE STUDY:The goal of the present study was to analyse the exclusive use of absorbable suture material (Vicryl) in the fixation of transposed bone segments in cranial vault reshaping without modification of the osteotomy design. CLINICAL RATIONALE FOR THE STUDY:In the surgical correction of craniosynostosis, bo...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：10.5603/PJNNS.a2019.0014
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Ongoing evaluation of the results of thrombolytic therapy in patients with ischaemic stroke (IS) in regions with different health care organization is absolutely crucial for making this method of treatment safer and efficient. The aim of this study was to analyse the efficacy and safety of treatm...
journal_title：Neurologia i neurochirurgia polska
pub_type： 临床试验,杂志文章
doi：10.5114/ninp.2013.36755
更新日期：2013-07-01 00:00:00
abstract：:The authors observed 88 patients (18 women and 70 men) aged 16 to 61 years with lack of lumbar vertebral arch fusion (spina bifid occulta without spinal cord involvement). In 63 cases the clinical symptom complex was that of sciatic pains, in the remaining 25 cases no neurological defect was found. In 63 cases operati...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1979-03-01 00:00:00
