Abstract:
BACKGROUND:The epilepsy treatment during pregnancy represents a balance between teratogenic hazard and seizure control. The aim of the study was to evaluate the safety and efficacy of lacosamide (LCS) during pregnancy and breastfeeding. METHODS:Patients referred to our Epilepsy Center for pregnancy planning who became pregnant while taking LCS were prospectively followed-up. Data on seizure frequency, side effects, pregnancy course, delivery and breastfeeding, birth outcome, congenital malformation and development of newborns were collected. RESULTS:Three cases of maternal exposure to LCS were reported. Treatment with LCS was continued throughout pregnancy and breastfeeding at a median daily dose of 400mg. Lacosamide was used as monotherapy in two patients and as add-on treatment in one woman. Seizure frequency did not change throughout pregnancy and two subjects remained seizure free. The median gestational age at delivery was 39 weeks. The median Apgar scores at 1 and 5min were 9 and 10, respectively; no major or minor congenital malformations were observed in the offspring. Normal developmental milestone were reached by all new-borns. CONCLUSIONS:Worldwide pregnancy registries have provided consistent and increasing information about the efficacy and safety of the older antiepileptic drugs during gestation, while data are lacking for many of the newer generations. These cases could suggest a good level of efficacy and safety for LCS throughout pregnancy and breastfeeding and argue against teratogenic or toxic potentialities.
journal_name
Neurol Neurochir Poljournal_title
Neurologia i neurochirurgia polskaauthors
Lattanzi S,Cagnetti C,Foschi N,Provinciali L,Silvestrini Mdoi
10.1016/j.pjnns.2017.03.003subject
Has Abstractpub_date
2017-01-01 00:00:00pages
266-269issue
3eissn
0028-3843issn
1897-4260pii
S0028-3843(16)30206-7journal_volume
51pub_type
杂志文章abstract::In the Department of Neurosurgery of the Medical University of Warsaw 11 patients with primary central nervous system lymphomas were diagnosed and treated between 1990 and 1999. The patients comprised of 6 females and 5 males, aged 23 to 86 years, with most patients presenting in the sixth decade. The time from first ...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract::The distribution of ABO blood groups was analysed statistically in 271 patients treated for glioblastoma multiforme. The control group included 500 patients treated for craniocerebral trauma. A statistically significant difference was observed in the distribution of ABO blood groups between these patient groups, with ...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1979-03-01 00:00:00
abstract::The aim of the work was to show the usefulness of neurological and radiological signs in the patients with L4 and L5 discopathy. The axial symptoms with the highest occurrence frequency and the differential symptoms closely connected with definite disc pathology: the type and/or the level of discopathy were defined. T...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章,评审
doi:
更新日期:1998-05-01 00:00:00
abstract::The authors studied the dynamics of EEG changes in 27 patients treated with L-dopa. The records obtained before treatment were compared with those made during treatment and with the clinical manifestations. In 8 cases the EEG pattern was normal before treatment and 6 of them improved (three-fourths of this subgroup). ...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract::In the years 1971-1981 in the Department of Neurosurgery, Military Medical Academy 293 patients were treated surgically for cervical spondylosis. The author describes the methods of surgical treatment calling particular attention to the necessity of wide decompression of the nervous structures and vessels of the verte...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1984-03-01 00:00:00
abstract::Disturbances of glucose metabolism in epilepsy and other neurodegenerative diseases. Impairment of glucose and acetyl-CoA metabolism is a characteristic feature of several degenerative brain diseases. Presented paper provides experimental evidences that NO, aluminum and thiamine deficiency result in concordant disturb...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00
abstract:INTRODUCTION:The superior cerebral artery is a clinically significant vessel, but little is known about its radiological anatomy. The aim of this study was to describe the anatomical variations of the proximal segment of the superior cerebellar artery using Computed Tomography Angiography. MATERIALS AND METHODS:The st...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:10.1016/j.pjnns.2014.07.006
更新日期:2014-01-01 00:00:00
abstract::The authors present four cases of acute epidural hematoma (three supratentorial and one in the posterior fossa), in which non-operative treatment was performed. The conditions to undertake this treatment were: good clinical and neurological state of the patients on admission (GCS equal or more than 14), absence or mil...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章,评审
doi:
更新日期:1999-07-01 00:00:00
abstract::Thanks to endocrinological and radiological diagnostic improvement and development of pituitary adenoma neurosurgery, CT-examination became a routine examination in such cases, in selected situations supported with MRI-examination. The authors report a short bibliography review of radiologically difficult cases, expla...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章,评审
doi:
更新日期:1991-09-01 00:00:00
abstract::Terminal ventriculostomy is one of the methods used in surgical treatment of syringomyelia. The procedure is well tolerated and may be used in cases in which atlanto-occipital decompression is too serious an operation. The author used the method in treatment of 10 patients with different stages of syringomyelia. In 5 ...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1978-11-01 00:00:00
abstract::A case of brain stem injury of vascular and traumatic origin, complicated with metabolic disturbances and with finally achieved cure is described. ...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract::The per cent and absolute numbers of lymphocytes T and B were calculated in 37 patients with hereditary diseases of the nervous system (torsion dystonia, hepatolenticular degeneration, idiopathic tremor) and in 22 donors. Reactions of active and full spontaneous complement-induced formation of rosettes and B cell dete...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1981-07-01 00:00:00
abstract::In the recent years the number of diagnosed cases of Lyme Disease has tended to increase. This is due to the possibility of serological examinations. Between 1992-95 at the Neurological Department of 2nd Chair of Pediatrics Silesian Medical Academy in Katowice 7 children with Lyme Disease were hospitalized. The author...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1998-05-01 00:00:00
abstract::The identification of reliable biomarkers of Parkinson's disease (PD) is a pivotal step in the introduction of causal therapies. Saliva is a biofluid which may be involved in synuclein pathology in PD. We have reviewed current studies on salivary proteins and compounds in PD patients and healthy controls, and their po...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章,评审
doi:10.5603/PJNNS.a2020.0011
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:White matter hyperintensities (WMHs) were often found in migraine patients. The aim of study was to characterize WMHs, assess their prevalence, determine relationship to clinical symptoms and homocysteine levels in migraine females. METHODS:69 women 38 with migraine without aura (MO), 31 with migraine with a...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:10.1016/j.pjnns.2018.09.007
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:According to the World Health Organization (WHO) assumptions every patient with a stroke should be treated by a specialized stroke team or in a specialized stroke unit. The aim of our study was to evaluate the accessibility and eligibility of stroke units in Poland. MATERIALS AND METHODS:We have...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:2004-09-01 00:00:00
abstract::The incidence of drug-induced dyskineses was evaluated in a group of 131 patients with Parkinson's disease on long-term treatment with L-DOPA preparations and the relationships were sought for between this incidence, and age of the patient at the onset of the disease and duration of treatment. Drug-induced dyskineses ...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1985-07-01 00:00:00
abstract::Progressive muscular dystrophies with primary or secondary dystrophin glycoprotein complex components' deficit are described. Some variants of limb--girdle and congenital muscular dystrophies as well as Duchenne/Becker muscular dystrophy belong to this group. The structure of dystrophin glycoprotein complex (DGC) whic...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章,评审
doi:
更新日期:1999-11-01 00:00:00
abstract::A case of cerebral angioma is described which was diagnosed by computer tomography and cerebral angiography. The role of computer tomography is discussed in the diagnosis of vascular intracranial anomalies. ...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
abstract::Two cases of ophthalmic zoster are reported in which several weeks after the appearance of skin changes hemiplegia developed. In one case the clinical course was unfavourable, and on autopsy extensive vasculitis was found in the brain with ischaemic foci situated mainly on the side of zoster. In the second case with f...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::Apoptosis is a physiological process of cell death by which a single cell may be eliminated from the living tissue. Since the process is mediated by specific proteins encoded in the host's genome, it is also a programmed cell death. Apoptosis is responsible for tissue remodelling during the development and turnover of...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章,评审
doi:
更新日期:2003-03-01 00:00:00
abstract:INTRODUCTION:The prevalence of intracranial aneurysms is estimated to be around 3% in the general population. Although these are often incidental findings, they potentially carry the risk of rupture, with all of the devastating consequences of SAH. STATE OF THE ART:Several risk factors of aneurysm rupture have been id...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:10.5603/PJNNS.a2020.0087
更新日期:2020-01-01 00:00:00
abstract::The course of regenerative processes was compared in rat sciatic nerve after its transection and anastomosis of the nerve. The nerves were united suturing the epineurium, laying sutures through the nerve trunk or were united with tissue adhesive. A comparison of the results of clinical, electromyographic and histologi...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1983-05-01 00:00:00
abstract::In a 57-year-old woman with a long history of multiple sclerosis a syndrome corresponding to the stiff-man syndrome was observed. ...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1987-03-01 00:00:00
abstract::Benign spinal neoplasm (b.s.n.) represented 11% (8 cases) of all histopathologically verified spinal neoplasm in 85 patients operated on between 1975 and 1990. Local back or neck pain were first clinical symptoms of b.s.n. On admission all the patients presented with bone lesions on X-ray plain radiograms of the spine...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1993-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Endovascular embolization is an approved method of treatment of cerebral aneurysms. Several difficulties can be caused by wide-neck aneurysms. In these cases vascular remodelling is required. It can be performed with the use of balloons or intracranial stents. This method allows expansion of the ...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:2009-03-01 00:00:00
abstract::Slowly progressive neuromuscular diseases include but are not limited to: facioscapulohumeral muscular dystrophy (FSHD) and limb-girdle muscular dystrophy (LGMD), hereditary motor and sensory neuropathy (HMSN) and spinal muscular atrophy type III (SMA3). The purpose of this study is to present an evaluation of basic a...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:10.1016/j.pjnns.2017.10.007
更新日期:2018-03-01 00:00:00
abstract::Authors present 38 patients treated non-operatively because of intracerebral haematomas since 1988 till 1990 in ++Neuro-traumatological Ward Medical Academy of Lódź. The aforementioned data revealed that patients could be treated non-invasively if: 1. On admittance to the ward they were in good general condition they ...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract::The authors studied 14 patients with epileptic seizures occurring from one to about 20 daily despite monitored pharmacological treatment. Two pairs of silver, properly insulated electrodes were applied to the subtentorial surface of both cerebellar hemispheres through burr-holes. The cerebellar surface was stimulated ...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1981-09-01 00:00:00
abstract::On the basis of a study of 218 control subjects in 10-year age groups the authors determined the mean levels and critical values of certain serum lipid components (cholesterol, triglycerides, beta-lipoproteins, esterified fatty acids and total lipids). Forty-two subjects were isolated (11.2%) with hyperlipoproteinaemi...
journal_title:Neurologia i neurochirurgia polska
pub_type: 杂志文章
doi:
更新日期:1981-07-01 00:00:00