Reproductive effects of tris(4-chlorophenyl)methanol in the rat.


:Tris(4-chlorophenyl)methanol (TCPM) is a global contaminant of unknown origin that is structurally related to the endocrine modulating pesticides 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) and Dicofol. Therefore, the potential reproductive toxic effects of TCPM were investigated in sexually mature male Sprague Dawley rats (n = 20) treated with 1.0, 10.0 or 100 ppm of TCPM mixed in the diet for 28 days. The calculated TCPM intake was 0.0, 0.1, 1.2 and 12.4 mg/kg/day, respectively. Serum concentrations of follicle stimulating hormone (FSH) in terminal blood samples were significantly (P < 0.02) elevated in the highest dose group compared to the controls. In contrast, dietary exposure to TCPM had no effect on circulating levels of luteinizing hormone (LH), testosterone (T) and the T/LH ratio. Incubation of MCF-7 cells with increasing concentrations of TCPM failed to either induce proliferation or to block the proliferative effect induced by estradiol indicating that TCPM is neither estrogenic or anti-estrogenic. Relative binding affinity studies using androgen receptors from the prostate revealed that TCPM has a binding affinity comparable to 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE), the principle metabolite of DDT. In addition, the calculated Ki (0.62 microM) for TCPM is lower than the reported Ki's for the antiandrogenic pesticides p,p'-DDE and vinclozolin. Although TCPM binds with the androgen receptor in vitro, the absence of both an effect on serum T levels and morphological changes in the testis suggests that the mechanism of action for elevated FSH levels seen in vivo may not involve an antiandrogenic effect of TCPM at the dose level used in this study. The no adverse effect level for reproductive effects of TCPM is 10 ppm which is equivalent to a calculated intake of 1.2 mg/kg/day.






Foster WG,Desaulniers D,Leingartner K,Wade MG,Poon R,Chu I




Has Abstract


1999-08-01 00:00:00














  • Uptake and transport mechanisms of decabromodiphenyl ether (BDE-209) by rice (Oryza sativa).

    abstract::The extensive industrial use of brominated flame retardants has aroused rapidly growing public concerns about their ubiquity in the environment. The feasibility of uptake and translocation of decabromodiphenyl ether (BDE-209) by three rice cultivars, namely Fengmeizhan, Hefengzhan and Guangyinzhan, and the uptake mech...


    pub_type: 杂志文章


    authors: Chow KL,Man YB,Tam NFY,Liang Y,Wong MH

    更新日期:2015-01-01 00:00:00

  • Synchronous-scan fluorescence spectra of Chlorella vulgaris solution.

    abstract::The characterization of the Chlorella vulgaris solution was carried out using synchronous-scan spectroscopy. The range of concentration of algae and Fe(III) in aqueous solutions were 5 x 10(8)-8 x 10(9) cells l(-1) and 10-60 microM, respectively. Effective characterization method used was synchronous-scan fluorescence...


    pub_type: 杂志文章


    authors: Liu X,Tao S,Deng N

    更新日期:2005-09-01 00:00:00

  • Soil dehydrogenase, phosphomonoesterase and arginine deaminase activities in an insecticide treated groundnut (Arachis hypogaea L.) field.

    abstract::Chlorpyrifos (O,O-diethyl O-3,5,6-trichloro-2 pyridyl phosphorothioate) 20 EC and Quinalphos (O,O-diethyl O-quinoxalin-2-yl phosphorothioate) 25 EC, were applied in groundnut (Arachis hypogaea L.) field as seed treatment at 25 ml/kg and soil treatment at 4 l/ha in 1998 and 1999. The residues of these insecticides were...


    pub_type: 杂志文章


    authors: Pandey S,Singh DK

    更新日期:2006-05-01 00:00:00

  • Cadmium level and soil type played a selective role in the endophytic bacterial community of hyperaccumulator Sedum alfredii Hance.

    abstract::Phytoremediation technology has been applied for heavy metal elimination for many years, however little research about the difference of remediation efficiency of hyperaccumulator in different soils was reported. Here, a pot experiment was conducted with a cadmium (Cd)/zinc hyperaccumulator Sedum alfredii Hance grown ...


    pub_type: 杂志文章


    authors: Qiong W,Fengshan P,Xiaomeng X,Rafiq MT,Xiao'e Y,Bao C,Ying F

    更新日期:2021-01-01 00:00:00

  • Effects of copper(II) and copper oxides on THMs formation in copper pipe.

    abstract::Little is known about how the growth of trihalomethanes (THMs) in drinking water is affected in copper pipe. The formation of THMs and chlorine consumption in copper pipe under stagnant flow conditions were investigated. Experiments for the same water held in glass bottles were performed for comparison. Results showed...


    pub_type: 杂志文章


    authors: Li B,Qu J,Liu H,Hu C

    更新日期:2007-08-01 00:00:00

  • Free and combined L- and D-amino acids in Arctic aerosol.

    abstract::Aerosol samples were collected with a high-volume cascade impactor with a 10 day sampling frequency at the Gruvebadet observatory, close to Ny-Ålesund (Svalbard Islands). A total of 42 filters were analyzed for free and combined amino acids, as they are key components of bio-aerosol. This article provides the first in...


    pub_type: 杂志文章


    authors: Feltracco M,Barbaro E,Kirchgeorg T,Spolaor A,Turetta C,Zangrando R,Barbante C,Gambaro A

    更新日期:2019-04-01 00:00:00

  • Effect of structural composition of humic acids on the sorption of a branched nonylphenol isomer.

    abstract::By using dialysis equilibrium experiments, the sorption of a branched nonylphenol isomer [4-(1-ethyl-1,3-dimethylpentyl)-phenol] (NP111) on various humic acids (HAs) isolated from river sediments and two reference HAs was studied. The HAs were characterized by solid-state (13)C direct polarization/magic angle spinning...


    pub_type: 杂志文章


    authors: Li C,Berns AE,Schäffer A,Séquaris JM,Vereecken H,Ji R,Klumpp E

    更新日期:2011-07-01 00:00:00

  • Cadmium availability to wheat grain in soils treated with sewage sludge or metal salts.

    abstract::Grain Cd concentrations were determined in wheat (Triticum aestivum L.) grown in 1999, 2001 and 2003, at six sludge cake field experiments. Three of these sites also had comparisons with Cd availability from metal amended liquid sludge and metal salts. Grain Cd concentrations in all years and at all sites were signifi...


    pub_type: 杂志文章


    authors: Chaudri A,McGrath S,Gibbs P,Chambers B,Carlton-Smith C,Godley A,Bacon J,Campbell C,Aitken M

    更新日期:2007-01-01 00:00:00

  • Responses of propagule germination and sexual reproduction of submerged macrophytes exposed to cadmium.

    abstract::Submerged macrophytes are considered the main primary producers in shallow lakes. Recently, they have experienced a decline due to increasing environmental impacts, e.g., excessive heavy metal loads. Compared to extensive studies on vegetative growth, reports on effects of heavy metals on propagule germination and rep...


    pub_type: 杂志文章


    authors: Cao Y,Liu H,Sun J,Liu Y,Jiang HS,Wang W,Li W

    更新日期:2019-03-01 00:00:00

  • Altitude dependence of polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in surface soil from Tibetan Plateau, China.

    abstract::Remote mountain areas besides high latitude regions are beginning to receive increased attention in studying the transport and behavior of persistent organic pollutants (POPs). In the present work, surface soil samples were collected from the Tibetan Plateau, the highest plateau in the world which includes the norther...


    pub_type: 杂志文章


    authors: Wang P,Zhang Q,Wang Y,Wang T,Li X,Li Y,Ding L,Jiang G

    更新日期:2009-09-01 00:00:00

  • Toxicological comparisons of Tetrahymena species, end points and growth media: supplementary investigations to the pilot ring test.

    abstract::Parallel to an international Pilot Ring Test to standardize a mutigeneration test protocol with the protozoon Tetrahymena pyriformis supplementary investigations were made. Effects on growth rate and 46 h population density were measured using an extended set of 12 chemicals, a further Tetrahymena-species (T. thermoph...


    pub_type: 杂志文章


    authors: Pauli W,Berger S

    更新日期:1997-09-01 00:00:00

  • Trace metals in green sea turtles (Chelonia mydas) inhabiting two southern California coastal estuaries.

    abstract::Foraging aggregations of east Pacific green sea turtles (Chelonia mydas) inhabit the Seal Beach National Wildlife Refuge (SBNWR) and San Diego Bay (SDB), two habitats in southern California, USA, located near urbanized areas. Both juvenile and adult green turtles forage in these areas and exhibit high site fidelity, w...


    pub_type: 杂志文章


    authors: Barraza AD,Komoroske LM,Allen C,Eguchi T,Gossett R,Holland E,Lawson DD,LeRoux RA,Long A,Seminoff JA,Lowe CG

    更新日期:2019-05-01 00:00:00

  • Perfluoroalkyl acids, hyperuricemia and gout in adults: Analyses of NHANES 2009-2014.

    abstract:BACKGROUND:Previous studies have reported a positive association of perfluoralkyl acids (PFAAs), including perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), with hyperuricemia. The objective of the study is to investigate whether there is an association between concurrent serum levels of several PFAAs...


    pub_type: 杂志文章


    authors: Scinicariello F,Buser MC,Balluz L,Gehle K,Murray HE,Abadin HG,Attanasio R

    更新日期:2020-11-01 00:00:00

  • A new indexing approach for evaluating heavy metal contamination in groundwater.

    abstract::Three indexing methods, namely heavy metal pollution index (HPI), contamination index (Cd) and heavy metal evaluation index (HEI), are commonly used for heavy metal evaluation in groundwater. These methods have several limitations. In HPI, 14 out of 15 groundwater samples collected in the study area of Nalagarh valley...


    pub_type: 杂志文章


    authors: Rajkumar H,Naik PK,Rishi MS

    更新日期:2020-04-01 00:00:00

  • Comparison of two reference black carbons using a planar PCB as a model sorbate.

    abstract::In studies assessing sorption of hydrophobic organic compounds (HOCs) in natural systems, the choice of an appropriate reference black carbon, which can represent environmental black carbon (BC), is essential. This study compared isotherms of two commonly available and distinct reference BCs (n-hexane soot (BCRM) and ...


    pub_type: 杂志文章


    authors: Im J,Lee CM,Coates JT

    更新日期:2008-03-01 00:00:00

  • Oxidative stress and DNA damage in zebrafish liver due to hydroxyapatite nanoparticles-loaded cadmium.

    abstract::This study investigated the acute and sub-acute toxicity responses in zebrafish following their exposure to hydroxyapatite-loaded cadmium nanoparticles (nHAP-Cd). The results indicate that cadmium chloride (Cd2+), 20 nm nHAP-Cd (nHAP20-Cd), and 40 nm nHAP-Cd (nHAP40-Cd) caused toxicity in zebrafish; the toxicity level...


    pub_type: 杂志文章


    authors: Gao M,Yang Y,Lv M,Song W,Song Z

    更新日期:2018-07-01 00:00:00

  • Photocatalytic degradation of an azo dye using N-doped NaTaO3 synthesized by one-step hydrothermal process.

    abstract::N-doped NaTaO(3) compounds (NaTaO(3-)(x)N(x)) with nano-cubic morphology were successfully synthesized by one-step hydrothermal method and Methyl Orange (MO) was used as a model dye to evaluate their photocatalytic efficiency under visible-light irradiation. The as-prepared NaTaO(3-)(x)N(x) samples were characterized ...


    pub_type: 杂志文章


    authors: Liu DR,Jiang YS,Gao GM

    更新日期:2011-06-01 00:00:00

  • Dermal exposure to plasticizers in nail polishes: An alternative major exposure pathway of phosphorus-based compounds.

    abstract::Phosphorus-based compounds are used as plasticizers in the manufacture of many products found in the indoor environment. Here we quantitatively investigated dermal exposure to phosphorus-based compounds contained in 45 nail polishes purchased in Japan. The alternative plasticizer triphenyl phosphate (TPhP) was detecte...


    pub_type: 杂志文章


    authors: Tokumura M,Seo M,Wang Q,Miyake Y,Amagai T,Makino M

    更新日期:2019-07-01 00:00:00

  • Perfluorooctanoic acid-induced liver injury is potentially associated with gut microbiota dysbiosis.

    abstract::Perfluorooctanoic acid (PFOA), an environmental pollutant, is widely engaged in industrial products and tends to accumulate in the liver. Emerging evidence has suggested that the gut microbiome is a pivotal player in maintaining animal health and can potentially altered by xenobiotic. However, few studies explored whe...


    pub_type: 杂志文章


    authors: Wang G,Pan R,Liang X,Wu X,Wu Y,Zhang H,Zhao J,Chen W

    更新日期:2021-03-01 00:00:00

  • Effects of dissolved organic carbon on sorption of 3,4-dichloroaniline and 4-bromoaniline in a calcareous soil.

    abstract::To evaluate the effects of dissolved organic carbon on sorption of 3,4-dichloroaniline (3,4-DCA) and 4-bromoaniline (4-BA) on soils, batch sorption experiments were carried out. The soil used was a typical calcareous soil from south-eastern Spain. Two different types of dissolved organic carbon were used, that is, dis...


    pub_type: 杂志文章


    authors: González-Pradas E,Fernández-Pérez M,Flores-Céspedes F,Villafranca-Sánchez M,Ureña-Amate MD,Socías-Viciana M,Garrido-Herrera F

    更新日期:2005-04-01 00:00:00

  • Biosorption and biomineralization of uranium(VI) by Saccharomyces cerevisiae-Crystal formation of chernikovite.

    abstract::Biosorption of heavy metal elements including radionuclides by microorganisms is a promising and effective method for the remediation of the contaminated places. The responses of live Saccharomyces cerevisiae in the toxic uranium solutions during the biosorption process and the mechanism of uranium biomineralization b...


    pub_type: 杂志文章


    authors: Zheng XY,Wang XY,Shen YH,Lu X,Wang TS

    更新日期:2017-05-01 00:00:00

  • Impacts of simulated acid rain on cation leaching from the Latosol in south China.

    abstract::Acid rain is a problem of increasing agricultural, environmental, and ecological concerns worldwide. This study investigated impacts of simulated acid rain (SAR) on cation leaching from the Latosol in south China. Latosol is an acidic red soil and occurs in the tropical rainforest biome. Laboratory experiments were pe...


    pub_type: 杂志文章


    authors: Zhang JE,Ouyang Y,Ling DJ

    更新日期:2007-05-01 00:00:00

  • Rapid and sensitive on-line monitoring 6 different kinds of volatile organic compounds in aqueous samples by spray inlet proton transfer reaction mass spectrometry (SI-PTR-MS).

    abstract::Rapid and sensitive monitoring of volatile organic compounds (VOCs) in aqueous samples is very important to human health and environmental protection. In this study, an on-line spray inlet proton transfer reaction mass spectrometry (SI-PTR-MS) method was developed for the rapid and sensitive monitoring of 6 different ...


    pub_type: 杂志文章


    authors: Zou X,Kang M,Wang H,Huang C,Shen C,Chu Y

    更新日期:2017-06-01 00:00:00

  • Use of a lux-marked rhizobacterium as a biosensor to assess changes in rhizosphere C flow due to pollutant stress.

    abstract::The flow of carbon from plant roots into soil supports a range of microbial processes and is therefore critical to ecosystem function and health. Pollution-induced stress, which influences rhizosphere C flow is of considerable potential importance, and therefore needs to be evaluated. This paper reports on a method, b...


    pub_type: 杂志文章


    authors: Porteous F,Killham K,Meharg A

    更新日期:2000-11-01 00:00:00

  • Determination and estimation of water solubilities and octanol/water partition coefficients for derivates of benzanilides.

    abstract::A shake-flask method was used to determine the water solubilities (Sw) and the octanol/water partition coefficients(Kow) of 14 derivates of benzanilides. The results showed that the octanol/water partition coefficients were correlated (r=-0.93) with Sw. The linear solvation energy relationship(LSER) and molecular conn...


    pub_type: 杂志文章


    authors: Dai J,Jin L,Wang L,Zhang Z

    更新日期:1998-10-01 00:00:00

  • Perfluoroalkyl and polyfluoroalkyl substances (PFASs) in consumer products in Norway - a pilot study.

    abstract::Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are used in numerous industrial and consumer products because of their special chemical properties, for instance the ability to repel both water and oil. A broad variety of PFAS have been introduced into the Norwegian market through industrial use (e.g. via fire fig...


    pub_type: 杂志文章


    authors: Herzke D,Olsson E,Posner S

    更新日期:2012-08-01 00:00:00

  • Human intake of PCDDs, PCDFs, and dioxin like PCBs in Japan, 2001 and 2002.

    abstract::PCDDs, PCDFs, and dioxin like PCBs (dioxin) surveillance results derived from regular environmental monitoring as well as other dioxin surveys by national and local governmental bodies in Japan were collected and analyzed. Several thousand data for air and soil in fiscal year 2001 (from 01/04/2001 to 31/03/2002) and 2...


    pub_type: 杂志文章


    authors: Mato Y,Suzuki N,Katatani N,Kadokami K,Nakano T,Nakayama S,Sekii H,Komoto S,Miyake S,Morita M

    更新日期:2007-04-01 00:00:00

  • Intra-specific variation in Ni tolerance, accumulation and translocation patterns in the Ni-hyperaccumulator Alyssum lesbiacum.

    abstract::A hydroponic experiment was conducted to investigate inter-population variation in Ni tolerance, accumulation and translocation patterns in Alyssum lesbiacum. The in vitro results were compared to field data (soil bioavailable and leaf Ni concentrations) so as to examine any potential relationship between hydroponic a...


    pub_type: 杂志文章


    authors: Adamidis GC,Aloupi M,Kazakou E,Dimitrakopoulos PG

    更新日期:2014-01-01 00:00:00

  • Technique for aerosol generation with controllable micrometer size distribution.

    abstract::The purpose of this study is to develop an aerosol generating system that can produce particles of micrometer size in a convenient and efficient way. This system is comprised of an ultrasonic atomizer, potassium sodium tartrate tetrahydrate (PST) as solute and a program-controlled solute feeding unit with different PS...


    pub_type: 杂志文章


    authors: Lee YC,Jeng FT,Chen CC

    更新日期:2008-10-01 00:00:00

  • Bioconcentration and metabolism of ketoconazole and effects on multi-biomarkers in crucian carp (Carassius auratus).

    abstract::The tissue distribution, bioconcentration, metabolism and biological effects of the antifungal medication ketoconazole were investigated in fish, crucian carp (Carassius auratus) were exposed to a series of nominal concentrations (0.2, 2 and 20 μg/L) for 14 days. The ultra-high performance liquid chromatography tandem...


    pub_type: 杂志文章


    authors: Liu J,Lu G,Yang H,Yan Z,Wang Y,Wang P

    更新日期:2016-05-01 00:00:00