当前位置： SCI文献检索 > CHEMOSPHERE期刊下所有文献 > Perfluorooctanoic acid-induced liver injury is potentially associated with gut microbiota dysbiosis.

Perfluorooctanoic acid-induced liver injury is potentially associated with gut microbiota dysbiosis.

Abstract：

:Perfluorooctanoic acid (PFOA), an environmental pollutant, is widely engaged in industrial products and tends to accumulate in the liver. Emerging evidence has suggested that the gut microbiome is a pivotal player in maintaining animal health and can potentially altered by xenobiotic. However, few studies explored whether PFOA-induced liver injury is associated with gut microbiota dysbiosis. In the present study, the effects of subacute and subchronic PFOA exposure on liver and gut microbiota in C57BL/6J mice were investigated. Our findings showed that both subacute and subchronic exposure to PFOA induced the liver inflammation, disrupted antioxidative homeostasis and caused liver histological abnormalities with detectable hepatomegaly, ultimately triggering liver injury. Besides, 16S rRNA sequencing analysis revealed that subacute PFOA exposure caused significant changes in the abundances of intestinal flora known to contribute to liver inflammation and oxidative stress, such as the Dehalobacterium and Bacteroides genera. Exposure to subchronic toxicity mainly induced the decrease in commensal probiotics including Lactobacillus and Bifidobacterium genera, which are potentially beneficial to liver damage, compared with that in the untreated group. They also resulted in disturbed functional capabilities of the microbial communities by a Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) analysis. Additionally, the levels of short-chain fatty acids (SCFAs), especially butyric acid, were significantly reduced by PFOA administration. Collectively, our observations suggested that liver damage induced by both subacute and subchronic PFOA exposures probably partly related to the gut microbiota dysbiosis and provided a new insight into the role of PFOA in liver injury.

journal_name

Chemosphere

journal_title

Chemosphere

authors

Wang G,Pan R,Liang X,Wu X,Wu Y,Zhang H,Zhao J,Chen W

doi

10.1016/j.chemosphere.2020.129004

subject

Has Abstract

pub_date

2021-03-01 00:00:00

pages

129004

eissn

0045-6535

issn

1879-1298

pii

S0045-6535(20)33201-X

journal_volume

266

pub_type

杂志文章

相关文献

CHEMOSPHERE文献大全
  • Sea urchin repelling Tannin- FeIII complex coating for ocean macroalgal afforestation.

    abstract：:Intense seaweed grazing by sea urchins has destroyed kelp forests and accelerated the transformation of these forests into barren areas known as urchin barrens. Once the sea urchins occupy the barren ground, it becomes more challenging to restore the kelp forests. Although phlorotannin, a primary herbivore defense che...

    journal_title：Chemosphere

    pub_type： 杂志文章

    doi：10.1016/j.chemosphere.2020.128276

    authors： Kim S,Jung SM,Jung S,Shin HW,Hwang DS

    更新日期：2021-01-01 00:00:00

  • Effects of dioxins and polychlorinated biphenyls (PCBs) on thyroid function in infants born in Japan--the second report from research on environmental health.

    abstract：:Dioxins (PCDD + PCDF) and polychlorinated biphenyl (PCB) are potentially hazardous compounds and have structural similarity to thyroid hormones. Our research group on "Dioxins and PCB in Human Milk" was organized in 1997 and has been active for the past three years. We collected breast milk from 80 mothers living in T...

    journal_title：Chemosphere

    pub_type： 杂志文章

    doi：10.1016/s0045-6535(01)00050-9

    authors： Matsuura N,Uchiyama T,Tada H,Nakamura Y,Kondo N,Morita M,Fukushi M

    更新日期：2001-12-01 00:00:00

  • Copper accumulation in vineyard soils: Rhizosphere processes and agronomic practices to limit its toxicity.

    abstract：:Viticulture represents an important agricultural practice in many countries worldwide. Yet, the continuous use of fungicides has caused copper (Cu) accumulation in soils, which represent a major environmental and toxicological concern. Despite being an important micronutrient, Cu can be a potential toxicant at high co...

    journal_title：Chemosphere

    pub_type： 杂志文章,评审

    doi：10.1016/j.chemosphere.2016.07.104

    authors： Brunetto G,Bastos de Melo GW,Terzano R,Del Buono D,Astolfi S,Tomasi N,Pii Y,Mimmo T,Cesco S

    更新日期：2016-11-01 00:00:00

  • Comparative studies of fungal degradation of single or mixed bioaccessible reactive azo dyes.

    abstract：:A screening using several fungi (Phanerochaete chrysosporium, Pleurotus ostreatus, Trametes versicolor and Aureobasidium pullulans) was performed on the degradation of syringol derivatives of azo dyes possessing either carboxylic or sulphonic groups, under optimized conditions previously established by us. T. versicol...

    journal_title：Chemosphere

    pub_type： 杂志文章

    doi：10.1016/S0045-6535(03)00286-8

    authors： Martins MA,Lima N,Silvestre AJ,Queiroz MJ

    更新日期：2003-08-01 00:00:00

  • Assessment of foliar dust deposition and elemental concentrations in foliar dust and long rows of grand tamarind leaves along two major roads of Coimbatore, India.

    abstract：:In this study, the concentration of foliar dust and 23 elemental concentrations in foliar dust and foliar tissues were studied using long rows of grand tamarind trees grown in two major roads in Coimbatore, India. Twenty-four sampling sites were chosen and categorized as urban (n = 5), suburban (n = 14), and rural (n ...

    journal_title：Chemosphere

    pub_type： 杂志文章

    doi：10.1016/j.chemosphere.2020.128444

    authors： Subpiramaniyam S,Boovaragamoorthy GM,Kaliannan T,Krishna K,Hong SC,Yi PI,Jang SH,Suh JM

    更新日期：2021-02-01 00:00:00

  • New insights into the interactions between cork chemical components and pesticides. The contribution of π-π interactions, hydrogen bonding and hydrophobic effect.

    abstract：:The role of chemical components of cork in the sorption of several pesticides has been investigated. For this purpose raw cork and three cork extracted fractions (i.e. cork free of aliphatic extractives, cork free of all extractives and cork free of all extractives and suberin) were used as sorbent of three ionic pest...

    journal_title：Chemosphere

    pub_type： 杂志文章

    doi：10.1016/j.chemosphere.2014.08.051

    authors： Olivella MÀ,Bazzicalupi C,Bianchi A,Fiol N,Villaescusa I

    更新日期：2015-01-01 00:00:00

  • Electrochemical oxidation of nitrogen-heterocyclic compounds at boron-doped diamond electrode.

    abstract：:Nitrogen-heterocyclic compounds (NHCs) are toxic and bio-refractory contaminants widely spread in environment. This study investigated electrochemical degradation of NHCs at boron-doped diamond (BDD) anode with particular attention to the effect of different number and position of nitrogen atoms in molecular structure...

    journal_title：Chemosphere

    pub_type： 杂志文章

    doi：10.1016/j.chemosphere.2011.10.020

    authors： Xing X,Zhu X,Li H,Jiang Y,Ni J

    更新日期：2012-01-01 00:00:00

  • Elevated atmospheric CO2 might increase the health risk of long-term ingestion of leafy vegetables cultivated in residual DDT polluted soil.

    abstract：:Residual dichlorodiphenyltrichloroethane (DDT) in the environment and a continuously increasing atmospheric carbon dioxide (CO2) concentration are two issues that have received a lot of attention. This study was conducted using a pot experiment to investigate the interactive effects of elevated CO2 and DDT on the upta...

    journal_title：Chemosphere

    pub_type： 杂志文章

    doi：10.1016/j.chemosphere.2019.04.024

    authors： Wu XR,Li YP,Tu SX,Ding YZ,Wang RG,Rensing C,Feng RW

    更新日期：2019-07-01 00:00:00

  • A simplified modeling approach using microbial growth kinetics for predicting exposure concentrations of organic chemicals in treated wastewater effluents.

    abstract：:Various mathematical relationships have been used to assess exposure concentrations of organic chemicals when emissions occur via wastewater treatment. These relationships range from a simple removal factor calculation to more sophisticated approaches using kinetic based mathematical models. While these existing appro...

    journal_title：Chemosphere

    pub_type： 杂志文章

    doi：10.1016/s0045-6535(97)10198-9

    authors： McAvoy DC,Grady CP Jr,Blok J,Feijtel TC,Federle TW,Larson RJ

    更新日期：1998-04-01 00:00:00

  • Detection of nitrifiers and evaluation of partial nitrification for wastewater treatment: A review.

    abstract：:Partial nitrification has gained broad interests in the biological nitrogen removal (BNR) from wastewater, since it alleviates carbon limitation issues and acts as a shortcut nitrogen removal system combined with anaerobic ammonium oxidation (Anammox) process. The occurrence and maintenance of partial nitrification re...

    journal_title：Chemosphere

    pub_type： 杂志文章,评审

    doi：10.1016/j.chemosphere.2015.02.004

    authors： Ge S,Wang S,Yang X,Qiu S,Li B,Peng Y

    更新日期：2015-12-01 00:00:00

  • The role of a combined coagulation and disk filtration process as a pre-treatment to microfiltration and reverse osmosis membranes in a municipal wastewater pilot plant.

    abstract：:A pilot study was conducted to assess the performance of a municipal wastewater reclamation plant consisting of a combined coagulation-disk filtration (CC-DF) process, microfiltration (MF) and reverse osmosis (RO) membranes, in terms of the removal of water contaminants and changes in characteristics of effluent organ...

    journal_title：Chemosphere

    pub_type： 杂志文章

    doi：10.1016/j.chemosphere.2014.05.042

    authors： Chon K,Cho J,Kim SJ,Jang A

    更新日期：2014-12-01 00:00:00

  • Dehalogenation of persistent halogenated organic compounds: A review of computational studies and quantitative structure-property relationships.

    abstract：:Dehalogenation is one of the highly important degradation reactions for halogenated organic compounds (HOCs) in the environment, which is also being developed as a potential type of the remediation technologies. In combination with the experimental results, intensive efforts have recently been devoted to the developme...

    journal_title：Chemosphere

    pub_type： 杂志文章,评审

    doi：10.1016/j.chemosphere.2015.02.013

    authors： Luo J,Hu J,Wei X,Fu L,Li L

    更新日期：2015-07-01 00:00:00

  • Simultaneous eco-toxicity assessment technique using an online monitoring system: effects of different environmental factors on swimming behavior of zebrafish (Danio rerio).

    abstract：:Environmental factors, such as photoperiod and temperature were the main limiting factors for the survival of organisms in the nature environment. Changes in environmental factors are well predicted but determining their effects on organisms are challenging hot topic in the field of eco-toxicology. Thus, technology ba...

    journal_title：Chemosphere

    pub_type： 杂志文章

    doi：10.1016/j.chemosphere.2020.126934

    authors： Hu Y,Zhao R,Poopal RK,Ren Z

    更新日期：2020-09-01 00:00:00

  • Antioxidative defense mechanism against lead-induced phytotoxicity in Fagopyrum kashmirianum.

    abstract：:The effect of lead (Pb)-induced oxidative stress was investigated in Fagopyrum kashmirianum. The seedlings absorbed the Pb readily by showing time (15 and 30 days) and concentration (0, 100, 200 and 300 μM) dependent effects. Pb caused reduction in both root and shoot lengths but its accumulation was more in roots (22...

    journal_title：Chemosphere

    pub_type： 杂志文章

    doi：10.1016/j.chemosphere.2018.10.131

    authors： Hakeem KR,Alharby HF,Rehman R

    更新日期：2019-02-01 00:00:00

  • Differentiating with fluorescence spectroscopy the sources of dissolved organic matter in soils subjected to drying

    abstract：:The relative fluorescence, normalised on dissolved organic carbon (DOC), and a humification index, based on the location of the fluorescence emission spectra, were used to investigate the possible sources of the increase in dissolved organic matter (DOM) when a soil is dried. From these 2 parameters it could be seen t...

    journal_title：Chemosphere

    pub_type： 杂志文章

    doi：10.1016/s0045-6535(98)00166-0

    authors： Zsolnay A,Baigar E,Jimenez M,Steinweg B,Saccomandi F

    更新日期：1999-01-01 00:00:00

  • Enhanced performance of crumb rubber filtration for ballast water treatment.

    abstract：:Waste-tire-derived crumb rubber was utilized as filter media to develop an efficient filter for ballast water treatment. In this study, the effects of coagulation, pressure filtration and dual-media (gravity) filtration on the performance of the crumb rubber filtration were investigated. The removal efficiencies of tu...

    journal_title：Chemosphere

    pub_type： 杂志文章

    doi：10.1016/j.chemosphere.2008.11.048

    authors： Tang Z,Butkus MA,Xie YF

    更新日期：2009-03-01 00:00:00

  • Human health perspectives on environmental exposure to benzidine: a review.

    abstract：:Benzidine, an odorless, white to slightly reddish-white crystalline organic compound, is an environmental contaminant that has been identified at about 30 National Priorities List (NPL) hazardous waste sites in the United States. In the environment, it is usually found attached to suspended particles either in its "fr...

    journal_title：Chemosphere

    pub_type： 杂志文章,评审

    doi：10.1016/0045-6535(95)00338-x

    authors： Choudhary G

    更新日期：1996-01-01 00:00:00

  • A technical mixture of 2,2',4,4'-tetrabromo diphenyl ether (BDE47) and brominated furans triggers aryl hydrocarbon receptor (AhR) mediated gene expression and toxicity.

    abstract：:Polybrominated diphenyl ethers (PBDE) are found as ubiquitous contaminants in the environment, e.g., in sediments and biota as well as in human blood samples and mother's milk. PBDEs are neuro- and developmental toxins, disturb the endocrine system and some are even carcinogenic. Structural similarities of PBDEs with ...

    journal_title：Chemosphere

    pub_type： 杂志文章

    doi：10.1016/j.chemosphere.2008.05.025

    authors： Wahl M,Lahni B,Guenther R,Kuch B,Yang L,Straehle U,Strack S,Weiss C

    更新日期：2008-09-01 00:00:00

  • Accumulation of phosphorus and calcium in different cells protects the phosphorus-hyperaccumulator Ptilotus exaltatus from phosphorus toxicity in high-phosphorus soils.

    abstract：:Ptilotus exaltatus accumulates phosphorus (P) to > 40 mg g-1 without toxicity symptoms, while Kennedia prostrata is intolerant of increased P supply. What physiological mechanisms underlie this difference and protect P. exaltatus from P toxicity? Ptilotus exaltatus and K. prostrata were grown in a sandy soil with low-...

    journal_title：Chemosphere

    pub_type： 杂志文章

    doi：10.1016/j.chemosphere.2020.128438

    authors： Ye D,Clode PL,Hammer TA,Pang J,Lambers H,Ryan MH

    更新日期：2021-02-01 00:00:00

  • Accelerated ciprofloxacin biodegradation in the presence of magnetite nanoparticles.

    abstract：:Ciprofloxacin (CIP) biodegradation was investigated using enrichments obtained in the presence of magnetite nanoparticles, CIP and human fecal sewage. CIP addition inhibited methanogenic activity and altered the bacterial community composition. The magnetite-supplemented enrichments significantly promoted CIP biodegra...

    journal_title：Chemosphere

    pub_type： 杂志文章

    doi：10.1016/j.chemosphere.2017.08.159

    authors： Yang Z,Xu X,Dai M,Wang L,Shi X,Guo R

    更新日期：2017-12-01 00:00:00

  • Exposure and ecotoxicological risk assessment of mixtures of top prescribed pharmaceuticals in Swedish freshwaters.

    abstract：:Surface water concentrations of 54 pharmaceuticals were predicted for seven major Swedish rivers and the Stockholm City area basins using the STREAM-EU model. These surface water concentrations were used to predict the ecotoxicological impact resulting from the exposure of aquatic organisms to this mixture of 54 pharm...

    journal_title：Chemosphere

    pub_type： 杂志文章

    doi：10.1016/j.chemosphere.2018.12.118

    authors： Lindim C,de Zwart D,Cousins IT,Kutsarova S,Kühne R,Schüürmann G

    更新日期：2019-04-01 00:00:00

  • Evaluation of natural and anthropogenic influences on the Guadalquivir River (Spain) by dissolved heavy metals and nutrients.

    abstract：:To evaluate both the natural and anthropogenic influences on surface waters of Guadalquivir River (SW-Spain), concentrations of dissolved trace metals (Mn, Co, Ni, Cu, Cd, Zn, and Pb), inorganic nutrients (N-NH(4)(+), N-NO(3)(-), N-NO(2)(-), and P-PO(4)(3-)) and other variables as conductivity, pH, dissolved oxygen (D...

    journal_title：Chemosphere

    pub_type： 杂志文章

    doi：10.1016/j.chemosphere.2007.05.082

    authors： Mendiguchía C,Moreno C,García-Vargas M

    更新日期：2007-11-01 00:00:00

  • The effect of dissolved glyphosate upon the sorption of copper by three selected soils.

    abstract：:The effect of the pesticide glyphosate (GPS) on adsorption processes of copper onto three soils of different characteristics has been studied. Cu adsorption decreases in general with increasing GPS concentration in solution, due principally to the lower equilibrium pHs, although this is not the only variable affecting...

    journal_title：Chemosphere

    pub_type： 杂志文章

    doi：10.1016/s0045-6535(01)00338-1

    authors： Morillo E,Undabeytia T,Maqueda C,Ramos A

    更新日期：2002-05-01 00:00:00

  • Personal exposure to PM2.5-bound organic species from domestic solid fuel combustion in rural Guanzhong Basin, China: Characteristics and health implication.

    abstract：:Domestic solid fuels combustion produces a mass of fine particulate matter (PM2.5). PM2.5-bound organics, including polycyclic aromatic hydrocarbons (PAHs), oxygenated-PAHs (OPAHs), phthalate esters (PAEs) and hopanes, were quantified in indoor, outdoor and personal exposure samples collected in rural Guanzhong Basin,...

    journal_title：Chemosphere

    pub_type： 杂志文章

    doi：10.1016/j.chemosphere.2019.04.010

    authors： Li Y,Xu H,Wang J,Ho SSH,He K,Shen Z,Ning Z,Sun J,Li L,Lei R,Zhang T,Lei Y,Yang L,Cao Y,Cao J

    更新日期：2019-07-01 00:00:00

  • The burden of disease attributable to ambient PM2.5-bound PAHs exposure in Nagpur, India.

    abstract：:Exposure to PM2.5-bound polycyclic aromatic hydrocarbons (PAHs) can elicit several types of cancer and non-cancer effects. Previous studies reported substantial burdens of PAH-induced lung cancer, but the burdens of other cancer types and non-cancer effects remain unknown. Thus, we estimate the cancer and non-cancer b...

    journal_title：Chemosphere

    pub_type： 杂志文章

    doi：10.1016/j.chemosphere.2018.04.054

    authors： Etchie TO,Sivanesan S,Etchie AT,Adewuyi GO,Krishnamurthi K,George KV,Rao PS

    更新日期：2018-08-01 00:00:00

  • The combination of in silico and in vivo approaches for the investigation of disrupting effects of tris (2-chloroethyl) phosphate (TCEP) toward core receptors of zebrafish.

    abstract：:Tris (2-chloroethyl) phosphate (TCEP), a substitute for brominated flame retardants (FRs) that have been phased out of use, is frequently detected in aqueous environments. However, previous studies on its endocrine disrupting effects have mainly focused on terrestrial mammals. Here, to comprehensively evaluate the pot...

    journal_title：Chemosphere

    pub_type： 杂志文章

    doi：10.1016/j.chemosphere.2016.10.038

    authors： Wu Y,Su G,Tang S,Liu W,Ma Z,Zheng X,Liu H,Yu H

    更新日期：2017-02-01 00:00:00

  • Physico-chemical characterization of playground sand dust, inhalable and bioaccessible fractions.

    abstract：:Dust is a mixture of natural and anthropogenic particles originated from multiple sources, which can represent an hazard for human health. Playgrounds are a site of particularly concern, due to sand dust ingestion by toddlers and inhalation. In this study, 37 sands used in public playgrounds in the city of Barcelona w...

    journal_title：Chemosphere

    pub_type： 杂志文章

    doi：10.1016/j.chemosphere.2017.09.101

    authors： H Valido I,Padoan E,Moreno T,Querol X,Font O,Amato F

    更新日期：2018-01-01 00:00:00

  • Analysis of the occurrence and risk assessment of polar pesticides in the Llobregat River Basin (NE Spain).

    abstract：:Contamination of surface waters by pesticides continues to be the focus of concern for water authorities due to the growing evidence of their deleterious effects on aquatic life. In this context, the present work investigates the occurrence of 16 selected pesticides belonging to the classes of triazines, phenylureas, ...

    journal_title：Chemosphere

    pub_type： 杂志文章

    doi：10.1016/j.chemosphere.2011.08.034

    authors： Köck-Schulmeyer M,Ginebreda A,González S,Cortina JL,de Alda ML,Barceló D

    更新日期：2012-01-01 00:00:00

  • Polybrominated diphenyl ether contamination levels in fish from the Antarctic and the Mediterranean Sea.

    abstract：:Polybrominated diphenyl ethers (PBDEs) concentrations and congener profiles were evaluated in four species of Antarctic fish (Chionodraco hamatus, Chaempsocephalus gunnari, Gymnoscopelus nicholsi,Trematomus eulepidotes) and in one Mediterranean species (Tuna, Thunnus thynnus). The GC/MS-ECNI analysis revealed that ave...

    journal_title：Chemosphere

    pub_type： 杂志文章

    doi：10.1016/j.chemosphere.2009.07.035

    authors： Borghesi N,Corsolini S,Leonards P,Brandsma S,de Boer J,Focardi S

    更新日期：2009-10-01 00:00:00

  • Effects of bioaugmentation on sorption and desorption of benzene, 1,3,5-trimethylbenzene and naphthalene in freshly-spiked and historically-contaminated sediments.

    abstract：:This work investigated the frequently observed "rebounds" of contaminants of concern in groundwater systems. Specifically, influences of bioaugmented microorganisms on the sorption and desorption of representative petroleum constituents [benzene, 1,3,5-trimethylbenzene and naphthalene (BTN)] were studied in freshly-sp...

    journal_title：Chemosphere

    pub_type： 杂志文章

    doi：10.1016/j.chemosphere.2016.07.051

    authors： Li Y,Chen L,Liu Y,Liu F,Fallgren PH,Jin S

    更新日期：2016-11-01 00:00:00