Alveolar macrophage reaction to Candida species.

Abstract:

:Candida species are increasingly important fungal pathogens. The reaction of rat alveolar macrophages (AM) to Candida albicans was compared with that to C. glabrata and C. krusei. Phagocytosis of C. glabrata was similar to that of C. albicans, but significantly slower for C. krusei due to reduced attachment. After opsonization, attachment of C. albicans and C. krusei to AM was significantly increased and there was no significant difference between the two species. The oxidative metabolism of AM with candida species was two to three times higher than that of the resting AM both during and 24 h after the phagocytosis. All three species showed a considerable fraction (5-10%) of phagolysosomes with pH > or = 6.5 after 3 h and a smaller percentage (1%) after 24 h.

journal_name

Lett Appl Microbiol

authors

Nessa K,Johansson A,Jarstrand C,Camner P

doi

10.1046/j.1472-765x.1997.00200.x

subject

Has Abstract

pub_date

1997-09-01 00:00:00

pages

181-5

issue

3

eissn

0266-8254

issn

1472-765X

journal_volume

25

pub_type

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