Ovarian cancer in female-to-male transsexuals: report of two cases.

abstract：:Fourteen patients with malignant nondysgerminomatous germ-cell tumors of the ovary were treated with a combination of high-dose cisplatin, vinblastine, bleomycin, and etoposide (PVeBV regimen). Nine patients received PVeBV as primary postoperative therapy, of whom four had no residual disease. Four patients received P...

journal_title：Gynecologic oncology

authors： Culine S,Kattan J,Lhomme C,Duvillard P,Michel G,Castaigne D,Leclere J,Pico J,Droz JP

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:To compare the efficacy of chemotherapy (C) combined with bevacizumab (Bev) versus Bev alone in recurrent, heavily pretreated epithelial ovarian cancer (EOC). METHODS:A multicenter analysis of patients treated from 2004 to 2011 was performed. Demographic, treatment, response, and adverse event information w...

journal_title：Gynecologic oncology

authors： Fuh KC,Secord AA,Bevis KS,Huh W,ElNaggar A,Blansit K,Previs R,Tillmanns T,Kapp DS,Chan JK

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE(S):To determine the feasibility of integrating an in vitro chemo-radiation response assay (IVRRA) with a gene microarray system to investigate the molecular patterns of expression that contribute to radiation resistance in cervical cancer. METHODS:Viable primary untreated cervical cancer specimens were obtai...

journal_title：Gynecologic oncology

authors： Tewari D,Monk BJ,Al-Ghazi MS,Parker R,Heck JD,Burger RA,Fruehauf JP

更新日期：2005-10-01 00:00:00

abstract：:CA 125 was measured during early chemotherapy in 121 patients with FIGO stage III or IV ovarian cancer to investigate if the antigen could be used as a prognostic parameter. CA 125 was determined before the start of chemotherapy and 1 month after the first, second, and third course. The antigen level before the start ...

journal_title：Gynecologic oncology

authors： Mogensen O

更新日期：1992-03-01 00:00:00

abstract：:Thirty patients with uterine papillary serous carcinoma were treated with intravenous cisplatin, doxorubicin, and cyclophosphamide (CAP) chemotherapy, a combination with proven efficacy against ovarian carcinoma. Nineteen patients were given CAP as an adjuvant soon after surgery. Eleven patients were treated after rec...

journal_title：Gynecologic oncology

authors： Price FV,Chambers SK,Carcangiu ML,Kohorn EI,Schwartz PE,Chambers JT

更新日期：1993-12-01 00:00:00

abstract：:Two cases of peritonitis carcinomatosa with gynecological cancer, which did not respond to conventional treatment, were treated by intraperitoneal adoptive immunotherapy with allogeneic or autologous lymphokine-activated killer (LAK) cells plus interleukin-2. In case 1, reduction of acute ascites and disappearance of ...

journal_title：Gynecologic oncology

authors： Kamada M,Sakamoto Y,Furumoto H,Mori K,Daitoh T,Irahara M,Aono T,Nii A,Yanagawa H,Sone S

更新日期：1989-07-01 00:00:00

abstract：OBJECTIVE:To review and summarize evidence from clinical, translational and epidemiologic studies which have examined the clinically relevant aspects of HPV type prevalence and cervical dysplasia in HIV-infected women. METHODS:Relevant studies were identified through a MEDLINE search. References of identified reports ...

journal_title：Gynecologic oncology

authors： McKenzie ND,Kobetz EN,Hnatyszyn J,Twiggs LB,Lucci JA 3rd

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:In Denmark, the proportion of women with ovarian cancer treated with neoadjuvant chemotherapy (NACT) has increased, and the use of NACT varies among center hospitals. We aimed to evaluate the impact of first-line treatment on surgical outcome and median overall survival (MOS). METHODS:All patients treated in...

journal_title：Gynecologic oncology

authors： Fagö-Olsen CL,Ottesen B,Kehlet H,Antonsen SL,Christensen IJ,Markauskas A,Mosgaard BJ,Ottosen C,Soegaard CH,Soegaard-Andersen E,Hoegdall C

更新日期：2014-02-01 00:00:00

abstract：:Survival rates were computed for 376 women diagnosed with carcinoma of the uterine cervix between 1964 and 1988. The 5-year survival rate for the entire group was 63%. The effect of age at diagnosis, clinical stage, histopathology, year of diagnosis, and screening program attendance was studied by univariate analysis ...

journal_title：Gynecologic oncology

authors： Sigurdsson K,Hrafnkelsson J,Geirsson G,Gudmundsson J,Salvarsdóttir A

更新日期：1991-10-01 00:00:00

abstract：:A total of 246 endocervical samples were collected for Papanicolaou staining and one-parameter flow cytometric DNA analysis (FCDA) using 4',6-diamidino-2-phenylindole as a DNA stain. Typical histograms derived from FCDA analysis were designated class I, II, III, and V. Two groups of patients were studied: 135 women re...

journal_title：Gynecologic oncology

authors： Tsou KC,Pearson S,Atkinson BF,Giuntoli R,Mangan C

更新日期：1983-06-01 00:00:00

abstract：:Three cases of papillary villoglandular carcinoma of the cervix are presented. Each patient was multiparous and presented with abnormal vaginal bleeding. The mean age at presentation was 35 years (range 28-42 years). All patients were staged as FIGO IB and underwent radical Wertheim hysterectomy and bilateral pelvic l...

journal_title：Gynecologic oncology

authors： Hopson L,Jones MA,Boyce CR,Tarraza HM Jr

更新日期：1990-11-01 00:00:00

abstract：:The cell line HTOA was established from a well-differentiated human ovarian serous cystadenocarcinoma. This line grew well and without interruption for 51 months and was subcultivated over 130 times. The cells were epithelial in shape, and neoplastic and pleomorphic features, a jigsaw puzzle-like arrangement, desmosom...

journal_title：Gynecologic oncology

authors： Ishiwata I,Ishiwata C,Soma M,Nozawa S,Ishikawa H

更新日期：1987-03-01 00:00:00

abstract：:Ninety-two patients with early invasive carcinoma of the cervix (5 mm or less) treated between July 1977 and June 1990 are reviewed. Eighty patients had squamous cell carcinomas and 12 had adenocarcinomas. The diagnosis was established by conization in 77 of 92 (83.6%) patients. Thirty-six patients (39%) had a depth o...

journal_title：Gynecologic oncology

authors： Jones WB,Mercer GO,Lewis JL Jr,Rubin SC,Hoskins WJ

更新日期：1993-10-01 00:00:00

abstract：OBJECTIVE:This study investigated the relationship between 13 proteins involved in DNA damage and the outcomes of patients with recurrent ovarian cancer (ROC). PATIENTS AND METHODS:Immunohistochemistry staining was performed in 114 diagnostic samples from patients with serous ROC who participated in the OVA-301 study,...

journal_title：Gynecologic oncology

authors： Monk BJ,Kaye SB,Poveda A,Herzog TJ,Aracil M,Nieto A,Badri N,Parekh TV,Tanović A,Galmarini CM

更新日期：2014-01-01 00:00:00

abstract：:Between October 1985 and January 1989, 33 patients with stage I (31) or clinically occult stage II (2) endometrial cancer at a high risk for recurrence were entered in a prospective study evaluating adjuvant cisplatin, doxorubicin, and cyclophosphamide (PAC) chemotherapy. Eligibility criteria included grade 2 tumors w...

journal_title：Gynecologic oncology

authors： Stringer CA,Gershenson DM,Burke TW,Edwards CL,Gordon AN,Wharton JT

更新日期：1990-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the hospital-acquired condition (HAC) following oophorectomy and/or hysterectomy for gynecologic cancer patients based on clinical outcomes and costs. MATERIALS AND METHODS:Data were obtained from the Nationwide Inpatient Sample from 2005 to 2011. Chi-squared and Wilcoxon rank sum two-sample test...

journal_title：Gynecologic oncology

authors： Chan JK,Gardner AB,Mann AK,Kapp DS

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:High fatality in ovarian cancer is attributed to metastasis, propagated by the release of multi-cellular aggregates/spheroids into the peritoneal cavity and their subsequent mesothelial invasion of peritoneal organs. Spheroids are therefore a common and clinically relevant in vitro model for ovarian cancer r...

journal_title：Gynecologic oncology

authors： Gunay G,Kirit HA,Kamatar A,Baghdasaryan O,Hamsici S,Acar H

更新日期：2020-11-01 00:00:00

abstract：:The c-erbB-2 mRNA was detected by the S1 nuclease protection assay and Northern blotting in breast cancer tissues. In contrast to the Northern blot analysis which has been used in all recent publications concerning c-erbB-2 expression on the level of RNA, the S1-nuclease protection assay has distinct advantages with r...

journal_title：Gynecologic oncology

authors： Tanner B,Friedberg T,Mitze M,Beck T,Oesch F,Knapstein PG

更新日期：1992-11-01 00:00:00

abstract：:The relationship between the amount of silver-stained nucleolar organizer regions (AgNORs) and the DNA content of interphase neoplastic cells in 63 cases of human endometrial adenocarcinoma was studied. Interphase AgNOR content was determined as the mean AgNOR area per nucleus by image cytometry in silver-stained samp...

journal_title：Gynecologic oncology

authors： Trerè D,Melchiorri C,Chieco P,Marabini A,Derenzini M

更新日期：1994-05-01 00:00:00

abstract：:Arterial thromboembolic disease almost always occurs in the setting of significant cardiovascular disease. Fewer than 10% of patients have no known etiology and only rarely is malignancy implicated. A review of the literature revealed only one prior report associated with a gynecologic malignancy, and this occurred in...

journal_title：Gynecologic oncology

authors： Minjarez DA,Delorit MA,Davidson SA

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:This study investigated the expression of cellular apoptosis susceptibility protein (CAS) in serous ovarian carcinoma by immunohistochemistry and compared it with topoisomerase IIalpha (topo IIalpha), bcl-2, bcl-x, the frequency of apoptotic bodies (ABI), mitotic activity, and c-erbB-2 with regard to clinicop...

journal_title：Gynecologic oncology

authors： Brustmann H

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:Brachytherapy plays a major role in the treatment of patients with carcinoma of the cervix. However, routine intracavitary brachytherapy may not be feasible or adequate to treat locally advanced disease. The purpose of this prospective study was to assess treatment outcome for patients with locally advanced g...

journal_title：Gynecologic oncology

authors： Agrawal PP,Singhal SS,Neema JP,Suryanarayan UK,Vyas RK,Rathi AK,Bahadur AK

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVE:Potential predictive/prognostic angiogenic markers were prospectively examined in a phase II trial of bevacizumab in epithelial ovarian cancer (EOC)/primary peritoneal cancer (PPC). METHODS:Recurrent/persistent EOC/PPC patients were treated with bevacizumab (15 mg/kg IV q21days) until disease progression. Va...

journal_title：Gynecologic oncology

authors： Han ES,Burger RA,Darcy KM,Sill MW,Randall LM,Chase D,Parmakhtiar B,Monk BJ,Greer BE,Connelly P,Degeest K,Fruehauf JP

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to evaluate the histological outcome of laser ring biopsies in patients with one or more smears showing cytological mild dyskaryosis where punch biopsies were not performed. The possibilities of predicting histological findings of CIN 2 and CIN 3 were analyzed. METHODS:The study com...

journal_title：Gynecologic oncology

authors： Risberg B,Andersson A,Lie KA,Nordin B,Zetterberg C

更新日期：1998-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy, feasibility and safety of image-based, inversely and adaptively planned high-dose rate interstitial brachytherapy (HDR-ISBT) to treat advanced primary or recurrent gynecologic malignancy in a single implant, three-consecutive-day regimen. METHODS:Clinical demographics and outcome da...

journal_title：Gynecologic oncology

authors： Hanania AN,Myers P,Yoder AK,Bulut A,Henry Yu Z,Eraj S,Bowers J,Bonnen MD,Echeverria A,Hall TR,Anderson ML,Ludwig M

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVES:To characterize the safety, tolerability, and anti-tumor activity of cemiplimab as monotherapy or in combination with hypofractionated radiation therapy (hfRT) in patients with recurrent or metastatic cervical cancer. To determine the association between histology and programmed death-ligand 1 (PD-L1) expres...

journal_title：Gynecologic oncology

authors： Rischin D,Gil-Martin M,González-Martin A,Braña I,Hou JY,Cho D,Falchook GS,Formenti S,Jabbour S,Moore K,Naing A,Papadopoulos KP,Baranda J,Fury W,Feng M,Stankevich E,Li J,Yama-Dang NA,Yoo SY,Lowy I,Mathias M,Fury

更新日期：2020-11-01 00:00:00

abstract：:Cyclin E1 (CCNE1) gene amplification occurs in approximately 20% of ovarian high grade serous carcinoma (HGSC) and is associated with chemotherapy resistance and, in some studies, overall poor prognosis. The role of cyclin E1 in inducing S phase entry relies upon its interactions with cyclin dependent kinases (CDK), s...

journal_title：Gynecologic oncology

authors： Kanska J,Zakhour M,Taylor-Harding B,Karlan BY,Wiedemeyer WR

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:The aim of this study is to evaluate the impact of the 1999 national recommendations for ovarian cancer surgery in England to be performed by specialist surgeons in specialist centres. METHODS:A retrospective analysis of English cancer registry records, Hospital Episode Statistics (HES) data for all English ...

journal_title：Gynecologic oncology

authors： Butler J,Gildea C,Poole J,Meechan D,Nordin A

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Granulosa cell tumors of the ovary are rare, primarily treated surgically. In advanced or recurrent disease, data are inconclusive regarding the benefit of either primary or adjuvant chemotherapy. Hormonal therapy has been suggested as an alternative treatment. CASE:Our patient had three recurrences of estr...

journal_title：Gynecologic oncology

authors： Hardy RD,Bell JG,Nicely CJ,Reid GC

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVES:MDM2 is an important negative regulator of the p53 tumor suppressor protein. A naturally occurring T/G single nucleotide polymorphism (SNP) in the MDM2 gene promoter, SNP309, causes an increase in MDM2 protein levels and impairment of p53 tumor suppressor activity. SNP309 occurs at a relatively high frequenc...

journal_title：Gynecologic oncology

authors： Walsh CS,Miller CW,Karlan BY,Koeffler HP

更新日期：2007-03-01 00:00:00