Specialist surgery for ovarian cancer in England.

abstract：OBJECTIVES:The objectives of this study were twofold: (1) to estimate the anti-tumor efficacy of CI-958 in patients with measurable platinum-resistant ovarian cancer; (2) to determine the nature and degree of toxicity of CI-958 in these patients. METHODS:Patients received CI-958 560 mg/m(2) intravenously every 3 weeks...

journal_title：Gynecologic oncology

authors： Hoffman MA,Blessing JA,Morgan M

更新日期：2000-12-01 00:00:00

abstract：:Between 1971 and 1979, seventy-four patients with metastatic or advanced recurrent sarcoma of uterine origin were treated with combination chemotherapy consisting of vincristine, actinomycin D, and cyclophosphamide (Cytoxan). The probability of survival at 2 and 5 years was 23 and 15%, respectively. The response rate ...

journal_title：Gynecologic oncology

authors： Hannigan EV,Freedman RS,Elder KW,Rutledge FN

更新日期：1983-04-01 00:00:00

abstract：OBJECTIVE:Uterine serous carcinoma (USC) is presumed to arise from endometrial intra-epithelial carcinoma (EIC), whereas tubo-ovarian high-grade serous carcinomas have similar precursor lesions in the Fallopian tube, i.e. serous tubal intra-epithelial carcinoma (STIC). The presence of Fallopian tube abnormalities and t...

journal_title：Gynecologic oncology

authors： Steenbeek MP,Bulten J,Snijders MPLM,Lombaers M,Hendriks J,van den Brand M,Kraayenbrink AA,Massuger LFAG,Sweegers S,de Hullu JA,Pijnenborg JMA,Küsters-Vandevelde HVN,Reijnen C

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:The aim of this study was to compare survival outcomes of total abdominal radical hysterectomy (TARH) versus laparoscopy-assisted radical vaginal hysterectomy (LARVH) in stage IA2-IB2 cervical cancer. METHODS:812 patients who underwent RH between 2008 and 2017 were evaluated in 3 institutions. Progression-free...

journal_title：Gynecologic oncology

authors： Kwon BS,Roh HJ,Lee S,Yang J,Song YJ,Lee SH,Kim KH,Suh DS

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVES:Although many clinicians practice empiric dose reduction to prevent toxicity, it is unknown whether obese patients given chemotherapy dosed according to actual body weight (ABW) experience excess toxicity. At our institution, cancer patients receive chemotherapy dosed by ABW unless on a protocol capping dose...

journal_title：Gynecologic oncology

authors： Schwartz J,Toste B,Dizon DS

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to examine whether there is a possible difference in patient survival (1) between node-positive and node-negative groups for Stage I, II, IIIA+B, and IIIC disease and (2) between node-positive Stage I through IIIB disease and Stage IIIC disease. METHODS:Medical records of 125 patien...

journal_title：Gynecologic oncology

authors： Kanazawa K,Suzuki T,Tokashiki M

更新日期：1999-05-01 00:00:00

abstract：OBJECTIVES:Host genetic factors may play a role in human papillomavirus (HPV)-associated tumorigenesis, although the issue continues to be a focus of much debate. Biotransformation is critical in carcinogenic activity of numerous environmental carcinogens. It is therefore possible that polymorphisms of genes producing ...

journal_title：Gynecologic oncology

authors： Joseph T,Chacko P,Wesley R,Jayaprakash PG,James FV,Pillai MR

更新日期：2006-06-01 00:00:00

abstract：OBJECTIVE:Early-stage epithelial ovarian cancer represents a prognostically heterogenous group. We studied prognostic factors in patients treated with adjuvant paclitaxel/carboplatin chemotherapy. METHODS:Data was extracted from 147 patients with FIGO stage IA/IB, grade 2/3 or stage IC/IIA (any grade) who underwent pr...

journal_title：Gynecologic oncology

authors： Bamias A,Karadimou A,Soupos N,Sotiropoulou M,Zagouri F,Haidopoulos D,Thomakos N,Rodolakis A,Antsaklis A,Dimopoulos MA

更新日期：2011-10-01 00:00:00

abstract：:Progress has been made in identifying the molecular changes that occur in ovarian carcinoma; still our understanding of these changes and their interactions remains incomplete. In the present study the authors examined the expression of retinoblastoma protein, a tumor suppressor protein, in a spectrum of ovarian epith...

journal_title：Gynecologic oncology

authors： Niemann TH,Trgovac TL,McGaughy VR,Lewandowski GS,Copeland LJ

更新日期：1998-06-01 00:00:00

abstract：OBJECTIVES:We previously reported high rates of urinary incontinence among gynecologic cancer survivors and aimed to evaluate the effectiveness of a simple intervention for treatment of urinary incontinence in this population. METHODS:We recruited 40 gynecologic cancer survivors who reported urinary incontinence on a ...

journal_title：Gynecologic oncology

authors： Rutledge TL,Rogers R,Lee SJ,Muller CY

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:In the US, second non-ocular malignancies are the primary cause of death in retinoblastoma survivors with the germline RB1 mutation. Soft tissue sarcomas are one of the most likely malignancies to pose a risk to these patients, with leiomyosarcoma (LMS) being the most common subtype. As our cohort is followed...

journal_title：Gynecologic oncology

authors： Francis JH,Kleinerman RA,Seddon JM,Abramson DH

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVE:This study's objective was to quantify the impact (utility) of common complications of early cervical cancer treatment on quality of life (QOL). Utilities assigned by survivors were compared to those assigned by providers. METHODS:30 survivors of early cervical cancer identified from our Tumor Registry and 1...

journal_title：Gynecologic oncology

authors： Einstein MH,Rash JK,Chappell RJ,Swietlik JM,Hollenberg JP,Connor JP

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:A phase II trial was performed to evaluate the efficacy and safety of gefitinib in patients with persistent/recurrent endometrial cancer. METHODS:Women with histologically confirmed persistent/recurrent endometrial cancer were treated with 500mg oral gefitinib daily until progression or severe toxicity, wit...

journal_title：Gynecologic oncology

authors： Leslie KK,Sill MW,Fischer E,Darcy KM,Mannel RS,Tewari KS,Hanjani P,Wilken JA,Baron AT,Godwin AK,Schilder RJ,Singh M,Maihle NJ

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:To identify molecular prognosticators and therapeutic targets for high-grade serous epithelial ovarian cancers (EOCs) using genetic analyses driven by biologic features of EOC pathogenesis. METHODS:Ovarian tissue samples (n = 172; 122 serous EOCs, 30 other EOCs, 20 normal/benign) collected prospectively from...

journal_title：Gynecologic oncology

authors： Karlan BY,Dering J,Walsh C,Orsulic S,Lester J,Anderson LA,Ginther CL,Fejzo M,Slamon D

更新日期：2014-02-01 00:00:00

abstract：:The response rate and the determinants of response to a cisplatin-based regimen of neodjuvant chemotherapy (NACT) in women with a histologically confirmed first-diagnosis of invasive bulky stage IB-IIB cervical cancer are analyzed. A total of 79 cases were treated with cisplatin (40 mg/m2) each 7 days for seven course...

journal_title：Gynecologic oncology

authors： Bolis G,van Zainten-Przybysz I,Scarfone G,Zanaboni F,Scarabelli C,Tateo S,Calabrese M,Parazzini F

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:Ovarian cancer arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy is rare. CASE:We herein report the case of a 67-year-old woman with a history of breast cancer, taking tamoxifen citrate 20 mg/day for 4 years, who underwent an operation for left ovarian tumor. The postopera...

journal_title：Gynecologic oncology

authors： Okugawa K,Hirakawa T,Ogawa S,Kaku T,Nakano H

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to determine the utility of DNA flow cytometry as a prognostic indicator for risk of recurrence and overall survival in patients with early stage adenocarcinomas of the uterine cervix. METHODS:DNA flow cytometry was performed to determine ploidy, DNA index, and proliferative ind...

journal_title：Gynecologic oncology

authors： Magtibay PM,Perrone JF,Stanhope CR,Katzmann JA,Keeney GL,Li H

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to estimate the efficacy of an intensive CDP program, as well as to identify the predictors associated with lymphedema severity and response to CDP in lower limb lymphedema (LLL) after pelvic cancer therapy. METHODS:We performed a retrospective review of post-pelvic cancer LLL patie...

journal_title：Gynecologic oncology

authors： Liao SF,Li SH,Huang HY

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVES:The role of adjuvant therapy in patients with early stage ovarian carcinoma has not been clearly defined. Most randomized trials examining this issue have not used the vigorous staging exploration accepted as today's standard. This report examines the natural history of patients after surgically documented s...

journal_title：Gynecologic oncology

authors： Le T,Krepart GV,Lotocki RJ,Heywood MS

更新日期：1999-08-01 00:00:00

abstract：:A case of high-grade endometrioid adenosquamous carcinoma of the ovary showing pilomatricoma-like areas and neuroendocrine differentiation is presented. The pilomatricoma-like areas were strongly positive for cytokeratin and vimentin, whereas the poorly differentiated areas of the tumor were positive for cytokeratin, ...

journal_title：Gynecologic oncology

authors： Fang J,Keh P,Katz L,Rao MS

更新日期：1996-05-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to determine the efficacy and hematologic toxicity of salvage chemotherapy in patients with recurrent ovarian cancer following high-dose chemotherapy and peripheral blood stem cell transplantation (PBSCT). METHODS:A retrospective analysis of 19 Massachusetts General Hospital c...

journal_title：Gynecologic oncology

authors： Cook S,Penson R,Duska L,Nikrui N,Goodman A,Fuller A,Seiden M

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Endometrial polyps are the most common endometrial pathology described in association with postmenopausal tamoxifen exposure. It is generally accepted that the occurrence of malignancy in endometrial polyps among healthy women is up to 0.5%. However, no one has yet described the incidence of this malignant t...

journal_title：Gynecologic oncology

authors： Cohen I,Bernheim J,Azaria R,Tepper R,Sharony R,Beyth Y

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVE:The expression of the CDK inhibitor p27Kip1 and the extent of endogenous oxidative DNA damage were evaluated in the multistep cervical carcinogenesis. METHODS:Archival specimens of low-grade (L) squamous intraepithelial lesions (SILs) (n=32), high-grade (H) SILs (n=24) and invasive carcinomas (n=48) of the c...

journal_title：Gynecologic oncology

authors： Sgambato A,Zannoni GF,Faraglia B,Camerini A,Tarquini E,Spada D,Cittadini A

更新日期：2004-03-01 00:00:00

abstract：OBJECTIVES:Epidermal Growth Factor Receptor (EGF-R) up-regulation in cervical cancer cells leads to an increase in cell proliferative Insulin-like Growth Factor II (IGF-II) and Vascular Endothelial Growth Factor (VEGF) and a decrease of the anti-proliferative IGF-binding protein-3 (IGF-BP3). The objectives for this stu...

journal_title：Gynecologic oncology

authors： Mathur RS,Mathur SP

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:Advanced ovarian cancer (OC) commonly spreads to cardiophrenic lymph nodes (CPLNs), and is often visible on preoperative imaging. We investigated the prognostic significance of abnormal CPLNs in OC detected by preoperative CT scans using three different definitions. METHODS:Patients undergoing primary debulk...

journal_title：Gynecologic oncology

authors： Mert I,Kumar A,Sheedy SP,Weaver AL,McGree ME,Kim B,Cliby WA

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study is to evaluate the efficacy of intraperitoneal cisplatin as consolidation treatment in epithelian ovarian cancer patients with complete pathologic response following front-line platin-based chemotherapy. PATIENTS AND METHODS:Thirty patients who had no evidence of disease as assessed by ...

journal_title：Gynecologic oncology

authors： Topuz E,Eralp Y,Saglam S,Saip P,Aydiner A,Berkman S,Yavuz E

更新日期：2004-01-01 00:00:00

abstract：:Primary lymphoma of the cervix is very rare. A case report is presented and 24 cases published in the English literature are reviewed. Evaluation, staging, treatment, and prognosis of this rare tumor are discussed. ...

journal_title：Gynecologic oncology

authors： Mann R,Roberts WS,Gunasakeran S,Tralins A

更新日期：1987-01-01 00:00:00

abstract：:An estimated 2-5% of endometrial cancers and 15-20% of high-grade, non-mucinous epithelial ovarian cancers have an underlying hereditary cause. Appropriate risk assessment, genetic counseling, and germline genetic testing for cancer predisposition genes in both gynecologic cancer patients and their at-risk relatives i...

journal_title：Gynecologic oncology

authors： Hinchcliff EM,Bednar EM,Lu KH,Rauh-Hain JA

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:We compared the self-sampling performance of the newly designed HerSwab™ device with a physician-collected cervical sample and another self-sample using the cobas® PCR Female swab for the detection of cervical intraepithelial neoplasia (CIN) and cancer. METHODS:Women referred for colposcopy at McGill Univers...

journal_title：Gynecologic oncology

authors： El-Zein M,Bouten S,Louvanto K,Gilbert L,Gotlieb W,Hemmings R,Behr MA,Franco EL,CASSIS Study Group.

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine prognostic factors of metachronous Krukenberg's tumors of gastric origin, thereby helping to establish a therapeutic plan for this rare entity. METHODS:Thirty-four female patients who underwent curative resection of gastric carcinoma from 1987 through 1996 and subsequen...

journal_title：Gynecologic oncology

authors： Kim HK,Heo DS,Bang YJ,Kim NK

更新日期：2001-07-01 00:00:00