Two-stage method of estimation for general linear growth curve models.

abstract：:Matched case-control designs are commonly used in epidemiologic studies for increased efficiency. These designs have recently been introduced to the setting of modern imaging and genomic studies, which are characterized by high-dimensional covariates. However, appropriate statistical analyses that adjust for the match...

journal_title：Biometrics

authors： Qian J,Payabvash S,Kemmling A,Lev MH,Schwamm LH,Betensky RA

更新日期：2014-03-01 00:00:00

abstract：:In controlled clinical trials there are usually several prognostic factors known or thought to influence the patient's ability to respond to treatment. Therefore, the method of sequential treatment assignment needs to be designed so that treatment balance is simultaneously achieved across all such patients factor. Tra...

journal_title：Biometrics

authors： Pocock SJ,Simon R

更新日期：1975-03-01 00:00:00

abstract：:A life table estimates probabilities of surviving and of dying as well as death rates, as these would apply in a stationary population with the same underlying continuous mortality curve as the observed population. We have derived approximations to the probability of surviving that require no iteration, do not depend ...

journal_title：Biometrics

authors： Keyfitz N,Frauenthal J

更新日期：1975-12-01 00:00:00

abstract：:In many applications of generalized linear mixed models to multilevel data, it is of interest to test whether a random effects variance component is zero. It is well known that the usual asymptotic chi-square distribution of the likelihood ratio and score statistics under the null does not necessarily hold. In this no...

journal_title：Biometrics

authors： Fitzmaurice GM,Lipsitz SR,Ibrahim JG

更新日期：2007-09-01 00:00:00

abstract：:We propose a design strategy for single-arm clinical trials in which the goals are to find a dose of an experimental treatment satisfying both safety and efficacy requirements, treat a sufficiently large number of patients to estimate the rates of these events at the selected dose with a given reliability, and stop th...

journal_title：Biometrics

authors： Thall PF,Russell KE

更新日期：1998-03-01 00:00:00

abstract：:We consider a semiparametric regression model that relates a normal outcome to covariates and a genetic pathway, where the covariate effects are modeled parametrically and the pathway effect of multiple gene expressions is modeled parametrically or nonparametrically using least-squares kernel machines (LSKMs). This un...

journal_title：Biometrics

authors： Liu D,Lin X,Ghosh D

更新日期：2007-12-01 00:00:00

abstract：:Patients who were previously treated for prostate cancer with radiation therapy are monitored at regular intervals using a laboratory test called Prostate Specific Antigen (PSA). If the value of the PSA test starts to rise, this is an indication that the prostate cancer is more likely to recur, and the patient may wis...

journal_title：Biometrics

authors： Taylor JM,Park Y,Ankerst DP,Proust-Lima C,Williams S,Kestin L,Bae K,Pickles T,Sandler H

更新日期：2013-03-01 00:00:00

abstract：:Statistical inference based on right-censored data for the proportional hazards (PH) model with missing covariates has received considerable attention, but interval-censored or current status data with missing covariates has not yet been investigated. Our study is partly motivated by the analysis of fracture data from...

journal_title：Biometrics

authors： Wen CC,Lin CT

更新日期：2011-09-01 00:00:00

abstract：:Adaptive line transect sampling offers the potential of improved population density estimation efficiency over conventional line transect sampling when populations are spatially clustered. In adaptive sampling, survey effort is increased when areas of high animal density are located, thereby increasing the number of o...

journal_title：Biometrics

authors： Pollard JH,Palka D,Buckland ST

更新日期：2002-12-01 00:00:00

abstract：:A Bayesian multivariate adaptive regression spline fitting approach is used to model univariate and multivariate survival data with censoring. The possible models contain the proportional hazards model as a subclass and automatically detect departures from this. A reversible jump Markov chain Monte Carlo algorithm is ...

journal_title：Biometrics

authors： Mallick BK,Denison DG,Smith AF

更新日期：1999-12-01 00:00:00

abstract：:Tang, Gnecco, and Geller (1989, Biometrika 76, 577-583) proposed an approximate likelihood ratio (ALR) test of the null hypothesis that a normal mean vector equals a null vector against the alternative that all of its components are nonnegative with at least one strictly positive. This test is useful for comparing a t...

journal_title：Biometrics

authors： Tamhane AC,Logan BR

更新日期：2002-09-01 00:00:00

abstract：:A procedure is given for estimating the ratio of the means of two populations using the data from two independent random samples when the observations are normally distributed with population variances that are related to the population means. ...

journal_title：Biometrics

authors： Cox CP

更新日期：1985-03-01 00:00:00

abstract：:A novel nonparametric regression model is developed for evaluating the covariate-specific accuracy of a continuous biological marker. Accurately screening diseased from nondiseased individuals and correctly diagnosing disease stage are critically important to health care on several fronts, including guiding recommenda...

journal_title：Biometrics

authors： Inácio de Carvalho V,de Carvalho M,Branscum AJ

更新日期：2017-12-01 00:00:00

abstract：:In this article, we study nonparametric estimation of the mean function of a counting process with panel observations. We introduce the gamma frailty variable to account for the intracorrelation between the panel counts of the counting process and construct a maximum pseudo-likelihood estimate with the frailty variabl...

journal_title：Biometrics

authors： Zhang Y,Jamshidian M

更新日期：2003-12-01 00:00:00

abstract：:This paper considers methods for estimating the relationship between a binary response Y and the genetic effects responsible for a second binary trait Z. The responses Y are observed only for target individuals, and the responses Z are observed only for the relatives of these targets. The analysis consists of two part...

journal_title：Biometrics

authors： Houwing-Duistermaat JJ,van Houwelingen HC,de Winter JP

更新日期：2000-09-01 00:00:00

abstract：:With advancements in technology, the collection of multiple types of measurements on a common set of subjects is becoming routine in science. Some notable examples include multimodal neuroimaging studies for the simultaneous investigation of brain structure and function and multi-omics studies for combining genetic an...

journal_title：Biometrics

authors： Zhao Y,Li L,Caffo BS

更新日期：2020-08-13 00:00:00

abstract：:Despite major methodological developments, Bayesian inference in Gaussian graphical models remains challenging in high dimension due to the tremendous size of the model space. This article proposes a method to infer the marginal and conditional independence structures between variables by multiple testing, which bypas...

journal_title：Biometrics

authors： Leday GGR,Richardson S

更新日期：2019-12-01 00:00:00

abstract：:In binomial group testing, unlike one-at-a-time testing, the test unit consists of a group of individuals, and each group is declared to be defective or nondefective. A defective group is one that is presumed to include one or more defective (e.g., infected, positive) individuals and a nondefective group to contain on...

journal_title：Biometrics

authors： Hung M,Swallow WH

更新日期：1999-03-01 00:00:00

abstract：:A stochastic model is presented for the analysis of incomplete repeated-measures experiments. The general linear model is used to relate the response measures to other variables which are thought to account for inherent variation; an autoregressive moving average (ARMA) time series representation is used to model dist...

journal_title：Biometrics

authors： Rochon J,Helms RW

更新日期：1989-03-01 00:00:00

abstract：:The concentration of carbon monoxide in the blood of a cigarette smoker varies in response to the frequency and dose of CO delivered by the cigarettes he smokes and by the rate at which CO washes out of his blood. Moments of first passage times or exit times above a nominal threshold can be calculated using a stochast...

journal_title：Biometrics

authors： Marcus AH,Czajkowski S Jr

更新日期：1979-09-01 00:00:00

abstract：:Neuroendocrine ensembles communicate with their remote and proximal target cells via an intermittent pattern of chemical signaling. The identification of episodic releases of hormonal pulse signals constitutes a major emphasis of endocrine investigation. Estimating the number, temporal locations, secretion rate, and e...

journal_title：Biometrics

authors： Yang YC,Liu A,Wang Y

更新日期：2006-03-01 00:00:00

abstract：:A class of adaptive weighted log-rank statistics is described where the vector of weights is chosen in a data-dependent way from a family of "smooth" weight vectors. A parametric family of weight vectors is identified which includes most shapes of weighting vectors that will be near optimal in many cancer prevention a...

journal_title：Biometrics

authors： Self SG

更新日期：1991-09-01 00:00:00

abstract：:Times between successive events (i.e., gap times) are of great importance in survival analysis. Although many methods exist for estimating covariate effects on gap times, very few existing methods allow for comparisons between gap times themselves. Motivated by the comparison of primary and repeat transplantation, our...

journal_title：Biometrics

authors： Shu X,Schaubel DE

更新日期：2016-06-01 00:00:00

abstract：:A method purporting to provide optimal allocations in bioequivalence studies fails to do so on both statistical and practical grounds. Reasons as to why this is so are given. ...

journal_title：Biometrics

authors： Senn S,Grieve AP

更新日期：1999-12-01 00:00:00

abstract：:Covariate-specific receiver operating characteristic (ROC) curves are often used to evaluate the classification accuracy of a medical diagnostic test or a biomarker, when the accuracy of the test is associated with certain covariates. In many large-scale screening tests, the gold standard is subject to missingness due...

journal_title：Biometrics

authors： Liu D,Zhou XH

更新日期：2011-09-01 00:00:00

abstract：:In multivariate matching, fine balance constrains the marginal distributions of a nominal variable in treated and matched control groups to be identical without constraining who is matched to whom. In this way, a fine balance constraint can balance a nominal variable with many levels while focusing efforts on other mo...

journal_title：Biometrics

authors： Yang D,Small DS,Silber JH,Rosenbaum PR

更新日期：2012-06-01 00:00:00

abstract：:If the regulatory requirements are symmetrical, the use of symmetrical confidence intervals as a decision rule for bioequivalence assessment leads, as shown by simulations, to better level properties and an inferior power compared to a rule based on shortest confidence intervals. A choice between these two approaches ...

journal_title：Biometrics

authors： Mandallaz D,Mau J

更新日期：1981-06-01 00:00:00

abstract：:In a period starting around 2007, the Hand, Foot, and Mouth Disease (HFMD) became wide-spreading in China, and the Chinese public health was seriously threatened. To prevent the outbreak of infectious diseases like HFMD, effective disease surveillance systems would be especially helpful to give signals of disease outb...

journal_title：Biometrics

authors： Zhang J,Kang Y,Yang Y,Qiu P

更新日期：2015-09-01 00:00:00

abstract：:Observational studies are often in peril of unmeasured confounding. Instrumental variable analysis is a method for controlling for unmeasured confounding. As yet, theory on instrumental variable analysis of censored time-to-event data is scarce. We propose a pseudo-observation approach to instrumental variable analysi...

journal_title：Biometrics

authors： Kjaersgaard MI,Parner ET

更新日期：2016-06-01 00:00:00

abstract：:The distribution of ventilation-perfusion ratio over the lung is a useful indicator of the efficiency of lung function. Information about this distribution can be obtained by observing the retention in blood of inert gases passed through the lung. These retentions are related to the ventilation-perfusion distribution ...

journal_title：Biometrics

authors： Lim LL,Whitehead J

更新日期：1992-03-01 00:00:00