[Preliminary assessment of felbamate effect on the cerebral bioelectrical activity in children with refractory epilepsy].

Abstract:

:Influence Felbamate on the cerebral bioelectric activity (EEG) in the group of 31 children (18 with syndrome Lennox-Gastaut, 13 with partial epilepsy) with refractory epilepsy was investigated. In the waking EEG was visually analysed: 1. Abnormalities distribution and morphology with special consideration of slow waves, sharp elements and paroxysmal character of discharges. 2. Influence of Felbamate on the duration time of discharges. 3. Range dominant frequency and length of segments (with non-disturbed topographic differentiation) of background activity EEG. During therapy the results showed more often EEG improvement among children with syndrome Lennox-Gastaut (near 70%) than in children with partial refractory epilepsy (near 30%). The EEG results correlated positively with the clinical improvement. In the both group of epilepsy background activity improvement had a statistical significance. In sleep EEG any influence of Felbamate on the sleep spindles was observed. No observation about increase beta activity in waking and sleep EEG records was noted.

journal_name

Neurol Neurochir Pol

authors

Pakszys M,Rusek G,Kuszczak B,Szamotulska K,Mazur J

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

203-14

eissn

0028-3843

issn

1897-4260

journal_volume

34 Suppl 1

pub_type

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