Abstract：
BACKGROUND AND PURPOSE:Sporadic amyotrophic lateral sclerosis (sALS) is a devastating neurodegenerative disease, which results from complex genetic and environmental interactions. Recent studies have reported an association between several polymorphisms of the PON1 and PON2 genes and risk of sALS. The aim of the present study was to identify an association between the -A162G polymorphism of the promoter region of the human PON1 gene and the risk of sALS in a Polish population. MATERIAL AND METHODS:We included 259 patients with a diagnosis of definite or probable sALS (76 bulbar onset, 183 limb onset) and 694 healthy controls matched for age and sex. The diagnosis of ALS was established according to El Escorial criteria. The polymorphism was studied by Single Nucleotide Polymorphism Real-Time Polymerase Chain Reaction analysis. RESULTS:No overall difference in the PON1 -A162G geno-type and allele distribution was seen between cases and controls (all p > 0.05). There was, however, a difference in the A allele frequency when the bulbar onset group was compared to the controls (p = 0.03), but this significance disappeared after the Bonferroni correction. CONCLUSIONS:The results did not show that the -A162G polymorphism of the PON1 gene is a risk factor of sALS in a Polish population; it may affect, however, bulbar onset of the disease.
journal_name
Neurol Neurochir Poljournal_title
Neurologia i neurochirurgia polskaauthors
Zawiślak D,Ostrowska M,Golenia A,Marona M,Tomik B,Wołkow P,Gryz-Kurek E,Szczudlik A,Słowik Adoi
10.1016/s0028-3843(14)60038-4subject
Has Abstractpub_date
2010-05-01 00:00:00pages
246-50issue
3eissn
0028-3843issn
1897-4260pii
S0028-3843(14)60038-4journal_volume
44pub_type
杂志文章abstract：:Investigations were performed on 13 cats with epileptogenic focus developed after sectioning the optic chiasm and corpus callosum. Learning was begun 3 months after producing the epileptogenic focus by the aluminium method when it was bioelectrically active. Additionally in 6 cats DPH in daily doses of 10--15 mg/kg wa...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1976-03-01 00:00:00
abstract：BACKGROUND AND PURPOSE:The growing incidence of paediatric brain tumours and improved treatment outcome result in longer survival time. In this context, the issue of palliative treatment is becoming increasingly important. THE AIM of this paper is to assess the role of palliative procedures in the treatment of paediatr...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：2007-07-01 00:00:00
abstract：:The study concerned the method of investigation of upper extremity nerves which makes possible a simultaneous measurement of the conduction velocity in the motor and sensory fibres over the whole length of the nerve. Recording of responses was based on the use of surface electrodes which are safe, less painful for the...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1989-07-01 00:00:00
abstract：:The authors analysed 95 SEEG records in epileptics with prevalent temporal-lobe changes comparing the bioelectric activity of the brain recorded simultaneously in the amygdala, hippocampus, temporal cortex and cranial surface during these investigations and relating them to EEG records obtained before the operation. I...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1979-05-01 00:00:00
abstract：:Dysarthria is an invalidating disability in ALS patients with motor neuron degeneration in the bulbar region. The methods to assess dysarthric disorders in ALS are seldom described in publications. This study was performed in 43 patients who had definite (n = 23) or probable (n = 20) ALS (of the bulbar group n = 15, o...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：2000-03-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Synovial cysts of the spine occur most frequently in the lumbosacral region. Methods of treatment vary, but in cases of chronic pain or neurological deficits surgical intervention is undertaken. The aim of this paper is to present indications, surgical technique and efficacy of surgical treatment...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：10.5114/ninp.2012.31356
更新日期：2012-09-01 00:00:00
abstract：:Stroke morbidity increases with age. That is the reason why it affects especially the middle aged and elderly. Life expectancy is longer for females than males by 10 years, that is why stroke is a major problem in women. Women die twice more frequently from stroke than men (16% vs. 8%). Stroke risk factors are basical...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章,评审
doi：
更新日期：2003-01-01 00:00:00
abstract：:Whipple's disease is a chronic infection caused by Gram-positive bacillus Thropheryma Whippelii picture with a wide range of clinical manifestation, not only systemic but also neurological. Seronegative arthritis or arthralgia may be the only presenting symptom, predating by years gastrointestinal, and also pulmonary,...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章,评审
doi：
更新日期：2002-09-01 00:00:00
abstract：:The reported case was observed in a patient aged 54 years with disseminated lesions in the central nervous system. The history of the disease covered 18 years with periods of exacerbations and remissions. Seven years after the appearance of neurological signs involvement of the internal organs and skin was noted. In t...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1984-09-01 00:00:00
abstract：:The contemporary measures against migraine attacks are not fully satisfying, thus the migraine episode is still a challenge in treatment. In 1993 Hering and Steiner proposed valproic acid for the interruption of migraine attacks. The authors present the results of their own study comparing the effects of sodium valpro...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1995-11-01 00:00:00
abstract：:Plasma exchange under controlled haemodilution was tried in 9 patients with Guillain-Barré syndrome repeating the procedure at 24-hour intervals for from 7 to 17 times with a total exchange of plasma ranging from 2.0 to 4.9 litres. All patients had significant paresis or paralysis of all four extremities, and 3 had ad...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1985-09-01 00:00:00
abstract：OBJECTIVE:Among pineal region lesions meningiomas are extremely rare and include falcotentorial and velum interpositum meningiomas. It is very difficult to discriminate between these two lesions and description of the clinical presentation and the surgical technique in approaching these tumors is limited. We respective...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：10.1016/j.pjnns.2014.09.009
更新日期：2014-01-01 00:00:00
abstract：INTRODUCTION:Gliomas are commonly associated with the development of epilepsy; in some cases the two conditions share common pathogenic mechanisms and may influence each other. Brain tumor related-epilepsy (BTRE) complicates the clinical management of gliomas and can substantially affect daily life. STATE OF THE ART:T...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章,评审
doi：10.1016/j.pjnns.2018.06.001
更新日期：2018-08-01 00:00:00
abstract：:One of the most common children's ailments are headaches--based on literature--about 75% of the population under the age of 15 suffers from them. The aim of the study was to evaluate the influence of headache on the quality of life in children and adolescents. The study group was made up of 86 persons between the age ...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:The authors report the results of EEG monitoring lasting many hours with cassette recording and with interpretation after reproduction on monitor screen. The Medilog 9000 System Oxford was used for that purpose. The group comprised 32 verified cases of epilepsy and 19 cases of seizures with unestablished aetiology. In...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Differential diagnosis in the material was based on the neurological and radiological findings made in 45 patients with third-ventricle tumours and 133 with subtentorial tumours. No clinical syndrome has been found which could help in reliable diagnosis concerning either of these locations of the tumour. Of decisive s...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:During 10 years 15 085 patients were treated at the surgical department of the County Hospital in Wyszków including 415 cases of severe craniocerebral injury (2.7%). The author stressed and justifies the necessity of organization of intensive therapy and resuscitation units at the admission rooms of county hospitals f...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1975-05-01 00:00:00
abstract：:140 patients with stroke (69 men and 71 women) aged 71.7 +/- 12.4 treated in the general neurology were compared with 102 patients (46 men, 56 women) aged 71.5 +/- 11.2 treated in the stroke unit during the period 1.11.95 to 31.10.97. Neurological status and state of environmental dependency during the discharge time ...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：2000-05-01 00:00:00
abstract：:Hydatid disease caused by Echinococcus granulosus and Echinococcus multilocularis commonly presents with pulmonary and hepatic cysts. Primary paraspinal muscle cysts are a rare presentation. We report a case of hydatid cyst within paraspinal muscles presenting with cervical mass and associated pain. The hydatid diseas...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章,评审
doi：10.1016/s0028-3843(14)60110-9
更新日期：2011-07-01 00:00:00
abstract：:In the years 1965-1990 in the hospital department for treatment of spinal injuries 1330 patients with spinal lesions at the C5-Th1 levels were treated after admission early after trauma. The most frequent causes of injuries of this part of the spine were falls from horsecarts, jumping into water head first and traffic...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1992-11-01 00:00:00
abstract：:Factors increasing blood viscosity grow in importance when the blood flow is reduced. Hemorheological parameters determining blood viscosity include hematocrit (Htc), red cells aggregation, red cell deformability, platelet aggregation and plasma viscosity. Platelet abnormalities seem to underlie transient ischemic att...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章,评审
doi：
更新日期：1990-09-01 00:00:00
abstract：:Three cases are presented of familial myasthenia gravis: two sisters and their cousin. Healthy members of this family were also examined. Myasthenia gravis was diagnosed on the ground of the clinical and electrophysiological examination (decrement test and SF EMG with jitter evaluation) as well as of the immunological...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1994-05-01 00:00:00
abstract：:Vertebral haemangioma is a slowly growing benign tumour arising from blood vessels. Haemangioma of the vertebrae is usually asymptomatic. Neurological symptoms occur when haemangioma causes compression of nerve roots or spinal cord. In this paper a case of a 59 year-old woman with, vertebral body L2 haemangioma is rep...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1999-03-01 00:00:00
abstract：INTRODUCTION:Patients with obstructive sleep apnoea syndrome (OSAS) can be more prone to accidents due to excessive daytime sleepiness which can lead to attention deficits and thereby cause balance problems. One of the tests evaluating postural balance is static posturography (SPG). In this study, we aimed to evaluate ...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：10.5603/PJNNS.a2019.0059
更新日期：2020-01-01 00:00:00
abstract：:A giant, unclippable right ICA aneurysm located partially intracavernously is reported with neck deriving at C3 level. The aneurysm caused optic chiasm compression, progressive left eye vision loss and exophthalmus as well as persistent headache. The presence of the aneurysm was first found in CT and confirmed by angi...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：2000-11-01 00:00:00
abstract：:The authors used hydrocortisone POLFA injecting it paravertebrally in painful syndromes of the cervical spine. The clinical material comprised 50 patients divided into groups A and B of 25 patients each. In both groups typical anti-inflammatory and analgesic agents and muscle relaxants were given and physiotherapy was...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1976-09-01 00:00:00
abstract：OBJECT:Intramedullary hemangioblastomas are rare lesions. They can be related to von Hippel-Lindau syndrome or they may be sporadic. This study describes surgical treatment for this infrequent tumor. METHODS:Twelve consecutive patients received surgery to remove sporadic or von Hippel-Lindau syndrome-associated intram...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：10.1016/j.pjnns.2016.06.003
更新日期：2016-01-01 00:00:00
abstract：:For assessment of the effect of trihexiphenidil on the excitability state of the alpha-motoneurons of the plantar flexor of the foot in patients with drug-induced parkinsonian rigidity curves of the excitability of motoneurons of the soleus muscle were plotted in two variants of experiments: I. with afferent stimulati...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
abstract：:The author analysed 124 cases of grand mal seizures in patients aged above 16 years observed for 2 to 15 years finding sporadic tongue or oral mucosa biting in 55.7% of cases, involuntary passing of urine in 49%, simultaneous occurrence of both these signs in 37% defection in 8.1%, ejaculation in 1.6%, conjunctival o ...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：1984-05-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Migraine is a common neurologic disorder whose etiology remains unknown. Migraine has been reported as a possible risk factor for ischemic stroke, especially in young women. The relationship between migraine and stroke is stronger in patients suffering from migraine with aura compared to those wi...
journal_title：Neurologia i neurochirurgia polska
pub_type： 杂志文章
doi：
更新日期：2004-03-01 00:00:00
